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11. 发明申请

US20170014642A1 SYSTEM AND METHOD FOR NOVEL CHANCE-CONSTRAINED OPTIMIZATION IN INTENSITY-MODULATED PROTON THERAPY PLANNING TO ACCOUNT FOR RANGE AND PATIENT SETUP UNCERTAINTIES 审中-公开
标题翻译：用于范围调整方案治疗方案中的新的限制性优化的系统和方法规划用于范围和患者设置不确定性的帐户
公开(公告)号：US20170014642A1
公开(公告)日：2017-01-19
申请号：US15209699
申请日：2016-07-13
申请人： Yu An , Jianming Liang , Wei Liu
发明人： Yu An , Jianming Liang , Wei Liu
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1043 , A61N5/1084 , A61N2005/1087
摘要： A system and methods are provided for generating intensity modulated proton therapy plans robust to various kinds of delivery uncertainties with the capability for treatment planners to control the balance between plan quality and robustness. The system obtains a representation of a subject and a proton beam configuration that describes a number of beamlets and their respective arrangement. The system computes an objective function, in the treatment planning system, first part of which is about dose deviations from the prescribed dose in the target volumes, second part of which is about dose deviations from the dose constraint in the non-target volumes, and computing dose volume constraints for targets using a probability to control the dose distribution in the target volumes to be between a lower threshold and an upper threshold. Based on this information, the system obtains a robust chance-constrained treatment planning model with a user-adjustable tolerance level.
摘要翻译：提供了一种系统和方法，用于产生强度调制的质子治疗计划，强大的各种传递不确定性，具有治疗计划人员控制计划质量和健壮性之间平衡的能力。系统获得对象的表示以及描述多个子束及其相应布置的质子束配置。该系统计算目标函数，在治疗计划系统中，其第一部分是关于目标体积中规定剂量的剂量偏差，其中第二部分是与非目标体积中的剂量约束的剂量偏差，以及使用将目标体积中的剂量分布控制在较低阈值和较高阈值之间的概率来计算目标的剂量体积约束。基于此信息，系统获得了具有用户可调容限水平的强大的机会约束治疗计划模型。

12. 发明申请

US20160310764A1 METHODS AND SYSTEMS FOR BEAM INTENSITY-MODULATION TO FACILITATE RAPID RADIATION THERAPIES 有权
标题翻译：光束强度调制方法和系统，以便于快速辐射治疗
公开(公告)号：US20160310764A1
公开(公告)日：2016-10-27
申请号：US15068387
申请日：2016-03-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： VINOD BHARADWAJ , VALERY A. DOLGASHEV , REBECCA FAHRIG , BILLY WISEMAN LOO , PETER G. MAXIM , SAMI TANTAWI , CECILE LIMBORG , LUDOVIC NICOLAS
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/1039 , A61N5/1043 , A61N5/1045 , A61N5/1064 , A61N5/1067 , A61N5/1078 , A61N5/1081 , A61N7/02 , A61N2005/1055 , A61N2005/1058 , A61N2005/1076 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098 , H05H9/048 , H05H2007/048
摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.
摘要翻译：本文提供了用于促进快速辐射治疗的方法和系统，特别涉及辐射产生和递送，电子源设计，束控制和整形/强度调制。当使用紧凑的高梯度，非常高能量的电子（VHEE）加速器和能够以高速度从多个波束方向治疗患者的递送系统（和相关过程）使用时，本文所描述的方法和系统是特别有利的，使用全电磁或提供射频偏转转向; 或者当与用于光子辐射治疗中更常规地使用的能量范围的大电流电子加速器系统一起使用以产生强度调制的光子辐射治疗的更快速的传递，这两种情况可以在两种情况下递送全部剂量或部分的高剂量辐射治疗足够快以冻结生理运动，但与常规光子疗法相比，具有相等或更好的剂量一致性或雕刻度。

13. 发明授权

US09433378B2 Modular processing of magnetic resonance data 有权
标题翻译：磁共振数据的模块化处理
公开(公告)号：US09433378B2
公开(公告)日：2016-09-06
申请号：US15074189
申请日：2016-03-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Ashwin Krishnakumar , Vinay Parthan
IPC分类号： A61B5/055 , A61B5/00 , A61N7/00 , G01R33/54
CPC分类号： A61B5/4836 , A61B5/015 , A61B5/055 , A61B2090/374 , A61N5/1049 , A61N5/1084 , A61N7/00 , A61N7/02 , A61N2005/1055 , G01R33/546
摘要： The invention provides for medical instrument comprising a magnetic resonance imaging system. Execution of the instruction cause a processor controlling the instrument to: execute a magnetic resonance data processing application thereby providing a plug-in framework, execute a protocol definition interface to load a first selection of the plug-ins into the plug-in framework, acquire the magnetic resonance data by using the pulse sequence data to control the magnetic resonance imaging system; and reconstruct a magnetic resonance image from the magnetic resonance data using the first selection of the plug-ins.
摘要翻译：本发明提供了包括磁共振成像系统的医疗器械。执行指令使处理器控制仪器：执行磁共振数据处理应用程序，从而提供插件框架，执行协议定义界面以将插件的第一选择加载到插件框架中，获取通过使用脉冲序列数据来控制磁共振成像系统的磁共振数据; 并使用插件的第一选择从磁共振数据重建磁共振图像。

