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11. 发明申请

US20060223820A1 Crystalline aripiprazole salts and processes for preparation and purification thereof 审中-公开
标题翻译：结晶阿立哌唑盐及其制备和纯化方法
公开(公告)号：US20060223820A1
公开(公告)日：2006-10-05
申请号：US11385412
申请日：2006-03-21
申请人： Michael Brand , Moti Shookrun , Irina Gribun , Itai Adin , Carmen Iustain , Oded Arad , Joseph Kaspi
发明人： Michael Brand , Moti Shookrun , Irina Gribun , Itai Adin , Carmen Iustain , Oded Arad , Joseph Kaspi
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/227 , C07B2200/13
摘要： Provided are novel crystalline carboxylic acid salts of aripiprazole, methods of using such salts, and processes for producing such salts.
摘要翻译：提供了阿立哌唑的新型结晶羧酸盐，使用这些盐的方法，以及这些盐的制备方法。

12. 发明申请

US20060069125A1 Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride 失效
公开(公告)号：US20060069125A1
公开(公告)日：2006-03-30
申请号：US11235106
申请日：2005-09-27
申请人： Oded Arad , Lior Zelikovitch , Mohammed Alnabari , Michael Brand , Irina Gribun , Ada Salman , Meital Shiffer , Moty Shookrun , Orna Kurlat , Moshe Bentolila , Joseph Kaspi
发明人： Oded Arad , Lior Zelikovitch , Mohammed Alnabari , Michael Brand , Irina Gribun , Ada Salman , Meital Shiffer , Moty Shookrun , Orna Kurlat , Moshe Bentolila , Joseph Kaspi
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D211/32
摘要： The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.

13. 发明授权

US07528254B2 Process for preparing montelukast and salts thereof 失效
标题翻译：孟鲁司特及其盐的制备方法
公开(公告)号：US07528254B2
公开(公告)日：2009-05-05
申请号：US11711042
申请日：2007-02-27
申请人： Michael Brand , Moty Shookrun , Oded Arad , Joseph Kaspi
发明人： Michael Brand , Moty Shookrun , Oded Arad , Joseph Kaspi
IPC分类号： C07D215/14
CPC分类号： C07D215/18
摘要： The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.
摘要翻译：本发明提供了一种通过使侧链前体1-（巯基甲基） - 环丙烷乙酸与2-（2-（3S） - （3-（7-氯-2-喹啉基）） - 乙烯基）苯基）-3-（甲磺酰氧基丙基）苯基-2-丙醇。

14. 发明申请

US20070213535A1 Process for the manufacture of aripiprazole by using purified carbostyril compounds such as 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones 审中-公开
标题翻译：通过使用纯化的喹诺酮化合物如7-（4-卤代丁氧基）-3,4-二氢-2（1H） - 喹啉酮制备阿立哌唑的方法
公开(公告)号：US20070213535A1
公开(公告)日：2007-09-13
申请号：US11714761
申请日：2007-03-07
申请人： Michael Brand , Irina Gribun , Oded Arad , Joseph Kaspi
发明人： Michael Brand , Irina Gribun , Oded Arad , Joseph Kaspi
IPC分类号： C07D403/02
CPC分类号： C07D215/227
摘要： The present invention provides a process for purifying carbostyril derivatives such as 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone and 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone and aripiprazole by passing a solution of the material in an organic solvent through a suitable absorbing material.
摘要翻译：本发明提供了一种纯化喹诺酮衍生物如7-（4-溴丁氧基）-3,4-二氢-2（1H） - 喹啉酮和7-（4-氯丁氧基）-3,4-二氢-2（1H ） - 喹啉酮和阿立哌唑，通过使材料在有机溶剂中的溶液通过合适的吸收材料。

