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11. 发明授权

US11633716B2 Immunosuppressive protein adsorption material and adsorption column 有权
公开(公告)号：US11633716B2
公开(公告)日：2023-04-25
申请号：US16638586
申请日：2018-09-07
申请人： TORAY INDUSTRIES, INC. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Junichi Kasuya , Ryo Matsunaga , Yoshiyuki Ueno , Yuji Ueda , Kazuo Teramoto , Kazumasa Ogasawara
IPC分类号： B01J20/26 , A61M1/36 , B01J20/28 , B01J20/32 , C07K14/495
摘要： An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.

12. 发明申请

US20220409229A1 MEDICAL TREATMENT TOOL AND ELECTROMAGNETIC WAVE MEDICAL SYSTEM 有权
公开(公告)号：US20220409229A1
公开(公告)日：2022-12-29
申请号：US17620765
申请日：2020-06-20
申请人： National University Corporation Shiga University of Medical Science
发明人： Tohru TANI , Shigeyuki NAKA , Atsushi YAMADA
IPC分类号： A61B17/3201 , A61B18/18
摘要： Provided is a scissors-type medical treatment tool capable of not only local tissue fixation in an incision/cutting part but also heating on side surfaces of electrodes of a forceps/tweezers type. It has been found out that a tissue part in which tissue is nipped between blades and a tissue part which is brought into abutment against side surfaces of the blades can be heated simultaneously or sequentially by optimizing arrangement of microwave application electrodes and microwave receiver electrodes in a blade pair (in particular, by causing coagulation to be performed evenly on the left and right of the blades), and the present invention has therefore been achieved.

13. 发明申请

US20220175410A1 CUTTING DEVICE, FORCEPS AND GRIPPING/CUTTING METHOD 有权
公开(公告)号：US20220175410A1
公开(公告)日：2022-06-09
申请号：US17554386
申请日：2021-12-17
申请人： NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Tohru TANI , Shigeyuki NAKA , Atsushi YAMADA , Tsuyoshi NAKAKUBO
IPC分类号： A61B17/3201 , A61B17/28 , A61B17/29 , A61B34/30
摘要： A cutting device including a first contact member and at second contact member assembled so as to be openable and closable, a contact mechanism that rotates the first contact member toward the second contact member to bring the first contact member and the second contact member into contact with a target portion, and a cutting mechanism for cutting the target portion in a state where the first contact member and the second contact member are in contact with the target portion by the contact mechanism.

14. 发明授权

US10890513B2 Cell-holding substrate holder for preparing observation specimen, kit including same, and observation specimen preparation method 有权
公开(公告)号：US10890513B2
公开(公告)日：2021-01-12
申请号：US15759719
申请日：2016-09-14
申请人： NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE , JAPAN VILENE COMPANY, LTD.
发明人： Ken-ichi Mukaisho , Takanori Hattori , Takuya Iwasa , Masaaki Kawabe , Satoshi Kumagai
IPC分类号： G01N1/31 , G01N1/30 , G02B21/34 , G01N1/40 , G01N33/483 , G01N1/28
摘要： Provided are a cell-holding substrate holder for preparing an observation specimen, and a cell-holding substrate kit, wherein the cell-holding substrate can be easily attached and detached. Also provided is a method of preparing an observation specimen, wherein cell organelles can be satisfactorily observed using an optical microscope, while three problems of cell detachment, drying, and loss of the three-dimensional properties can be simultaneously solved. The cell-holding substrate holder comprises (1) a support plate 1 having a cell-holding substrate arrangement portion 12 having a window portion through which water can pass; and (2) a removable sandwiching plate 2, 3 which has a window portion through which water can pass, and is capable of working in conjunction with the support plate 1 to sandwich and fix a cell-holding substrate 9 in the cell-holding substrate arrangement portion 12. The cell-holding substrate kit 10 comprises the cell-holding substrate holder and a cell-holding substrate 9. In the preparation method, cells are collected with an inorganic fiber aggregate, wet-fixed as they are, stained, and mounted with a mounting medium having a refractive index equivalent to that of the inorganic fiber.

15. 发明申请

US20170290623A1 ENERGY DEVICE FOR SURGICAL OPERATIONS 审中-公开
公开(公告)号：US20170290623A1
公开(公告)日：2017-10-12
申请号：US15512647
申请日：2015-07-13
申请人： TOCALO CO., LTD. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Shinya MIKI , Megumi ADACHI , Toru TANI , Shigeyuki NAKA , Tomoharu SHIMIZU
IPC分类号： A61B18/14 , A61L31/08 , A61L31/10 , A61B18/18 , A61B17/32
CPC分类号： A61B18/1445 , A61B17/320068 , A61B18/1402 , A61B2017/00849 , A61B2017/320069 , A61B2017/320082 , A61B2018/0013 , A61B2018/00601 , A61B2018/00607 , A61B2018/0097 , A61B2018/1412 , A61B2018/1452 , A61B2018/1462 , A61L31/088 , A61L31/10 , A61L2420/08
摘要： There is provided an energy device for surgical operation capable of suppressing fixation of body tissue, wherein a coating layer is formed on an outer periphery of a base material constituting an operational area portion transmitting energy in an energy device for surgical operation operating in the operational area portion, and is comprised of a base coating formed on the base material and an outermost coating formed on the base coating. The base coating is made from silicon oxide or a compound containing silicon oxide, and the outermost coating is made from polysiloxane or a compound containing polysiloxane or a compound containing a partly fluorinated polysiloxane, and the coating layer has a good adhesiveness and is applicable to a complicated form.

