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11. 发明申请

US20150224506A1 PROCESSING CONTAINERS 有权
标题翻译：加工容器
公开(公告)号：US20150224506A1
公开(公告)日：2015-08-13
申请号：US14692131
申请日：2015-04-21
申请人： Argos Therapeutics, Inc.
发明人： Simon Jonathon Spence , Richard Alexander Grant , Timothy Doyle Peele , William Samuel Hunter , Ashraf F. Abdelmoteleb , David Thomas Kneen , Robert Alister Neil , Simon Harris
IPC分类号： B01L9/00 , B01L7/00
CPC分类号： G01N35/0099 , B01L1/00 , B01L1/02 , B01L3/021 , B01L3/0293 , B01L3/5085 , B01L7/52 , B01L9/06 , B01L9/523 , B01L2200/02 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/06 , B01L2300/0838 , B01L2300/123 , B01L2400/0481 , G01L1/00 , G01N1/34 , G01N35/00732 , G01N35/00871 , G01N2021/0378 , Y10T436/11 , Y10T436/2575
摘要： Processing containers include a first member having a substantially rigid body with a plurality of regions defining spaced apart workstations and a flexible barrier member sealably attached to the first member to define a closed chamber over the plurality of workstations. The flexible barrier is substantially impermeable and includes or is a manipulation tool that is sealably attached to the barrier. The manipulation tool has a first internal interface that resides in the closed chamber under the flexible barrier and a second external interface that resides outside the closed chamber. The processing containers are particularly suitable for automated processing of nucleic acids and other samples. The manipulation tool can cooperate with or include a pipette head. When the barrier is sealed, the barrier separates the contents of the container from a robotic arm or other manipulation device.
摘要翻译：处理容器包括具有基本上刚性的第一构件，其具有限定间隔开的工作站的多个区域以及密封地附接到第一构件以在多个工作站上限定闭合腔室的柔性阻挡构件。柔性屏障基本上是不可渗透的，并且包括或者是可密封地附接到屏障的操纵工具。操纵工具具有位于柔性屏障下方的封闭腔室中的第一内部接口和位于封闭腔室外部的第二外部接口。处理容器特别适用于核酸和其他样品的自动加工。操作工具可配合或包括移液管头。当屏障被密封时，屏障将容器的内容物与机器手臂或其他操纵装置分开。

12. 发明申请

US20150099262A1 FLOW CYTOMETER BIOSAFETY HOOD AND SYSTEMS INCLUDING THE SAME 有权
标题翻译：流式细胞仪生物安全帽和系统，包括它们
公开(公告)号：US20150099262A1
公开(公告)日：2015-04-09
申请号：US14505028
申请日：2014-10-02
申请人： Becton, Dickinson and Company
发明人： Steven MURDOCH , Scott HORTON , Gil REININ
IPC分类号： G01N15/14 , A61L2/20 , B01L1/02
CPC分类号： A61L2/20 , B01L1/02 , B01L2200/082 , B01L2300/0681 , G01N15/1459 , G01N2015/1006 , G01N2035/00306
摘要： Flow cytometer systems are provided that mitigate aerosols generated during operation of a flow cytometer. A flow cytometer system can include various combinations of: a flow cytometer instrument base, a flow cytometer, and a biosafety hood (BSH). In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base, a flow cytometer, and a BSH. In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base and a flow cytometer. In some cases, a BSH includes an aerosol management system, which provides a redundant air filtration system. Also provided are components of a flow cytometer system (e.g., a BSH configured to attach to a flow cytometer instrument base, a flow cytometer instrument base configured to attach to a BSH, etc.). Also provided are methods, including methods of performing a flow cytometric procedure using a flow cytometer system; and methods of decontaminating a flow cytometer system.
摘要翻译：提供了流式细胞仪系统，其减轻在流式细胞仪操作期间产生的气溶胶。流式细胞仪系统可以包括以下各种组合：流式细胞仪器基座，流式细胞仪和生物安全罩（BSH）。在一些实施方案中，受试者流式细胞仪系统包括流式细胞仪仪器基座，流式细胞仪和BSH。在一些实施方案中，受试者流式细胞仪系统包括流式细胞仪仪器基座和流式细胞仪。在某些情况下，BSH包括气溶胶管理系统，其提供冗余的空气过滤系统。还提供了流式细胞计数器系统的组件（例如，被配置为附着到流式细胞仪器基座的BSH，被配置为附接到BSH的流式细胞仪器基座等）。还提供了方法，包括使用流式细胞仪系统进行流式细胞术程序的方法; 以及对流式细胞仪系统进行净化的方法。

