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11. 发明授权

US07919494B2 Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound 有权
标题翻译：吡啶基非芳族含氮杂环-1-羧酸酯化合物
公开(公告)号：US07919494B2
公开(公告)日：2011-04-05
申请号：US12543690
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：新型吡啶基非芳族含氮杂环-1-羧酸酯化合物及其药学上可接受的盐具有有效的FAAH抑制活性。此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

12. 发明申请

US20100009971A1 Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound 有权
标题翻译：含吡啶基非芳香族氮的杂环-1-羧酸酯化合物
公开(公告)号：US20100009971A1
公开(公告)日：2010-01-14
申请号：US12543659
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K31/444 , C07D413/12 , C07D401/12 , A61P25/00 , C07D405/14 , A61P13/00
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：新型吡啶基非芳族含氮杂环-1-羧酸盐化合物或其药学上可接受的盐具有有效的FAAH抑制活性。此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

13. 发明授权

US06489324B2 Piperazine compounds as inhibitors of MMP or TNF 失效
标题翻译：哌嗪化合物作为MMP或TNF的抑制剂
公开(公告)号：US06489324B2
公开(公告)日：2002-12-03
申请号：US09982869
申请日：2001-10-22
申请人： Masahiro Neya , Hitoshi Yamazaki , Natsuko Kayakiri , Kentaro Sato , Teruo Oku
发明人： Masahiro Neya , Hitoshi Yamazaki , Natsuko Kayakiri , Kentaro Sato , Teruo Oku
IPC分类号： C07D24104
CPC分类号： C07D405/12 , C07D241/04 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R1 is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R2 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R3 is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substituted lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substituted amino; R4 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R5 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R10 is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP-or TNF&agr;-medicated diseases.
摘要翻译：式（I）的化合物，其中A是磺酰基或羰基; R1是任选取代的芳基，任选取代的杂环基，任选取代的低级烷基或任选取代的低级烯基; R2是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R3是任选取代的低级烷基，任选取代的低级烷氧基，任选取代的芳氧基，任选取代的低级烯基，任选取代的芳基，任选取代的杂环基或任选取代的氨基; R4是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R5是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 10为羟基或被保护的羟基及其药学上可接受的盐。本发明的化合物可用作用于预防和治疗MMP或TNFα药物疾病的药物。

14. 发明授权

US08453492B2 Breath alcohol measuring apparatus 有权
标题翻译：呼吸酒精测量仪器
公开(公告)号：US08453492B2
公开(公告)日：2013-06-04
申请号：US13162030
申请日：2011-06-16
申请人： Hanzo Tsuzuki , Kentaro Sato , Yuji Yamazawa
发明人： Hanzo Tsuzuki , Kentaro Sato , Yuji Yamazawa
IPC分类号： G01N33/497
CPC分类号： G01N33/98 , G01N33/4972
摘要： When a pressure of a breath is kept to fall within a valid range, a CPU of a breath alcohol measuring apparatus updates a breath amount accumulation value that is an accumulation value of the amount of the breath blown into a mouth piece; when the breath pressure reaches the range outside the valid range, the CPU resets the breath amount accumulation value; and when the breath amount accumulation value reaches a valid breath amount, the CPU measures the alcohol concentration by an alcohol sensor. A breath pressure display portion is arranged at the position that can visually be recognized by a to-be-measured person who is blowing into the mouth piece.
摘要翻译：当呼吸压力保持在有效范围内时，呼吸酒精测量装置的CPU更新作为吹入口部件的呼吸量的累积值的呼吸量累积值; 当呼吸压力达到超出有效范围的范围时，CPU复位呼吸量积累值; 当呼吸量积累值达到有效呼吸量时，CPU通过酒精传感器测量酒精浓度。呼吸压力显示部配置在能够被吹入口部的被测量人物视觉识别的位置。

15. 发明授权

US07919495B2 Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound 有权
标题翻译：吡啶基非芳族含氮杂环-1-羧酸酯化合物
公开(公告)号：US07919495B2
公开(公告)日：2011-04-05
申请号：US11816508
申请日：2006-02-16
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：提供可用于治疗与脂肪酸酰胺水解酶（FAAH）相关的疾病的化合物，特别是用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。我们已经发现，新的吡啶基非芳族含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有有效的FAAH抑制活性。此外，本发明的吡啶基非芳香族含氮杂环-1-羧酸酯衍生物对提高膀胱容量有效，尿失禁效果优异，抗异常性疼痛效果优异，因此可以使用用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

16. 发明授权

US07915261B2 Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound 有权
标题翻译：吡啶基非芳族含氮杂环-1-羧酸酯化合物
公开(公告)号：US07915261B2
公开(公告)日：2011-03-29
申请号：US12543659
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：新型吡啶基非芳族含氮杂环-1-羧酸盐化合物或其药学上可接受的盐具有有效的FAAH抑制活性。此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

