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11. 发明申请

US20130044370A1 DEVICE AND METHOD FOR SCANNING AN OBJECT AND A MICROSCOPE 审中-公开
标题翻译：用于扫描对象和显微镜的装置和方法
公开(公告)号：US20130044370A1
公开(公告)日：2013-02-21
申请号：US13578608
申请日：2011-02-11
申请人： Volker Seyfried , Bernd Widzgowski , Holger Birk
发明人： Volker Seyfried , Bernd Widzgowski , Holger Birk
IPC分类号： G02B21/33
CPC分类号： G02B21/33 , G02B21/0036
摘要： The invention relates to a device for scanning an object comprising a focusing lens system (30) which focuses an illuminating light beam (24) onto a region of the object to be analyzed. An actuator assembly is coupled to the focusing lens system (30) and moves the focusing lens system (30) in accordance with a predefined scanning pattern transversely to the cecenternter axis of the illumination light beam (24) in a reference position of the illumination light beam (24). A front glass (38) is disposed downstream of the focusing lens system (30) viewed in the direction of the illuminating light beam (24). An internal immersion medium (40) is disposed between the focusing lens system (30) and the front glass (38). An external immersion medium (48) can be introduced between the front glass (38) and the object.
摘要翻译：本发明涉及一种用于扫描物体的装置，包括聚焦透镜系统（30），其将照明光束（24）聚焦在被分析物体的区域上。致动器组件联接到聚焦透镜系统（30）并且在照明光的参考位置中根据预定的扫描图案横向于照明光束（24）的入射角轴线移动聚焦透镜系统（30）梁（24）。从照明光束（24）的方向观察，配置在聚焦透镜系统（30）的下游的前玻璃（38）。在聚焦透镜系统（30）和前玻璃（38）之间设置内部浸没介质（40）。可以在前玻璃（38）和物体之间引入外部浸没介质（48）。

12. 发明授权

US09450118B2 Detector apparatus 有权
标题翻译：检测仪
公开(公告)号：US09450118B2
公开(公告)日：2016-09-20
申请号：US14238849
申请日：2012-08-15
申请人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
发明人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
IPC分类号： H01J40/16 , H01L31/024 , H01J40/02 , H01J43/02 , H01J43/28
CPC分类号： H01L31/024 , H01J40/02 , H01J40/16 , H01J43/02 , H01J43/28
摘要： A detector apparatus that is embodied to receive light and to generate electrical signals has a housing and a detector arranged in the housing. The detector includes a light sensor that is embodied to receive light and to release electrons. The light sensor is at a lower electrical potential level than the housing; and that the detector is in thermally conductive contact with the housing via an electrically insulating intermediate arrangement, the thermal conduction direction inside the housing being opposite to the light propagation direction of the light to be detected.
摘要翻译：体现为接收光并产生电信号的检测器装置具有设置在壳体中的壳体和检测器。检测器包括被实现为接收光并释放电子的光传感器。光传感器处于比壳体更低的电位电平; 并且检测器经由电绝缘的中间布置与壳体导热接触，壳体内部的热传导方向与待检测光的光传播方向相反。

13. 发明申请

US20140306098A1 DETECTOR APPARATUS 有权
标题翻译：检测仪器
公开(公告)号：US20140306098A1
公开(公告)日：2014-10-16
申请号：US14238849
申请日：2012-08-15
申请人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
发明人： Bernd Widzgowski , Volker Seyfried , Holger Birk , Frank Schreiber
IPC分类号： H01L31/024 , H01J40/02
CPC分类号： H01L31/024 , H01J40/02 , H01J40/16 , H01J43/02 , H01J43/28
摘要： A detector apparatus that is embodied to receive light and to generate electrical signals has a housing and a detector arranged in the housing. The detector includes a light sensor that is embodied to receive light and to release electrons. The light sensor is at a lower electrical potential level than the housing; and that the detector is in thermally conductive contact with the housing via an electrically insulating intermediate arrangement, the thermal conduction direction inside the housing being opposite to the light propagation direction of the light to be detected.
摘要翻译：体现为接收光并产生电信号的检测器装置具有设置在壳体中的壳体和检测器。检测器包括被实现为接收光并释放电子的光传感器。光传感器处于比壳体更低的电位电平; 并且检测器经由电绝缘的中间布置与壳体导热接触，壳体内部的热传导方向与待检测光的光传播方向相反。

