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11. 发明申请

US20150164750A1 Dental Restorative Materials Based on Polymerizable Azides and Alkynes 有权
标题翻译：基于可聚合叠氮化物和炔烃的牙科修复材料
公开(公告)号：US20150164750A1
公开(公告)日：2015-06-18
申请号：US14569894
申请日：2014-12-15
申请人： Ivoclar Vivadent AG
发明人： Norbert Moszner , Peter Burtscher , Ulrich S. Schubert , Martin Hager , Bobby Happ , Benedict Sandmann
IPC分类号： A61K6/087 , C08G73/00
CPC分类号： A61K6/087 , A61K6/0023 , C07D251/54 , C07D493/10 , C08G63/52 , C08G63/676 , C08G73/00 , C08G73/0605 , C08L33/10
摘要： The invention relates to a dental restorative material on the basis of at least one compound of one of the Formulae The invention also relates to the use of the dental restorative materials according to the invention for preparing dental composites, preferably composite blanks, which are suitable in particular for mechanical processing by means of computer-aided processing techniques such as milling and grinding processes, and which are suitable above all for preparing dental restoration materials such as inlays, onlays, crowns, bridges or veneering materials.
摘要翻译：本发明涉及基于至少一种本发明之一的化合物的牙齿修复材料。本发明还涉及根据本发明的牙齿修复材料用于制备牙科复合材料，优选复合材料坯料的应用，其适用于特别用于通过计算机辅助加工技术如铣削和磨削工艺进行机械加工，并且首先适用于制备诸如镶嵌，镶嵌，冠，桥或镶嵌材料的牙科修复材料。

12. 发明申请

US20150087532A1 AFFINITY REAGENTS FOR PROTEIN PURIFICATION 有权
标题翻译：蛋白质纯化的亲和试剂
公开(公告)号：US20150087532A1
公开(公告)日：2015-03-26
申请号：US14385586
申请日：2013-03-15
申请人： Impossible Foods Inc. , The Board of Trustees of the Leland Stanford Junior University
发明人： Patrick Brown , R. Edward Watts , Pehr Harbury
IPC分类号： B01J20/281 , C07D251/54 , G01N33/68
CPC分类号： B01J20/281 , A61K31/53 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3248 , B01J20/3251 , C07D251/54 , C07D251/70 , C07K1/22 , G01N33/543 , G01N33/6818
摘要： Disclosed herein are methods and compositions for purifying proteins from crude solutions.
摘要翻译：本文公开了用于从粗溶液中纯化蛋白质的方法和组合物。

13. 发明申请

US20140371224A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES 有权
标题翻译：用于治疗呼吸控制疾病或疾病的新型化合物和组合物
公开(公告)号：US20140371224A1
公开(公告)日：2014-12-18
申请号：US14473229
申请日：2014-08-29
申请人： GALLEON PHARMACEUTICALS, INC.
发明人： JAMES C. MANNION , SCOTT L. DAX , DUNCAN EUAN MACINTYRE , FRANCIS JOHN GOLDER , JAMES FRANCIS MCLEOD
IPC分类号： C07D251/54
CPC分类号： A61K31/53 , A61K31/505 , A61K31/519 , A61K31/522 , A61K31/5355 , A61K31/57 , A61K45/06 , C07D251/44 , C07D251/54 , C07D401/14 , C07D403/12 , C07D413/04 , C07D487/04 , A61K2300/00
摘要： The present invention includes compounds, and compositions comprising the same, that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.
摘要翻译：本发明包括可用于治疗有需要的受试者的呼吸控制疾病或病症的化合物及其组合物。本发明还包括治疗有需要的受试者的呼吸系统疾病或病症的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还包括在有需要的受试者中防止不稳定或稳定呼吸节律的方法，包括向受试者施用治疗有效量的本发明化合物。

