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11. 发明授权

US11284838B2 Non-invasive wearable biomechanical and physiology monitor for injury prevention and rehabilitation 有权
公开(公告)号：US11284838B2
公开(公告)日：2022-03-29
申请号：US16169295
申请日：2018-10-24
申请人： George Mason University
发明人： Marissa A. Howard , Lance A. Liotta , Rachel Naidich , Matthew Luu Trang , Ish Sethi , Rebecca Woodhouse , Kshamata Neupane
IPC分类号： A61B5/01 , A61B5/00 , A61B5/11
摘要： A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.

12. 发明申请

US20220017969A1 A METHOD OF DETERMINING RISK FOR SKIN CANCER DEVELOPMENT AND SKIN CANCER THERAPEUTIC PREVENTION BY MEASURING PD-1/PD-L1 SIGNALING PATHWAY MEMBERS 有权
公开(公告)号：US20220017969A1
公开(公告)日：2022-01-20
申请号：US17311538
申请日：2019-12-06
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , George Mason University
发明人： Clara N. Curiel , Amanda Fern Baker , Sally E. Dickinson , Emanuel F. Petricoin, III
IPC分类号： C12Q1/6886 , C07K14/705
摘要： The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-Li signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway suppressing therapy to prevent skin cancer development.

13. 发明授权

US10935645B2 Method and apparatus for low-power ultraportable ultrasound imaging 有权
公开(公告)号：US10935645B2
公开(公告)日：2021-03-02
申请号：US15793969
申请日：2017-10-25
申请人： George Mason University
发明人： Siddhartha Sikdar , Parag Chitnis , Nima Akhlaghi , Elizabeth Tarbox , Paul Otto , Paul Gammell
IPC分类号： G01S7/52 , G01N29/06 , G01S15/89 , G01N29/26 , G01N29/34 , G01N29/42 , A61B8/08 , G01N29/07 , G01N29/265 , A61B8/00
摘要： Methods, systems, and apparatuses are disclosed for ultrasound imaging comprising Time Delay Spectrometry. A frequency swept signal can be transmitted through a medium, such as human tissue. The signal can be a low-voltage signal (e.g., 0 volts to 5 volts peak-to-peak) transmitted for long duration (e.g., 20 milliseconds) at various frequencies. As the signal propagates through the medium it can be reflected and delayed. A delay associated with the signal the can cause a change in the associated frequencies. The signal can be filtered to retain only frequencies in an audio frequency range. The signal can be beamformed and processed to produce an image.

14. 发明授权

US10927155B2 Dual inhibitory action peptidomimetic inhibitor for IL-33 and IL-1beta 有权
公开(公告)号：US10927155B2
公开(公告)日：2021-02-23
申请号：US15776932
申请日：2016-11-18
申请人： GEORGE MASON UNIVERSITY
发明人： Lance Liotta , Alessandra Luchini , Virginia Espina , Mikell Paige
IPC分类号： C07K14/47 , A61K38/00 , C07D307/91
摘要： In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1β receptor/cytokine complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

15. 发明授权

US10643480B2 Method and apparatus for probabilistic alerting of aircraft unstabilized approaches using big data 有权
公开(公告)号：US10643480B2
公开(公告)日：2020-05-05
申请号：US15491671
申请日：2017-04-19
申请人： George Mason University
发明人： Lance Sherry , John Shortle , Zhenming Wang
IPC分类号： G08G5/02 , G08G5/00 , G06N7/00 , G06N20/00 , G06N3/04
CPC分类号： G08G5/025 , G06N7/005 , G06N20/00 , G08G5/0021 , G08G5/0091 , G06N3/0436
摘要： Traditional approaches to predicting aircraft trajectories using kinematic models cannot work due to the complexity of the approach maneuver including flaps/slats, landing gear, ATC vectors, winds, and other traffic. The methods and systems disclosed can utilize Big Data Analytics (e.g., massive amounts of data of flights on each approach) to nowcast the approach stability given the state of the flight prior to the 1000′/500′ check points.

16. 发明授权

US10168309B2 Method for manufacturing an array of sensors on a single chip 有权
公开(公告)号：US10168309B2
公开(公告)日：2019-01-01
申请号：US15891699
申请日：2018-02-08
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE , GEORGE MASON UNIVERSITY , THE GEORGE WASHINGTON UNIVERSITY
发明人： Abhishek Motayed , Geetha Aluri , Albert V. Davydov , Mulpuri V. Rao , Vladimir P. Oleshko , Ritu Bajpai , Mona E. Zaghloul
IPC分类号： G01N27/00 , G01N33/00 , G01N27/12
摘要： A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.