16. 发明申请

US20140194865A1 Microwave Surgical Instrument 审中-公开
标题翻译：微波手术器械
公开(公告)号：US20140194865A1
公开(公告)日：2014-07-10
申请号：US14238167
申请日：2012-08-09
申请人： Tohru Tani , Shigeyuki Naka , Hisanori Shiomi
发明人： Tohru Tani , Shigeyuki Naka , Hisanori Shiomi
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B2018/00446 , A61B2018/00589 , A61B2018/0063 , A61B2018/1838
摘要： It is an object to provide a surgical instrument capable of locally applying microwaves to a minute biological tissue. It has been found that microwaves can be transmitted to a tip of a tapered coaxial body (9) and that microwaves are radiated from the entire central conductor exposed in a major axis direction by decreasing a sectional area (preferably diameter) of a central conductor (1) and a sectional area (preferably inner diameter) of an external conductor gradually or in a step-by-step manner with a ratio between the sectional area (diameter) of the central conductor (1) and the sectional area (inner diameter) of the external conductor being set to be constant, thereby achieving the present invention.
摘要翻译：本发明的目的是提供能够将微波局部应用于微小生物组织的手术器械。已经发现，微波可以传递到锥形同轴体（9）的尖端，并且通过减小中心导体的截面积（优选直径），从沿着长轴方向暴露的整个中心导体辐射微波（ 1）和外部导体的截面积（优选内径）逐渐或逐步地以中心导体（1）的截面面积（直径）与截面积（内径）之比将外部导体设定为恒定，从而实现本发明。

17. 发明授权

US08313483B2 Microwave endoscope forceps 有权
标题翻译：微波内窥镜镊子
公开(公告)号：US08313483B2
公开(公告)日：2012-11-20
申请号：US12513559
申请日：2007-11-08
申请人： Makoto Hosaka , Tohru Tani , Yoshimasa Kurumi , Shigeyuki Naka
发明人： Makoto Hosaka , Tohru Tani , Yoshimasa Kurumi , Shigeyuki Naka
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1445 , A61B18/1815 , A61B2017/2932
摘要： Provided is an operating tool for organism, in particular, a microwave endoscope forceps. In terms of the operating tool for organism, provided is a multifunctional operating tool which has holding and scissors functions simultaneously, and may further perform coagulation (tissue fixation) by microwaves. The operating tool has no definite fulcrum, and has both the holding and scissors functions with a simple structure by deforming a long-track rod called beam. Two blades are insulated from each other so as to allow microwave current supply. With this structure, an operating tool having three functions, i.e., “a holding function”, “a coagulating function”, and “a cutting function” with a single tool may be developed.
摘要翻译：本发明提供一种生物体的操作工具，特别是微波内窥镜镊子。就生物的操作工具而言，提供了一种多功能操作工具，其具有同时保持和剪刀功能，并且可以进一步通过微波进行凝固（组织固定）。操作工具没有明确的支点，通过使称为梁的长轨杆变形，具有简单结构的保持和剪刀功能。两个叶片彼此绝缘，以便允许微波电流供应。利用这种结构，可以开发具有三个功能的操作工具，即保持功能，凝结功能和具有单个工具的切割功能。

18. 发明公开

US20230337899A1 MOVABLE ELONGATED STRUCTURE AND METHOD 审中-公开
公开(公告)号：US20230337899A1
公开(公告)日：2023-10-26
申请号：US18143451
申请日：2023-05-04
申请人： NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Atsushi YAMADA , Tohru TANI
IPC分类号： A61B1/005 , A61B1/00 , A61B34/30
CPC分类号： A61B1/0052 , A61B1/00087 , A61B1/00133 , A61B34/30 , A61B1/0057 , A61B2034/302 , A61B2034/305 , A61B2034/301
摘要： A movable elongated structure includes a distal end side tube, a base end side tube, traction wires, and a wiring aid routed by the traction wires arranged between the distal end side tube and the base end side tube, wherein the wiring aid guides the pair of traction wires from a pair of base end side wire lumens provided in the base end side tube to be introduced into a pair of distal end side wire lumens provided in the distal end side tube.

19. 发明授权

US11414693B2 Phosphatidylinositol quantification method and quantification kit 有权
公开(公告)号：US11414693B2
公开(公告)日：2022-08-16
申请号：US16615705
申请日：2018-05-24
申请人： NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Shin-Ya Morita
IPC分类号： C12Q1/44 , C12Q1/28 , C12Q1/32 , G01N21/76
摘要： Disclosed is a method for quantifying phosphatidylinositol in a sample, comprising the following step: (1) treating the sample with phospholipase D and inositol dehydrogenase; and a kit for quantifying phosphatidylinositol, containing phospholipase D and inositol dehydrogenase.

20. 发明申请

US20210381008A1 METHOD FOR PRODUCING FOREIGN ANTIGEN RECEPTOR GENE-INTRODUCED CELL 有权
公开(公告)号：US20210381008A1
公开(公告)日：2021-12-09
申请号：US17262400
申请日：2019-07-26
申请人： KYOTO UNIVERSITY , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Hiroshi KAWAMOTO , Yasutoshi AGATA , Seiji NAGANO , Koji TERADA , Kyoko MASUDA
IPC分类号： C12N15/90 , C12N5/0783 , C07K14/725 , A61K35/17
摘要： Provided is a method for producing a cell incorporating an antigen specific receptor gene, which comprises the step of introducing an exogenous TCR or CAR gene into a material cell so that the introduced gene is expressed under the T cell receptor expression control system of the material cell.

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