14. 发明申请

US20140357634A1 SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES 有权
标题翻译：取代的4-氨基羰基衍生物
公开(公告)号：US20140357634A1
公开(公告)日：2014-12-04
申请号：US14459540
申请日：2014-08-14
申请人： GRÜNENTHAL GMBH
发明人： BERT NOLTE , WOLFGANG SCHRÖDER , KLAUS LINZ , WERNER ENGLBERGER , HANS SCHICK , HEINZ GRAUBAUM , BIRGIT ROLOFF , SIGRID OZEGOWSKI , JÓZSEF BÁLINT , HELMUT SONNENSCHEIN
IPC分类号： C07D209/20 , A61K45/06 , C07D403/08 , C07C211/54 , A61K31/136 , A61K31/5377 , A61K31/165 , C07C311/37 , A61K31/18 , C07D251/48 , A61K31/53 , A61K31/404 , C07C237/24
CPC分类号： C07D209/20 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , A61K45/06 , C07C211/40 , C07C211/54 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C237/24 , C07C275/24 , C07C311/07 , C07C311/18 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/48 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译：本发明涉及对μ-阿片受体和ORL1-受体具有亲和性的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。

15. 发明授权

US08796449B2 s-Triazine compounds, pharmaceutical compositions and methods of using the same 有权
标题翻译： s-三嗪化合物，药物组合物及其使用方法
公开(公告)号：US08796449B2
公开(公告)日：2014-08-05
申请号：US13049988
申请日：2011-03-17
申请人： Neville Robert Kallenbach
发明人： Neville Robert Kallenbach
IPC分类号： C07D251/70 , C07D403/12 , C07D403/14 , A61K31/53 , A61P31/04
CPC分类号： C07D251/54 , A61K31/53 , C07D251/70 , C07D403/12 , C07D403/14 , Y02A50/473
摘要： Novel s-triazine compounds are disclosed that have a formula represented by the following: L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.
摘要翻译：公开了具有下列表示的式的新型三嗪化合物：L1，L2，L3，R1，R2，R3，R4，R5a，R5b和R5c如本文所述。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，其中微生物感染是直接原因或相关病症。

16. 发明申请

US20140147397A1 STABLE AMORPHOUS SOLID FORM OF A TRIAZINE DERIVATIVE AND THE CORRESPONDING MANUFACTURING PROCESS 审中-公开
标题翻译： TRIAZINE衍生物的稳定非晶态固体形式和相应的制造工艺
公开(公告)号：US20140147397A1
公开(公告)日：2014-05-29
申请号：US13750329
申请日：2013-01-25
申请人： 3V SIGMA S.P.A.
发明人： Ferruccio BERTE' , Francesco MAESTRI , Luca BEMPORAD , Massimo FABBI
IPC分类号： C07D251/54
CPC分类号： C07D251/54 , A61K8/0245 , A61K8/4966 , A61Q17/04
摘要： Disclosed is an amorphous solid form of the compound of formula (I), characterised by an exothermic transition at temperatures lower than 125° C., determined by differential scanning calorimetry (DSC).
摘要翻译：公开了式（I）化合物的无定形固体形式，其特征在于通过差示扫描量热法（DSC）测定的低于125℃的放热转变。

17. 发明申请

US20130281692A1 TRIAZINE DERIVATIVES 有权
标题翻译： TRIAZINE衍生物
公开(公告)号：US20130281692A1
公开(公告)日：2013-10-24
申请号：US13492525
申请日：2012-06-08
申请人： Francesco Maestri , Luca Bemporad , Ferruccio Berte'
发明人： Francesco Maestri , Luca Bemporad , Ferruccio Berte'
IPC分类号： C07D413/12 , C07D251/54
CPC分类号： C07D413/12 , C07D251/54 , C07D413/14
摘要： The invention relates to novel intermediates for the preparation of substituted triazines used in particular in the cosmetic, detergent, coating, plastics and textile industries. The invention also relates to the processes for preparation of said intermediates and for the conversion of the latter into final products.
摘要翻译：本发明涉及用于制备特别用于化妆品，洗涤剂，涂料，塑料和纺织工业中的取代三嗪的新型中间体。本发明还涉及制备所述中间体并将其转化成最终产物的方法。