17. 发明申请

US20180280164A1 ARTIFICIAL BODY PART CONTROL SYSTEM USING ULTRASONIC IMAGING 审中-公开
公开(公告)号：US20180280164A1
公开(公告)日：2018-10-04
申请号：US15937613
申请日：2018-03-27
申请人： Siddhartha Sikdar , Joseph J. Pancrazio , Ira A. Hunt , Andrew J. Nelson , Abdullah Al-Imran
发明人： Siddhartha Sikdar , Joseph J. Pancrazio , Ira A. Hunt , Andrew J. Nelson , Abdullah Al-Imran
IPC分类号： A61F2/72 , A61B8/08 , A61F2/58 , A61B5/11 , A61B8/00 , A61F2/68 , A61F2/76
摘要： The artificial body part control system using ultrasonic imaging includes of an ultrasonic transducer coupled with an ultrasonic image analyzer which may be adapted to transmit a control signal to an artificial body part.

18. 发明申请

US20170038326A1 Highly Selective Nanostructure Sensors and Methods of Detecting Target Analytes 有权
标题翻译：高选择性纳米结构传感器和检测目标分析物的方法
公开(公告)号：US20170038326A1
公开(公告)日：2017-02-09
申请号：US15297693
申请日：2016-10-19
申请人： University of Maryland, College Park , United States of America, as Represented by the Secretary of Commerce , George Mason University , The George Washington University
发明人： Abhishek Motayed , Geetha Aluri , Albert V. Davydov , Mulpuri V. Rao , Vladimir P. Oleshko , Ritu Bajpai , Mona E. Zaghloul
IPC分类号： G01N27/16 , G01N33/00
CPC分类号： G01N33/0057 , G01N27/127 , G01N33/0031 , G01N33/0037 , G01N33/004 , G01N33/0042 , G01N33/0044 , G01N33/0047 , G01N33/0049 , G01N33/005 , G01N33/0054 , Y02A50/245 , Y02A50/246
摘要： A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
摘要翻译：纳米结构感测装置包括具有外表面的半导体纳米结构和金属或金属氧化物纳米颗粒簇中的至少一个，其功能化纳米结构的外表面并形成光导纳体结构/纳米簇混合传感器，其能够对靶分析物进行光辅助感测。

19. 发明授权

US09476813B2 Extraction chamber for collecting analytes from samples and method thereof 有权
标题翻译：用于从样品中收集分析物的萃取室及其方法
公开(公告)号：US09476813B2
公开(公告)日：2016-10-25
申请号：US13439290
申请日：2012-04-04
申请人： Robin Couch
发明人： Robin Couch
IPC分类号： G01N1/18 , B01D21/00 , G01N1/40
CPC分类号： G01N1/405 , Y10T436/24 , Y10T436/255
摘要： Apparatus and methods are disclosed for the collection and analysis of analytes from samples. In one embodiment an extraction chamber is provided that includes a sample holder and an extraction lid that allows for simultaneous multifiber solid phase microextraction of analytes from a sample held in the sample holder. Methods of collection and analysis include using simultaneous multifiber solid phase microextraction of analytes from a sample.
摘要翻译：公开了收集和分析样品中分析物的装置和方法。在一个实施方案中，提供了一种提取室，其包括样品保持器和提取盖，其允许来自保持在样品保持器中的样品的分析物的同时多纤维固相微萃取。收集和分析方法包括使用来自样品的分析物的同时多纤维固相微萃取。

20. 发明授权

US09009095B1 Method and system for utilizing Markov chain Monte Carlo simulations 有权
标题翻译：利用马尔科夫链蒙特卡洛模拟的方法和系统
公开(公告)号：US09009095B1
公开(公告)日：2015-04-14
申请号：US13005433
申请日：2011-01-12
申请人： Mohsin Saleet Fafri , Tuan Minh Hoang-Trong , George Stuart Blair Williams
发明人： Mohsin Saleet Fafri , Tuan Minh Hoang-Trong , George Stuart Blair Williams
IPC分类号： G06N7/06 , G06F9/44 , G06N7/00 , G06F19/00
CPC分类号： G06N7/005 , G06F17/18
摘要： Systems and methods for determining a probability of changing from one state to another in a stochastic entity, comprising: determining the compact component matrix utilizing characteristic information of the stochastic entity; determining the compact composite component matrix by taking a Kroneker product of the compact component matrix and an identity matrix; determining and placing all current states for the stochastic entity into a state space matrix; determining a Q matrix and/or a transition rate matrix using the compact composite component matrix and basic conditions or variables of the problem domain and/or a compact transition rate matrix; and performing Markov chain Monte Carlo (MCMC) simulation using information from the state space matrix and information from the transition rate matrix to determine the probability of changing from one state to another state in the stochastic entity.
摘要翻译：用于确定在随机实体中从一个状态变化到另一个状态的概率的系统和方法，包括：利用所述随机实体的特征信息确定所述紧凑分量矩阵; 通过采用紧凑分量矩阵的Kroneker积和单位矩阵来确定紧凑复合成分矩阵; 确定并将随机实体的所有当前状态置于状态空间矩阵中; 使用紧凑复合分量矩阵和问题域的基本条件或变量和/或紧凑转换速率矩阵来确定Q矩阵和/或转换速率矩阵; 并使用来自状态空间矩阵的信息和来自转换速率矩阵的信息来执行马尔可夫链蒙特卡洛（MCMC）模拟，以确定随机实体中从一种状态变为另一种状态的概率。

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