13. 发明申请

US20140120009A1 ISOLATOR 有权
标题翻译：隔离器
公开(公告)号：US20140120009A1
公开(公告)日：2014-05-01
申请号：US14149127
申请日：2014-01-07
申请人： PANASONIC HEALTHCARE CO., LTD.
发明人： Yasuhiko Yokoi , Jiro Ohnishi , Akifumi Iwama , Masaki Harada , Yoshiaki Noguchi
IPC分类号： C12M1/12
CPC分类号： B01L1/02 , A61L2/0094 , A61L2/025 , A61L2/208 , A61L2202/11 , A61L2202/122 , A61L2202/13 , A61L2202/14 , B01L2300/14 , C12M37/00 , G01M3/26
摘要： An isolator includes a work chamber, a sterilizing substance supply unit, a gas flow channel pressure adjustment unit, a work chamber barometer, and a controller. The controller is configured to control execution of a gas flow channel leak test for checking a gas leak in a gas flow channel based on a detection result by the work chamber barometer after making the gas flow channel pressure adjustment unit increase or decrease the pressure in the gas flow channel, and is configured to control supply of the sterilizing substance by the sterilizing substance supply unit. The controller performs heating of a heater, which accompanies the supply of the sterilizing substance, in parallel with the gas flow channel leak test.
摘要翻译：隔离器包括工作室，灭菌物质供给单元，气体流路压力调节单元，工作室气压计和控制器。控制器被配置为在使气体流路压力调节单元增加或减小气体流动通道压力调节单元中的压力之后，基于工作室气压计的检测结果来控制用于检查气体流路中的气体泄漏的气体流路泄漏测试的执行气体流路，被配置为控制由灭菌物质供给部供给灭菌物质。与气体流路泄漏试验并行地进行伴随灭菌物质的供给的加热器的加热。

14. 发明申请

US20130217105A1 APPARATUS FOR MEASURING VOLUME OF A FLUID 有权
标题翻译：用于测量流体体积的装置
公开(公告)号：US20130217105A1
公开(公告)日：2013-08-22
申请号：US13845725
申请日：2013-03-18
申请人： Argos Therapeutics, Inc.
发明人： Simon Jonathon Spence , Richard Alexander Grant
IPC分类号： G01N1/34
CPC分类号： G01N35/0099 , B01L1/00 , B01L1/02 , B01L3/021 , B01L3/0293 , B01L3/5085 , B01L7/52 , B01L9/06 , B01L9/523 , B01L2200/02 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/06 , B01L2300/0838 , B01L2300/123 , B01L2400/0481 , G01L1/00 , G01N1/34 , G01N35/00732 , G01N35/00871 , G01N2021/0378 , Y10T436/11 , Y10T436/2575
摘要： An apparatus for transfer of a liquid using a diaphragm that separates a working fluid volume from a working air volume and can controllably induce a change pressure to draw or expel a target fluid into a tube. The apparatus is particularly suitable for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier under the diaphraghm, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device.
摘要翻译：一种用于使用将工作流体体积与工作空气体积分离并可以可控制地引起变化压力以将目标流体吸入或排出到管中的隔膜传送液体的装置。该装置特别适用于核酸的自动处理，其它样品包括一个包含托盘和柔性屏障的一次性容器。阻挡件被构造成与托盘的顶部边缘密封，在密封托盘内提供封闭的无菌工作区域。移液管头和/或其他样品操纵装置可以在隔膜下面附着到阻挡层的内侧，并且阻挡层可以包括用于机器臂或其它装置的界面。当屏障被密封在托盘上时，屏障将托盘的内容物与机器人或其他操纵装置分开。

