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11. 发明授权

US07938824B2 Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation 有权
公开(公告)号：US07938824B2
公开(公告)日：2011-05-10
申请号：US11106835
申请日：2005-04-15
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/00 , A61N5/00 , C12N13/00
CPC分类号： A61N1/325 , A61N1/0424 , A61N1/327 , A61N1/328 , A61N1/36014
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

12. 发明申请

US20100002840A1 FIELD EMISSION X-RAY APPARATUS, METHODS, AND SYSTEMS 有权
标题翻译：场发射X射线装置，方法和系统
公开(公告)号：US20100002840A1
公开(公告)日：2010-01-07
申请号：US12337290
申请日：2008-12-17
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： H01J35/00 , G21F3/00
CPC分类号： H01J35/065 , H01J35/32
摘要： Disclosed herein is an x-ray field emission apparatus, system and method, the apparatus having a hollow probe held at vacuum; a cathode enclosed within the probe, the cathode producing an electron stream when connected to a high negative potential; an anode enclosed within the probe and separated from the cathode by a gap, said the providing a target for the electron stream; and a shield assembly comprising a hollow shield electrode positioned within the probe and about the cathode.
摘要翻译：本文公开了一种x射线场发射装置，系统和方法，该装置具有保持在真空下的中空探针; 封装在探针内的阴极，阴极在连接到高负电位时产生电子流; 阳极包围在探针内并与阴极隔开间隙，所述提供电子流的靶; 以及屏蔽组件，其包括位于探针内并围绕阴极的中空屏蔽电极。

13. 发明授权

US07211083B2 Apparatus and method for hair removal by electroporation 有权
标题翻译：通过电穿孔脱毛的装置和方法
公开(公告)号：US07211083B2
公开(公告)日：2007-05-01
申请号：US10801783
申请日：2004-03-16
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61N1/0424 , A61B18/14 , A61B2018/00476 , A61N1/325
摘要： The present invention provides apparatus and method for removal of body hair using electroporation. The apparatus has a pulse generator capable of generator electrical pulses of the desired amplitude and duration to kill hair follicles and an applicator having a first electrode placed in contact with a hair follicle and a second electrode interacting with the first electrode to provide an electroporating field in the tissue volume surrounding a hair to be removed. The apparatus may include a TENS system to provide patient relief from discomfort experienced by application of the electroporation pulses.
摘要翻译：本发明提供使用电穿孔去除体毛的装置和方法。该装置具有脉冲发生器，其能够产生具有期望幅度和持续时间的电脉冲以杀死毛囊;以及施加器，其具有与毛囊接触的第一电极和与第一电极相互作用的第二电极，以提供电穿孔围绕要去除的毛发的组织体积。该装置可以包括TENS系统，以提供患者缓解由施加电穿孔脉冲所经历的不适。

14. 发明授权

US06795728B2 Apparatus and method for reducing subcutaneous fat deposits by electroporation 有权
标题翻译：通过电穿孔减少皮下脂肪沉积物的装置和方法
公开(公告)号：US06795728B2
公开(公告)日：2004-09-21
申请号：US10369020
申请日：2003-02-19
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61N118
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/328
摘要： An apparatus and method for minimally invasive treatment of deep subcutaneous fat deposits in lieu of cosmetic surgery is disclosed. The apparatus comprises a high voltage pulse generator connected to two or more needle electrodes at least one of which is configured for placement deeply under the skin in a treatment site of the patient's body. High voltage pulses, delivered to the electrodes, create an electric field that kills subcutaneous fat cells.
摘要翻译：公开了用于代替整容手术的深层皮下脂肪沉积物的微创治疗的装置和方法。该装置包括连接到两个或更多个针电极的高电压脉冲发生器，其中至少一个针电极被配置为深深地放置在患者身体的治疗部位的皮肤下方。输送到电极的高电压脉冲产生杀死皮下脂肪细胞的电场。

15. 发明授权

US08251986B2 Method of destroying tissue cells by eletroporation 有权
标题翻译：通过电穿孔破坏组织细胞的方法
公开(公告)号：US08251986B2
公开(公告)日：2012-08-28
申请号：US12501225
申请日：2009-07-10
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.
摘要翻译：提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

