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11. 发明授权

US06752928B2 Flow matching method and system using two transducers 失效
标题翻译：流量匹配方法和系统使用两个换能器
公开(公告)号：US06752928B2
公开(公告)日：2004-06-22
申请号：US10045776
申请日：2002-01-10
申请人： Michael C. Pfeil , Gary C. Fulks
发明人： Michael C. Pfeil , Gary C. Fulks
IPC分类号： B01D6132
CPC分类号： A61M1/1656 , A61M1/1647 , A61M1/3441 , Y10S210/929 , Y10T137/0368
摘要： A property of unconnected first and second fluid flows is matched, such as, but not limited to, matching the flow rate of the replacement water stream with the waste water stream in kidney dialysis. The first and second flow paths are interconnected so substantially the same flow from the first flow source encounters a first flow transducer which is in the first flow path and a second flow transducer which is in the second flow path. Transducer readings are taken for various identical values of the property of the first fluid flow. Then the first and second flow paths are disconnected, and the property, such as but not limited to flow rate, of one of the fluid flows in one of the flow paths is controlled using transducer readings and the previous interconnected-path transducer readings to match the property in the two flows. In one example, the transducers are uncalibrated transducers.
摘要翻译：匹配不连接的第一和第二流体流的性质，例如但不限于使肾脏透析中的替代水流与废水流的流速相匹配。第一和第二流动路径相互连接，使得基本相同的来自第一流动源的流体遇到位于第一流动路径中的第一流量变换器和位于第二流动路径中的第二流量变换器。对于第一流体流的性质的各种相同的值，采集传感器读数。然后断开第一和第二流动路径，并且使用换能器读数和先前的互连路径换能器读数来控制其中一个流动路径中的一个流体流的特性，例如但不限于流量，以匹配财产在两个流。在一个示例中，换能器是未校准的换能器。

12. 发明申请

US20030130608A1 Flow matching method and system using two transducers 失效
标题翻译：流量匹配方法和系统使用两个换能器
公开(公告)号：US20030130608A1
公开(公告)日：2003-07-10
申请号：US10045776
申请日：2002-01-10
发明人： Michael C. Pfeil , Gary C. Fulks
IPC分类号： A61M037/00
CPC分类号： A61M1/1656 , A61M1/1647 , A61M1/3441 , Y10S210/929 , Y10T137/0368
摘要： A property of unconnected first and second fluid flows is matched, such as, but not limited to, matching the flow rate of the replacement water stream with the waste water stream in kidney dialysis. The first and second flow paths are interconnected so substantially the same flow from the first flow source encounters a first flow transducer which is in the first flow path and a second flow transducer which is in the second flow path. Transducer readings are taken for various identical values of the property of the first fluid flow. Then the first and second flow paths are disconnected, and the property, such as but not limited to flow rate, of one of the fluid flows in one of the flow paths is controlled using transducer readings and the previous interconnected-path transducer readings to match the property in the two flows. In one example, the transducers are uncalibrated transducers.
摘要翻译：匹配不连接的第一和第二流体流的性质，例如但不限于使肾脏透析中的替代水流与废水流的流速相匹配。第一和第二流动路径相互连接，使得基本相同的来自第一流动源的流体遇到位于第一流动路径中的第一流量变换器和位于第二流动路径中的第二流量变换器。对于第一流体流的性质的各种相同的值，采集传感器读数。然后断开第一和第二流动路径，并且使用换能器读数和先前的互连路径换能器读数来控制其中一个流动路径中的一个流体流的特性，例如但不限于流量，以匹配财产在两个流。在一个示例中，换能器是未校准的换能器。

13. 发明授权

US06331252B1 Methods for priming a blood compartment of a hemodialyzer 失效
标题翻译：启动血液透析器血液隔室的方法
公开(公告)号：US06331252B1
公开(公告)日：2001-12-18
申请号：US09126761
申请日：1998-07-31
申请人： Waleed Mutasem El Sayyid , Cameron Scott Casterline
发明人： Waleed Mutasem El Sayyid , Cameron Scott Casterline
IPC分类号： B01D6100
CPC分类号： A61M1/16 , A61M1/1601 , A61M1/1647 , A61M1/165 , A61M1/3403 , A61M1/3427 , A61M1/3643 , A61M1/3644 , A61M1/365 , A61M2205/50 , Y10S210/929
摘要： A method for priming a hemodialyzer is disclosed. Hemodialyzer comprises a dialysate compartment, a blood compartment, and a dialysis membrane separating the dialysate and blood compartments. The method comprises the steps of delivering a liquid to a dialysate inlet of the dialysate compartment at a first volumetric delivery rate, passing the liquid through the dialysate compartment from the dialysate inlet to a dialysate outlet of the hemodialyzer and delivering the liquid from the dialysate outlet at a second volumetric delivery rate that is less than the first volumetric delivery rate so as to cause a net flow of the liquid from the dialysate compartment to the blood compartment through the dialysis membrane.
摘要翻译：公开了一种用于启动血液透析器的方法。血液透析器包括透析液隔室，血液隔室和分离透析液和血液隔室的透析膜。该方法包括以第一体积输送速率将液体输送到透析液隔室的透析液入口的步骤，使液体从透析液入口透过透析液入口至血液透析器的透析液出口，并从透析液出口输送液体以小于第一体积输送速率的第二体积输送速率，以便通过透析膜引起液体从透析液室到血液室的净流量。

