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11. 发明授权

US06926726B2 Thrombectomy and tissue removal method 失效
标题翻译：血栓切除术和组织清除法
公开(公告)号：US06926726B2
公开(公告)日：2005-08-09
申请号：US10405872
申请日：2003-04-02
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method for removing thrombus or other material from a natural or synthetic body vessel or cavity without the need for direct surgical access. The method includes providing a device supplying high pressure fluid to at least one distal orifice, causing high pressure fluid to emanate from the orifice creating at least one fluid jet, and using the fluid jet to break up material in the vessel. The method further includes directing at least one fluid jet at the opening of an exhaust lumen or target incorporated into the device and using the jet to provide a localized negative pressure which entrains material into the jet for break-up. The method optionally includes using the jet to provide stagnation pressure which drives material along the exhaust lumen. The method optionally includes metering the exhaust to match the fluid input or to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the distal end of the catheter.
摘要翻译：一种用于从天然或合成的身体血管或腔中去除血栓或其它物质而不需要直接外科手术的方法。该方法包括提供向至少一个远端孔提供高压流体的装置，从而产生高压流体从孔产生至少一个流体射流，并使用流体射流分解容器中的材料。该方法还包括将至少一个流体射流引导到排入管腔或靶的开口处并入该装置中，并使用喷射器提供局部负压，其将材料夹带到喷射器中用于分解。该方法可选地包括使用喷射器来提供沿排气腔驱动材料的停滞压力。该方法可选地包括计量排气以匹配流体输入或大于或小于输入。以稳定或脉动流动运行的正排量泵将高压盐水提供给导管的远端。

12. 发明授权

US06544209B1 Thrombectomy and tissue removal method and device 失效
标题翻译：血栓切除术和组织清除方法及装置
公开(公告)号：US06544209B1
公开(公告)日：2003-04-08
申请号：US08351613
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

13. 发明授权

US08894682B2 PFO clip 有权
标题翻译： PFO剪辑
公开(公告)号：US08894682B2
公开(公告)日：2014-11-25
申请号：US11518753
申请日：2006-09-11
申请人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
发明人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
IPC分类号： A61B17/08 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/083 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00893
摘要： Embodiments for a device, system and method for occluding an opening in a septum. Embodiments of the device can include a first control component, a first elongate member that extends from the first control component, a second elongate member, a connecting member that positions the first elongate member adjacent the second elongate member and a retraction member releasably coupled to the first control component. The retraction member can be used to change a relative position of the first elongate member and the second elongate member of the device.
摘要翻译：用于封闭隔膜中的开口的装置，系统和方法的实施例。该装置的实施例可以包括第一控制部件，从第一控制部件延伸的第一细长部件，第二细长部件，将第一细长部件定位成邻近第二细长部件的连接部件和可释放地联接到第一控制组件。缩回构件可用于改变第一细长构件和装置的第二细长构件的相对位置。

14. 发明授权

US08430837B2 Thrombectomy apparatus and method 有权
标题翻译：血栓切除装置及方法
公开(公告)号：US08430837B2
公开(公告)日：2013-04-30
申请号：US12026317
申请日：2008-02-05
申请人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
发明人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
IPC分类号： A61N1/30
CPC分类号： A61B17/32037 , A61B17/221 , A61B2017/2212 , A61F2/013
摘要： A thrombectomy system may include an elongate shaft that defines a high pressure lumen and a low pressure lumen. The high pressure lumen may terminate near an end of the low pressure lumen. An expandable capture basket may be disposed near the end of the low pressure lumen. A thrombectomy apparatus may include an elongate shaft, an evacuation lumen extending within the elongate shaft and a high pressure lumen extending within the elongate shaft. A capture apparatus may be disposed within a wire lumen that extends within the elongate shaft such that the capture apparatus extends distally from the wire lumen.
摘要翻译：血栓切除系统可以包括限定高压腔和低压腔的细长轴。高压腔可以在低压腔的端部附近终止。可扩张的捕获篮可以设置在低压腔的端部附近。血栓切除装置可以包括细长轴，在细长轴内延伸的抽空腔和在细长轴内延伸的高压腔。捕获装置可以设置在细长轴内延伸的线腔内，使得捕获装置从线腔向远侧延伸。

