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11. 发明申请

US20160206226A1 Detection, Measurement, And Imaging Of Cells Using Cellular Internalization of Nanoparticles 审中-公开
标题翻译：使用纳米颗粒细胞内化的细胞的检测，测量和成像
公开(公告)号：US20160206226A1
公开(公告)日：2016-07-21
申请号：US15083051
申请日：2016-03-28
申请人： Senior Scientific LLC
发明人： Edward R. Flynn , Erika Vreeland
IPC分类号： A61B5/05
CPC分类号： A61B5/0515 , A61B5/04005 , A61B5/06 , A61B5/415 , A61B5/416 , A61B5/418 , A61B2090/3954 , A61B2562/0285 , G01R33/26
摘要： The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic magnetometers. The magnetic systems can detect, measure, or location particles preferentially internalized by cells due to the action of antibodies, proteins, macromolecules, or nutrients required for cellular metabolism. Example magnetic systems are capable of detecting sub-nanogram amounts of these nanoparticles.
摘要翻译：本发明提供了用于使用靶磁性纳米颗粒和特殊磁系统来检测，测量或定位体内甚至非常低的体内浓度的细胞或物质的方法和装置。磁性系统可以包括磁化子系统和传感器子系统，包括例如SQUID传感器和原子磁强计。由于细胞代谢所需的抗体，蛋白质，大分子或营养物质的作用，磁系统可以检测，测量或定位优先由细胞内化的颗粒。示例磁系统能够检测亚纳米量的这些纳米颗粒。

12. 发明授权

US09186512B2 Method and apparatus for organ specific inflammation monitoring 有权
标题翻译：器官特异性炎症监测的方法和装置
公开(公告)号：US09186512B2
公开(公告)日：2015-11-17
申请号：US12565233
申请日：2009-09-23
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
IPC分类号： A61N1/365 , A61N1/362 , A61B5/00 , A61B5/01 , A61B5/03 , A61B5/053 , A61B5/107 , A61B8/08
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译：一种装置包括可植入传感器和检测电路。植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。

13. 发明授权

US09144383B2 Device and method for in vivo noninvasive magnetic manipulation of circulating objects in bioflows 有权
标题翻译：用于生物流中循环物体的体内非侵入性磁操作的装置和方法
公开(公告)号：US09144383B2
公开(公告)日：2015-09-29
申请号：US12945576
申请日：2010-11-12
申请人： Vladimir Pavlovich Zharov
发明人： Vladimir Pavlovich Zharov
IPC分类号： A61B8/00 , A61B6/00 , A61B5/00 , A61K49/22 , B03C1/28 , B03C1/30 , A61B8/08 , A61B18/18 , A61B18/20 , G01N15/14
CPC分类号： A61B5/0059 , A61B5/0095 , A61B5/412 , A61B5/415 , A61B5/416 , A61B5/418 , A61B8/08 , A61B8/481 , A61B18/1815 , A61B18/20 , A61K49/22 , B03C1/288 , B03C1/30 , B03C2201/06 , B03C2201/26 , G01N15/1425 , G01N15/1434 , G01N15/147 , G01N2015/1477
摘要： A device and methods for the non-invasive manipulation and detection of target objects such as cells, pathogens, microparticles, and nanoparticles in vivo using an external magnetic field are described. In one aspect, a device and method for capturing and detecting intrinsically magnetic target objects or target objects labeled with at least one magnetic particle within the area of interest using an in vivo flow cytometer are described.
摘要翻译：描述了使用外部磁场在体内非侵入性地操纵和检测诸如细胞，病原体，微粒和纳米颗粒的目标物体的装置和方法。在一个方面，描述了使用体内流式细胞仪来捕获和检测在目标区域内用至少一个磁性颗粒标记的本征磁性目标物体或目标物体的装置和方法。

