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11. 外观设计

USD1015954S1 Bike trailer hitch arm 有权
公开(公告)号：USD1015954S1
公开(公告)日：2024-02-27
申请号：US29819754
申请日：2021-12-17
申请人： Yan Chen
设计人： Yan Chen
摘要： FIG. 1 is a front perspective view of bike trailer hitch arm, showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

12. 发明授权

US11012285B2 Methods, apparatus, servers, and systems for vital signs detection and monitoring 有权
公开(公告)号：US11012285B2
公开(公告)日：2021-05-18
申请号：US16127151
申请日：2018-09-10
申请人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
发明人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
IPC分类号： H04L27/36 , H04W72/04 , H04B1/38 , H04L5/00
摘要： The present teaching relates to vital sign detection and monitoring based on channel state information (CSI). In one example, an apparatus for vital sign detection is disclosed. The apparatus comprises a receiver, a processor and a memory communicatively coupled with the processor. The receiver is configured for receiving at least one wireless signal from a multipath channel that can be impacted by a vital sign of at least one living being. The processor is configured for: extracting a time series of channel state information (CSI) for the multipath channel from the at least one wireless signal, obtaining one or more periodic fluctuations based on a spectral analysis of the time series of CSI, and determining whether the vital sign is present based on the one or more periodic fluctuations.

13. 发明授权

US10010552B2 Combination therapy comprising a CDK4/6 inhibitor and a PI3K inhibitor for use in the treatment of cancer 有权
公开(公告)号：US10010552B2
公开(公告)日：2018-07-03
申请号：US15003860
申请日：2016-01-22
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/519 , C07D487/02 , A61K31/4439 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.

14. 发明授权

US09815667B2 Coated sheave 有权
公开(公告)号：US09815667B2
公开(公告)日：2017-11-14
申请号：US14401378
申请日：2012-05-16
申请人： Xiaomei Yu , Yan Chen , David R. Polak , Daniel V. Viens , John P. Wesson
发明人： Xiaomei Yu , Yan Chen , David R. Polak , Daniel V. Viens , John P. Wesson
IPC分类号： B05D3/12 , B66B15/02 , B66B15/04 , B05D3/10 , F16H55/36 , B05D5/08 , B05D3/00
CPC分类号： B66B15/02 , B05D3/002 , B05D3/10 , B05D3/12 , B05D5/083 , B66B15/04 , F16H2055/366
摘要： A method for applying a coating to a substrate includes obtaining a fluorinated polymer compound, where the fluorine is chemically or covalently bonded to the polymer molecule; and coating the surface of the substrate with the fluorinated polymer compound.

15. 发明申请

US20160184311A1 Combination Therapy for the Treatment of Cancer 审中-公开
标题翻译：联合治疗癌症治疗
公开(公告)号：US20160184311A1
公开(公告)日：2016-06-30
申请号：US14911160
申请日：2014-08-07
申请人： Yan Chen , Xizhong Huang , Sunkyu Kim
发明人： Yan Chen , Xizhong Huang , Sunkyu Kim
IPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K31/138 , A61K31/565 , A61K31/5685 , A61K31/551 , A61K31/4196 , A61K31/436
CPC分类号： A61K31/519 , A61K31/138 , A61K31/4196 , A61K31/436 , A61K31/4439 , A61K31/5377 , A61K31/551 , A61K31/5513 , A61K31/565 , A61K31/5685 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.
摘要翻译：本公开涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，和（2）第二药剂，其是抗激素剂或其药学上可接受的盐。本公开还涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，（2）第二药剂，其是抗激素剂或其药学上可接受的盐，和 3）作为调节PI3K / Akt / mTOR途径的药剂的第三药剂或其药学上可接受的盐。

16. 发明授权

US09134304B2 Protein screening methods 有权
标题翻译：蛋白筛选方法
公开(公告)号：US09134304B2
公开(公告)日：2015-09-15
申请号：US13009500
申请日：2011-01-19
申请人： Richard W. Wagner , Alexander Litovchick , Yan Chen
发明人： Richard W. Wagner , Alexander Litovchick , Yan Chen
IPC分类号： C12N15/10 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： C12N15/1086 , C07K19/00 , C07K2317/10 , C07K2317/40 , C07K2317/56 , C12N15/1062 , C12N15/1075 , G01N33/5308 , G01N33/54366 , G01N33/6845
摘要： The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
摘要翻译：本发明提供了可用于在体外鉴定具有所需特征的多肽的方法和组合物。

