专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US10005810B2 Process for preparing nucleoside prodrugs 有权
公开(公告)号：US10005810B2
公开(公告)日：2018-06-26
申请号：US14442987
申请日：2013-11-15
申请人： University College Cardiff Consultants Limited
发明人： Chirstopher McGuigan , Fabrizio Pertusati
IPC分类号： C07H19/20 , C07H19/173 , A01N43/04 , A61K31/70 , C07H1/00 , C07H19/06 , C07H19/16 , B82Y20/00 , B01J27/128 , C07H19/10 , H01S5/343
CPC分类号： C07H19/20 , B01J27/128 , B82Y20/00 , C07H1/00 , C07H19/06 , C07H19/10 , C07H19/16 , H01S5/34326
摘要： Provided are phosphoramidate nucleoside compounds of Formula (I), or pharmaceutically acceptable salts or esters or solvates thereof, useful in the treatment of cancer, viral infections and other diseases: Also provided is a process for the synthesis of the compounds of Formula (I) where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb.

12. 发明授权

US09896729B2 Method for diagnosing a neurodegenerative disease 有权
公开(公告)号：US09896729B2
公开(公告)日：2018-02-20
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
IPC分类号： C07H21/04 , C12Q1/68 , A61K38/17 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.

13. 发明申请

US20170267653A1 BCL-3 INHIBITORS 审中-公开
公开(公告)号：US20170267653A1
公开(公告)日：2017-09-21
申请号：US15500016
申请日：2015-07-31
申请人： University College Cardiff Consultants Limited
发明人： Andrew David WESTWELL , Andrea BRANCALE , Richard William Ernest CLARKSON
IPC分类号： C07D295/13 , C07C237/44 , C07C237/42 , C07D213/82 , C07D213/81
CPC分类号： C07D295/13 , C07C237/42 , C07C237/44 , C07D213/81 , C07D213/82 , C07D241/04 , C07D295/125
摘要： The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure: wherein A, B, W, Y, Z, R2, R4, R5, R6, Rq and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.

14. 发明申请

US20150252421A1 METHOD FOR DIAGNOSING A NEURODEGENERATIVE DISEASE 有权
标题翻译：诊断神经病变疾病的方法
公开(公告)号：US20150252421A1
公开(公告)日：2015-09-10
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/50 , A61K38/17
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.
摘要翻译：本发明涉及评价受试者是否具有或可能发展神经变性疾病的方法，包括确定受试者是否具有C9orf72基因中的突变，其中所述突变阻止或破坏C9orf72表达相对于来自没有突变。

15. 发明申请

US20150164947A1 NOVEL ADULT PROGENITOR CELL 审中-公开
标题翻译：新的成人细胞
公开(公告)号：US20150164947A1
公开(公告)日：2015-06-18
申请号：US14617709
申请日：2015-02-09
申请人： University College Cardiff Consultants Limited
发明人： Philip Stephens , Lindsay Catrina Davies
IPC分类号： A61K35/12 , C12N5/071
CPC分类号： A61K35/12 , C12N5/0632
摘要： The invention relates to the isolation and use of a novel progenitor cell population from the lamina propria of the oral mucosa. The novel progenitor cell population is highly proliferative and can be differentiated into a range of cell lineages. Further, these novel progenitor cells possess immunomodulatory activity and so can be used in the allogeneic transfer of tissue or to help combat immune disorders.
摘要翻译：本发明涉及分离和使用来自口腔粘膜固有层的新型祖细胞群。新型祖细胞群高度增殖，可分化成一系列细胞系。此外，这些新型祖细胞具有免疫调节活性，因此可用于组织的同种异体转移或帮助对抗免疫疾病。

16. 发明申请

US20130267616A1 Polymerisation Method 有权
标题翻译：聚合方法
公开(公告)号：US20130267616A1
公开(公告)日：2013-10-10
申请号：US13822900
申请日：2011-09-12
申请人： Neil Bruce McKeown , Mariolino Carta , Matthew James Croad
发明人： Neil Bruce McKeown , Mariolino Carta , Matthew James Croad
IPC分类号： C08G73/06
CPC分类号： C08G73/0694 , C08G12/08 , C08G12/26
摘要： A method of forming a polymer is provided, the method comprising: Providing a first monomer comprising one or more aromatic moieties, the first monomer comprising at least two amino groups, each of the amino groups being attached to an aromatic moiety; and contacting said first monomer with formaldehyde or a source of methylene. Polymers made by such a method and uses of such polymers are also described.
摘要翻译：提供了一种形成聚合物的方法，所述方法包括：提供包含一个或多个芳族部分的第一单体，所述第一单体包含至少两个氨基，每个氨基连接到芳族部分; 并使所述第一单体与甲醛或亚甲基源接触。还描述了通过这种聚合物的这种方法和用途制备的聚合物。