14. 发明申请

US20150085249A1 NONINVASIVE MEASUREMENT OF CHEMICAL SUBSTANCES 审中-公开
标题翻译：化学物质的无意识测量
公开(公告)号：US20150085249A1
公开(公告)日：2015-03-26
申请号：US14551895
申请日：2014-11-24
申请人： GEELUX HOLDING, LTD.
发明人： Marcio Marc ABREU
IPC分类号： A61B3/10 , A61B3/00 , A61B3/16 , A61B5/145
CPC分类号： A61B3/10 , A61B3/0025 , A61B3/0058 , A61B3/1241 , A61B3/16 , A61B3/185 , A61B5/0002 , A61B5/01 , A61B5/031 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/14555 , A61B5/1486 , A61B5/18 , A61B5/412 , A61B5/416 , A61B5/445 , A61B5/4839 , A61B5/6814 , A61B8/06 , A61B8/56 , A61B2560/0214 , A61B2560/0219 , A61B2560/0252 , A61B2560/0418 , A61B2562/0238 , A61B2562/12 , A61F9/0017 , A61F9/0026 , G02C7/04 , Y02A90/26
摘要： Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like.
摘要翻译：利用放置在眼睛上的接触装置，以便根据这些物理和化学参数检测身体的物理和化学参数以及化合物的非侵入性递送，其中信号作为电磁波，无线电波，红外线等。要检测的参数之一包括使用在结膜和泪液膜中发现的化学变化和化学产物的非侵入性血液分析。安装在敷设在角膜或眼睛表面上的接触装置中的传感器能够评估和测量眼睛中的物理和化学参数，包括非侵入性血液分析。该系统利用眼罩运动和/或关闭眼罩来启动安装在接触装置中的微型射频敏感传感器。该信号可以通过电线或遥控的无线电通信到外部放置的接收器。然后可以处理，分析和存储信号。可以检测到几个参数，包括血液成分的全面无创分析，全身和眼部血流量的测量，心率和呼吸频率的测量，跟踪操作，排卵检测，辐射检测和药物作用，眼睛和全身性疾病等。

15. 发明授权

US08942451B2 Method and system for mapping tissue status of acute stroke 有权
标题翻译：绘制急性脑卒中组织状态的方法和系统
公开(公告)号：US08942451B2
公开(公告)日：2015-01-27
申请号：US13128645
申请日：2009-11-13
申请人： Qing Yang
发明人： Qing Yang
IPC分类号： G06K9/00 , A61B5/055 , A61B5/00 , A61B6/00
CPC分类号： A61B5/055 , A61B5/416 , A61B6/501 , A61B6/507 , A61B6/5217 , A61B6/5247 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2207/10072 , G06T2207/30104
摘要： The current invention provides a method of identifying a ischemic lesion. The method includes loading perfusion imaging data into an electronic memory element and deriving perfusion maps from the perfusion imaging data, where the perfusion maps include a cerebral blood volume (CBV) map and an arterial delay time (DT) map, which utilize arterial delay and dispersion effects. Ischemic pixels are determined from the perfusion imaging data, where the DT is greater than a predetermined first threshold value and the CBV is below a second threshold value and the infarct portion of the ischemic lesion is determined, where DT is greater than a predetermined third threshold value and/or the CBV is below a forth threshold value. A cluster analysis is applied to all of the determined ischemic lesion and infarct pixels and the penumbra is then determined, where mismatch regions between the ischemic lesion and the infarct core define the penumbra.
摘要翻译：本发明提供了鉴定缺血性病变的方法。所述方法包括将灌注成像数据加载到电子存储元件中并从灌注成像数据中导出灌注图，其中灌注图包括使用动脉延迟的脑血容量（CBV）图和动脉延迟时间（DT）图，分散效应。从灌注成像数据确定缺血像素，其中DT大于预定的第一阈值，并且CBV低于第二阈值，并且确定缺血性损伤的梗塞部分，其中DT大于预定的第三阈值值和/或CBV低于第四阈值。对所有确定的缺血性病变和梗死像素进行聚类分析，然后确定半暗带，其中缺血性病变与梗死核之间的不匹配区域定义半暗带。