14. 发明授权

US5861555A Method and apparatus for measuring the flow differential in a dialysis machine, and method for calibrating the apparatus 失效
标题翻译：用于测量透析机中的流量差的方法和装置以及用于校准该装置的方法
公开(公告)号：US5861555A
公开(公告)日：1999-01-19
申请号：US964732
申请日：1997-11-05
申请人： Sture Hobro , Erik Linderup , Leif Mattisson
发明人： Sture Hobro , Erik Linderup , Leif Mattisson
IPC分类号： A61M1/14 , A61M1/16 , G01F25/00 , G01F1/68
CPC分类号： A61M1/16 , A61M1/1647 , A61M1/1662 , A61M1/1664 , A61M1/1692
摘要： Methods for measuring the flow differential through a dialysis machine are disclosed in which the dialysis machine includes a heat exchanger having a primary side and a secondary side for exchanging heat therebetween. The method includes measuring the temperature differences across the primary and secondary sides of the heat exchanger and calculating the flow differential based upon these measured temperature differences. Apparatus for measuring such a flow differential is also disclosed, as are methods for calibrating that apparatus.
摘要翻译：公开了通过透析机测量流量差的方法，其中透析机包括具有初级侧和次级侧之间用于在其间进行热交换的热交换器。该方法包括测量热交换器的一次侧和二次侧的温差，并基于这些测量的温度差来计算流量差。还公开了用于测量这种流量差的装置，校准该装置的方法也是如此。

15. 发明授权

US5792367A System and method for monitoring a flow of dialysis fluid in a dialysis machine 失效
标题翻译：用于监测透析机中透析液流量的系统和方法
公开(公告)号：US5792367A
公开(公告)日：1998-08-11
申请号：US693263
申请日：1996-08-16
申请人： Leif Mattisson , Gunilla Wejfeldt
发明人： Leif Mattisson , Gunilla Wejfeldt
IPC分类号： G01F1/00 , A61M1/14 , A61M1/16 , B01D61/32 , G01F1/36 , G01F25/00 , G05D7/06 , B01D61/30 , B01D65/10
CPC分类号： G05D7/0682 , A61M1/16 , A61M1/1647 , G01F1/363 , G01F25/003 , Y10S210/929
摘要： Apparatus for monitoring flow of a dialysis fluid through a dialyzer is disclosed including a computer for calculating the flow rate of the dialysis fluid into and out of the dialyzer based on the formula P-P.sub.O =k*Q.sup.n in which P is the pressure in the dialysis fluid between a throttle and a pump either upstream or downstream of the dialyzer, P.sub.O is the pressure in the dialysis fluid on the opposite side of the throttles from the pump, k is a characteristic coefficient for the throttle, Q is the flow of the dialysis fluid through the throttle, and N is a characteristic exponent for the throttle, and the apparatus includes microprocessor for calculating the values of k and P.sub.O prior to use and for calculating the value of P.sub.O during use of the dialyzer. Methods for carrying out such monitoring are also disclosed.
摘要翻译： PCT No.PCT / SE95 / 00166 Sec。 371日期：1996年8月16日 102（e）日期1996年8月16日PCT提交1995年2月17日PCT公布。第WO95 / 22743号公报日期1995年8月24日公开了一种通过透析器监测透析液流量的装置，其包括计算机，用于根据公式P-PO = k * Qn计算透析液进出透析器的流量，其中P 是在透析器上游或下游的节流阀和泵之间的透析液中的压力，PO是来自泵的节流阀相对侧的透析液体中的压力，k是节流阀的特征系数，Q 是通过节气门的透析流体的流动，N是节气门的特征指数，并且该装置包括用于在使用之前计算k和PO的值的微处理器，以及在使用透析器期间计算PO的值。还公开了进行这种监视的方法。

