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11. 发明授权

US06365366B1 T2k kinase assays 有权
标题翻译： T2k激酶测定
公开(公告)号：US06365366B1
公开(公告)日：2002-04-02
申请号：US09524435
申请日：2000-03-13
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C12Q142
CPC分类号： C12Q1/485 , G01N33/573 , Y10S435/968
摘要： T2K kinase activity is detected by forming a mixture of a T2K kinase and a substrate; incubating the mixture under conditions whereby the kinase phosphorylates the substrate at a first rate; and detecting the first rate as an indication of the kinase activity. The substrate comprises SX1X2X3SX4 (SEQ ID NO:1) wherein X1 and X4 are aliphatic residues and both of the S residues are targets of the kinase, and especially, IKK&agr; or IKK&bgr;. In another embodiment, the mixture substrate comprises a particular IL-1 or TNF signaling cascade component. The mixture may be used to screen for agents which modulate the activity of the kinase, e.g. as an immuno-chemiluminescent assay.
摘要翻译：通过形成T2K激酶和底物的混合物来检测T2K激酶活性; 在使激酶以第一速率磷酸化底物的条件下孵育混合物; 并检测第一个速率作为激酶活性的指示。底物包含SX1X2X3SX4（SEQ ID NO：1），其中X 1和X 4是脂族残基，并且S残基都是激酶的靶标，特别是IKKα或IKKβ。在另一个实施方案中，混合物底物包含特定的IL-1或TNF信号传导级联组分。该混合物可用于筛选调节激酶活性的试剂，例如，作为免疫化学发光测定。

12. 发明授权

US07045613B2 IKK-αproteins, nucleic acids and methods 失效
标题翻译： IKK-alphaproteins，核酸和方法
公开(公告)号：US07045613B2
公开(公告)日：2006-05-16
申请号：US10243408
申请日：2002-09-13
申请人： Mike Rothe , Zhaodan Cao , Catherine Régnier
发明人： Mike Rothe , Zhaodan Cao , Catherine Régnier
IPC分类号： C12N15/54
CPC分类号： G01N33/6842 , C12N9/1205 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N2333/9121
摘要： The invention provides methods and compositions relating to an IκB kinase, IKK-α, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-α encoding nucleic acids or purified from human cells. The invention provides isolated IKK-α hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-α genes, IKK-α-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与IkappaB激酶，IKK-α和相关核酸有关的方法和组合物。可以从所公开的IKK-α编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的IKK-α基因，IKK-α特异性结合剂如特异性抗体特异性杂交的分离的IKK-α杂交探针和引物，以及制备和使用受试者组合物在诊断，治疗和生物制药行业。

13. 发明授权

US06280955B1 Interleukin-1 receptor accessory proteins, nucleic acids and methods 失效
标题翻译：白细胞介素-1受体辅助蛋白，核酸和方法
公开(公告)号：US06280955B1
公开(公告)日：2001-08-28
申请号：US08991944
申请日：1997-12-16
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C07K14705
CPC分类号： C07K14/7155 , G01N2500/20
摘要： The invention provides methods and compositions relating to IL-1RAcP proteins that regulate cellular signal transduction and transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IL-1RAcP encoding nucleic acids purified from human cells. The invention provides isolated IL-1RAcP hybridization probes and primers capable of specifically hybridizing with the disclosed IL-1RAcP genes, IL-1RAcP-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与调节细胞信号转导和转录激活的IL-1RAcP蛋白相关的方法和组合物以及相关的核酸。可以从编码从人细胞纯化的核酸的公开的IL-1RAcP转化的宿主细胞重组产生多肽。本发明提供了能够与所公开的IL-1RAcP基因，IL-1RAcP特异性结合剂如特异性抗体特异性杂交的分离的IL-1RAcP杂交探针和引物，以及制备和使用受试者组合物在诊断，治疗和生物制药行业。

14. 发明授权

US06235492B1 IKK-&agr; proteins, nucleic acids and methods 失效
标题翻译： IKK-α蛋白，核酸和方法
公开(公告)号：US06235492B1
公开(公告)日：2001-05-22
申请号：US09032476
申请日：1998-02-26
申请人： Mike Rothe , Zhaodan Cao , Catherine Régnier
发明人： Mike Rothe , Zhaodan Cao , Catherine Régnier
IPC分类号： C12Q148
CPC分类号： G01N33/6842 , C12N9/1205 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N2333/9121
摘要： The invention provides methods and compositions relating to an I&kgr;B kinase, IKK-&agr;, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-&agr; encoding nucleic acids or purified from human cells. The invention provides isolated IKK-&agr; hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-&agr; genes, IKK-&agr;-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与IkappaB激酶，IKK-α和相关核酸有关的方法和组合物。可以从所公开的IKK-α编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的IKK-α基因，IKK-α特异性结合剂如特异性抗体特异性杂交的分离的IKK-α杂交探针和引物，以及制备和使用受试者组合物在诊断，治疗和生物制药行业。

