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11. 发明授权

US09403874B2 Peptides and use thereof 有权
标题翻译：肽及其用途
公开(公告)号：US09403874B2
公开(公告)日：2016-08-02
申请号：US14412020
申请日：2013-07-03
申请人： IL YANG PHARM. CO.,LTD. , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SOOKMYUNG WOMEN'S UNIVERSITY , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： Dae Ho Cho , Min Kyung Jung , Soo Gyeong Ha , Jeong Min Park , Jin Young Lee , Sang Yoon Kim , Seung Beom Park , Hee Jong Kim , Hyun Soo Ju , Si Nae Lee , Hae Kyoung Lim , Sa Ik Bang
IPC分类号： C07K7/08 , C07K7/06 , C07K5/083 , C07K5/09 , C07K5/11 , C07K5/072 , C07K5/068 , A23L1/305 , C07K5/087 , A61K38/00
CPC分类号： C07K7/08 , A23L33/18 , A23V2002/00 , A61K38/00 , C07K5/06086 , C07K5/06095 , C07K5/06113 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K7/06
摘要： The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (OTC) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.
摘要翻译：本发明涉及新型肽及其用途，更具体地涉及具有抗炎作用的肽，编码该肽的多核苷酸，包含用于预防或治疗炎性疾病的肽或多核苷酸的药物组合物，抗炎药，包含用于预防或改善炎症的肽的非处方药（OTC）药物组合物，用于缓解或改善炎症的保健食品组合物，用于预防或改善炎症的化妆品组合物，治疗炎性疾病的方法，包括给予涉及怀疑患有炎性疾病的受试者的药物组合物，制备肽模拟物的方法及其设计方法。

12. 发明申请

US20150353601A1 COMPOUNDS FOR ENZYME INHIBITION 审中-公开
标题翻译：用于酶抑制的化合物
公开(公告)号：US20150353601A1
公开(公告)日：2015-12-10
申请号：US14591351
申请日：2015-01-07
申请人： Onyx Therapeutics, Inc.
发明人： Kevin D. Shenk , Francesco Parlati , Han-jie Zhou , Catherine Sylvain , Mark S. Smyth , Mark K. Bennett , Guy J. Laidig
IPC分类号： C07K5/107 , C07K5/087 , C07K5/093 , C07K5/083 , C07K5/097
CPC分类号： C07K5/1016 , A61K38/00 , C07D303/32 , C07D405/12 , C07D409/12 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06113 , C07K5/08 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K5/1008 , Y02A50/409 , Y02A50/411 , Y02A50/491
摘要： One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.
摘要翻译：本发明的一个方面涉及优先抑制免疫蛋白酶体活性超过组成型蛋白酶体活性的抑制剂。在某些实施方案中，本发明涉及治疗免疫相关疾病，包括施用本发明的化合物。在某些实施方案中，本发明涉及治疗癌症，包括施用本发明的化合物。

13. 发明申请

US20150297735A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS 有权
标题翻译：用于治疗由PSMA表达细胞引起的疾病的结合物
公开(公告)号：US20150297735A1
公开(公告)日：2015-10-22
申请号：US14443212
申请日：2013-11-14
申请人： ENDOCYTE, INC.
发明人： Iontcho Radoslavov VLAHOV , Joseph Anand REDDY , Alicia BLOOMFIELD , Ryan DORTON , Melissa NELSON , Marilynn VETZEL , Christopher Paul LEAMON
IPC分类号： A61K47/48 , A61K38/05
CPC分类号： A61K47/64 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/542 , A61K47/547 , A61K49/0002 , A61K51/04 , C07K5/021 , C07K5/06113 , C07K5/10 , C07K5/1019
摘要： The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
摘要翻译：本文描述的本发明涉及致病细胞群体的诊断，成像和/或治疗。特别地，本文描述的发明涉及使用能够靶向表达PSMA的细胞的化合物来诊断，成像和/或治疗由表达PSMA的细胞引起的疾病，例如前列腺癌细胞。

14. 发明授权

US09067084B2 Amphiphilic linear peptide/peptoid and hydrogel comprising the same 有权
标题翻译：两亲性线性肽/拟肽和包含其的水凝胶
公开(公告)号：US09067084B2
公开(公告)日：2015-06-30
申请号：US13638152
申请日：2010-12-15
申请人： Charlotte A. E. Hauser , Ulung Gondo Kusumo Khoe , Archana Mishra
发明人： Charlotte A. E. Hauser , Ulung Gondo Kusumo Khoe , Archana Mishra
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N5/00 , C12N5/02 , A61Q19/00 , A61K8/04 , A61K8/64 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/103 , C07K7/06
CPC分类号： A61L27/22 , A61K8/042 , A61K8/64 , A61K38/00 , A61L27/52 , A61L27/54 , A61L2430/00 , A61Q19/00 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06104 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/1008 , C07K5/101 , C07K7/06
摘要： The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear peptide/peptoid is capable of forming a hydrogel. These peptides/peptoids include short amphiphilic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such peptides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
摘要翻译：本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的水凝胶。两亲性线性肽/拟肽能够形成水凝胶。这些肽/拟肽包括具有脂族氨基酸的疏水部分和至少一种酸性，中性或碱性极性氨基酸的短两亲序列。两亲性线性肽/拟肽是由非重复脂肪族氨基酸组成的，它们可以是L-或D-形式。多个这样的肽/拟肽组装成超分子螺旋纤维，并在组装后形成肽水凝胶。在生理pH下在水溶液中形成相应的水凝胶，因此可用于特别是细胞培养，组织工程和药物释放。这种刚性，生物相容性和捕获高达99.9％的水的水凝胶也非常适合于利用电子设备的应用。

