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11. 发明授权

US08795316B2 Implantable medical device delivery system with a frangible portion and methods of making and using the same 有权
标题翻译：具有易碎部分的植入式医疗装置输送系统及其使用方法
公开(公告)号：US08795316B2
公开(公告)日：2014-08-05
申请号：US11739744
申请日：2007-04-25
申请人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61B17/12
CPC分类号： A61B17/12027 , A61B17/0057 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B2017/00526 , A61B2017/12054
摘要： An implantable medical device delivery system is provided with a carrier member having a proximal portion, a distal portion, and a frangible portion intermediate the proximal and distal portions. The frangible portion includes at least one notch providing a break hinge. A locking member is fixedly secured to the proximal portion of the carrier member and is releasably connected to an implantable medical device at or adjacent to the distal portion of the carrier member. In use, the implantable medical device is positioned generally adjacent to a target location of a body vessel and the frangible portion is broken about the break hinge. The proximal portion of the carrier member is then moved away from the distal portion to retract the locking member, thereby deploying the implantable medical device.
摘要翻译：植入式医疗装置输送系统设置有具有近端部分，远端部分和在近端部分和远端部分之间的易碎部分的载体部件。易碎部分包括提供断裂铰链的至少一个切口。锁定构件固定地固定到承载构件的近端部分上，并且在承载构件的远端部分处或邻近承载构件的可靠地可释放地连接到可植入医疗装置。在使用中，可植入医疗装置通常邻近身体容器的目标位置定位，并且易碎部分围绕断裂铰链破裂。然后，承载构件的近侧部分远离远侧部分移动以缩回锁定构件，从而展开可植入的医疗装置。

12. 发明授权

US08366720B2 Interventional medical device system having an elongation retarding portion and method of using the same 有权
标题翻译：具有延伸延迟部分的介入医疗装置系统及其使用方法
公开(公告)号：US08366720B2
公开(公告)日：2013-02-05
申请号：US11461231
申请日：2006-07-31
申请人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
发明人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B2017/12054 , A61B2090/037
摘要： An interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to a method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.
摘要翻译：在身体容器内可操作的介入医疗装置系统设置有大致中空的管状近端部分，远侧部分和中间部分。近端部分和远侧部分的至少一部分在使用中保持在身体的外部，而远侧部分的其余部分位于体内。中间部分包括具有相邻匝的螺旋带，在两个相邻匝之间具有至少一个易碎的桥构件。近端部分和远端部分通过延长螺旋带并且最终破坏易碎的桥接部件而彼此远离。根据使用这种系统来部署可植入医疗装置（例如栓塞线圈）的方法，致动构件与近端部分向近侧移动以使致动构件和可植入医疗装置之间的结合或关节脱离。

13. 发明申请

US20130006345A1 METHOD OF USING INTERVENTIONAL MEDICAL DEVICE SYSTEM HAVING AN ELONGATION RETARDING PORTION 有权
标题翻译：使用具有延伸延迟部分的传统医疗装置系统的方法
公开(公告)号：US20130006345A1
公开(公告)日：2013-01-03
申请号：US13608532
申请日：2012-09-10
申请人： Vladimir Mitelberg , John H. Thinnes, JR. , Keith Balgobin , William W. Sowers
发明人： Vladimir Mitelberg , John H. Thinnes, JR. , Keith Balgobin , William W. Sowers
IPC分类号： A61F2/84
CPC分类号： A61B17/12022 , A61B2017/12054 , A61B2090/037
摘要： Use of an interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to the method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.
摘要翻译：在身体容器内可操作的介入医疗装置系统的使用设置有大致中空的管状近端部分，远侧部分和中间部分。近端部分和远侧部分的至少一部分在使用中保持在身体的外部，而远侧部分的其余部分位于体内。中间部分包括具有相邻匝的螺旋带，在两个相邻匝之间具有至少一个易碎的桥构件。近端部分和远端部分通过延长螺旋带并且最终破坏易碎的桥接部件而彼此远离。根据使用这种系统来部署诸如栓塞线圈的可植入医疗装置的方法，致动构件与近侧部分向近侧移动，以解除致动构件和可植入医疗装置之间的结合或接合。

14. 发明授权

US08197442B2 Interventional medical device system having a slotted section and radiopaque marker and method of making the same 有权
标题翻译：具有开槽部分和不透射线标记的介入医疗装置系统及其制造方法
公开(公告)号：US08197442B2
公开(公告)日：2012-06-12
申请号：US11741116
申请日：2007-04-27
申请人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes, Jr.
IPC分类号： A61M29/00
CPC分类号： A61B17/1214 , A61B17/00234 , A61B17/12022 , A61B90/39 , A61B90/80 , A61B2017/00292 , A61B2017/00526 , A61B2017/12054 , A61B2090/3966 , A61M25/0012 , A61M25/0108 , B21D39/046 , Y10T29/49904 , Y10T29/49908
摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a slotted section. A radiopaque marker is secured to at least a portion of the slotted section such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the slotted section is formed by a laser cutting operation and a pre-assembly radiopaque marker member is crimped onto the slotted section.
摘要翻译：提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。推动器部件包括具有开槽部分的管状部分。不透射线的标记被固定到开槽部分的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面基本上齐平，并且和/或紧邻不透射线标记的远侧。根据制造这种部件的方法，通过激光切割操作形成开槽部分，并将预组装不透射线的标记部件压接到开槽部分上。