17. 发明授权

US09001537B2 Power factor correction circuit 有权
标题翻译：功率因数校正电路
公开(公告)号：US09001537B2
公开(公告)日：2015-04-07
申请号：US13523615
申请日：2012-06-14
申请人： Hong-Yuan Jin , Yan Chen , Hong-Jian Gan , Jian-Ping Ying
发明人： Hong-Yuan Jin , Yan Chen , Hong-Jian Gan , Jian-Ping Ying
IPC分类号： H02H7/125 , H02M1/42 , H02M1/00 , H02M7/219
CPC分类号： H02M1/4233 , H02M2001/0048 , H02M2007/2195 , Y02B70/126 , Y02B70/1408 , Y02B70/1491
摘要： A power factor correction (PFC) circuit includes an AC power, a first bridge arm and a second bridge arm. The first bridge arm includes first and second switches connected in series with each other. A second terminal of the first switch is connected to a first terminal of the second switch, and coupled to a first end of the AC power via a first inductor. The second bridge arm includes third and fourth switches connected in series with each other. A second terminal of the third switch is connected to a first terminal of the fourth switch and a second end of the AC power. The third and fourth switches operate in ON/OFF states by use of a control signal having an operation frequency consistent with that of the AC power. The on-state resistance of the third and fourth switches is lower than that of the first or second switch.
摘要翻译：功率因数校正（PFC）电路包括AC电力，第一桥臂和第二桥臂。第一桥臂包括彼此串联连接的第一和第二开关。第一开关的第二端子连接到第二开关的第一端子，并且经由第一电感器耦合到AC电力的第一端。第二桥臂包括彼此串联连接的第三和第四开关。第三开关的第二端子连接到第四开关的第一端子和交流电源的第二端。第三和第四开关通过使用具有与AC电力的操作频率一致的操作频率的控制信号来操作ON / OFF状态。第三和第四开关的导通电阻低于第一或第二开关的导通电阻。

18. 发明授权

US08766627B2 Angle position sensor 有权
标题翻译：角度位置传感器
公开(公告)号：US08766627B2
公开(公告)日：2014-07-01
申请号：US13119482
申请日：2009-09-15
申请人： Wang Chunjian , Shun Zhang , Yan Chen , Yu Deng , Manuel Schoepke
发明人： Wang Chunjian , Shun Zhang , Yan Chen , Yu Deng , Manuel Schoepke
IPC分类号： G01B7/30 , G01D5/14
CPC分类号： G01D5/145
摘要： The present invention discloses an angular position sensor, which includes a rotor core as well as a stator core coaxially around this rotor core. Between the rotor core and the stator core is a first air gap, and inside the rotor core a second air gap, which is provided inside with a hard magnet. The stator core has a third air gap inside, which is provided inside with a magnetic flux sensing element. It is obvious that the present invention, by substituting the combination of the hard magnet and the rotor core for the design of ring magnet in the prior art, obtains the good linearity within a wider range.
摘要翻译：本发明公开了一种角位置传感器，其包括转子芯以及围绕该转子芯同轴的定子芯。在转子铁芯和定子铁芯之间是第一气隙，并且在转子铁芯的内部具有设置在内部的硬磁体的第二气隙。定子铁心内部具有第三气隙，内部设有磁通量感应元件。很明显，本发明通过用现有技术中的环形磁铁的设计代替硬磁体和转子铁芯的组合来获得较宽的线性度。

19. 发明授权

US08758009B2 Restorative dental appliances 有权
标题翻译：修复牙科用具
公开(公告)号：US08758009B2
公开(公告)日：2014-06-24
申请号：US12055010
申请日：2008-03-25
申请人： Yan Chen , Chunhua Li
发明人： Yan Chen , Chunhua Li
IPC分类号： A61C3/00
CPC分类号： A61C7/08 , A61C2201/007
摘要： A dental appliance including a concave trough conforming to a plurality of teeth when placed over the plurality of teeth. The concave trough is configured to transition from a first shape to a second shape if a deforming force is applied. The concave trough further includes a shape memory material. The shape memory material is configured to restore the concave trough to an approximate first shape upon an application of an external stimulus. The first shape is configured to apply a first force on a tooth when the trough conforms.
摘要翻译：一种牙科器具，当放置在所述多个牙齿上时，包括符合多个牙齿的凹槽。如果施加变形力，凹槽被构造成从第一形状转变到第二形状。凹槽还包括形状记忆材料。形状记忆材料配置成在施加外部刺激时将凹槽恢复到近似的第一形状。第一形状构造成当槽符合时在牙齿上施加第一力。

20. 发明授权

US08748415B2 C-28 amines of C-3 modified betulinic acid derivatives as HIV maturation inhibitors 有权
标题翻译： C-28修饰的桦木酸衍生物的C-28胺作为HIV成熟抑制剂
公开(公告)号：US08748415B2
公开(公告)日：2014-06-10
申请号：US13359680
申请日：2012-01-27
申请人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
发明人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
IPC分类号： A61K31/58 , C07J53/00
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula I a compound of formula II and a compound of formula III
摘要翻译：阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，具有独特抗病毒活性的C-3修饰的桦木酸衍生物的C-28胺被提供为HIV成熟抑制剂。这些化合物可用于治疗艾滋病毒和艾滋病。特别地，本文提供以下化合物，包括其药学上可接受的盐：式I化合物式II化合物和式III化合物

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