16. 发明授权

US4827430A Flow measurement system 失效
标题翻译：流量测量系统
公开(公告)号：US4827430A
公开(公告)日：1989-05-02
申请号：US48307
申请日：1987-05-11
申请人： James D. Aid , Norman F. Cameron , Thomas P. Hartranft
发明人： James D. Aid , Norman F. Cameron , Thomas P. Hartranft
IPC分类号： A61M1/14 , A61M1/16 , G01F1/00 , G01F1/08 , G01F1/12 , G01F25/00 , G01F15/075 , G01P5/20
CPC分类号： G01F1/00 , A61M1/16 , A61M1/1647 , G01F1/08 , G01F1/125
摘要： A flow rate measurement system and method suitable for monitoring filtrate flow in a hemodialysis apparatus, provides a pair of flow meters in series at the input of a dialyzer for producing electrical signals indicative of dialysate flow rate and a pair of flow meters in series at the output of the dialyzer for producing electrical signals indicative of dialysate plus filtrate flow rate. A computer receives the flow rate signals and is programmed to calibrate each flow meter during a calibration phase to correct for any variations in each pair to thereby produce corrective scale factors. During an operational phase of the apparatus, the program monitors the flow meters and provides an alarm if any changes between the readings of either of the pairs of flow meters occurs.

17. 发明公开

US20240181142A1 DETERMINING INTERNAL FILTRATION RATE WITHIN A CAPILLARY HEMODIALYZER 审中-公开
公开(公告)号：US20240181142A1
公开(公告)日：2024-06-06
申请号：US17768516
申请日：2020-10-13
申请人： GAMBRO LUNDIA AB
发明人： Danilo DONATO , Markus STORR
IPC分类号： A61M1/16
CPC分类号： A61M1/1605 , A61M1/1627 , A61M1/1647
摘要： The present disclosure relates to a method and a device for determining an internal filtration rate IFR within a capillary hemodialyzer.

18. 发明授权

US11964089B2 Blood purification apparatus and method of trapping bubbles therein 有权
公开(公告)号：US11964089B2
公开(公告)日：2024-04-23
申请号：US17022633
申请日：2020-09-16
申请人： Nikkiso Company Limited
发明人： Shingo Ikuma
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/3626 , A61M1/1647 , A61M1/3629 , A61M1/3638 , A61M1/3663
摘要： A blood purification apparatus that includes a blood circuit including an arterial blood circuit and a venous blood circuit and having a flow route that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier connected to a proximal end of the arterial blood circuit and to a proximal end of the venous blood circuit and that purifies the blood flowing through the blood circuit; an air-trap chamber connected to the blood circuit and that traps bubbles contained in liquid flowing in the flow route of the blood circuit; and a blood pump provided to the arterial blood circuit and being capable of delivering the liquid within the blood circuit. An upstream bubble-detecting unit attached to a position of the blood circuit on an upstream side with respect to the air-trap chamber and that detects bubbles contained in the liquid flowing in the blood circuit; and a control unit that reduces, at the detection of any bubbles by the upstream bubble-detecting unit, a flow rate of the liquid flowing into the air-trap chamber.

19. 发明授权

US11850341B2 Flow balancing devices, methods, and systems 有权
公开(公告)号：US11850341B2
公开(公告)日：2023-12-26
申请号：US17879455
申请日：2022-08-02
申请人： NxStage Medical, Inc.
发明人： Jeffrey H. Burbank , Dennis M. Treu , Daniel Joseph Rubery, Jr. , Scott W. Newell , James M. Brugger , William J. Schnell , William K. Weigel , Steven A. White , Mark T. Wyeth , Jerome James , David Desouza , Joseph E. Turk, Jr. , Garrett Casey
IPC分类号： A61M1/14 , A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/1605 , A61M1/14 , A61M1/165 , A61M1/1613 , A61M1/1615 , A61M1/1647 , A61M1/341 , A61M1/3403 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3609 , A61M1/3635 , A61M1/34 , A61M1/3607 , A61M2205/05 , A61M2205/058 , A61M2205/3331 , A61M2205/3334 , A61M2205/3341 , A61M2205/3351 , A61M2205/3355 , A61M2205/3365 , A61M2205/3368 , A61M2205/502 , A61M2205/702
摘要： The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

20. 发明公开

US20230293790A1 SYSTEMS, DEVICES, AND METHODS FOR EXTRACORPOREAL REMOVAL OF CARBON DIOXIDE 审中-公开
公开(公告)号：US20230293790A1
公开(公告)日：2023-09-21
申请号：US18116092
申请日：2023-03-01
申请人： Steven Paul KELLER , Brian Yale CHANG , Jayon WANG
发明人： Steven Paul KELLER , Brian Yale CHANG , Jayon WANG
IPC分类号： A61M1/16 , B01D19/00
CPC分类号： A61M1/1647 , A61M1/1627 , B01D19/0031 , A61M2202/0225 , A61M2230/208
摘要： Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient’s blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate’s composition can be selected such that charge neutrality is maintained.

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