15. 发明授权

US08864789B2 Interventional medical device system having a spiral section and radiopaque marker and method of making the same 有权
标题翻译：具有螺旋段和不透射线标记的介入医疗装置系统及其制造方法
公开(公告)号：US08864789B2
公开(公告)日：2014-10-21
申请号：US11741079
申请日：2007-04-27
申请人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/962 , A61F2/88 , A61B17/12 , A61F2/966 , A61F2/95 , A61F2/30 , A61M25/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B2017/12054 , A61F2/88 , A61F2/962 , A61F2/966 , A61F2002/3008 , A61F2002/9511 , A61F2250/0098 , A61M25/0105 , Y10T29/49904
摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a spiral ribbon. A radiopaque marker is secured to at least a portion of the spiral ribbon such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the spiral ribbon is formed by a spiral cutting operation and a pre-assembly radiopaque marker member is crimped onto the spiral ribbon. According to another method of manufacturing such a component, the spiral ribbon is formed by winding a filament and a pre-assembly radiopaque marker member is crimped onto the spiral ribbon.
摘要翻译：提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。推动器部件包括具有螺旋带的管状部分。不透射线的标记被固定到螺旋带的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面齐平，并且紧邻不透射线标记的远侧。根据制造这种部件的方法，通过螺旋切割操作形成螺旋带，并将预组装不透射线的标记部件卷曲到螺旋带上。根据制造这种部件的另一种方法，螺旋带通过缠绕细丝而形成，并且将预组件不透射线的标记部件压接到螺旋带上。

16. 发明授权

US07985238B2 Embolic coil delivery system with spring wire release mechanism 有权
标题翻译：带弹簧丝释放机构的栓塞线圈输送系统
公开(公告)号：US07985238B2
公开(公告)日：2011-07-26
申请号：US11471770
申请日：2006-06-21
申请人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00862 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member which takes the form of a generally U-shaped wire spring which extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。采用大体上U形的线弹簧的形式的起动器构件，其从推动器构件的远端延伸并且被偏压以便将保持环从接合构件提起以确保当栓塞装置释放时脱离构件从接合构件的孔中取出。

17. 发明授权

US07811305B2 Stretch resistant embolic coil delivery system with spring release mechanism 有权
标题翻译：具弹簧释放机构的抗张力线栓输送系统
公开(公告)号：US07811305B2
公开(公告)日：2010-10-12
申请号：US11395700
申请日：2006-03-31
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00862 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member, which takes the form of a helical spring, extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。采取螺旋弹簧形式的起动器构件从推动器构件的远端延伸并且被偏置以便将保持环从接合构件提升离开以确保当分离构件是释放构件时释放栓塞装置从接合构件的孔中取出。

18. 发明授权

US07371252B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07371252B2
公开(公告)日：2008-05-13
申请号：US11301664
申请日：2005-12-13
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A91F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00867 , A61B2017/12054
摘要： A medical device for placing an embolic device, such as an embolic coil at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes a deflectable engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. When the detachment member is withdrawn from the aperture of the engagement member the engagement member deflects to release the embolic device.
摘要翻译：一种用于将栓塞装置（例如栓塞线圈）放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械联锁机构包括附接到推动器构件的远端的可偏转接合构件，并且延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。当分离构件从接合构件的孔中取出时，接合构件偏转以释放栓塞装置。

19. 发明授权

US07367987B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07367987B2
公开(公告)日：2008-05-06
申请号：US11301865
申请日：2005-12-12
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00862 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。推动器构件从推动器构件的远端延伸并且被偏压以便将保持环从接合构件提起，以确保当分离构件从接合构件的孔中取出时栓塞装置的释放。

20. 发明申请

US20080269675A1 INTERVENTIONAL MEDICAL DEVICE SYSTEM HAVING A SLOTTED SECTION AND RADIOPAQUE MARKER AND METHOD OF MAKING THE SAME 有权
标题翻译：具有插槽部分和放射性标记的传统医疗装置系统及其制造方法
公开(公告)号：US20080269675A1
公开(公告)日：2008-10-30
申请号：US11741116
申请日：2007-04-27
申请人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes
发明人： Keith Balgobin , Vladimir Mitelberg , Jason T. Rainer , John H. Thinnes
IPC分类号： A61M31/00
CPC分类号： A61B17/1214 , A61B17/00234 , A61B17/12022 , A61B90/39 , A61B90/80 , A61B2017/00292 , A61B2017/00526 , A61B2017/12054 , A61B2090/3966 , A61M25/0012 , A61M25/0108 , B21D39/046 , Y10T29/49904 , Y10T29/49908
摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a slotted section. A radiopaque marker is secured to at least a portion of the slotted section such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the slotted section is formed by a laser cutting operation and a pre-assembly radiopaque marker member is crimped onto the slotted section.
摘要翻译：提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。推动器部件包括具有开槽部分的管状部分。不透射线的标记被固定到开槽部分的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面基本上齐平，并且和/或紧邻不透射线标记的远侧。根据制造这种部件的方法，通过激光切割操作形成开槽部分，并将预组装不透射线的标记部件压接到开槽部分上。

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