16. 发明授权

US08920725B2 Portable apparatus for improved sample analysis 有权
标题翻译：便携式设备，用于改进样品分析
公开(公告)号：US08920725B2
公开(公告)日：2014-12-30
申请号：US13248307
申请日：2011-09-29
申请人： Edward W. Withrow, III , Jorn Gorlach
发明人： Edward W. Withrow, III , Jorn Gorlach
IPC分类号： G01N33/53 , A61B5/00 , A61B5/145 , G06F19/00 , A61B5/1455 , B01L3/00
CPC分类号： G01N33/54366 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/411 , A61B5/415 , A61B5/416 , A61B5/418 , B01L3/5023 , B01L2200/028 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0663 , B01L2400/0478 , G01N35/00871 , G06F19/00 , G16H40/63 , Y02A90/26 , Y10S435/809
摘要： The present invention is an improved apparatus for sample analysis. The apparatus employs an assay component containing a membrane having one or a plurality of analyte-specific binding agents attached thereto, a means for absorbing liquid, and a piston means for drawing analytes through said membrane into said means for absorbing liquid. The apparatus is configured to be portable and provide a detector for detecting binding of an analyte to an analyte-specific binding agent, a plurality of data acquisition components, and a computer for integrating, analyzing and storing the detected analyte specific binding and acquired data.
摘要翻译：本发明是用于样品分析的改进装置。该装置采用包含附着有一种或多种分析物特异性结合剂的膜的测定组分，用于吸收液体的装置，以及用于将分析物通过所述膜吸入所述用于吸收液体的装置的活塞装置。该装置被配置为便携式并且提供用于检测分析物与分析物特异性结合剂的结合的检测器，多个数据采集组件和用于整合，分析和存储检测到的分析物特异性结合和获取的数据的计算机。

17. 发明授权

US08855985B2 Method and system of obtaining improved data in perfusion measurements 有权
标题翻译：在灌注测量中获得改进数据的方法和系统
公开(公告)号：US08855985B2
公开(公告)日：2014-10-07
申请号：US10523353
申请日：2004-06-23
申请人： Qing Yang
发明人： Qing Yang
IPC分类号： G01N33/48 , G01N31/00 , G06F17/10 , G06G7/50 , A61B6/03 , G06F17/13 , G06F19/12 , A61B5/026 , A61B5/0275 , A61B5/00 , A61B6/00 , G06F17/11 , G06F19/24
CPC分类号： A61B6/032 , A61B5/0263 , A61B5/0275 , A61B5/4064 , A61B5/416 , A61B6/481 , A61B6/507 , A61B6/5217 , G06F17/10 , G06F17/11 , G06F17/13 , G06F19/12 , G06F19/24
摘要： A method of deriving blood perfusion indices for a region of interest (ROI) of a subject, comprising the steps of administering a contrast agent to the subject during a dynamic imaging scan, converting signal intensity data from raw images of the scan into contrast agent concentration data, deriving parameters from the contrast agent concentration data using at least one transport function that accounts for delay and dispersion of the contrast agent, and calculating the blood perfusion indices from the derived parameters.
摘要翻译：一种导出受试者感兴趣区域（ROI）的血液灌注指数的方法，包括以下步骤：在动态成像扫描期间向受试者施用造影剂，将来自扫描原始图像的信号强度数据转换成造影剂浓度数据，使用考虑造影剂的延迟和分散的至少一种传递函数从造影剂浓度数据导出参数，以及根据导出的参数计算血液灌注指数。

18. 发明授权

US08837794B2 Medical image display apparatus, medical image display method, and medical image display program 有权
标题翻译：医用图像显示装置，医用图像显示方法以及医学图像显示程序
公开(公告)号：US08837794B2
公开(公告)日：2014-09-16
申请号：US13499202
申请日：2010-09-29
申请人： Keigo Nakamura
发明人： Keigo Nakamura
IPC分类号： G06K9/00
CPC分类号： A61B5/416 , A61B5/7445 , A61B6/032 , A61B6/463 , A61B6/563 , G06F19/00 , G06F19/321
摘要： A keyword extracting section extracts anatomical structures and/or information related to diseases from image observation reports regarding input image data. A display protocol determining section determines display protocols by selecting display protocols from among those stored in a display protocol table, based on the extracted anatomical structures and/or information related to diseases. Medical images for display are displayed based on the determined display protocols.
摘要翻译：关键词提取部分从关于输入图像数据的图像观察报告中提取与疾病相关的解剖结构和/或信息。显示协议确定部分基于所提取的解剖结构和/或与疾病相关的信息，通过从存储在显示协议表中的显示协议中选择显示协议来确定显示协议。基于确定的显示协议显示用于显示的医疗图像。