15. 发明授权

US08376172B2 Container lid gasket protective strip for double door transfer system 有权
标题翻译：集装箱盖垫片保护带双门传送系统
公开(公告)号：US08376172B2
公开(公告)日：2013-02-19
申请号：US12380330
申请日：2009-02-26
申请人： Burgess M. Allen, Jr.
发明人： Burgess M. Allen, Jr.
IPC分类号： B65D51/18
CPC分类号： G21F7/047 , B01L1/02 , Y10T156/10
摘要： An apparatus and a process for forming a protective barrier seal along a “ring of concern” of a transfer container used with double door systems is provided. A protective substrate is supplied between a “ring of concern” and a safety cover in which an adhesive layer of the substrate engages the “ring of concern”. A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the “ring of concern” and the adhesive layer of the substrate.
摘要翻译：提供了一种用于沿着与双门系统一起使用的转移容器的关注环形成保护性屏障密封件的装置和方法。保护衬底被提供在关注环和安全盖之间，其中衬底的粘合剂层与所关注的环接合。沿着衬底的相对侧的压缩泡沫带与安全盖接合，使得在所关注的环和衬底的粘合剂层之间保持压缩力。

16. 发明授权

US08328042B2 Vessel port configured for use with a glove bag 有权
标题翻译：船舶口配置用于手套袋
公开(公告)号：US08328042B2
公开(公告)日：2012-12-11
申请号：US12353771
申请日：2009-01-14
申请人： Thomas M. Canty , Richard Marinelli
发明人： Thomas M. Canty , Richard Marinelli
IPC分类号： B65D25/54 , B65D43/26 , B65D51/00 , H02G3/14
CPC分类号： B01L1/02
摘要： A port and closure device for a vessel that is configured for use with a glove bag. The port comprising includes a first annular flange with an opening, a second annular flange disposed a predetermined distance from the first flange and also having an opening, and a seal ring disposed adjacent the first annular flange and having an additional opening. At least a portion of the openings are aligned so that a path is provided through the flanges and the seal ring. A slideable door is included in the port between the seal ring and the second annular flange. The slideable door has a first position that obstructs the path and a second position that is outside of the path. Springs are disposed between the first flange and the seal ring that urge the seal ring toward the slideable door. To reduce contamination sites, the springs may be sealed within an annular interface between the first annular flange and the seal ring. Alternatively, or in addition, a funnel pipe may be used with the port disposed in the openings of the first and second flange and the seal ring. The port may also include an adapter configured to hold a glove bag thereon.
摘要翻译：用于容器的用于与手套袋一起使用的端口和封闭装置。所述端口包括具有开口的第一环形凸缘，与所述第一凸缘隔开预定距离并且还具有开口的第二环形凸缘以及邻近所述第一环形凸缘设置并具有附加开口的密封环。开口的至少一部分对准，使得通过凸缘和密封环设置路径。密封环和第二环形凸缘之间的端口中包括可滑动的门。可滑动门具有妨碍路径的第一位置和位于路径外侧的第二位置。弹簧设置在第一凸缘和密封环之间，该密封环将密封环推向可滑动的门。为了减少污染部位，弹簧可以密封在第一环形凸缘和密封环之间的环形界面内。或者或另外，可以使用漏斗管，其中端口设置在第一和第二凸缘和密封环的开口中。端口还可以包括配置成在其上容纳手套袋的适配器。

17. 发明申请

US20110209410A1 Barrier Isolator Port Assembly 有权
标题翻译：隔离隔离器端口组件
公开(公告)号：US20110209410A1
公开(公告)日：2011-09-01
申请号：US13127294
申请日：2009-11-05
申请人： Paul H. Norton , Edward Vander Bush , W. Edward Hill , Robert Nase
发明人： Paul H. Norton , Edward Vander Bush , W. Edward Hill , Robert Nase
IPC分类号： E06B3/70 , E05B65/00
CPC分类号： G21F7/005 , B01L1/02 , Y10T292/102 , Y10T292/205
摘要： A barrier isolator port assembly for connecting to a conventional docking port of an isolated enclosure is provided. The port assembly includes an annular body, a door assembly and a lock. The annular body is configured to engage a docking port of the isolated enclosure. The port assembly also includes a door assembly mountable within the annular body and a lock operatively connected to the annular body. The lock includes a lever and a pin. The lever is pivotably connected to the annular body about a pivoting member and configured to pivot about the pivoting member to removably insert the pin into the recess of the door assembly.
摘要翻译：提供了用于连接到隔离外壳的常规对接端口的隔离隔离器端口组件。端口组件包括环形体，门组件和锁。环形体配置成接合隔离外壳的对接端口。端口组件还包括可安装在环形体内的门组件和可操作地连接到环形体的锁。锁包括一个杠杆和一个销。所述杠杆围绕枢转构件枢转地连接到所述环形体，并且构造成围绕所述枢转构件枢转以可拆卸地将所述销插入所述门组件的凹部中。