14. 发明授权

US08718414B2 Acousto-optical tunable filter element 有权
标题翻译：声光可调谐滤光片
公开(公告)号：US08718414B2
公开(公告)日：2014-05-06
申请号：US13366670
申请日：2012-02-06
申请人： Hilmar Gugel , Volker Seyfried
发明人： Hilmar Gugel , Volker Seyfried
IPC分类号： G02F1/335 , G02F1/11
CPC分类号： G02F1/116 , G02B3/0087 , G02B21/0032 , G02B21/0064 , G02B21/16 , G02B27/0927 , G02B27/42 , G02B27/46 , G02F1/00 , G02F1/01 , G02F1/03 , G02F1/11 , G02F1/29 , G02F1/33 , G02F1/353 , G02F2201/305 , G02F2202/32 , G02F2203/12 , G02F2203/18 , G02F2203/24
摘要： An acousto-optical filter element (114) is provided which has an acousto-optical crystal (118) having an acoustic signal transmitter (120) for generating acoustic signals in the acousto-optical crystal (118). The acousto-optical crystal (118) is designed to selectively spatially deflect light of a target wavelength from an input light beam (116) entering into the acousto-optical crystal (118), as a function of a high frequency applied to the acoustic signal transmitter (120), and to thereby produce a target light beam (126) having the target wavelength. In addition, the acousto-optical filter element (114) includes a spatial filter element (132) which is located in the target light beam (126) and is designed to selectively suppress the intensity of the target light beam (126) in a plane perpendicular to the propagation direction of the target light beam (126).
摘要翻译：提供一种声光滤波器元件（114），其具有声光晶体（118），该声光晶体具有用于在声光晶体（118）中产生声信号的声信号发射器（120）。声光晶体（118）被设计为根据进入声光晶体（118）的输入光束（116）选择性地空间偏转目标波长的光，作为施加到声信号的高频的函数发射器（120），从而产生具有目标波长的目标光束（126）。此外，声光滤波器元件（114）包括位于目标光束（126）中的空间滤光元件（132），并被设计成选择性地抑制平面中的目标光束（126）的强度垂直于目标光束（126）的传播方向。

15. 发明申请

US20130222568A1 Method and Device for Light-Microscopic Imaging of a Sample Structure 有权
标题翻译：用于样品结构的光显微镜成像的方法和装置
公开(公告)号：US20130222568A1
公开(公告)日：2013-08-29
申请号：US13806047
申请日：2011-06-27
申请人： Marcus Dyba , Volker Seyfried
发明人： Marcus Dyba , Volker Seyfried
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G01N21/6428 , G01N21/6458 , G02B21/16 , G02B21/367 , G02B27/58
摘要： A method for light-microscopy imaging of a sample structure (2, 34) is described, having the following steps: preparing the sample structure (2, 34) with markers that are transferrable into a state imageable by light microscopy, generating a sequence of individual-image data sets by sequential imaging of the sample structure (2, 34), in such a way that for each image, only a subset of the totality of the markers is in each case transferred into the state imageable by light microscopy, the markers of the respective subset having an average spacing from one another which is greater than the resolution limit of light-microscopy imaging which determines the extent of a light distribution representing one of the respectively imaged markers, generating at least two data blocks in which multiple successive individual-image data sets are respectively combined, superposing the individual-image data sets contained in the respective data block to yield a superposed-image data set, identifying an image offset between the superposed-image data sets, correcting the individual-image data sets that are contained in at least one of the superposed-image data sets on the basis of the identified image offset, determining center point positions of the light distributions representing the imaged markers, and assembling the center point positions into an offset-corrected overall image.
摘要翻译：描述了一种用于样品结构（2,34）的光学显微镜成像的方法，具有以下步骤：用可转移到可通过光学显微镜成像的状态的标记物制备样品结构（2,34），产生序列通过对样本结构（2,34）进行顺序成像，通过对每个图像进行顺序成像的单个图像数据集，只有标记的全部子集在每种情况下都转移到通过光学显微镜可成像的状态，相应子集的标记具有彼此之间的平均间隔，其大于光学显微镜成像的分辨率极限，其确定表示分别成像的标记之一的光分布的程度，生成至少两个数据块，其中多个连续分别组合各个图像数据集，将包含在各个数据块中的各个图像数据集叠加以产生叠加图像数据集，识别叠加图像数据组之间的图像偏移，基于所识别的图像偏移来校正包含在至少一个叠加图像数据集中的各个图像数据集，确定表示所述图像偏移的光分布的中心点位置成像标记，以及将中心点位置组装成偏移校正的整体图像。

16. 发明授权

US07817271B2 Confocal microscope and method for detecting by means of a confocal microscope 有权
标题翻译：共聚焦显微镜和共聚焦显微镜检测方法
公开(公告)号：US07817271B2
公开(公告)日：2010-10-19
申请号：US12044951
申请日：2008-03-08
申请人： Volker Seyfried , Frank Schreiber
发明人： Volker Seyfried , Frank Schreiber
IPC分类号： G01J3/28
CPC分类号： G02B21/0064
摘要： The invention relates to a confocal microscope which illuminates a sample (15) by means of at least one light source. A detection light beam (17) is emitted from the sample (15). The detection light beam (17) is spectrally split up in a spatial manner by the dispersive element (20) and subsequently formed on a photosensor chip (19) by means of a detection optical system (22). At least one expanding optical system (23) is arranged in front of the dispersive element (20) in the direction of the detection light beam (17). The expanding optical system (23) is embodied in such a manner that the numerical aperture of the detection optical system (22) is independent from the numerical aperture of the detection light beam (17) on the detection apertured diaphragm (18).
摘要翻译：本发明涉及通过至少一个光源照射样品（15）的共聚焦显微镜。从样品（15）发射检测光束（17）。检测光束（17）通过色散元件（20）以空间方式进行光谱分离，随后通过检测光学系统（22）形成在光电传感器芯片（19）上。至少一个扩展光学系统（23）沿着检测光束（17）的方向布置在色散元件（20）的前面。扩展的光学系统（23）以使得检测光学系统（22）的数值孔径独立于检测孔径隔膜（18）上的检测光束（17）的数值孔径的方式实现。