17. 发明申请

US20090141287A1 Surface-distortion Measuring Device and Method 有权
标题翻译：表面失真测量装置及方法
公开(公告)号：US20090141287A1
公开(公告)日：2009-06-04
申请号：US11991788
申请日：2006-09-14
申请人： Kentaro Sato , Takanobu Saito , Takashi Iwama , Akihide Yoshitake , Mitsuaki Uesugi
发明人： Kentaro Sato , Takanobu Saito , Takashi Iwama , Akihide Yoshitake , Mitsuaki Uesugi
IPC分类号： G01B11/25
CPC分类号： G01B11/2536 , G01B11/2527 , G01B11/2531 , G01M11/005 , G01N21/8806 , G06T7/521
摘要： A surface-distortion measuring device and a surface-distortion measuring method can quantitatively, rapidly, and highly accurately measure and evaluate surface-distortion distribution at all of observable points on a specular or semi-specular surface of a measurement target. The device includes pattern displaying means 2 capable of switching and displaying a plurality of kinds of light-and-shade patterns 5, capturing means 3 for capturing mirror images, reflected in the specular or semi-specular surface of a measurement target 1, of the plurality of light-and-shade patterns displayed on the pattern displaying means, and surface-distortion distribution calculating means 10 for performing image processing on the captured mirror images of the plurality of light-and-shade patterns to calculate surface-distortion distribution of the measurement-target surface.
摘要翻译：表面失真测量装置和表面失真测量方法可以定量，快速和高精度地测量和评估测量目标的镜面或半镜面上的所有可观察点处的表面失真分布。该装置包括能够切换和显示多种光和阴影图案的图案显示装置2，用于捕获反射在测量对象1的镜面或半镜面中的镜像的拍摄装置3，在图案显示装置上显示的多个光和阴影图案;以及表面失真分布计算装置10，用于对多个光和阴影图案的所拍摄的镜像进行图像处理，以计算出测量目标表面。

18. 发明申请

US20080306046A1 Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative 有权
标题翻译：含吡啶基非芳香族氮的杂环-1-羧酸酯衍生物
公开(公告)号：US20080306046A1
公开(公告)日：2008-12-11
申请号：US11816508
申请日：2006-02-16
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , A61K31/472 , A61K31/55 , A61P13/00 , A61P25/00 , A61K31/551 , A61K31/496 , C07D401/04 , C07D243/08
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： [Problem] To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.[Means for Solution] We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：提供可用于治疗与脂肪酰胺水解酶（FAAH）相关的疾病的化合物，特别是用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛的化合物。 [解决方案]我们已经发现，新的吡啶基非芳族含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有有效的FAAH抑制活性。此外，本发明的吡啶基非芳香族含氮杂环-1-羧酸酯衍生物对提高膀胱容量有效，尿失禁效果优异，抗异常性疼痛效果优异，因此可以使用用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

19. 发明授权

US06869691B2 High strength hot-dip galvanized steel sheet and method for manufacturing the same 有权
标题翻译：高强度热浸镀锌钢板及其制造方法
公开(公告)号：US06869691B2
公开(公告)日：2005-03-22
申请号：US10273052
申请日：2002-10-17
申请人： Yasunobu Nagataki , Fusato Kitano , Kentaro Sato , Masahiro Iwabuchi , Akira Gamou
发明人： Yasunobu Nagataki , Fusato Kitano , Kentaro Sato , Masahiro Iwabuchi , Akira Gamou
IPC分类号： C21D9/46 , C21D8/02 , C22C38/00 , C22C38/02 , C22C38/26 , C22C38/38 , C23C2/02 , C23C2/06 , C23C2/40 , B32B15/00 , C21D8/00
CPC分类号： C22C38/02 , C21D8/0205 , C21D8/0278 , C21D2211/002 , C21D2211/005 , C21D2211/008 , C22C38/26 , C22C38/38 , C23C2/02 , C23C2/06 , C23C2/40 , Y10T428/12799
摘要： The invention relates to a high strength hot-dip galvanized steel sheet consisting essentially of 0.03 to 0.25% C, 0.7% or less Si, 1.4 to 3.5% Mn, 0.05% or less P, 0.01% or less S, 0.05 to 1% Cr, 0.005 to 0.1% Nb, by mass, and balance of Fe, and being made of a composite structure of ferrite and secondary phase, and having an average grain size of the composite structure of 10 μm or smaller. Since the high strength hot-dip galvanized steel sheet of the present invention hardly induces softening at HAZ during welding, it is applicable to structural members of automobiles for “Tailor Welded Blanks” (TWB).
摘要翻译：本发明涉及基本上由0.03-0.25％C，0.7％或更少的Si，1.4到3.5％的Mn，0.05％或更少的P，0.01％或更少的S，0.05到1％ Cr，0.005〜0.1％Nb，余量为Fe，由铁素体和二次相的复合结构构成，复合结构的平均粒径为10μm以下。由于本发明的高强度热浸镀锌钢板在焊接时在HAZ几乎不发生软化，因此适用于“裁缝焊接坯料”（TWB）的汽车结构件。

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