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11. 发明申请

US20100081664A1 METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO ENABLE RAPID RELIEF OF MIGRAINE WHILE MINIMIZING SIDE EFFECT PROFILE 审中-公开
公开(公告)号：US20100081664A1
公开(公告)日：2010-04-01
申请号：US12548304
申请日：2009-08-26
申请人： Robert O. Cook , Stephen B. Shrewsbury , Nabih N. Ramadan , Thomas A. Armer
发明人： Robert O. Cook , Stephen B. Shrewsbury , Nabih N. Ramadan , Thomas A. Armer
IPC分类号： A61K31/4985 , A61P25/06 , A61M15/00
CPC分类号： A61K31/4985 , A61K9/0073 , A61K9/0075 , A61K31/10 , A61K31/48
摘要： Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

12. 发明申请

US20100081663A1 METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO ENABLE RAPID RELIEF OF MIGRAINE WHILE MINIMIZING SIDE EFFECT PROFILE 有权
标题翻译： DHE治疗方法可以使最小化侧面影响特征的影像快速缓解
公开(公告)号：US20100081663A1
公开(公告)日：2010-04-01
申请号：US12548292
申请日：2009-08-26
申请人： Robert O. Cook , Stephen B. Shrewsbury , Nabih N. Ramadan , Thomas A. Armer
发明人： Robert O. Cook , Stephen B. Shrewsbury , Nabih N. Ramadan , Thomas A. Armer
IPC分类号： A61K31/4985 , A61P25/06 , A61M15/00
CPC分类号： A61K31/4985 , A61K9/0073 , A61K9/0075 , A61K31/10 , A61K31/48
摘要： Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.
摘要翻译：公开了含有二氢麦角胺（DHE）的药物组合物和其中向患者施用DHE以治疗偏头痛而没有副作用或副作用的方法。公开了用DHE快速治疗偏头痛的方法，其包括：抑制峰值血浆浓度（C max）并稍微延迟峰值，以避免激活多巴胺能和肾上腺素能受体，同时实现足够的活性结合5-羟色胺受体以缓解偏头痛在允许快速解决偏头痛症状的时间范围内的症状。公开了适用于该方法的吸入器。公开了实施发明方法的试剂盒。

13. 发明授权

US09833451B2 Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile 有权
公开(公告)号：US09833451B2
公开(公告)日：2017-12-05
申请号：US14921860
申请日：2015-10-23
申请人： MAP Pharmaceuticals, Inc.
发明人： Robert O. Cook , Stephen B. Shrewsbury , Nabih N. Ramadan , Thomas A. Armer
IPC分类号： A61K31/4985 , A61K9/00 , A61K31/48 , A61K31/10
CPC分类号： A61K31/4985 , A61K9/0073 , A61K9/0075 , A61K31/10 , A61K31/48
摘要： Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

14. 发明授权

US09610415B2 Enhanced eductor design 有权
公开(公告)号：US09610415B2
公开(公告)日：2017-04-04
申请号：US14944335
申请日：2015-11-18
申请人： MAP Pharmaceuticals, Inc.
发明人： Benjamin Stedman , Prashant Kakade , Darrell Woehler , John Leonard
IPC分类号： A61M25/00 , F15D1/02 , A61M15/00
CPC分类号： A61M15/0091 , A61M15/0021 , A61M15/0026 , A61M15/009 , A61M15/0096 , A61M2206/16 , A61M2206/20 , B01F5/0428 , F04F5/463 , F15D1/02
摘要： The present invention provides for an enhanced eductor element that significantly increases the amount of pressure generated at the siphon tube without significantly increasing the flow resistance through the eductor. The invention further provides for breath-actuated inhalation devices including the enhanced eductor element as an actuation mechanism.