15. 发明申请

US20080312645A1 Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation 审中-公开
标题翻译：血管密封装置和使用凝块增强气球和电场的方法
公开(公告)号：US20080312645A1
公开(公告)日：2008-12-18
申请号：US12026067
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B18/14 , A61M29/02
CPC分类号： A61B18/14 , A61B17/0057 , A61B2017/00654 , A61N1/18 , A61N1/32
摘要： An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons
摘要翻译：公开了一种用于封闭血管壁中的开口的装置和方法。该装置包括至少一个构件，其延伸穿过通过表皮和皮下皮肤层形成的组织通道并且穿过血管中的开口。该构件包括近端和远端，远端可靠近血管壁中的开口定位。正电极位于远端附近，负极位于近端的旁边。当电极通电时，电极之间产生电场，血细胞被吸引到正电极，并且在开口处形成血栓在血管壁。该构件可以包括在远端处的气囊，以暂时阻断从血管到组织道的血流，以促进血栓的形成。此外，气囊的形状可以被调整以促进血栓的形成，包括但不限于创建口袋和自支撑气球

16. 发明授权

US09254124B2 Self-orientating suture wound closure device 有权
标题翻译：自定向缝合伤口闭合装置
公开(公告)号：US09254124B2
公开(公告)日：2016-02-09
申请号：US12026207
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B17/04 , A61B17/00 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/047 , A61B2017/0472 , A61B2017/3484 , A61B2090/067 , A61B2090/0811
摘要： A device is disclosed for providing an indication as to the relative position of a vessel or artery opening thereby facilitating the choice of which several closure techniques to use. A disclosed device includes an outer tube and a collapsible foot slidably disposed within a distal end of the outer tube. The device may further include one or more threaded suture needles, a biodegradable plug or other wound closing device that is connected to another shaft. The collapsed or folded foot is pushed distally out of the tube and through the opening in the vessel whereupon the foot expands. Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out.
摘要翻译：公开了一种用于提供关于血管或动脉开口的相对位置的指示的装置，从而便于选择使用哪些闭合技术。所公开的装置包括外管和可滑动地设置在外管的远端内的可折叠的脚。该装置还可以包括一个或多个螺纹缝合针，可生物降解的塞子或其它连接到另一轴的闭合装置。折叠或折叠的脚从管中向远侧推出并穿过容器中的足部膨胀的开口。沿着近端方向拉动扩张的脚提供关于容器中的开口的取向的指示，这有助于确定要执行的关闭程序的类型。

17. 发明申请

US20080312684A1 Apparatus and Method for Closing an Opening in a Blood Vessel Using a Permanent Implant 失效
标题翻译：使用永久植入物关闭血管开口的装置和方法
公开(公告)号：US20080312684A1
公开(公告)日：2008-12-18
申请号：US12026115
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadisiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadisiva
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00654 , A61B2017/00659 , A61B2017/0069 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884
摘要： An apparatus and method for closing an arteriotomy site is disclosed. The apparatus includes inner and outer frames adapted to sandwich a blood vessel wall therebetween. The inner and outer frames may be manufactured from memory metals such that they can be compressed during the insertion into the tissue tract proximate the arteriotomy site, and then deployed into an expanded configuration larger than the dimensions of the arteriotomy opening itself. A universal joint connects the inner and outer frames to ensure proper pivoting therebetween. In addition, polymeric coverings can be provided on the inner and outer frames to ensure closure, while a collagen plug can also be provided between inner and outer frames to facilitate closure as well.
摘要翻译：公开了一种闭合动脉切开部位的装置和方法。该装置包括适于将血管壁夹在其间的内框架和外框架。内框架和外框架可以由记忆金属制成，使得它们可以在插入到接近动脉切开部位的组织道中被压缩，然后展开成比动脉切开术本身的尺寸更大的扩张构型。万向接头连接内框架和外框架，以确保其间的适当枢转。此外，聚合物覆盖物可以设置在内框架和外框架上以确保关闭，同时也可以在内框架和外框架之间提供胶原塞以便于封闭。

