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11. 发明申请

US20120220476A1 BIOMARKERS FOR OVARIAN CANCER 有权
标题翻译： OVARIAN癌症生物标志物
公开(公告)号：US20120220476A1
公开(公告)日：2012-08-30
申请号：US13372137
申请日：2012-02-13
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
IPC分类号： C40B30/04 , G06F19/10 , C40B40/10
CPC分类号： G06F19/34 , G01N33/57449
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译：本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。

12. 发明申请

US20120046185A1 PANEL OF BIOMARKERS FOR OVARIAN CANCER 审中-公开
标题翻译： OVARIAN癌症生物标志物小组
公开(公告)号：US20120046185A1
公开(公告)日：2012-02-23
申请号：US13204566
申请日：2011-08-05
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung
IPC分类号： C40B30/04 , H01J49/26 , C07K16/18 , G01N33/574 , C07K16/30
CPC分类号： G01N33/57449
摘要： The present invention provides a panel of protein-based biomarkers that are useful in diagnosing ovarian cancer in a subject. In particular, the panel of biomarkers of the invention are useful to classify a subject sample as having ovarian cancer or non-ovarian cancer.
摘要翻译：本发明提供了一组可用于诊断受试者卵巢癌的基于蛋白质的生物标志物。特别地，本发明的生物标志物组对于将受试者样品分类为具有卵巢癌或非卵巢癌是有用的。

13. 发明申请

US20110129849A1 DETECTION OF PROSTATE CANCER USING PSA GLYCOSYLATION PATTERNS 审中-公开
标题翻译：使用PSA糖蛋白模式检测前列腺癌
公开(公告)号：US20110129849A1
公开(公告)日：2011-06-02
申请号：US13055868
申请日：2009-07-27
申请人： Hui Zhang , Danni Li Meany , Daniel W. Chan , Zhen Zhang , Yan Li , Lori J. Sokoll
发明人： Hui Zhang , Danni Li Meany , Daniel W. Chan , Zhen Zhang , Yan Li , Lori J. Sokoll
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N2333/4724 , G01N2400/00
摘要： The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze α2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and α2,3-linked sialylation of total and free serum PSA. These novel assays were used then to conduct a clinical investigation of the potential role of glycoprotein analysis in improving PSA's cancer specificity. The present invention also features kits for determining if a subject has prostate cancer comprising one or more lectins and a PSA specific antibody and instructions for use.
摘要翻译：本发明的特征在于确定受试者是否患有前列腺癌的新方法。本发明是基于通过黑曲霉凝集素（SNA）分析总血清PSA的α2,6连锁唾液酸化和总和游离血清PSA的α2,3连锁唾液酸化的凝集素免疫吸附测定的发展。然后使用这些新型测定法对糖蛋白分析在改善PSA的癌症特异性中的潜在作用进行临床研究。本发明还具有用于确定受试者是否具有包含一种或多种凝集素和PSA特异性抗体的前列腺癌以及使用说明书的试剂盒。

14. 发明授权

US07605003B2 Use of biomarkers for detecting ovarian cancer 有权
标题翻译：使用生物标志物检测卵巢癌
公开(公告)号：US07605003B2
公开(公告)日：2009-10-20
申请号：US10635308
申请日：2003-08-05
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
IPC分类号： G01N33/43 , G01N33/50 , G01N33/53 , G01N30/72
CPC分类号： G01N33/543 , G01N33/57449 , Y10S435/807 , Y10S435/967 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/255
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译：本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。

15. 发明授权

US09551703B2 High precision quantitative assay composition and methods of use therefor 有权
标题翻译：高精度定量测定组合物及其使用方法
公开(公告)号：US09551703B2
公开(公告)日：2017-01-24
申请号：US13388978
申请日：2010-08-04
申请人： Zhen Zhang , Daniel W. Chan
发明人： Zhen Zhang , Daniel W. Chan
IPC分类号： G01N33/543 , G01N33/58 , B01J19/00
CPC分类号： G01N33/543 , B01J19/0046 , G01N33/582
摘要： The invention features compositions and methods that are useful for precisely determining the amount of one or more analytes present in a sample. In one aspect, the invention provides a composition for measuring the abundance of one or more target analytes in a sample, where the composition contains a set of detection units for each analyte fixed to a substrate (e.g., a membrane, bead, filter, chip, polymer-based film or glass slide, or other printable surface), where each detection unit contains a discrete amount of a capture agent that specifically binds the target analyte, and the amount of capturing agent varies over the set to form a concentration gradient.
摘要翻译：本发明的特征在于可用于精确测定样品中存在的一种或多种分析物的量的组合物和方法。一方面，本发明提供了一种用于测量样品中一种或多种目标分析物的丰度的组合物，其中组合物包含用于固定到基底上的每种分析物的一组检测单元（例如，膜，珠粒，过滤器，芯片，基于聚合物的膜或载玻片或其它可印刷的表面），其中每个检测单元包含离散量的特异性结合靶分析物的捕获剂，并且捕获剂的量在组上变化以形成浓度梯度。