15. 发明授权

US09066901B2 C-Met receptor regulation by angiotensin IV (AT4) receptor ligands 有权
标题翻译：血管紧张素IV（AT4）受体配体的C-Met受体调节
公开(公告)号：US09066901B2
公开(公告)日：2015-06-30
申请号：US13547601
申请日：2012-07-12
申请人： Joseph W. Harding , John W. Wright , Patrick D. Elias , Brent J. Yamamoto , Leen H. Kawas
发明人： Joseph W. Harding , John W. Wright , Patrick D. Elias , Brent J. Yamamoto , Leen H. Kawas
IPC分类号： A61K38/22 , C07K14/475 , A61K38/00 , A61P3/04 , A61P25/00 , C07K14/47 , A61K38/08 , A61K38/18 , C07K14/705 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/11 , C07K5/113 , G01N33/50 , G01N33/68 , C07K5/107 , C07K5/083 , C07K5/065 , C07K5/072 , C07K5/062 , C07K5/068
CPC分类号： A61K38/085 , A61K38/1833 , C07K5/06034 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06113 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/101 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K14/705 , G01N33/502 , G01N33/5023 , G01N33/6893 , G01N2800/044
摘要： Angiotensin-like factor compositions and methods for using them to diagnose, prevent and/or treat conditions associated with c-Met dysregulation, are provided. The conditions include cancer, obesity, conditions associated with obesity, and neurodegenerative diseases such as general dementia, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, traumatic brain injury and spinal cord trauma.
摘要翻译：提供血管紧张素样因子组合物及其用于诊断，预防和/或治疗与c-Met失调相关的病症的方法。条件包括癌症，肥胖症，与肥胖相关的病症，以及神经变性疾病如一般性痴呆，阿尔茨海默病，帕金森病，肌萎缩性侧索硬化，创伤性脑损伤和脊髓创伤。

16. 发明申请

US20150111828A1 DIPEPTIDE MIMETICS OF NGF AND BDNF NEUROTROPHINS 有权
标题翻译：神经生长因子和BDNF神经营养因子的神经递质
公开(公告)号：US20150111828A1
公开(公告)日：2015-04-23
申请号：US14460881
申请日：2014-08-15
申请人： UCHREZHDENIE ROSSIISKOI AKADEMII MEDITSYNSKIKH NAUK NAUCHNO-ISSLEDOVATELSKY INSTITUT FARMAKOLOGII
发明人： Sergey Borisovich SEREDENIN , Alexandrovna Tatyana GUDASHEVA
IPC分类号： C07K5/072 , C07K5/062 , C07K5/068
CPC分类号： C07K5/06104 , A61K38/00 , C07K5/02 , C07K5/06 , C07K5/06026 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06113
摘要： The invention relates to compounds having either agonist or antagonist activities for the neurotrophins NGF and BDNF and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure. The dimeric structure is produced advantageously by using hexamethylenediamine to which dipeptides are attached via their carboxyl groups. The claimed compounds displayed neuroprotective and differentiation-inducing activities in cellular models and enhanced the amount of phosphorylated tyrosine kinase A and the heat shock proteins Hsp32 and Hsp70 in the concentration range of 10−9 to 10−5 M. They also displayed neuroprotective, anti-parkinsonian, anti-stroke, anti-ischemic, anti-depressant and anti-amnestic activities in animal models and were active in experimental models of Alzheimer's disease. These in vivo effects of the claimed compounds are displayed in the dose range of 0.01 to 10 mg/kg when administered intraperitoneally.
摘要翻译：本发明涉及具有针对神经营养蛋白NGF和BDNF的激动剂或拮抗剂活性的化合物，并且由单体或二聚取代的二肽代表，所述二肽是这些神经营养因子的环1或环4区域的暴露部分的类似物，接近或处于β-转角各自的循环。这些二肽的N-酰化取代基是神经营养蛋白一级结构中这些二肽序列之前的氨基酸残基的生物立体异构体。通过使用通过其羧基连接二肽的六亚甲基二胺有利地产生二聚结构。所要求保护的化合物在细胞模型中显示神经保护和分化诱导活性，并且在10-9至10-5M的浓度范围内增强磷酸化酪氨酸激酶A和热休克蛋白Hsp32和Hsp70的量。它们还显示神经保护，抗帕金森病，抗中风，抗缺血，抗抑郁和抗惊厥活动，并在阿尔茨海默病的实验模型中活跃。当腹膜内给药时，所要求保护的化合物的这些体内作用以0.01至10mg / kg的剂量范围显示。