14. 发明申请

US20160114189A1 SYSTEM AND METHOD FOR DOSE VERIFICATION AND GAMMA RAY IMAGING IN ION BEAM THERAPY 有权
标题翻译：在离子束治疗中用于剂量验证和伽玛射线成像的系统和方法
公开(公告)号：US20160114189A1
公开(公告)日：2016-04-28
申请号：US14886862
申请日：2015-10-19
申请人： Lucian Mihailescu
发明人： Lucian Mihailescu
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1045 , A61N5/1071 , A61N5/1084 , A61N2005/1087 , G21K1/025
摘要： This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive detector configured to detect gamma rays generated by an ion beam interacting with a target. The collimator is positioned between the target and the position sensitive detector. The collimator includes a plurality of knife-edge slits, with a first knife-edge slit intersecting with a second knife-edge slit.
摘要翻译：本公开提供了与离子束治疗相关的系统，方法和装置。一方面，系统包括位置敏感检测器和准直器。所述位置敏感检测器被配置为检测由与靶相互作用的离子束产生的伽马射线。准直器位于目标和位置敏感检测器之间。准直器包括多个刀刃狭缝，第一刀刃狭缝与第二刀刃狭缝相交。

15. 发明申请

US20160010094A1 TRANSGENIC CELL SELECTION 审中-公开
标题翻译：转基因细胞选择
公开(公告)号：US20160010094A1
公开(公告)日：2016-01-14
申请号：US14771599
申请日：2014-02-28
申请人： UNIVERSITE DE GENEVE , UNIVERSITY OF PRETORIA
发明人： Karl-Heinz Krause , David Suter , Patrick Salmon , Renier Myburgh , Michael Pepper
IPC分类号： C12N15/65 , A61N5/10 , A61K31/17 , A61K48/00 , A61K31/517
CPC分类号： C12N15/65 , A61K31/17 , A61K31/517 , A61K35/28 , A61K48/00 , A61N5/1084 , C12N15/1034
摘要： Methods for selecting transgenic cells comprising two or more drug resistance genes with a combination of cytotoxic drugs (e.g., trimetrexate (TMTX) and hydroxyurea (HU)). Such selection can be completed in vitro or in vivo. Transgenic cells and vectors comprising combinations of resistance genes are also provided. Transgenic cells of the embodiments can be used as cell based therapeutics, such as for treatment of HIV infection.
摘要翻译：用于选择包含细胞毒性药物（例如三甲氧甲酰胺（TMTX）和羟基脲（HU））的组合的两种或更多种耐药性基因的转基因细胞的方法。这样的选择可以在体外或体内完成。还提供了包含抗性基因组合的转基因细胞和载体。实施方案的转基因细胞可用作基于细胞的治疗剂，例如用于治疗HIV感染。

16. 发明申请

US20150374443A1 CRANIAL ALIGNMENT DEVICE FOR USE IN INTRACRANIAL STEREOTACTIC SURGERY 审中-公开
标题翻译：用于脊髓外科手术的螺钉对位装置
公开(公告)号：US20150374443A1
公开(公告)日：2015-12-31
申请号：US14316396
申请日：2014-06-26
申请人： University of Florida Research Foundation, Incorporated
发明人： Kathryn Elizabeth Mittauer , Guanghua Yan , Richard Helmig , Chihray Liu , Bo Lu
IPC分类号： A61B19/00 , A61F9/04 , A61N5/10
CPC分类号： A61N5/1049 , A61B90/18 , A61B90/39 , A61B2034/2055 , A61B2090/101 , A61B2090/397 , A61B2090/3979 , A61B2090/3983 , A61F9/04 , A61F2210/0071 , A61F2240/001 , A61F2250/0096 , A61N5/1084 , A61N2005/1059 , A61N2005/1097
摘要： A cranial alignment device for use in intracranial stereotactic radiotherapy includes a nosepiece that is custom shaped to mate with the dorsum and alae of the patient's nose.
摘要翻译：用于颅内立体定向放射治疗的头部对准装置包括定制成形以与患者鼻部的背部和外侧相配合的鼻梁。

17. 发明申请

US20150352113A1 TREATMENT OF ASTROCYTES-TUMOR CELLS INHIBITORS OF ENDOTHELIN RECEPTORS 审中-公开
标题翻译：内皮素受体的ASTROCYTES-TUMOR细胞抑制剂的治疗
公开(公告)号：US20150352113A1
公开(公告)日：2015-12-10
申请号：US14640662
申请日：2015-03-06
申请人： Board of Regents, The University of Texas System
发明人： Isaiah FIDLER , Sun-jin KIM
IPC分类号： A61K31/513 , A61N5/10 , A61K31/337
CPC分类号： A61K31/513 , A01K67/027 , A01K2227/105 , A01K2267/0331 , A61K31/337 , A61K31/4188 , A61K31/495 , A61K31/506 , A61K45/06 , A61N5/1084 , C12N5/0622 , C12N5/0693 , C12N2502/08 , C12N2502/30 , G01N33/5008 , A61K2300/00
摘要： The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The endothelin receptor antagonist may for example be bosentan, macitentan or a mixture of bosentan and macitentan.
摘要翻译：本公开涉及用于预防或治疗脑转移的内皮素受体拮抗剂，其与细胞毒性化疗剂，放射疗法或两者结合使用。内皮缩血管肽受体拮抗剂可以是例如波生坦，微生物素或波生坦和麦可坦的混合物。

