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    • 11. 发明授权
    • Soft .beta.-adrenergic blocking agents
    • 软β-肾上腺素能阻滞剂
    • US5135926A
    • 1992-08-04
    • US692260
    • 1991-04-26
    • Nicholas S. Bodor
    • Nicholas S. Bodor
    • C07C217/36
    • C07C217/36C07C2101/14C07C2101/18C07C2102/42C07C2103/74
    • New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p - (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
    • 可用于治疗或预防心血管疾病和治疗青光眼的新型软β-肾上腺素能阻断剂具有式(I)其中n为0至10的整数; R为C6-C12环烷基-C1H2p-,C6-C18多环烷基-C1H2p-,C6-C18多环烯基-C1H2p-或C6-C12环烯基-C1H2p-(其中p为0,1,2或3),或与 相邻的组代表各种其他复杂的酯基团; R1是C1-C7烷基; 并且Ar是含有至少一个芳香核的二价基团。 还描述了相应的药学上可接受的酸加成盐。