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11. 发明申请

US20060142337A1 Piperidine derivative and use thereof 审中-公开
标题翻译：哌啶衍生物及其用途
公开(公告)号：US20060142337A1
公开(公告)日：2006-06-29
申请号：US11358070
申请日：2006-02-22
申请人： Yoshinori Ikeura , Tadatoshi Hashimoto , Haruyuki Nishida , Junya Shirai , Nobuki Sakauchi
发明人： Yoshinori Ikeura , Tadatoshi Hashimoto , Haruyuki Nishida , Junya Shirai , Nobuki Sakauchi
IPC分类号： C07D211/54 , A61K31/445
CPC分类号： C07D211/46 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound represented by the formula: wherein Ar is an aryl group optionally having substituents, R is a C1-6 alkyl group, R1 is a hydrogen atom, a hydrocarbon group optionally having substituents, an acyl group or a heterocyclic group optionally having substituents, X is an oxygen atom or an imino group optionally having substituents, ring A is a piperidine ring optionally further having substituents, and ring B is a benzene ring having substituents, or a salt thereof, and an agent for the prophylaxis or treatment of lower urinary tract abnormality and the like, which contains the compound.
摘要翻译：本发明提供由下式表示的化合物：其中Ar是任选具有取代基的芳基，R是C 1-6烷基，R 1是氢任选具有取代基的烃基，任选具有取代基的酰基或杂环基，X是任选具有取代基的氧原子或亚氨基，环A是任选还具有取代基的哌啶环，环B是苯具有取代基的环或其盐，以及含有该化合物的预防或治疗下尿路异常等的药剂。

12. 发明授权

US07008940B1 Dihydrobenzofuran derivatives, process for the preparing thereof and agents 失效
标题翻译：二氢苯并呋喃衍生物，其制备方法和试剂
公开(公告)号：US07008940B1
公开(公告)日：2006-03-07
申请号：US10069314
申请日：2000-08-18
申请人： Shigenori Ohkawa , Tadatoshi Hashimoto , Tetsuya Tsukamoto
发明人： Shigenori Ohkawa , Tadatoshi Hashimoto , Tetsuya Tsukamoto
IPC分类号： A61P9/00 , A61P25/00 , A61K31/407 , A61K31/55 , C07D491/48
CPC分类号： C07D491/04
摘要： A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein ring A denotes a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, B ring denotes a benzene ring which may be further substituted, C ring denotes a dihydrofuran ring which may be further substituted, and R denotes hydrogen atom or an acyl group.
摘要翻译：由式（I）表示的化合物或其盐表现出优异的脂质过氧化抑制活性，可用作抑制脂肪过氧化物产生的试剂，其中环A表示非芳香族5至7元含氮杂环环可以进一步被取代，B环表示可以被进一步取代的苯环，C环表示可以被进一步取代的二氢呋喃环，R表示氢原子或酰基。

13. 发明申请

US20050038072A1 Nitrogeneous cyclic ketone derivative, process for producing the same, and use 审中-公开
标题翻译：亚硝基环酮衍生物，其制备方法和用途
公开(公告)号：US20050038072A1
公开(公告)日：2005-02-17
申请号：US10498228
申请日：2002-12-26
申请人： Masayoshi Yamaoka , Yoshinori Ikeura , Tadatoshi Hashimoto , Naoki Tarui
发明人： Masayoshi Yamaoka , Yoshinori Ikeura , Tadatoshi Hashimoto , Naoki Tarui
IPC分类号： A61P1/00 , A61P1/08 , A61P9/00 , A61P11/00 , A61P11/06 , A61P11/14 , A61P13/02 , A61P15/00 , A61P15/10 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/18 , A61P35/00 , A61P43/00 , C07D207/24 , C07D211/74 , C07D211/86 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D43/02 , A61K31/445 , A61K31/454
CPC分类号： C07D405/04 , C07D207/24 , C07D211/74 , C07D211/86 , C07D401/06 , C07D401/10 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D417/04
摘要： A novel compound represented by the formula (I): wherein rings A and B each represents an optionally substituted aromatic ring, or rings A and B may be bonded to each other through linking between bonds or substituents thereof to form a ring; ring C represents a nitrogenous saturated heterocycle optionally having one or more substituents besides the oxo (provided that 2,3-dioxopyrrolidine ring is excluded); R1 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group; and indicates a single bond or a double bond. It has high antagonistic activity against a tachykinin receptor, especially an SP receptor.
摘要翻译：由式（I）表示的新化合物：其中环A和B各自表示任选取代的芳环，或者环A和B可以通过键或取代基之间的连接键合而形成环; 环C表示除了氧代外，任选具有一个或多个取代基的氮饱和杂环（只要不包括2,3-二氧代吡咯烷环）; R 1表示氢，任选取代的烃基或任选取代的杂环基; 并表示单键或双键。对速激肽受体，特别是SP受体具有较高的拮抗作用。

14. 发明授权

US06172085B2 Cyclic ether compounds as sodium channel modulators 失效
标题翻译：环状醚化合物作为钠通道调节剂
公开(公告)号：US06172085B2
公开(公告)日：2001-01-09
申请号：US09242067
申请日：1999-02-08
申请人： Shigenori Ohkawa , Tadatoshi Hashimoto , Kohji Fukatsu
发明人： Shigenori Ohkawa , Tadatoshi Hashimoto , Kohji Fukatsu
IPC分类号： C07D40506
CPC分类号： C07D405/06 , C07D307/81 , C07D407/12
摘要： A compound of the formula: wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.
摘要翻译：下式的化合物：其中R1和R2各自表示氢，可被取代的或低级烷基的酰基; R 3，R 4和R 5各自表示可以被取代的低级烷基或可被取代的低级烷氧基，或者R 4和R 5一起代表5-或6-元碳环基; R6代表低级烷基; Ar表示可以被取代的芳基; 环A表示可以被取代的5至8元含氮杂环; X表示可以被取代的低级亚烷基; Y表示碳或氮; Za表示CH2，COCH2，OCH2，SCH2，NHCH2等; Zb表示可以被取代并可以含有O，N或S的键或二价脂族烃基; m表示1〜3的整数，或其盐可用于调制钠通道的药物组合物。

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