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11. 发明申请

US20110270342A1 THERAPY USING PERTURBATION AND EFFECT OF PHYSIOLOGICAL SYSTEMS 有权
标题翻译：使用生理系统的治疗和效果的治疗
公开(公告)号：US20110270342A1
公开(公告)日：2011-11-03
申请号：US13094231
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
发明人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.
摘要翻译：用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。例如，公开了一种使用可植入医疗装置的方法，其涉及将电刺激递送至与选定器官相关的传出神经。在传递电刺激到传出神经时监测传入的电活动，所监测的传入电活动包括复合动作电位（CAP）的间接成分。所选器官的状态根据间接成分进行评估。根据评估所选器官的状态，确定是否对所选择的器官进行治疗。

12. 发明授权

US08888699B2 Therapy using perturbation and effect of physiological systems 有权
标题翻译：治疗使用扰动和生理系统的影响
公开(公告)号：US08888699B2
公开(公告)日：2014-11-18
申请号：US13094327
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
发明人： Hendrik Peter Johan Buschman , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
IPC分类号： A61B5/00 , A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves a method for using an implantable medical device delivering electrical stimuli to an afferent nerve associated with the selected organ. The efferent electrical activity is monitored in an efferent nerve responsive to delivering electrical stimuli to the afferent nerve, the monitored efferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component.
摘要翻译：用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。例如，公开了一种使用可植入医疗装置的方法，该方法涉及使用将植入式医疗装置向与所选择的器官相关的传入神经递送电刺激的方法。响应于传递对传入神经的电刺激，传出的神经中监测传出的电活动，所监测的传出电活动包括复合动作电位（CAP）的间接成分。所选器官的状态根据间接成分进行评估。

13. 发明授权

US08725259B2 Vagal stimulation 有权
公开(公告)号：US08725259B2
公开(公告)日：2014-05-13
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

14. 发明授权

US08423134B2 Therapy using perturbation and effect of physiological systems 有权
公开(公告)号：US08423134B2
公开(公告)日：2013-04-16
申请号：US13094392
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
发明人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.

15. 发明授权

US08406868B2 Therapy using perturbation and effect of physiological systems 有权
标题翻译：治疗使用扰动和生理系统的影响
公开(公告)号：US08406868B2
公开(公告)日：2013-03-26
申请号：US13094231
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
发明人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.
摘要翻译：用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。例如，公开了一种使用可植入医疗装置的方法，其涉及将电刺激递送至与选定器官相关的传出神经。在传递电刺激到传出神经时监测传入的电活动，所监测的传入电活动包括复合动作电位（CAP）的间接成分。所选器官的状态根据间接成分进行评估。根据评估所选器官的状态，确定是否对所选择的器官进行治疗。

16. 发明授权

US08437850B2 Automatic enabling of post long pause overdrive pacing 有权
公开(公告)号：US08437850B2
公开(公告)日：2013-05-07
申请号：US11679330
申请日：2007-02-27
申请人： Lilian Kornet , Roger Kessels
发明人： Lilian Kornet , Roger Kessels
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for controlling an atrial overdrive pacing therapy include detecting an atrial arrhythmia episode and determining if the atrial arrhythmia episode is an early recurring episode. Delivery of the atrial overdrive pacing therapy is enabled in response to the early recurring episode and commences upon detection of an atrial arrhythmia episode or a long pause.

17. 发明申请

US20120290030A1 AV NODAL STIMULATION DURING ATRIAL TACHYARRHYTHMIA TO PREVENT INAPPROPRIATE THERAPY DELIVERY 有权
标题翻译：急性心肌梗塞期间的AV NODAL刺激，以防止不准确的治疗方案
公开(公告)号：US20120290030A1
公开(公告)日：2012-11-15
申请号：US13105689
申请日：2011-05-11
申请人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
发明人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3624
摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.
摘要翻译：本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。在房性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者传递不适当的治疗。

18. 发明申请

US20120185010A1 VAGAL STIMULATION 有权
公开(公告)号：US20120185010A1
公开(公告)日：2012-07-19
申请号：US13353891
申请日：2012-01-19
申请人： Xiaohong Zhou , Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Xiaohong Zhou , Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/368 , A61N1/37235
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

19. 发明申请

US20120029587A1 NERVE SIGNAL DIFFERENTIATION IN CARDIAC THERAPY 有权
公开(公告)号：US20120029587A1
公开(公告)日：2012-02-02
申请号：US12848019
申请日：2010-07-30
申请人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
发明人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/36514 , A61N1/3937 , A61N1/3987
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.

20. 发明申请

US20110105926A1 HEART RATE VARIABILITY DISTINCTION 有权
标题翻译：心率变异性评估
公开(公告)号：US20110105926A1
公开(公告)日：2011-05-05
申请号：US12610009
申请日：2009-10-30
申请人： Lilian Kornet , Hans-Juergen Bruns , Raphael Schneider
发明人： Lilian Kornet , Hans-Juergen Bruns , Raphael Schneider
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/0464 , A61N1/36514 , A61N1/36578 , A61N1/36592
摘要： Systems, methods and devices for monitoring, analyzing, and processing a patient's heart rate signal for HRV characteristics are described herein. A first heart rate signal is acquired. The first heart rate signal includes at least one indication of an interval duration of cardiac activity. At least one accelerating portion and at least one decelerating portion of the first heart rate signal are identified. An average heart rate signal is acquired. The accelerating portion or the decelerating portion of the first heart rate signal is replaced with the average heart rate signal to produce a second heart rate signal. A frequency spectrum of the second heart rate signal may be obtained and utilized to predict or detect one or more autonomic conditions of a patient. Therapy may initiated or titrated in response to prediction or detection of the autonomic condition.
摘要翻译：本文描述了用于监测，分析和处理HRV特征的患者心率信号的系统，方法和装置。获取第一个心率信号。第一心率信号包括心脏活动的间隔持续时间的至少一个指示。识别出第一心率信号的至少一个加速部分和至少一个减速部分。获取平均心率信号。将第一心率信号的加速部分或减速部分替换为平均心率信号以产生第二心率信号。第二心率信号的频谱可以被获得并用于预测或检测患者的一个或多个自主状况。治疗可以根据对自主神经病症的预测或检测而启动或滴定。

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