18. 发明申请

US20080312683A1 Apparatus and Method for Closing an Opening in a Blood Vessel Using Memory Metal and Collagen 有权
标题翻译：使用记忆金属和胶原封闭血管开口的装置和方法
公开(公告)号：US20080312683A1
公开(公告)日：2008-12-18
申请号：US12026046
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00867
摘要： An apparatus and method for closing an arteriotomy site are disclosed. The apparatus and method employ the use of a delivery sheath within which is provided an anchoring device formed of memory metal. The delivery sheath can be inserted through a tissue tract extending from an epidermal layer to the blood vessel wall, whereupon the anchoring device can be extended from the delivery sheath into the blood vessel itself The memory metal, once freed from the delivery sheath, obtains a non-linear or coiled configuration which can then be pulled back against the inner surface of the blood vessel to form a backstop. A biodegradable plug is then introduced into the tissue tract until it engages the backstop formed by the anchoring device thereby ensuring proper positioning of the biodegradable plug. The anchoring device can then be retracted through the biodegradable plug leaving the arteriotomy site substantially closed with hemostasis being formed therearound The various biodegradable plugs disclosed provide for improved retention of the biodegradable plug and proper positioning of the plug within the tissue tract.
摘要翻译：公开了一种用于闭合动脉切开术部位的装置和方法。该装置和方法采用输送鞘，其中提供有由存储金属形成的锚定装置。输送鞘可以穿过从表皮层延伸到血管壁的组织管，从而锚固装置可以从输送鞘延伸到血管本身。一旦从输送鞘释放出来的记忆金属获得非线性或盘绕结构，然后可以将其拉回血管的内表面以形成止回。然后将可生物降解的塞子引入组织管道中，直到其接合由锚固装置形成的止挡件，从而确保生物可降解塞子的适当定位。锚定装置然后可以缩回通过可生物降解的塞子，留下动脉切开术位置基本上封闭，并在其周围形成止血。所公开的各种可生物降解的栓塞提供可改进的生物可降解塞的保持性并且将栓塞适当地定位在组织道内。

19. 发明申请

US20080312667A1 Self-Orientating Suture Wound Closure Device 有权
标题翻译：自定向缝合线封闭装置
公开(公告)号：US20080312667A1
公开(公告)日：2008-12-18
申请号：US12026207
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/047 , A61B2017/0472 , A61B2017/3484 , A61B2090/067 , A61B2090/0811
摘要： A device is disclosed for providing an indication as to the relative position of a vessel or artery opening thereby facilitating the choice of which suturing or plugging technique to thereafter use. A disclosed device includes an outer tube and a collapsible foot slidably disposed within a distal end of the outer tube. The foot is connected to a shaft that passes through the tube and exits a proximal end thereof. The device may further include one or more threaded suture needles, a biodegradable plug or other wound closing device that is connected to another shaft. The collapsed or folded foot is pushed distally out of the tube and through the opening in the vessel whereupon the foot expands. Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out. The shaft connected to the foot is preferably connected to an indicator that indicates to the operator or physician that the vessel opening is in one of three positions on the vessel—left, top or right. As an alternative, the indicator bar may indicate a relative position in degrees, mm or μm in deviation from a top stick (or top position).
摘要翻译：公开了一种用于提供关于血管或动脉开口的相对位置的指示的装置，从而便于选择其后使用哪种缝合或堵塞技术。所公开的装置包括外管和可滑动地设置在外管的远端内的可折叠的脚。脚连接到穿过管并离开其近端的轴。该装置还可以包括一个或多个螺纹缝合针，可生物降解的塞子或其它连接到另一轴的闭合装置。折叠或折叠的脚从管中向远侧推出并穿过容器中的足部膨胀的开口。沿着近端方向拉动扩张的脚提供关于容器中的开口的取向的指示，这有助于确定要执行的关闭程序的类型。连接到脚的轴优选地连接到指示器，该指示器向操作者或医师指示血管开口处于血管左，上或右的三个位置之一。作为替代，指示条可以指示与顶部棒（或顶部位置）偏离的度数，毫米或者母体的相对位置。

20. 发明申请

US20080255596A1 THROMBECTOMY APPARATUS AND METHOD 有权
标题翻译：镜像装置和方法
公开(公告)号：US20080255596A1
公开(公告)日：2008-10-16
申请号：US12026317
申请日：2008-02-05
申请人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
发明人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B17/221 , A61B2017/2212 , A61F2/013
摘要： A thrombectomy system may include an elongate shaft that defines a high pressure lumen and a low pressure lumen. The high pressure lumen may terminate near an end of the low pressure lumen. An expandable capture basket may be disposed near the end of the low pressure lumen. A thrombectomy apparatus may include an elongate shaft, an evacuation lumen extending within the elongate shaft and a high pressure lumen extending within the elongate shaft. A capture apparatus may be disposed within a wire lumen that extends within the elongate shaft such that the capture apparatus extends distally from the wire lumen.
摘要翻译：血栓切除系统可以包括限定高压腔和低压腔的细长轴。高压腔可以在低压腔的端部附近终止。可扩张的捕获篮可以设置在低压腔的端部附近。血栓切除装置可以包括细长轴，在细长轴内延伸的抽空腔和在细长轴内延伸的高压腔。捕获装置可以设置在细长轴内延伸的线腔内，使得捕获装置从线腔向远侧延伸。

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