16. 发明申请

US20120142554A1 HIGH PRECISION QUANTITATIVE ASSAY COMPOSITION AND METHODS OF USE THEREFOR 有权
标题翻译：高精度定量测定组合物及其使用方法
公开(公告)号：US20120142554A1
公开(公告)日：2012-06-07
申请号：US13388978
申请日：2010-08-04
申请人： Zhen Zhang , Daniel W. Chan
发明人： Zhen Zhang , Daniel W. Chan
IPC分类号： C40B30/04 , G06F19/00 , C40B40/06 , C40B40/04 , C40B40/00 , C40B40/10
CPC分类号： G01N33/543 , B01J19/0046 , G01N33/582
摘要： The invention features compositions and methods that are useful for precisely determining the amount of one or more analytes present in a sample. In one aspect, the invention provides a composition for measuring the abundance of one or more target analytes in a sample, where the composition contains a set of detection units for each analyte fixed to a substrate (e.g.,a membrane, bead, filter, chip, polymer-based film or glass slide, or other printable surface), where each detection unit contains a discrete amount of a capture agent that specifically binds the target analyte, and the amount of capturing agent varies over the set to form a concentration gradient.
摘要翻译：本发明的特征在于可用于精确测定样品中存在的一种或多种分析物的量的组合物和方法。一方面，本发明提供了一种用于测量样品中一种或多种目标分析物的丰度的组合物，其中组合物包含用于固定到基底上的每种分析物的一组检测单元（例如，膜，珠粒，过滤器，芯片，基于聚合物的膜或载玻片或其它可印刷的表面），其中每个检测单元包含离散量的特异性结合靶分析物的捕获剂，并且捕获剂的量在组上变化以形成浓度梯度。

17. 发明申请

US20110033867A1 Use of biomarkers for detecting ovarian cancer 审中-公开
标题翻译：使用生物标志物检测卵巢癌
公开(公告)号：US20110033867A1
公开(公告)日：2011-02-10
申请号：US12586462
申请日：2009-09-21
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
IPC分类号： G01N33/68 , C12Q1/37 , G01N33/566 , C07K14/81
CPC分类号： G01N33/543 , G01N33/57449 , Y10S435/807 , Y10S435/967 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/255
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译：本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。

18. 发明申请

US20090221672A1 Biomarker for Prostate Cancer 失效
标题翻译：前列腺癌生物标志物
公开(公告)号：US20090221672A1
公开(公告)日：2009-09-03
申请号：US11992000
申请日：2006-09-19
申请人： Zhen Zhang , Daniel W. Chan , Carolyn N. Rosenzwelg
发明人： Zhen Zhang , Daniel W. Chan , Carolyn N. Rosenzwelg
IPC分类号： A61K31/7105 , C12Q1/02 , C07K14/81 , C07K16/38 , C07K19/00
CPC分类号： G01N33/57434 , G01N2333/8121
摘要： The present invention provides a protein-based biomarker, Protein C Inhibitor (PCI) that is useful in qualifying prostate cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as prostate cancer or non-prostate cancer. The biomarker can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了一种蛋白质生物标志物蛋白C抑制剂（PCI），其可用于鉴定患者中的前列腺癌状态。特别地，本发明的生物标志物可用于将受试者样品分类为前列腺癌或非前列腺癌。可通过SELDI质谱法检测生物标志物。

19. 发明申请

US20140005059A1 BIOMARKERS FOR CANCER 审中-公开
标题翻译：癌症生物标志物
公开(公告)号：US20140005059A1
公开(公告)日：2014-01-02
申请号：US12530456
申请日：2009-09-08
申请人： Zhen Zhang , Jin Song , Daniel Wan- Yui Chan
发明人： Zhen Zhang , Jin Song , Daniel Wan- Yui Chan
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , G01N33/574
摘要： The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant.
摘要翻译：本发明提供了用于诊断和治疗癌症的方法和组合物。本发明还提供了用于确定受试者是否具有成为化疗耐药性的风险的方法和组合物。

20. 发明申请

US20120004289A1 ANNEXIN A11 AND ASSOCIATED GENES AS BIOMARKERS FOR CANCER 审中-公开
标题翻译： ANNEXIN A11和相关基因作为癌症生物标志物
公开(公告)号：US20120004289A1
公开(公告)日：2012-01-05
申请号：US13255015
申请日：2010-03-05
申请人： Jin Song , Zhen Zhang
发明人： Jin Song , Zhen Zhang
IPC分类号： A61K31/7088 , C40B30/02 , A61P35/00 , C07K16/24 , C07K16/18 , G01N33/53 , C40B30/04
CPC分类号： C12Q1/6886 , C12N15/113 , C12N2310/14 , C12Q2600/106 , C12Q2600/142 , G01N33/574 , G01N33/57449 , G01N2333/4718 , G01N2800/52
摘要： The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant.
摘要翻译：本发明提供了用于诊断和治疗癌症的方法和组合物。本发明还提供了用于确定受试者是否具有成为化疗耐药性的风险的方法和组合物。

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