16. 发明授权

US07965818B2 Field emission X-ray apparatus, methods, and systems 有权
标题翻译：场发射X射线装置，方法和系统
公开(公告)号：US07965818B2
公开(公告)日：2011-06-21
申请号：US12337290
申请日：2008-12-17
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： H01J35/02 , H01J35/06 , H01J35/14
CPC分类号： H01J35/065 , H01J35/32
摘要： Disclosed herein is an x-ray field emission apparatus, system and method, the apparatus having a hollow probe held at vacuum; a cathode enclosed within the probe, the cathode producing an electron stream when connected to a high negative potential; an anode enclosed within the probe and separated from the cathode by a gap, said the providing a target for the electron stream; and a shield assembly comprising a hollow shield electrode positioned within the probe and about the cathode.
摘要翻译：本文公开了一种x射线场发射装置，系统和方法，该装置具有保持在真空下的中空探针; 封装在探针内的阴极，阴极在连接到高负电位时产生电子流; 阳极包围在探针内并与阴极隔开间隙，所述提供电子流的靶; 以及屏蔽组件，其包括位于探针内并围绕阴极的中空屏蔽电极。

17. 发明授权

US07765010B2 Apparatus and method for treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的装置和方法
公开(公告)号：US07765010B2
公开(公告)日：2010-07-27
申请号：US11347965
申请日：2006-02-06
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

18. 发明授权

US07267676B2 Method for hair removal by electroporation 失效
标题翻译：通过电穿孔脱毛的方法
公开(公告)号：US07267676B2
公开(公告)日：2007-09-11
申请号：US11690175
申请日：2007-03-23
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61N1/0424 , A61B18/14 , A61B2018/00476 , A61N1/325
摘要： The present invention provides method for removal of body hair using electroporation using an apparatus having a pulse generator capable of generating electrical pulses of the desired amplitude and duration to kill hair follicles and an applicator having a first electrode placed in contact with a hair follicle and a second electrode interacting with the first electrode to provide an electroporating field in the tissue volume surrounding a hair to be removed. The method utilize a TENS system to provide patient relief from discomfort experienced by application of the electroporation pulses.
摘要翻译：本发明提供了使用具有脉冲发生器的装置的电穿孔去除身毛的方法，所述脉冲发生器能够产生所需振幅和持续时间的电脉冲以杀死毛囊，以及具有放置成与毛囊接触的第一电极的施用器和第二电极与第一电极相互作用，以在围绕要去除的毛发的组织体积中提供电穿孔区域。该方法利用TENS系统来提供患者缓解通过施加电穿孔脉冲所经历的不适。

19. 发明授权

US06692486B2 Apparatus and method for treatment of cerebral aneurysms, arterial-vascular malformations and arterial fistulas 失效
公开(公告)号：US06692486B2
公开(公告)日：2004-02-17
申请号：US09849324
申请日：2001-05-07
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/22051 , A61B2018/2261 , A61N2005/0661 , A61N2005/067
摘要： An apparatus and method for stabilization of aneurysm is disclosed. The apparatus comprises an ultraviolet radiation generator for generating UV radiation having a wavelength, strongly absorbed by the DNA and a catheter including means for delivering the ultraviolet radiation to the aneurysm. The distal end of the catheter is placed inside the aneurysm. Stabilization of the aneurysm is achieved by forming a mural arterial thrombus inside the aneurysm. To make irradiation possible, the blood is displaced from the aneurysm by a steady stream of UV radiation transparent fluid. The injury to the endothelium that triggers the thrombus formation is caused by UV radiation delivered to the aneurysm. In several days after intervention the thrombus becomes fully organized, leaving on the inside surface of the aneurysm a thick layer of fibrotic tissue that stabilizes the aneurysm.

20. 发明授权

US08634929B2 Method for treatment of neoplastic cells in the prostate of a patient 有权
标题翻译：治疗患者前列腺肿瘤细胞的方法
公开(公告)号：US08634929B2
公开(公告)日：2014-01-21
申请号：US12820955
申请日：2010-06-22
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。电脉冲的幅度，持续时间和数量通常被选择为引起良性前列腺增生体积的显着部分的坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

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