15. 发明授权

US5837514A I.kappa.B kinases 失效
公开(公告)号：US5837514A
公开(公告)日：1998-11-17
申请号：US812533
申请日：1997-03-07
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12Q1/48 , C12Q1/68 , G01N33/68 , C07H21/04 , C12N1/20 , C12N5/00
CPC分类号： G01N33/6872 , C07K14/4702 , C12Q1/48 , A61K38/00 , G01N2500/00
摘要： The invention provides methods and compositions relating to I.kappa.B regulating proteins, known as T2K proteins, and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed T2K encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed T2K gene, T2K-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

16. 发明申请

US20060019365A1 IKK-alpha proteins, nucleic acids and methods 审中-公开
公开(公告)号：US20060019365A1
公开(公告)日：2006-01-26
申请号：US11222158
申请日：2005-09-07
申请人： Mike Rothe , Zhaodan Cao , Catherine Regnier
发明人： Mike Rothe , Zhaodan Cao , Catherine Regnier
IPC分类号： C12N9/12 , C07H21/04 , C12P21/06
CPC分类号： G01N33/6842 , C12N9/1205 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N2333/9121
摘要： The invention provides methods and compositions relating to an IκB kinase, IKK-α, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-α encoding nucleic acids or purified from human cells. The invention provides isolated IKK-α hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-α genes, IKK-α-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

17. 发明授权

US5776717A I.kappa.B kinases 失效
标题翻译：我kappa B激酶
公开(公告)号：US5776717A
公开(公告)日：1998-07-07
申请号：US971937
申请日：1997-11-17
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12Q1/48 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6872 , C07K14/4702 , C12Q1/48 , A61K38/00 , G01N2500/00
摘要： The invention provides methods and compositions relating to I.kappa.B regulating proteins, known as T2K proteins, and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed T2K encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed T2K gene, T2K-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了涉及IκB调节蛋白（称为T2K蛋白）和相关核酸的方法和组合物。可以从所公开的T2K编码核酸的转化的宿主细胞重组产生蛋白质，或从人细胞纯化。本发明提供能够与所公开的T2K基因，特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用本发明组合物的方法。

18. 发明授权

US5747317A Human telomerase RNA interacting protein gene 失效
标题翻译：人端粒酶RNA相互作用蛋白基因
公开(公告)号：US5747317A
公开(公告)日：1998-05-05
申请号：US676967
申请日：1996-07-08
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C12N9/12 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1241
摘要： The invention provides methods and compositions relating to a human telomerase and related nucleic acids, including four distinct human telomerase subunit proteins called p140, p105, p48 and p43 having human telomerae-specific activity. The proteins may be produced recombinantly from transformed host cells from the disclosed telomerase encoding nucleic acids or purified from human cells. Also included are human telomerase RNA components, as well as specific, functional derivative thereof. The invention provides isolated telomerase hybridization probes and primers capable of specifically hybridizing with the disclosed telomerase gene, telomerase-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与人类端粒酶和相关核酸相关的方法和组合物，包括具有人类端粒特异性活性的称为p140，p105，p48和p43的四种不同的人端粒酶亚基蛋白。可以从所公开的编码端粒酶的核酸转化的宿主细胞重组产生蛋白质，或从人细胞纯化。还包括人端粒酶RNA组分以及其具体的功能衍生物。本发明提供了能够与所公开的端粒酶基因，端粒酶特异性结合剂如特异性抗体特异性杂交的分离的端粒酶杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用该主题组合物的方法。

19. 发明授权

US08022061B2 N-aryl pyrazole compounds, compositions, and methods for their use 有权
标题翻译： N-芳基吡唑化合物，组合物及其使用方法
公开(公告)号：US08022061B2
公开(公告)日：2011-09-20
申请号：US11973900
申请日：2007-10-09
申请人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
发明人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
IPC分类号： C07D403/04 , C07D417/14 , A61K31/506
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds having formula I: where A1, A2, L, V, W, R1, R2, R3, R4 and R5 are as described herein, compositions thereof, and their use for the treatment or prevention of type 2 diabetes and type 2 diabetes-related conditions are provided herein.
摘要翻译：具有式I的化合物：其中A1，A2，L，V，W，R1，R2，R3，R4和R5如本文所述，其组合物及其用于治疗或预防2型糖尿病和2型糖尿病 - 在此提供相关条件。

20. 发明授权

US06479266B1 IKK-&agr; proteins nucleic acids and methods 失效
标题翻译： IKK-α蛋白核酸和方法
公开(公告)号：US06479266B1
公开(公告)日：2002-11-12
申请号：US09109986
申请日：1998-07-02
申请人： Mike Rothe , Zhaodan Cao , Catherine Régnier
发明人： Mike Rothe , Zhaodan Cao , Catherine Régnier
IPC分类号： C12N912
CPC分类号： G01N33/6842 , C12N9/1205 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N2333/9121
摘要： The invention provides methods and compositions relating to an I&kgr;B kinase, IKK-&agr;, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-&agr; encoding nucleic acids or purified from human cells. The invention provides isolated IKK-&agr; hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-&agr; genes, IKK-&agr;-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与IkappaB激酶，IKK-α和相关核酸有关的方法和组合物。可以从所公开的IKK-α编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的IKK-α基因，IKK-α特异性结合剂如特异性抗体特异性杂交的分离的IKK-α杂交探针和引物，以及制备和使用受试者组合物在诊断，治疗和生物制药行业。

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