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11. 发明授权

US07917215B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07917215B2
公开(公告)日：2011-03-29
申请号：US12276070
申请日：2008-11-21
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos A. Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos A. Ricci , Scott A. Meyer
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

12. 发明申请

US20110160808A1 IMPLANTABLE MEDICAL DEVICE INCLUDING ISOLATION TEST CIRCUIT 失效
标题翻译：包括隔离测试电路的可植入医疗设备
公开(公告)号：US20110160808A1
公开(公告)日：2011-06-30
申请号：US12977158
申请日：2010-12-23
申请人： Michael J. Lyden , Joseph M. Bocek , Jeffrey E. Stahmann
发明人： Michael J. Lyden , Joseph M. Bocek , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/37 , A61N1/086 , A61N1/3706 , A61N1/3718 , A61N1/37258 , A61N1/3752 , A61N2001/083
摘要： An implantable medical device can include a hermetically-sealed implantable housing, an exposed first conductor located on or near the housing, and at least one insulated second conductor located near the exposed first conductor. In an example, the implantable medical device can include an isolation test circuit to provide a test stimulus to the exposed first conductor and configured to measure a portion of the test stimulus coupled to the second conductor.
摘要翻译：可植入医疗装置可以包括密封的可植入壳体，位于壳体上或附近的暴露的第一导体，以及位于暴露的第一导体附近的至少一个绝缘的第二导体。在一个示例中，可植入医疗设备可以包括隔离测试电路，以向暴露的第一导体提供测试刺激，并且被配置为测量耦合到第二导体的测试刺激的一部分。

13. 发明申请

US20110160783A1 MRI CARDIAC OPTIMIZATION 审中-公开
标题翻译： MRI心脏优化
公开(公告)号：US20110160783A1
公开(公告)日：2011-06-30
申请号：US12974774
申请日：2010-12-21
申请人： Joseph M. Bocek , Jeffrey E. Stahmann
发明人： Joseph M. Bocek , Jeffrey E. Stahmann
IPC分类号： A61N1/362 , A61N1/39 , A61N1/365
CPC分类号： A61N1/08
摘要： An implantable or other ambulatory device, such as a pacer, defibrillator, or other cardiac function management device, can use imaging information, such as one or more of cardiac functional magnetic resonance imaging (fMRI) information or cardiac magnetic resonance imaging (MRI) information, such as for helping optimize one or more parameters of the implantable or other ambulatory device.
摘要翻译：诸如起搏器，去纤颤器或其他心脏功能管理装置之类的可植入或其它移动装置可以使用成像信息，例如心脏功能磁共振成像（fMRI）信息或心脏磁共振成像（MRI）信息中的一种或多种，例如用于帮助优化可植入或其他移动装置的一个或多个参数。

14. 发明授权

US08750997B2 Implantable medical device including isolation test circuit 失效
标题翻译：可植入医疗器械包括隔离测试电路
公开(公告)号：US08750997B2
公开(公告)日：2014-06-10
申请号：US12977158
申请日：2010-12-23
申请人： Michael J. Lyden , Joseph M. Bocek , Jeffrey E. Stahmann
发明人： Michael J. Lyden , Joseph M. Bocek , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/086 , A61N1/3706 , A61N1/3718 , A61N1/37258 , A61N1/3752 , A61N2001/083
摘要： An implantable medical device can include a hermetically-sealed implantable housing, an exposed first conductor located on or near the housing, and at least one insulated second conductor located near the exposed first conductor. In an example, the implantable medical device can include an isolation test circuit to provide a test stimulus to the exposed first conductor and configured to measure a portion of the test stimulus coupled to the second conductor.
摘要翻译：可植入医疗装置可以包括密封的可植入壳体，位于壳体上或附近的暴露的第一导体，以及位于暴露的第一导体附近的至少一个绝缘的第二导体。在一个示例中，可植入医疗设备可以包括隔离测试电路，以向暴露的第一导体提供测试刺激，并且被配置为测量耦合到第二导体的测试刺激的一部分。

15. 发明授权

US08597197B2 Monitoring of heart sounds 有权
标题翻译：心音监听
公开(公告)号：US08597197B2
公开(公告)日：2013-12-03
申请号：US13491848
申请日：2012-06-08
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/02
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： A system comprises an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：一种系统包括可植入医疗装置（IMD），其包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生代表对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

16. 发明申请

US20080119750A1 MONITORING OF HEART SOUNDS 有权
标题翻译：心脏监测
公开(公告)号：US20080119750A1
公开(公告)日：2008-05-22
申请号：US11777739
申请日：2007-07-13
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/02 , A61N1/36
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： This document discusses, among other things, a system comprising an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：本文件尤其涉及一种包括可植入医疗装置（IMD）的系统，该可植入医疗装置（IMD）包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生表示被检体的心脏声音的电心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

17. 发明申请

US20120310099A1 MONITORING OF HEART SOUNDS 有权
标题翻译：心脏监测
公开(公告)号：US20120310099A1
公开(公告)日：2012-12-06
申请号：US13491848
申请日：2012-06-08
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/0205 , A61B7/00
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： A system comprises an implantable medical device (MID) including an implantableimplantabie heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：一种系统包括可植入医疗装置（MID），其包括可植入式植入物心音传感器电路，其被配置为产生表示对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

18. 发明授权

US07127290B2 Cardiac rhythm management systems and methods predicting congestive heart failure status 有权
公开(公告)号：US07127290B2
公开(公告)日：2006-10-24
申请号：US10213268
申请日：2002-08-06
申请人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
发明人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/4842
摘要： This document describes, among other things, systems, devices, and methods for predicting how the status of the patient's congestive heart failure (CHF) condition will progress in the future. In one example, a therapy is provided or adjusted at least in part in response to the prediction.

19. 发明授权

US08211034B2 Monitoring of heart sounds 有权
标题翻译：心音监听
公开(公告)号：US08211034B2
公开(公告)日：2012-07-03
申请号：US11777739
申请日：2007-07-13
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/02
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： This document discusses, among other things, a system comprising an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：本文件尤其涉及一种包括可植入医疗装置（IMD）的系统，该可植入医疗装置（IMD）包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生代表对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

20. 发明申请

US20100094102A1 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 有权
标题翻译：心脏失败患者管理的多传感器策略
公开(公告)号：US20100094102A1
公开(公告)日：2010-04-15
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

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