18. 发明申请

US20150283406A1 Medical Robot 审中-公开
标题翻译：医疗机器人
公开(公告)号：US20150283406A1
公开(公告)日：2015-10-08
申请号：US14541104
申请日：2014-11-13
申请人： Daegu Gyeongbuk Institute of Science and Technology
发明人： Pyung Hun Chang , Gezgin Erkin , Seung Ho Kim
IPC分类号： A61N5/10
CPC分类号： A61N5/1083 , A61B6/04 , A61B6/0407 , A61B6/0457 , A61B6/4429 , A61B6/4458 , A61B6/4464 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N5/1084
摘要： A medical robot includes a bed on which an object is to be disposed, and a robot arm unit disposed above or below the bed, and including an emitting member movable within a trajectory on a sphere having a center at which a target point is disposed, wherein the bed and the robot arm unit may move relatively in a vertical or horizontal direction, and the object may be repositioned to the target point by relatively moving the bed and the robot arm unit in the vertical or horizontal direction, and the emitting member may move to face the target point.
摘要翻译：一种医疗机器人包括：物体被放置在其上的床，以及设置在所述床的上方或下方的机器人手臂单元，并且包括能够在具有设置有目标点的中心的球体的轨迹内移动的发射构件，其中床和机器人手臂单元可以在垂直或水平方向上相对移动，并且可以通过在垂直或水平方向上相对移动床和机器人手臂单元将物体重新定位到目标点，并且发射构件可以移动面对目标点。

19. 发明授权

US09008271B2 System for X-ray irradiation of target volume 有权
标题翻译：目标体积X射线照射系统
公开(公告)号：US09008271B2
公开(公告)日：2015-04-14
申请号：US13817562
申请日：2011-08-18
申请人： Zeev Burshtein , Aharon Bar-David , Zeev Harel
发明人： Zeev Burshtein , Aharon Bar-David , Zeev Harel
IPC分类号： G21K1/06 , A61N5/10 , G21K5/04
CPC分类号： G21K1/06 , A61N5/1042 , A61N5/1084 , A61N2005/1091 , A61N2005/1095 , G21K1/046 , G21K5/04 , G21K2201/062 , G21K2201/064 , G21K2201/067
摘要： An X-ray system is arranged for providing X-ray exposure to a target volume. The aforesaid X-ray system comprises an X-ray source and at least one focusing lens. The provided exposure is distributed over a volume of the target in a substantially uniform manner.
摘要翻译：布置X射线系统以提供对目标体积的X射线曝光。上述X射线系统包括X射线源和至少一个聚焦透镜。所提供的曝光以基本均匀的方式分布在目标体积上。

20. 发明授权

US08948341B2 Radiation therapy techniques using targeted wave superposition, magnetic field direction and real-time sensory feedback 有权
标题翻译：使用靶向波叠加，磁场方向和实时感觉反馈的放射治疗技术
公开(公告)号：US08948341B2
公开(公告)日：2015-02-03
申请号：US13371461
申请日：2012-02-12
申请人： Christopher V. Beckman
发明人： Christopher V. Beckman
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61B2090/0481 , A61N5/1084 , A61N2005/1094
摘要： New techniques for radiotherapy and radiosurgery are provided. In some aspects of the invention, multiple sources of radiation with a frequency, phase and polarization that are projected to constructively interfere at a treatment target are provided. In other aspects, hardware directs multiple radiation sources from the same side of a treatment target, and focuses the initiation of substantial interference on a leading structure in the target. In other aspects, refractive models updated by live feedback are used to improve dosage distribution by, among other things, optimizing the number, length, superposition overlap, angle and nature of radiation beams. In additional aspects, interstitial beacons and radiation path diversion structures are inserted to improve dosage distribution to a target and avoid critical neighboring structures. In particle therapy, regionally actuable external magnetic fields are also provided, to improve dosage accuracy and avoid collateral damage.
摘要翻译：提供放射治疗和放射外科的新技术。在本发明的一些方面，提供了具有频率，相位和极化的多个辐射源，这些辐射源投影到建设性地干扰治疗目标。在其他方面，硬件从治疗目标的同一侧引导多个辐射源，并且将目标上的引导结构的实质性干扰集中起来。在其他方面，通过实时反馈更新的折射模型用于通过优化辐射束的数量，长度，叠加重叠，角度和性质来改善剂量分布。在另外的方面，插入间质信标和辐射路径转移结构以改善对目标的剂量分布并避免关键的相邻结构。在颗粒治疗中，还提供了区域可致动的外部磁场，以提高剂量准确度并避免附带损伤。

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