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11. 发明授权

US5135926A Soft .beta.-adrenergic blocking agents 失效
标题翻译：软β-肾上腺素能阻滞剂
公开(公告)号：US5135926A
公开(公告)日：1992-08-04
申请号：US692260
申请日：1991-04-26
申请人： Nicholas S. Bodor
发明人： Nicholas S. Bodor
IPC分类号： C07C217/36
CPC分类号： C07C217/36 , C07C2101/14 , C07C2101/18 , C07C2102/42 , C07C2103/74
摘要： New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p - (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
摘要翻译：可用于治疗或预防心血管疾病和治疗青光眼的新型软β-肾上腺素能阻断剂具有式（I）其中n为0至10的整数; R为C6-C12环烷基-C1H2p-，C6-C18多环烷基-C1H2p-，C6-C18多环烯基-C1H2p-或C6-C12环烯基-C1H2p-（其中p为0,1,2或3），或与相邻的组代表各种其他复杂的酯基团; R1是C1-C7烷基; 并且Ar是含有至少一个芳香核的二价基团。还描述了相应的药学上可接受的酸加成盐。

12. 发明授权

US08906979B2 Macrophotoinitiators 有权
标题翻译：大分子引发剂
公开(公告)号：US08906979B2
公开(公告)日：2014-12-09
申请号：US13386954
申请日：2010-07-26
申请人： Markus Frey , Christophe Frossard , Katia Studer , Bruno Spony , Patrizia Sgambati
发明人： Markus Frey , Christophe Frossard , Katia Studer , Bruno Spony , Patrizia Sgambati
IPC分类号： G03F7/031 , C08F2/46 , C07C221/00 , C07C67/00 , C07C225/10 , C07C69/00 , C07C217/36 , C07C219/06 , C08F2/50
CPC分类号： C07C217/36 , C07C219/06 , C08F2/50 , G03F7/031
摘要： The invention pertains to high-molecular photoinitiator compounds comprising a photoactive moiety Q and an amine functionality, preferably a tertiary amino group, where the photoactive moiety Q is a benzoyl photoactive moiety.
摘要翻译：本发明涉及包含光活性部分Q和胺官能团，优选叔氨基的高分子光引发剂化合物，其中光活性部分Q是苯甲酰基光活性部分。

13. 发明授权

US07365085B2 Compounds and methods 有权
标题翻译：化合物和方法
公开(公告)号：US07365085B2
公开(公告)日：2008-04-29
申请号：US10508894
申请日：2003-03-26
申请人： Ajita Bhat , John Jeffrey McAtee , Scott K. Thompson , James S. Frazee , Lara S. Kallander , Chun Ma , Joseph Marino , Michael J. Neeb , Robert A. Stavenger
发明人： Ajita Bhat , John Jeffrey McAtee , Scott K. Thompson , James S. Frazee , Lara S. Kallander , Chun Ma , Joseph Marino , Michael J. Neeb , Robert A. Stavenger
IPC分类号： A01N43/40 , A01N43/64 , A01N43/08 , A61K31/44 , A61K31/41
CPC分类号： C07C311/29 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/36 , C07C219/22 , C07C229/34 , C07C233/25 , C07C271/28 , C07C275/34 , C07C291/02 , C07C309/73 , C07C311/08 , C07C311/09 , C07C311/21 , C07C323/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D211/34 , C07D211/60 , C07D213/38 , C07D213/64 , C07D213/74 , C07D231/14 , C07D233/64 , C07D239/42 , C07D249/08 , C07D257/04 , C07D295/096 , C07D295/125 , C07D295/185 , C07D307/66 , C07D307/68 , C07D317/58 , C07D317/68 , C07D319/18 , C07D333/20
摘要： Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
摘要翻译：公开了具有下式的化合物：其药学上可接受的盐或溶剂化物和含有该化合物的药物组合物，其中结构变量如本文所定义。本发明的化合物，盐和溶剂化物可用作LXR激动剂。

14. 发明申请

US20070155819A1 Calcilytic compounds 审中-公开
标题翻译：钙化合物
公开(公告)号：US20070155819A1
公开(公告)日：2007-07-05
申请号：US10587626
申请日：2005-02-04
申请人： Robert Marquis , Joshi Ramanjulu , Linda Casillas
发明人： Robert Marquis , Joshi Ramanjulu , Linda Casillas
IPC分类号： A61K31/277 , A61K31/22
CPC分类号： A61K31/22 , A61K31/277 , A61K45/06 , C07C217/36 , C07C219/06 , C07C255/57 , C07C2601/02 , C07C2602/08 , A61K2300/00
摘要： Novel calcilytic compounds and methods of using them are provided.
摘要翻译：提供新的钙质化合物及其使用方法。

15. 发明申请

US20040147575A1 Nitrate salts of antihypertensive medicines 审中-公开
标题翻译：抗高血压药物的硝酸盐
公开(公告)号：US20040147575A1
公开(公告)日：2004-07-29
申请号：US10671746
申请日：2003-09-29
申请人： Nicox S.A.
发明人： Piero Del Soldato
IPC分类号： A61K031/4178 , C07D49/02 , C07D43/02
CPC分类号： C07D257/04 , C07C211/27 , C07C215/30 , C07C215/38 , C07C217/12 , C07C217/22 , C07C217/30 , C07C217/32 , C07C217/34 , C07C217/36 , C07C233/25 , C07C235/06 , C07C235/34 , C07C235/60 , C07C237/30 , C07C255/43 , C07C255/54 , C07C311/44 , C07C2601/02 , C07C2601/08 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07D211/12 , C07D211/90 , C07D221/18 , C07D237/34 , C07D239/50 , C07D241/26 , C07D285/10 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/13 , C07D295/15 , C07D403/10 , C07D487/04
摘要： Nitric acid salts with medicines having an antihypertensive activity.