15. 发明申请

US20060069263A1 Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole 审中-公开
标题翻译：还原（S）-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑的方法
公开(公告)号：US20060069263A1
公开(公告)日：2006-03-30
申请号：US11233096
申请日：2005-09-23
申请人： Irina Gribun , Ada Salman , Meital Shiffer , Moty Shookrun , Michael Brand , Oded Arad , Joseph Kaspi
发明人： Irina Gribun , Ada Salman , Meital Shiffer , Moty Shookrun , Michael Brand , Oded Arad , Joseph Kaspi
IPC分类号： C07D277/82
CPC分类号： C07D277/62
摘要： A process is disclosed for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole, which comprises reacting (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole with a borane reagent in the presence of suitable organic solvent to yield (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole base, which may be converted to an acid addition salt thereof. The process provided herein can be easily, conveniently and inexpensively scaled-up.
摘要翻译：公开了用于还原（S）-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑的方法，其包括使（S）-2-氨基-6-丙酰胺基-4,5,6 ，7-四氢苯并噻唑与硼烷试剂在合适的有机溶剂存在下反应，得到（S）-2-氨基-6-丙基氨基-4,5,6,7-四氢苯并噻唑碱，其可以转化为其酸加成盐。本文提供的方法可以容易地，方便地和低成本地放大。

16. 发明申请

US20060063927A1 Processes for preparing quetiapine and salts thereof 审中-公开
标题翻译：制备喹硫平及其盐的方法
公开(公告)号：US20060063927A1
公开(公告)日：2006-03-23
申请号：US11229678
申请日：2005-09-20
申请人： Olga Etlin , Michael Brand , Julia Ditkovich , Guy Davidi , Moty Shookrun , Oded Arad , Joseph Kaspi
发明人： Olga Etlin , Michael Brand , Julia Ditkovich , Guy Davidi , Moty Shookrun , Oded Arad , Joseph Kaspi
IPC分类号： C07D498/02
CPC分类号： C07D285/36
摘要： The present invention provides herein a two-step process for preparing pharmaceutically pure quetiapine and salts thereof by obtaining the starting material 11-chloro-dibenzo-thiazepine followed by reacting the 11-chloro-dibenzo-thiazepine with 1-(2-hydroxyethoxy)ethylpiperazine, or its salt, in the presence of an inorganic or organic base in an organic solvent or in a two-phase solvent system. The present invention provides also a novel, one-pot reaction process for preparing pharmaceutically pure quetiapine and salts thereof. The two processes provided herein can be easily, conveniently and inexpensively scaled-up.
摘要翻译：本发明在此提供了制备药学上纯的喹硫平及其盐的两步法，其方法是通过获得原料11-氯 - 二苯并 - 氮杂，然后将11-氯 - 二苯并噻吖庚因与1-（2-羟基乙氧基）乙基哌嗪，或其盐，在无机或有机碱存在下在有机溶剂中或在两相溶剂体系中。本发明还提供了一种用于制备药学上纯的喹硫平及其盐的新型一锅反应方法。这里提供的两个方法可以容易地，方便地和低成本地放大。

17. 发明授权

US06610886B2 Intermediate for preparing midodrine 失效
标题翻译：中间体用于制备midodrine
公开(公告)号：US06610886B2
公开(公告)日：2003-08-26
申请号：US10206968
申请日：2002-07-30
申请人： Michael Brand , Ronit Chen , Deby Yigal , Joseph Kaspi
发明人： Michael Brand , Ronit Chen , Deby Yigal , Joseph Kaspi
IPC分类号： C07C23305
CPC分类号： C07C237/08 , C07C231/12
摘要： The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2′,5′-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar′ are aryl groups.
摘要翻译：本发明提供了通过氢解取代的2-二苄基氨基-N- [2-（2（2-羟基苯基）-2-羟乙基）-2-羟乙基]乙酰胺来制备式1的2-氨基-N- [2-（2,5-二甲氧基苯基） '，5'-二甲氧基苯基）-2-羟基 - 乙基]乙酰胺，其中Ar和Ar'是芳基。

