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    • 20. 发明授权
    • Enzymatically debranched starches as tablet excipients
    • 酶促脱水淀粉作为片剂赋形剂
    • US5468286A
    • 1995-11-21
    • US316664
    • 1994-09-30
    • Chung Wai-ChiuJames J. Kasica
    • Chung Wai-ChiuJames J. Kasica
    • A61K9/20C08B30/12C12P19/14C09D103/02C08L3/02
    • C08B30/12A61K9/2059C12P19/14
    • A process for preparing a tablet excipient, comprising the steps:(a) enzymatically treating a starch containing greater than 90% amylopectin with an alpha-1,6-D-glucanohydrolase to debranch the starch and yield a mixture comprising a starch component selected from the group consisting of amylopectin, partially debranched amylopectin, and a combination thereof, and at least 20%, by weight, of a short chain amylose of from about 5 to 65 anhydroglucose units linked by alpha-1,4-D-glucoside bonds; and(b) drying the starch mixture,wherein the starch mixture is characterized by sufficient compressibility for use as an excipient, a binder, a binder-disintegrant, a binder-diluent, a filler or diluent, a moisture absorbent, a glidant, lubricant or flow agent, a surface gloss or hardness agent, or a combination thereof, in tablets.
    • 一种制备片剂赋形剂的方法,包括以下步骤:(a)用α-1,6-D-葡聚糖水解酶酶解处理含有大于90%支链淀粉的淀粉,以将淀粉脱支并产生包含选自 由支链淀粉,部分脱支链的支链淀粉及其组合组成的组,以及至少20重量%的通过α-1,4-D-葡萄糖苷键连接的约5至65个脱水葡萄糖单元的短链直链淀粉; 和(b)干燥淀粉混合物,其中淀粉混合物的特征在于用作赋形剂的足够的压缩性,粘合剂,粘合剂 - 崩解剂,粘合剂 - 稀释剂,填充剂或稀释剂,吸湿剂,助流剂,润滑剂 或流动剂,表面光泽或硬度剂,或其组合。