17. 发明授权

US07471817B2 Method for performing interactions on microscopic subjects that change in space and time, and system therefor 有权
标题翻译：在空间和时间上改变的微观科目上执行相互作用的方法及其系统
公开(公告)号：US07471817B2
公开(公告)日：2008-12-30
申请号：US10809960
申请日：2004-03-26
申请人： Frank Olschewski , Volker Seyfried
发明人： Frank Olschewski , Volker Seyfried
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/00127
摘要： The method and the system simplify moving interactions by means of virtual reference subjects and flux-based coordinate transformations in order to generate a changeable frame of reference.
摘要翻译：该方法和系统通过虚拟参考对象和基于通量的坐标变换简化移动交互，以便生成可变的参考框架。

18. 发明申请

US20070200052A1 Apparatus, microscope with an apparatus, and method for calibration of a photosensor chip 有权
标题翻译：装置，具有装置的显微镜和用于校准光电传感器芯片的方法
公开(公告)号：US20070200052A1
公开(公告)日：2007-08-30
申请号：US11649877
申请日：2007-01-05
申请人： Volker Seyfried , Frank Schreiber
发明人： Volker Seyfried , Frank Schreiber
IPC分类号： G02B27/40
CPC分类号： H01L27/14806 , G01J1/02 , G01J1/0295 , G01J1/04 , G01J1/0414 , G01J1/0437 , G01J1/0444 , G01J1/0488 , G01J1/08 , G01J1/10
摘要： An apparatus, a microscope having an apparatus, and a method for calibration of a photosensor chip (19) are disclosed. The apparatus has a photosensor chip (19) which has a multiplicity of light-sensitive elements. A reference light source (30) is provided and directs the light at at least one part of the photosensor chip (19). In addition, an open-loop or closed-loop control unit (19a) is provided and determines and corrects variances between the individual light-sensitive elements.
摘要翻译：公开了一种装置，具有装置的显微镜和用于校准光传感器芯片（19）的方法。该装置具有光传感器芯片（19），其具有多个感光元件。提供参考光源（30）并将光引导到光传感器芯片（19）的至少一部分。此外，提供开环或闭环控制单元（19a），并确定和校正各个感光元件之间的差异。

19. 发明授权

US07223961B2 Device for selectively detecting specific wavelength components of a light beam 有权
标题翻译：用于选择性地检测光束的特定波长分量的装置
公开(公告)号：US07223961B2
公开(公告)日：2007-05-29
申请号：US10923239
申请日：2004-08-20
申请人： Holger Birk , Volker Seyfried , Rafael Storz
发明人： Holger Birk , Volker Seyfried , Rafael Storz
IPC分类号： G01J3/50 , G01J3/28
CPC分类号： G01N21/6458 , G01J3/0229 , G01J3/14 , G01J3/2803 , G01J3/36 , G01J3/4406
摘要： A device for selectively detecting specific wavelength components of a light beam includes a spectral spreading element for spectrally spreading the light beam, and a detector array arranged downstream of the element. The detector array includes light-insensitive regions and light-sensitive regions. The element and the detector array are matched to each other so that selectable wavelength components of the light beam hit the light-insensitive regions and remaining wavelength components of the light beam hit the light-sensitive regions.
摘要翻译：用于选择性地检测光束的特定波长分量的装置包括用于光谱扩展光束的光谱扩展元件和布置在元件下游的检测器阵列。检测器阵列包括光不敏感区域和光敏区域。元件和检测器阵列彼此匹配，使得光束的可选择的波长分量撞击光不敏感区域，并且光束的剩余波长分量撞击光敏区域。

20. 发明申请

US20060215264A1 Apparatus for the detection of photons of a light beam 有权
标题翻译：用于检测光束的光子的装置
公开(公告)号：US20060215264A1
公开(公告)日：2006-09-28
申请号：US10568002
申请日：2004-04-02
申请人： Holger Birk , Rafael Storz , Volker Seyfried
发明人： Holger Birk , Rafael Storz , Volker Seyfried
IPC分类号： G02B27/28 , G02B5/30
CPC分类号： G02B21/26
摘要： An apparatus for detecting photons of a light beam emanating from a spatially limited source includes a detection device having a plurality of detectors forming a three-dimensional array with semitranslucent EMCCDs disposed one behind another. A light splitting device is disposed in a path of rays of the light beam for splitting the light beam so as to distribute the photons over the detectors for detection.
摘要翻译：用于检测从空间有限的源发出的光束的光子的装置包括具有多个检测器的检测装置，所述检测器形成具有一个彼此设置的半透明EMCCD的三维阵列。光分离装置设置在光束的光线路径中，用于分离光束，以将光子分布在检测器上用于检测。

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