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11. 发明申请

US20060121080A1 Medical devices having nanoporous layers and methods for making the same 审中-公开
标题翻译：具有纳米多孔层的医疗装置及其制造方法
公开(公告)号：US20060121080A1
公开(公告)日：2006-06-08
申请号：US11200655
申请日：2005-08-10
申请人： Whye Lye , Gary Owens , Matthew Hudson , Joshua Spradlin , Brian Warnhoff , Michael Reed , Kareen Looi
发明人： Whye Lye , Gary Owens , Matthew Hudson , Joshua Spradlin , Brian Warnhoff , Michael Reed , Kareen Looi
IPC分类号： A61F2/06 , A61K35/12
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

12. 发明申请

US20060193889A1 Nanoporous layers using thermal dealloying 审中-公开
标题翻译：使用热脱金属的纳米多孔层
公开(公告)号：US20060193889A1
公开(公告)日：2006-08-31
申请号：US11352427
申请日：2006-02-10
申请人： Joshua Spradlin , Whye-Kei Lye , Michael Reed , Matthew Hudson
发明人： Joshua Spradlin , Whye-Kei Lye , Michael Reed , Matthew Hudson
IPC分类号： A61H21/00 , A61F2/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

13. 发明申请

US20130198912A1 DNA SEQUENCE THAT CONFERS APHID RESISTANCE IN SOYBEAN 审中-公开
标题翻译： DNA序列在大豆中构成抗性
公开(公告)号：US20130198912A1
公开(公告)日：2013-08-01
申请号：US13577227
申请日：2011-02-04
申请人： Matthew Hudson , Brian Diers , Ki-Seung Kim , Jianping Wang
发明人： Matthew Hudson , Brian Diers , Ki-Seung Kim , Jianping Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C07K14/415 , C12N15/8286 , Y02A40/162
摘要： Provided herein are isolated nucleic acid molecules representing a genetically defined region of the genome of the aphid resistant soybean plant (Glycine max) cultivar Dowling that confers resistance to soybean aphid (Aphis glycines). Within the region is a gene encoding the aphid resistance protein Rag1. Rag1 aphid resistance amino acid sequences are also provided. Also provided herein are methods for conferring aphid resistance on a plant or enhancing aphid resistance in a plant by transforming it to contain and express such nucleic acid sequences encoding Rag1 aphid resistance or introgressing DNA encoding the trait into the plant by plant breeding. Further provided are polymorphic markers useful for identifying plant germplasm containing aphid resistance, and methods for makings such markers.
摘要翻译：本文提供了代表赋予对大豆蚜虫（蚜虫甘氨酸）抗性的蚜虫抗性大豆植物（Glycine max）栽培品种Dowling的基因组遗传定义区域的分离的核酸分子。该区域内是编码蚜虫抗性蛋白Rag1的基因。还提供了Rag1蚜虫抗性氨基酸序列。本文还提供了赋予植物蚜虫抗性或增强植物蚜虫抗性的方法，方法是将其转化成含有并表达编码Rag1蚜虫抗性的核酸序列或通过植物育种将编码该性状的DNA插入植物。还提供了可用于鉴定含有蚜虫抗性的植物种质的多态性标记，以及用于制备这种标记的方法。

14. 发明申请

US20130305410A1 RHG1 MEDIATED RESISTANCE TO SOYBEAN CYST NEMATODE 审中-公开
标题翻译： RHG1对大豆CYST NEMATODE的耐药性
公开(公告)号：US20130305410A1
公开(公告)日：2013-11-14
申请号：US13843447
申请日：2013-03-15
申请人： Andrew Farmer Bent , Matthew Hudson , Brian Diers , Sara Melito , David Edward Cook , Teresa Hughes , Adam Bayless , Jianping Wang , Tong Geon Lee , Xiaoli Guo
发明人： Andrew Farmer Bent , Matthew Hudson , Brian Diers , Sara Melito , David Edward Cook , Teresa Hughes , Adam Bayless , Jianping Wang , Tong Geon Lee , Xiaoli Guo
IPC分类号： C12N15/82
CPC分类号： C12N15/8285 , A01H5/10 , C07K14/415 , Y02A40/164
摘要： Methods of increasing the resistance of plants, in particular soybeans, to nematodes, in particular soybean cyst nematodes, are provided herein. The methods include increasing the expression of Glyma18g02580, Glyma18g02590 and/or Glyma18g2610 in cells of a plant and in particular in root cells of a plant to increase the resistance of the plant and plant cells to nematodes. The methods include increasing the expression using constitutive promoters or by increasing the copy number of the polynucleotides. Constructs for expressing these polypeptides, transgenic cells, transgenic plants and methods of generating the same are also provided. Methods of screening plant cells for resistance or susceptibility to nematodes are also provided.
摘要翻译：本文提供了将植物，特别是大豆，特别是大豆孢囊线虫的抗性增加的方法。所述方法包括增加植物细胞中Glyma18g02580，Glyma18g02590和/或Glyma18g2610的表达，特别是在植物的根细胞中增加植物和植物细胞对线虫的抗性。所述方法包括使用组成型启动子增加表达或增加多核苷酸的拷贝数。还提供了用于表达这些多肽，转基因细胞，转基因植物和产生其的方法的构建体。还提供了筛选植物细胞对线虫抗性或易感性的方法。

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