18. 发明授权

US08323624B2 S-triazine sunscreens bearing hindered para-aminobenzalmalonate/para-aminobenzalmalonamide and aminobenzoate/aminobenzamide substituents 有权
标题翻译：带有受阻对氨基苯甲醛丙二酸酯/对氨基苯甲醛丙二酰胺和氨基苯甲酸酯/氨基苯甲酰胺取代基的S-三嗪防晒剂
公开(公告)号：US08323624B2
公开(公告)日：2012-12-04
申请号：US11214865
申请日：2005-08-31
申请人： Herve Richard , Catherine Lejuste
发明人： Herve Richard , Catherine Lejuste
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04 , C07D403/00 , C07D251/54 , C07D251/18 , C07D251/48
CPC分类号： C07D251/54 , A61K8/4966 , A61Q17/04
摘要： Novel s-triazine sunscreens have the structural formula (I): and are formulated into cosmetic/dermatological photoprotective compositions useful for photoprotecting keratinous substances against the damaging effects of UV-radiation.
摘要翻译：新型s-三嗪防晒剂具有结构式（I）：并且被配制成用于光保护角质物质以抵抗UV辐射的损伤作用的化妆品/皮肤病学光保护组合物。

19. 发明申请

US20120238171A1 Concentrated Storage-Stable Aqueous Optical Brightening Solutions 有权
标题翻译：浓缩储存稳定的水性荧光增白溶液
公开(公告)号：US20120238171A1
公开(公告)日：2012-09-20
申请号：US13513369
申请日：2010-12-01
申请人： Cedric Klein , Frederic Reveaud , David Puddiphatt , Andrew Clive Jackson
发明人： Cedric Klein , Frederic Reveaud , David Puddiphatt , Andrew Clive Jackson
IPC分类号： C09K11/06 , D04H13/00 , D21H17/09
CPC分类号： C07D251/54 , D21H21/30 , Y10T428/249921 , Y10T442/2582 , Y10T442/60
摘要： Concentrated storage stable aqueous solutions (S) comprising components (a), (b) and (c), wherein component (a) is at least one optical brightening agent of formula (1), in which the anionic charge on the brightener is balanced by a cationic charge composed of one or more cations selected from the group consisting of hydrogen, alkali metal cation, alkaline earth metal cation, ammonium, ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched alkyl radical and ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched hydroxyalkyl radical, and the concentration of component (a) is 0.08 to 0.3 mol per kg, based on the total weight of the concentrated storage-stable aqueous solutions (S), component (b) is at least one inorganic salt (SA), in a concentration of 2 to 15% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S), and component (c) is water, in a concentration of 10% to 88% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S).
摘要翻译：包含组分（a），（b）和（c）的浓缩储存稳定的水溶液（S），其中组分（a）是至少一种式（1）的荧光增白剂，其中增白剂上的阴离子电荷是平衡的通过由一个或多个选自氢，碱金属阳离子，碱土金属阳离子，铵，铵，被C 1-4直链或支链烷基单，二或三取代的阳离子组成的阳离子电荷，以及铵，其是由C 1-4直链或支链羟烷基单取代，二取代或三取代的，并且组分（a）的浓度基于浓缩储存稳定水溶液的总重量为0.08至0.3mol / kg （S）中，成分（b）为至少一种无机盐（SA），浓度为2〜15重量％，基于浓缩储存稳定水溶液（S）的总重量，成分（c ）为基于总W的浓度为10％至88％重量的水八个浓缩储存稳定的水溶液（S）。

20. 发明授权

US08227466B2 Prostaglandin transporter inhibitors 有权
标题翻译：前列腺素转运蛋白抑制剂
公开(公告)号：US08227466B2
公开(公告)日：2012-07-24
申请号：US12227267
申请日：2007-05-15
申请人： Victor L. Schuster , Yuling Chi , Young-Tae Chang , Jaeki Min
发明人： Victor L. Schuster , Yuling Chi , Young-Tae Chang , Jaeki Min
IPC分类号： A61K31/53 , C07D251/54
CPC分类号： A61K31/53 , A61K31/713 , C07D251/54 , G01N33/68
摘要： Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided.
摘要翻译：提供了哺乳动物抑制前列腺素转运蛋白（PGT）活性的方法。还提供了确定测试化合物是否为前列腺素转运蛋白抑制剂的方法。另外提供了抑制前列腺素转运蛋白活性的化合物和那些化合物的药物组合物。还提供了抑制哺乳动物中COX-2的方法。另外，提供了治疗哺乳动物疼痛或炎症的方法。

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