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11. 发明申请

US20120142596A1 AGENT FOR STIMULATING MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS 审中-公开
标题翻译：刺激内源性原核细胞动员的药剂
公开(公告)号：US20120142596A1
公开(公告)日：2012-06-07
申请号：US13389954
申请日：2010-08-12
申请人： Young Sook Son , Hyun Sook Hong
发明人： Young Sook Son , Hyun Sook Hong
IPC分类号： A61K38/08 , A61P27/16 , A61P1/04 , C07K7/06 , A61P25/00
CPC分类号： A61K38/046
摘要： The present invention provides a composition for stimulating the mobilization of endothelial precursor cells, which comprises substance-P (SP). Substance-P according to the invention exhibits an activity of stimulating the mobilization of endothelial precursor cells from the bone marrow, thereby stimulating vasculogenesis. Thus, substance-P exhibits excellent effects on the prevention or treatment of diseases, including myocardial infarction, angina, ischemic stroke, cerebrovascular dementia, cerebral infarction, sequelae of cerebral injury, spinal cord injury, sequelae of spinal nerve injury, degenerative diseases, sequelae of cerebral infarction, peripheral nerve disorders, presbyopia, degenerative hearing loss, sequelae of brain surgery, and diabetic ulcer, which are accompanied by ischemic vascular injury or traumatic vascular injury.
摘要翻译：本发明提供了一种用于刺激内皮前体细胞动员的组合物，其包括物质-P（SP）。根据本发明的物质-P表现出刺激内皮前体细胞从骨髓的动员，从而刺激血管发生的活性。因此，物质-P对预防或治疗包括心肌梗死，心绞痛，缺血性中风，脑血管性痴呆，脑梗塞，脑损伤后遗症，脊髓损伤，脊髓神经损伤后遗症，退行性疾病，后遗症等疾病的预防或治疗具有优异的效果的脑梗塞，周围神经障碍，老花眼，退行性听力损失，脑外科后遗症和糖尿病性溃疡，伴有缺血性血管损伤或创伤性血管损伤。

12. 发明授权

US09107976B2 Bio-adhesive agent comprising surface-modified hydroxyapatite and use thereof 有权
标题翻译：包含表面改性羟基磷灰石的生物粘合剂及其用途
公开(公告)号：US09107976B2
公开(公告)日：2015-08-18
申请号：US13702852
申请日：2011-11-10
申请人： Young Sook Son , Eun Ah Lee , Seung Woo Nam
发明人： Young Sook Son , Eun Ah Lee , Seung Woo Nam
IPC分类号： A61L24/00 , A61L24/02 , A61L27/32
CPC分类号： A61L24/00 , A61L24/02 , A61L27/32 , A61L2400/18
摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.
摘要翻译：本发明涉及一种包含表面改性羟基磷灰石的生物粘合剂及其用途。更具体地，本发明涉及用于骨与骨，骨和组织，骨和软骨或骨和腱之间的粘附的生物粘合剂，或用于在骨骼或人造关节之间粘合屏蔽物包括表面改性的羟基磷灰石作为活性成分，其中表面改性的羟基磷灰石的特征在于某些接头化合物共价键合到羟基磷灰石的表面上; 使用表面改性羟基磷灰石涂覆金属假体的表面的方法; 以及通过所述方法获得的涂覆有表面改性羟基磷灰石的金属假体。

13. 发明申请

US20140065109A1 USE OF SUBSTANCE P FOR MOBILIZATION OF MESENCHYMAL STEM CELLS OR PROLIFERATION OF MESENCHYMAL STEM CELLS AND FOR WOUND HEALING OR FACILITATING WOUND HEALING 有权
标题翻译：使用物质P用于移植细胞干细胞或增殖细胞干细胞，并用于治疗或促进创伤愈合
公开(公告)号：US20140065109A1
公开(公告)日：2014-03-06
申请号：US14018772
申请日：2013-09-05
申请人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
发明人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
IPC分类号： A61K38/04
CPC分类号： A61K38/046 , A61K35/28 , A61K2300/00
摘要： The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
摘要翻译：本发明涉及物质-P在制备用于从骨髓中移动或增殖间充质干细胞（MSC）或促进所述动员或增殖的药物的用途，以及使用物质-P来制造用于伤口愈合或促进伤口愈合的药物。

14. 发明授权

US08551470B2 Use of substance P for mobilization of Mesenchymal stem cells or proliferation of Mesenchymal stem cells and for wound healing or facilitating wound healing 有权
标题翻译：使用物质P用于间充质干细胞的移动或间充质干细胞的增殖和伤口愈合或促进伤口愈合
公开(公告)号：US08551470B2
公开(公告)日：2013-10-08
申请号：US11259550
申请日：2005-10-25
申请人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
发明人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： A61K38/046 , A61K35/28 , A61K2300/00
摘要： The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
摘要翻译：本发明涉及物质-P在制备用于骨髓间充质干细胞（MSC）的移动或增殖或促进所述动员或增殖的药物中的用途，以及使用物质-P来制造用于伤口愈合或促进伤口愈合的药物。

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