19. 发明授权

US08774885B2 Device for generating a detectable signal based upon concentration of at least one substance 失效
标题翻译：用于基于至少一种物质的浓度产生可检测信号的装置
公开(公告)号：US08774885B2
公开(公告)日：2014-07-08
申请号：US12805036
申请日：2010-07-08
申请人： Marcio Marc Abreu
发明人： Marcio Marc Abreu
IPC分类号： A61B5/1455
CPC分类号： A61B3/10 , A61B3/0025 , A61B3/0058 , A61B3/1241 , A61B3/16 , A61B3/185 , A61B5/0002 , A61B5/01 , A61B5/031 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/14555 , A61B5/1486 , A61B5/18 , A61B5/412 , A61B5/416 , A61B5/445 , A61B5/4839 , A61B5/6814 , A61B8/06 , A61B8/56 , A61B2560/0214 , A61B2560/0219 , A61B2560/0252 , A61B2560/0418 , A61B2562/0238 , A61B2562/12 , A61F9/0017 , A61F9/0026 , G02C7/04 , G06F19/00 , Y02A90/26
摘要： Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like.
摘要翻译：利用放置在眼睛上的接触装置，以便根据这些物理和化学参数检测身体的物理和化学参数以及化合物的非侵入性递送，其中信号作为电磁波，无线电波，红外线等。要检测的参数之一包括使用在结膜和泪液膜中发现的化学变化和化学产物的非侵入性血液分析。安装在敷设在角膜或眼睛表面上的接触装置中的传感器能够评估和测量眼睛中的物理和化学参数，包括非侵入性血液分析。该系统利用眼罩运动和/或关闭眼罩来启动安装在接触装置中的微型射频敏感传感器。该信号可以通过电线或遥控的无线电通信到外部放置的接收器。然后可以处理，分析和存储信号。可以检测到几个参数，包括血液成分的全面无创分析，全身和眼部血流量的测量，心率和呼吸频率的测量，跟踪操作，排卵检测，辐射检测和药物作用，眼睛和全身性疾病等。

20. 发明授权

US08498692B2 Method for displaying a medical implant in an image and a medical imaging system 有权
标题翻译：用于在图像和医学成像系统中显示医疗植入物的方法
公开(公告)号：US08498692B2
公开(公告)日：2013-07-30
申请号：US11515303
申请日：2006-08-31
申请人： Frank Deinzer , Thomas Brunner , Michael Pflaum
发明人： Frank Deinzer , Thomas Brunner , Michael Pflaum
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/416 , A61B6/504 , A61B34/20 , A61B90/11 , A61B90/36 , A61B2034/107 , A61B2090/376
摘要： To allow safe treatment of a patient, in particular a puncture or biopsy using a needle, a 2D sectional image of an implant plane and a further 2D sectional image of an orthogonal plane are generated from a 3D image data record of a region to be examined. The two planes are hereby oriented such that the needle is on the one hand located within the implant plane and on the other hand is oriented in a perpendicular manner in respect of the orthogonal plane. The parallel display of the 2D images allows the doctor to acquire the relative position of the needle in relation to the region to be examined in a simple and intuitive manner.
摘要翻译：为了允许患者的安全治疗，特别是使用针的穿刺或活组织检查，从待检查区域的3D图像数据记录产生植入平面的2D截面图像和正交平面的另外的2D截面图像。因此，这两个平面被定向成使得针一方面位于植入平面内，另一方面相对于正交平面以垂直方式定向。 2D图像的平行显示允许医生以简单和直观的方式获得针相对于被检查区域的针的相对位置。

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