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    • 13. 发明授权
    • Methods of use for peptides having activities of insulin like growth factor-1
    • 使用具有胰岛素样生长因子-1活性的肽的方法
    • US08263095B2
    • 2012-09-11
    • US12659546
    • 2010-03-12
    • Yong Ji ChungYoung Deug KimEun Mi Kim
    • Yong Ji ChungYoung Deug KimEun Mi Kim
    • A61K8/64A61K8/00A61K38/30A61K38/08C07K14/65
    • C07K14/65A61K38/00
    • The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
    • 本发明涉及具有胰岛素样生长因子-1(IGF-1)的活性并衍生自IGF-1的肽,用于改善皮肤病症或治疗包含该肽的牙周病的组合物。 本发明的IGF-1模拟肽与天然存在的IGF-1具有与天然存在的IGF-1相同的功能或作用,并且比天然存在的IGF-1具有更好的稳定性和皮肤渗透性。 在这些连接中,包含本发明的肽的组合物可以在治疗,预防和改善需要IGF-1活性的疾病或病症方面表现出优异的功效。 此外,本发明的肽可以有利地应用于药物组合物,准药物和化妆品。
    • 15. 发明申请
    • Peptides for Promoting Hair Growth and Improving Wrinkle and Cosmetic Compositions Comprising the same
    • 用于促进头发生长和改善皱纹和化妆品组合物的肽包括它们
    • US20090054349A1
    • 2009-02-26
    • US12083969
    • 2006-10-24
    • Yong Ji ChungYoung Deug KimChung Ryul Kim
    • Yong Ji ChungYoung Deug KimChung Ryul Kim
    • A61K38/00C07K7/00A61P17/00
    • C07K14/57581
    • The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin β-4 (Tβ4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tβ4 and its biological activity is almost identical to natural-occurring Tβ4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tβ4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin β-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics. Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.
    • 本发明涉及包含具有人胸腺素β-4(Tbeta4)活性的特定氨基酸序列的肽及其用途。 本发明的肽对人Tbeta4具有相同或相似的功能或作用,其生物活性几乎与天然存在的Tbeta4相同。 此外,本发明的肽比天然存在的Tbeta4显示出更高的稳定性和皮肤渗透性。 在这些连接中,包含本发明的肽的组合物可以在改善胸腺素β-4有效障碍或病症方面表现出优异的效力。 此外,本发明的肽可以有利地应用于药物,化妆品,牙膏和用于口腔清洁和护理的组合物,最优选化妆品。 具体地说,本发明的肽有利地用于促进头发生长的化妆品中。
    • 16. 发明授权
    • Peptides for promoting hair growth and improving wrinkle and cosmetic compositions comprising the same
    • 用于促进毛发生长和改善皱纹的肽和包含其的化妆品组合物
    • US08106017B2
    • 2012-01-31
    • US12083969
    • 2006-10-24
    • Yong Ji ChungYoung Deug KimChung Ryul Kim
    • Yong Ji ChungYoung Deug KimChung Ryul Kim
    • A61K38/08
    • C07K14/57581
    • The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin β-4 (Tβ4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tβ4 and its biological activity is almost identical to natural-occurring Tβ4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tβ4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin β-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics. Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.
    • 本发明涉及包含具有人胸腺素和特异性-4(T&bgr; 4)活性的特定氨基酸序列的肽及其用途。 本发明的肽对人类T细胞具有相同或相似的功能或作用;其生物学活性几乎与天然发生的T&bgr相同; 4。 此外,本发明的肽表现出比天然存在的T&bgr更高的稳定性和皮肤渗透性。 在这些连接中,包含本发明的肽的组合物可以在改善胸腺素和/或b-4-有效障碍或病症方面表现出优异的功效。 此外,本发明的肽可以有利地应用于药物,化妆品,牙膏和用于口腔清洁和护理的组合物,最优选化妆品。 具体地说,本发明的肽有利地用于促进头发生长的化妆品中。