18. 发明申请

US20130197772A1 Hydrostatic Drive System 有权
标题翻译：静液压驱动系统
公开(公告)号：US20130197772A1
公开(公告)日：2013-08-01
申请号：US13699348
申请日：2011-05-25
申请人： Michael Brand
发明人： Michael Brand
IPC分类号： B60K28/16
CPC分类号： B60K28/16 , B60K17/356 , B60K23/08 , B60W2520/26
摘要： A hydrostatic drive system includes an anti-slip control unit having a hydraulic pump which supplies a plurality of hydraulic motors of a plurality of axles with pressure medium. Based on a detected slip, a control device switches over between a two-wheel and a multiple-wheel drive and controls the driving torque. Optimal distribution of driving torque and traction between the axles or wheels of the drive system is set in the drive system. A method for anti-slip control of a hydrostatic drive system includes reacting to a slip situation by activating a hydraulic motor for axles or wheels which until then were not driven, or driven only with low driving torque or by increasing the driving torque of wheels which until then did not slip. The capacity of the hydraulic motor of the axles or wheels is raised to enable the activation/increase.
摘要翻译：液压驱动系统包括具有液压泵的防滑控制单元，所述液压泵将多个轴的多个液压马达提供给压力介质。基于检测到的滑移，控制装置在两轮和多轮驱动之间切换，并控制驱动扭矩。在驱动系统中设置驱动系统的轴或车轮之间的驱动扭矩和牵引力的最佳分配。静液压驱动系统的防滑控制方法包括通过启动用于轴或车轮的液压马达来反应滑动状态，直到那时它们不被驱动，或仅以较低的驱动扭矩驱动或通过增加车轮的驱动扭矩直到那时才不滑。轴或车轮的液压马达的容量升高以使得能够启动/增加。

19. 发明授权

US08195459B1 Augmentation and calibration of output from non-deterministic text generators by modeling its characteristics in specific environments 有权
标题翻译：通过对特定环境中的特征进行建模来增强和校准非确定性文本生成器的输出
公开(公告)号：US08195459B1
公开(公告)日：2012-06-05
申请号：US12876207
申请日：2010-09-06
申请人： Michael Brand
发明人： Michael Brand
IPC分类号： G10L15/00
CPC分类号： G10L15/197 , G06F17/30705 , G06F17/30722 , G06F17/30867 , G06K9/03 , G06K9/685 , G10L15/26
摘要： Outputs of an automatic probabilistic event detection system, such as a fact extraction system, a speech-to-text engine or an automatic character recognition system, are matched with comparable results produced manually or by a different system. This comparison allows statistical modeling of the run-time behavior of the event detection system. This model can subsequently be used to give supplemental or replacement data for an output sequence of the system. In particular, the model can effectively calibrate the system for use with data of a particular statistical nature.
摘要翻译：自动概率事件检测系统（例如事实提取系统，语音到文本引擎或自动字符识别系统）的输出与手动或不同系统产生的可比结果相匹配。该比较允许对事件检测系统的运行时行为进行统计建模。该模型随后可用于为系统的输出序列提供补充或替换数据。特别地，该模型可以有效地校准系统以用于特定统计性质的数据。

20. 发明申请

US20100156407A1 Arragement and method for recognising and classifying preferably hidden objects in object and/or human traffic 失效
标题翻译：用于识别和分类对象和/或人类交通中的隐藏物体的方法和方法
公开(公告)号：US20100156407A1
公开(公告)日：2010-06-24
申请号：US12311157
申请日：2007-09-19
申请人： Holger Lausch , Wilfried Andrae , Michael Brand , Christoph Werner
发明人： Holger Lausch , Wilfried Andrae , Michael Brand , Christoph Werner
IPC分类号： G01R33/02 , G06N5/02
CPC分类号： G01V3/081 , G01V8/10
摘要： An arrangement and method recognizes and classifies preferably hidden objects in object and/or human traffic. Objects relevant to security are recognized, located and tracked through the surroundings thereof in moving object and human traffic isolated in real time. Use is made of a combination of a field generator, the field of which is modified by at least one corresponding object within the scanned space, first sensors which repeatedly record the changes in the field and provide corresponding signals, second sensors which record defined surroundings of the object in real-time with relation to the first sensors and provide corresponding signals and analytical means which correlate and collate the signals from the sensors with each other and which give from the same the shape, spatial position and/or spatial orientation of the object.
摘要翻译：布置和方法优选地将物体和/或人类交通中的隐藏物体识别和分类。与安全相关的对象在实时隔离的移动物体和人流中通过其周围地被识别，定位和跟踪。使用场发生器的组合，场的发生器由扫描空间内的至少一个对应物体修改，第一传感器重复地记录场中的变化并提供相应的信号，第二传感器记录定义的周围环境该物体与第一传感器实时相关，并提供相应的信号和分析装置，其将来自传感器的信号彼此相关联并且将其分类，并且从相同的方式给出物体的形状，空间位置和/或空间取向。

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