16. 发明授权

US5482961A Soft .beta.-adrenergic blocking agents 失效
公开(公告)号：US5482961A
公开(公告)日：1996-01-09
申请号：US239414
申请日：1994-05-06
申请人： Nicholas S. Bodor
发明人： Nicholas S. Bodor
IPC分类号： C07C69/732 , C07C217/36 , C07C235/06 , C07D209/18 , C07D215/22 , C07D215/227 , C07D295/185 , C07D307/54 , A61K31/40 , A61K31/215 , C07C235/34 , C07D209/43
CPC分类号： C07C217/36 , C07C235/06 , C07C69/732 , C07D209/18 , C07D215/227 , C07D295/185 , C07D307/54 , C07C2101/14 , C07C2101/18 , C07C2102/42 , C07C2103/74 , Y10S514/912
摘要： New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p -- or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p -- (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.

17. 发明授权

US5334601A Soft .beta.-adrenergic blocking agents 失效
标题翻译：软β-肾上腺素能阻滞剂
公开(公告)号：US5334601A
公开(公告)日：1994-08-02
申请号：US997248
申请日：1992-12-28
申请人： Nicholas S. Bodor
发明人： Nicholas S. Bodor
IPC分类号： C07C69/732 , C07C217/36 , C07C235/06 , C07D209/18 , C07D215/22 , C07D215/227 , C07D295/185 , C07D307/54 , A61K31/34 , A61K31/405 , C07D209/08 , C07D307/83
CPC分类号： C07C217/36 , C07C235/06 , C07C69/732 , C07D209/18 , C07D215/227 , C07D295/185 , C07D307/54 , C07C2101/14 , C07C2101/18 , C07C2102/42 , C07C2103/74 , Y10S514/912
摘要： New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p - (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
摘要翻译：可用于治疗或预防心血管疾病和治疗青光眼的新型软β-肾上腺素能阻断剂具有式（I）其中n为0至10的整数; R为C6-C12环烷基-C1H2p-，C6-C18多环烷基-C1H2p-，C6-C18多环烯基-C1H2p-或C6-C12环烯基-C1H2p-（其中p为0,1,2或3），或与相邻的组代表各种其他复杂的酯基团; R1是C1-C7烷基; 并且Ar是含有至少一个芳香核的二价基团。还描述了相应的药学上可接受的酸加成盐。

18. 发明授权

US4958046A Hydroxypropafenone glycerides 失效
标题翻译：羟基丙泊酚酮甘油酯
公开(公告)号：US4958046A
公开(公告)日：1990-09-18
申请号：US410050
申请日：1989-09-19
申请人： Joerg Rosenberg , Juergen Heberger , Hans-Heinrich Gruenhagen , Egon Brode , Gerda von Philipsborn
发明人： Joerg Rosenberg , Juergen Heberger , Hans-Heinrich Gruenhagen , Egon Brode , Gerda von Philipsborn
IPC分类号： A61K31/225 , A61P9/06 , C07C69/353 , C07C213/06 , C07C217/36
CPC分类号： C07C217/36
摘要： Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,x is 2 or 3,y is 12, 14, 16, 18 or 20, anda and b differ from one another and are 0 or 1,as well as the stereoisomers thereof and the preparation thereof are described. The compounds are suitable as active substances for antiarrhythmics.
摘要翻译：其中R为正丙基或1,1-二甲基丙基，x为2或3，y为12,14,16,18或20，a和b不同于式I的羟基丙酰丙酮 - 甘油三酯彼此并且为0或1，以及其立体异构体及其制备。该化合物适合作为抗心律失常药物的活性物质。

19. 发明申请

US20060041164A1 Acid and ester compounds and methods of using the same 有权
公开(公告)号：US20060041164A1
公开(公告)日：2006-02-23
申请号：US10508893
申请日：2003-03-26
申请人： Scott Thompson , Lara Kallander , Chun Ma , Joseph Marino , Dennis Lee
发明人： Scott Thompson , Lara Kallander , Chun Ma , Joseph Marino , Dennis Lee
IPC分类号： C07C229/52
CPC分类号： C07D213/38 , C07B2200/07 , C07C45/515 , C07C47/24 , C07C217/18 , C07C217/22 , C07C217/36 , C07C217/58 , C07C2601/08
摘要： Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.

20. 发明申请

US20050130966A1 Sodium channel modulators 有权
标题翻译：钠通道调节剂
公开(公告)号：US20050130966A1
公开(公告)日：2005-06-16
申请号：US11052504
申请日：2005-02-04
申请人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
IPC分类号： A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , A61P25/00 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07D207/09 , C07D211/26 , C07D213/30 , C07D213/38 , C07D213/65 , C07D215/20 , C07D231/12 , C07D233/54 , C07D233/61 , C07D233/76 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16 , A61K31/5377 , A61K31/4025 , A61K31/4545
CPC分类号： C07D213/30 , A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07C2601/18 , C07C2602/10 , C07D207/09 , C07D211/26 , C07D213/38 , C07D213/65 , C07D215/20 , C07D233/56 , C07D233/64 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16
摘要： The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
摘要翻译：本发明提供了钠通道调节化合物，其可用于治疗与钠通道活性相关的疾病或病症，例如神经性疼痛。本发明还提供包含本发明化合物的药物组合物，以及包括向哺乳动物（例如人）施用此类化合物或盐的治疗方法。

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