17. 发明授权

US08993780B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators 有权
标题翻译： N-脲取代氨基酸的酰胺衍生物作为甲酰肽受体1（FPRL-1）受体调节剂
公开(公告)号：US08993780B2
公开(公告)日：2015-03-31
申请号：US14102145
申请日：2013-12-10
申请人： Allergan, Inc.
发明人： Richard L. Beard , Tien T. Duong , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： C07C275/30 , C07C317/50 , C07C323/44 , C07D233/64 , C07C317/42 , C07D209/20 , C07K5/062 , C07K5/078 , C07K5/072 , C07C323/60
CPC分类号： A61K31/417 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/4045 , C07C275/30 , C07C317/42 , C07C317/50 , C07C323/44 , C07C323/60 , C07D209/20 , C07D233/64 , C07K5/06017 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K5/06113 , C07K5/06147 , C07K5/06156 , Y02A50/401
摘要： The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译：本发明涉及N-脲取代氨基酸的新型酰胺衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。

18. 发明授权

US08993717B2 Gadd45beta targeting agents 有权
标题翻译： Gadd45beta靶向剂
公开(公告)号：US08993717B2
公开(公告)日：2015-03-31
申请号：US13502781
申请日：2010-10-22
申请人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
发明人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K5/107 , C07K5/065 , C07K5/072 , C07K5/087
CPC分类号： C07K5/08 , A61K38/00 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0812 , C07K5/1016
摘要： Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
摘要翻译：基于四肽，三肽和二肽的化合物和相应的肽酶。用于治疗癌症，炎性疾病和其他疾病的相关方法和药物组合物。

19. 发明申请

US20140328868A1 T-CELL ANTIGEN PEPTIDE FROM ALLERGEN FOR STIMULATION OF IL-10 PRODUCTION 审中-公开
标题翻译：来自用于刺激IL-10生产的过敏原的T细胞抗原肽
公开(公告)号：US20140328868A1
公开(公告)日：2014-11-06
申请号：US14268702
申请日：2014-05-02
申请人： Circassia Limited
发明人： Mark LARCHE , Roderick Peter HAFNER , Paul LAIDLER
IPC分类号： A61K39/35
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/577 , C07K5/06113 , C07K5/1008 , C07K5/1021 , C07K14/43531 , C07K14/705
摘要： A first or second polypeptide for use in a method of treating or preventing a disorder by tolerisation, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterised by an inappropriate immune response to the protein allergen from which the second polypeptide derives.
摘要翻译：用于通过耐受治疗或预防病症的方法中的第一或第二多肽，其中所述方法包括施用第一和第二多肽; 并且其中第一和第二多肽均为：i）长度为7至30个氨基酸; ii）包含至少一种MHC II类结合T细胞表位; 和iii）是蛋白质变应原或所述片段的同源变体的片段; 其中所述第一多肽诱导释放一定量的IL-10，其量大于响应于第一多肽衍生的全蛋白变应原释放的IL-10的量; 其中所述病症的特征在于对第二多肽衍生的蛋白质过敏原的不适当的免疫应答。

20. 发明申请

US20140303080A1 N-ACYLDIPEPTIDE DERIVATIVES AND THEIR USES 有权
标题翻译： N-亚胺代谢衍生物及其用途
公开(公告)号：US20140303080A1
公开(公告)日：2014-10-09
申请号：US14354711
申请日：2012-10-31
申请人： Ruey J. Yu , Eugene J. Van Scott
发明人： Ruey J. Yu , Eugene J. Van Scott
IPC分类号： C07K5/062 , C07K5/065 , A61Q19/08 , C07K5/06 , A61Q19/00 , A61Q5/00 , A61K8/64 , C07K5/078
CPC分类号： A61K8/64 , A61K8/671 , A61K9/0014 , A61K31/07 , A61K38/05 , A61K2800/10 , A61K2800/92 , A61Q5/00 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07K5/00 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06113 , C07K5/06147 , C07K5/06156 , C07K5/06165 , C07K5/06191 , Y02A50/463
摘要： N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject.
摘要翻译：描述N-酰基二肽衍生物。包含N-酰基二肽衍生物的组合物对于局部或全身给药是治疗有效的，以缓解或改善与肿瘤，癌症，免疫，神经，血管，肌肉骨骼或皮肤系统或其他组织相关的病症，疾病，症状或综合征，或系统在一个主题。

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