18. 发明申请

US20100314960A1 DYNAMIC BARRIER ISOLATION CHAMBER 有权
标题翻译：动态障碍隔离室
公开(公告)号：US20100314960A1
公开(公告)日：2010-12-16
申请号：US11585631
申请日：2006-10-24
申请人： Robert H. Polsky
发明人： Robert H. Polsky
IPC分类号： H02K49/10 , B01L1/04
CPC分类号： A61G10/02 , B01L1/02 , H02K49/104
摘要： The invention concerns an isolation chamber for isolating substances from the ambient. The isolation chamber comprises a first container surrounding and defining an isolation space for holding the substances and a second container surrounding the first container. A barrier space is positioned between the first and the second containers. Preferably, the pressure of the isolation space is lower than the pressure of the barrier space.
摘要翻译：本发明涉及用于将物质与环境隔离的隔离室。隔离室包括围绕并限定用于保持物质的隔离空间的第一容器和围绕第一容器的第二容器。隔离空间位于第一和第二容器之间。优选地，隔离空间的压力低于阻挡空间的压力。

19. 发明授权

US07847455B1 Dynamic barrier isolation chamber 有权
标题翻译：动态屏障隔离室
公开(公告)号：US07847455B1
公开(公告)日：2010-12-07
申请号：US11585631
申请日：2006-10-24
申请人： Robert H. Polsky
发明人： Robert H. Polsky
IPC分类号： H02K47/10
CPC分类号： A61G10/02 , B01L1/02 , H02K49/104
摘要： The invention concerns an isolation chamber for isolating substances from the ambient. The isolation chamber comprises a first container surrounding and defining an isolation space for holding the substances and a second container surrounding the first container. A barrier space is positioned between the first and the second containers. Preferably, the pressure of the isolation space is lower than the pressure of the barrier space.
摘要翻译：本发明涉及用于将物质与环境隔离的隔离室。隔离室包括围绕并限定用于保持物质的隔离空间的第一容器和围绕第一容器的第二容器。隔离空间位于第一和第二容器之间。优选地，隔离空间的压力低于阻挡空间的压力。

20. 发明授权

US07282176B2 Method of mounting a piece of handling equipment to a containment chamber containing a sterile medium 有权
标题翻译：将一件处理设备安装在容纳无菌介质的容纳室中的方法
公开(公告)号：US07282176B2
公开(公告)日：2007-10-16
申请号：US10499654
申请日：2003-01-07
申请人： Charles Glachet , Jean-Pierre Brossard
发明人： Charles Glachet , Jean-Pierre Brossard
IPC分类号： A61L2/02
CPC分类号： G21F7/047 , B01L1/02 , B25J21/02 , G21Y2002/304 , G21Y2002/50 , G21Y2004/40 , Y10T29/49826 , Y10T29/49877 , Y10T29/53096
摘要： A method to mount handling equipment on an interface of a confinement chamber that is to contain a sterile environment. In the method a unit including the handling equipment is prepared and sterilized, and the chamber and a hidden part of the interface are sterilized after coupling impervious tooling to a chamber flange and partially opening the chamber door. The unit is then coupled to the interface. Finally, the double door formed by the equipment door and the chamber door connected to one another is opened, using a handle provided for this purpose on the equipment door.
摘要翻译：将处理设备安装在包含无菌环境的约束室的界面上的方法。在该方法中，制备并处理包括处理设备的单元并消毒，并且将不透水工具连接到腔室凸缘并部分地打开室门之后，将腔室和界面的隐藏部分消毒。然后将该单元耦合到该接口。最后，由设备门和室门连接的双门打开，使用设备门上提供的手柄。

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