17. 发明授权

US08551965B2 Anti-viral pyrimidine nucleoside analogues 有权
标题翻译：抗病毒嘧啶核苷类似物
公开(公告)号：US08551965B2
公开(公告)日：2013-10-08
申请号：US12889980
申请日：2010-09-24
申请人： Christopher McGuigan , Jan Balzarini
发明人： Christopher McGuigan , Jan Balzarini
IPC分类号： A61K31/706 , A61K31/498 , A61K31/4985 , C07D403/02 , C07D405/04 , C07H19/23 , C07H19/24
CPC分类号： C07H19/24 , A61K31/498 , A61K31/4985 , A61K31/706 , C07D403/02 , C07D405/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/23
摘要： A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; Q can be O, S or CY2, where Y may be H, alkyl or halogens; X can be O, NH, S, N-alkyl, (CHR2)m where m is 1 to 10, and CY2; Z can be O, S, NH, or N-alkyl; U″ is H and U′ can be H or CH2; wherein: T can be OH, H, halogens, O-alkyl, O-acyl, O-aryl, CN, NH2. or N3; T′ and T″ can be H or halogen; and W can be H or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus.
摘要翻译：式（I）的化合物，其中Ar可以是一个六元或两个稠合的六元芳环; R 8和R 9可以是氢，烷基，环烷基，卤素，氨基，烷基氨基，二烷基氨基，硝基，氰基，烷氧基，芳氧基，硫醇，烷基硫醇，仲胺或芳基; Q可以是O，S或CY2，其中Y可以是H，烷基或卤素; X可以是O，NH，S，N-烷基，（CHR2）m，其中m是1-10，CY2; Z可以是O，S，NH或N-烷基; U“是H，U'可以是H或CH2; 其中：T可以是OH，H，卤素，O-烷基，O-酰基，O-芳基，CN，NH 2。或N3; T'和T“可以是H或卤素; W可以是H或磷酸基。化合物显示出抗病毒活性，例如关于水痘带状疱疹病毒。

18. 发明授权

US08501427B2 Factor H polymorphisms in the diagnosis and therapy of inflammatory diseases such as age-related macular degeneration 有权
标题翻译：因子H多态性在炎症性疾病如年龄相关性黄斑变性的诊断和治疗中的作用
公开(公告)号：US08501427B2
公开(公告)日：2013-08-06
申请号：US12524196
申请日：2008-01-23
申请人： Bryan Paul Morgan , Claire Louise Harris , Svellana Hakobyan
发明人： Bryan Paul Morgan , Claire Louise Harris , Svellana Hakobyan
IPC分类号： A61K39/395 , C07K16/28 , C12N5/20 , G01N33/53 , G01N33/535 , G01N33/536 , G01N33/543 , G01N33/563 , G01N33/577 , C12P21/08
CPC分类号： G01N33/564 , C07K16/18 , G01N2333/4716 , G01N2800/164
摘要： The invention relates to antibodies, including monoclonal and polyclonal, or fragments thereof, which discriminate between the histidine and tyrosine isoforms of Complement Factor H and to their use in diagnostic methods and therapeutic treatments relating to Complement Factor H mediated diseases.
摘要翻译：本发明涉及区分补体因子H的组氨酸和酪氨酸同种型的单克隆和多克隆或其片段的抗体及其在与补体因子H介导的疾病相关的诊断方法和治疗性治疗中的用途。

19. 发明授权

US08357534B2 Isolation of human articular cartilage stem cells 失效
标题翻译：人关节软骨干细胞的分离
公开(公告)号：US08357534B2
公开(公告)日：2013-01-22
申请号：US12526194
申请日：2008-02-06
申请人： Charles William Archer , Samantha Nichola Haven , Gary Dowthwaite
发明人： Charles William Archer , Samantha Nichola Haven , Gary Dowthwaite
IPC分类号： C12N15/02 , C12N5/00
CPC分类号： A61L27/3817 , A61L2430/06 , C12N5/0668 , C12N2509/00 , C12N2533/52
摘要： The invention concerns a human stem cell isolated from the full depth of human cartilage tissue and/or isolated from aged human cartilage; and uses thereof.
摘要翻译：本发明涉及从人类软骨组织的全深度分离和/或从老年人软骨分离的人类干细胞; 及其用途。

20. 发明申请

US20110306494A1 COMPOSITION BASED ON BACILLUS SPP. AND CORRELATE GENERA AND THEIR USE IN PEST CONTROL 有权
标题翻译：基于BACILLUS SPP的组合物。和相关GENERA及其在病虫害控制中的使用
公开(公告)号：US20110306494A1
公开(公告)日：2011-12-15
申请号：US12438289
申请日：2007-08-29
申请人： Rose Gomes Monnerat Solon De Pontes , Carlos Marcelo Silveira Soares , Colin Berry
发明人： Rose Gomes Monnerat Solon De Pontes , Carlos Marcelo Silveira Soares , Colin Berry
IPC分类号： A01N63/00 , A01P5/00 , A01N63/02 , A01P13/00 , A01P21/00 , A01P7/04 , A01P7/00 , A01P9/00
CPC分类号： A01N63/00
摘要： The objective of the current invention is the control of agricultural infestations based on alternative methods that are less aggressive to the environment and that are harmless to other invertebrates and to man; for instance biological control using bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus. A first embodiment of the invention refers to compositions based on the systemic utilization of bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus to protect plants by using the composition containing the above referred bacteria in wild-type, conjugated, mutant or transgenic forms and/or the substances produced by them. A second embodiment of the invention refers to a method of bioinsecticide application based on bacteria from the genera Bacillus, Brevibacillus and/or Paenibacillus. A third embodiment of the invention is related to the bioinsecticide usage of the formulations based on bacteria from the genera Bacillus, Brevibacillus and/or Paenibacillus.
摘要翻译：本发明的目标是根据对环境侵略性较小并且对其他无脊椎动物和人类无害的替代方法来控制农业侵害; 例如使用属于芽孢杆菌属，短杆菌属和/或Paenibacillus属的物种的细菌菌株的生物控制。本发明的第一个实施方案是指基于属于芽孢杆菌属，短杆菌属和/或Paenibacillus属的细菌菌株的系统利用的组合物，以通过在野生型，缀合的突变体中使用含有上述细菌的组合物来保护植物或转基因形式和/或由它们产生的物质。本发明的第二个实施方案是指基于来自芽孢杆菌属，短杆菌属和/或芽孢杆菌属的细菌的生物杀虫剂施用方法。本发明的第三个实施方案涉及基于来自芽孢杆菌属，短杆菌属和/或Paenibacillus属的细菌的制剂的生物杀灭剂用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式