15. 发明授权

US09394314B2 8′-hydroxy-dihydroergotamine compounds and compositions 有权
标题翻译： 8'-羟基 - 二氢麦角胺化合物和组合物
公开(公告)号：US09394314B2
公开(公告)日：2016-07-19
申请号：US14134100
申请日：2013-12-19
申请人： MAP PHARMACEUTICALS, INC.
发明人： Donald J. Kellerman , Thomas Armer , Jian Zhang
IPC分类号： C07D498/04
CPC分类号： A61K31/48 , A61K9/007 , A61K9/008 , C07D498/04
摘要： 8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of migraine disorders using the compounds, compositions, dosage forms and administration techniques disclosed herein.
摘要翻译：提供8'-羟基 - 二氢麦角胺（8'-OH DHE）药物化合物，组合物和含有这些组合物的剂型。本文还提供使用本文公开的化合物，组合物，剂型和给药技术来治疗，预防或改善偏头痛疾病的方法。

16. 发明授权

US09365591B2 Fluoroergoline analogs 有权
公开(公告)号：US09365591B2
公开(公告)日：2016-06-14
申请号：US14838956
申请日：2015-08-28
申请人： MAP Pharmaceuticals, Inc.
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： C07D519/02 , C07D498/14 , A61K9/00 , A61K31/4985 , C07D519/00 , C07D457/04 , A61K31/495 , C07D498/04
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

17. 发明申请

US20140194435A1 NOVEL SUBSTITUTED INDOLO 4,3 FG QUINOLINES USEFUL FOR TREATING MIGRAINE 审中-公开
标题翻译：新的替代印度4,3 FG金刚石用于处理MIGRAINE
公开(公告)号：US20140194435A1
公开(公告)日：2014-07-10
申请号：US14202875
申请日：2014-03-10
申请人： MAP Pharmaceuticals, Inc.
发明人： Robert O. COOK , Thomas A. ARMER , Sergey Alexandrovich KOSAREV , Dejian XIE , Jian ZHANG
IPC分类号： C07D457/04 , C07D519/02
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are novel ergoline derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and or 5-HT1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了新的麦角灵衍生物及其药物组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

18. 发明授权

US08722699B2 Iso-ergoline derivatives 有权
标题翻译：异麦角灵衍生物
公开(公告)号：US08722699B2
公开(公告)日：2014-05-13
申请号：US14045767
申请日：2013-10-03
申请人： Map Pharmaceuticals, Inc.
发明人： Jian Zhang , Robert O. Cook
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D457/12 , C07D519/00 , C07D519/02
摘要： Provided herein are novel iso-ergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新颖的异麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

19. 发明授权

US08720433B2 Dose counter with lockout mechanism 有权
标题翻译：剂量计数器具有锁定机构
公开(公告)号：US08720433B2
公开(公告)日：2014-05-13
申请号：US12387867
申请日：2009-05-07
申请人： Alfred Sugianto
发明人： Alfred Sugianto
IPC分类号： A61M11/00 , A62B7/00 , A62B9/00
CPC分类号： A61M15/0081 , A61M11/04 , A61M15/0026 , A61M15/0065 , A61M15/0076 , A61M15/009 , A61M15/0091 , A61M15/0096
摘要： A medicament dispenser, in particular a metered dose inhaler, which is able to count the number of time the dispenser is activated and then disable the device, which then prevents any additional medicament from being dispensed. Additional embodiments include a medicament dispenser which are adapted to display either the number of activations that have occurred or the number of activations remaining.
摘要翻译：药物分配器，特别是计量剂量吸入器，其能够计数分配器被激活的时间数量，然后禁用装置，然后防止任何额外的药物被分配。另外的实施例包括适于显示所发生的激活次数或剩余的激活次数的药物分配器。

20. 发明申请

US20140073790A1 NOVEL FLUOROERGOLINE ANALOGS 有权
公开(公告)号：US20140073790A1
公开(公告)日：2014-03-13
申请号：US14047815
申请日：2013-10-07
申请人： MAP PHARMACEUTICALS, INC.
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： C07D519/02
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

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