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11. 发明授权

US08050746B2 Tissue visualization device and method variations 有权
标题翻译：组织可视化装置和方法的变化
公开(公告)号：US08050746B2
公开(公告)日：2011-11-01
申请号：US11775771
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir A. Abolfathi , Chris A. Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir A. Abolfathi , Chris A. Rothe
IPC分类号： A61B6/00
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Tissue visualization device and method variations are described herein where an imaging hood is temporarily sealed against a region of tissue to be treated while under direct visualization. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. The imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid is pumped into the hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element. Temporary sealing against the tissue can be achieved in a number of ways such as circumferential balloons inflatable within the hood or other sealing techniques. A field of view of the imaging element can be expanded by inflating the balloon beyond the imaging hood.
摘要翻译：本文描述了组织可视化装置和方法变化，其中成像罩在直接可视化期间临时密封待处理组织的区域。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。将成像罩放置在通常用不透明的体液如血液填充的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体被泵送到罩中，直到流体移动通过成像元件离开要成像的组织的清晰区域的任何血液。可以以多种方式实现对组织的临时密封，例如在罩内充气的周向气囊或其他密封技术。成像元件的视野可以通过使气囊膨胀超过成像罩而扩大。

12. 发明授权

US08758229B2 Axial visualization systems 有权
标题翻译：轴向可视化系统
公开(公告)号：US08758229B2
公开(公告)日：2014-06-24
申请号：US11962029
申请日：2007-12-20
申请人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B1/04 , A61B1/00
CPC分类号： A61B1/00096 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/00135 , A61B1/00154 , A61B1/005 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B2018/00577
摘要： Axial visualization systems which utilize axially aligned imaging instruments for visualizing through an imaging hood purged of blood via a transparent fluid are described where an imaging element extending from a support shaft may be aligned within a working lumen defined through a deployment catheter. The imaging element may be positioned distal to the hood in its collapsed state and within the hood in its expanded state. The imaging element may be configured to seat itself securely within the catheter or to angle itself to adjust the viewing angle. Additionally, a disposable visualization sheath having a transparent lens may also be utilized to house an imaging instrument therein.
摘要翻译：描述了轴向可视化系统，其利用轴向对齐的成像仪器通过透明流体清除血液的成像罩进行可视化，其中从支撑轴延伸的成像元件可以在通过展开导管限定的工作腔内对准。成像元件可以位于处于其收缩状态的罩的远侧并且处于其展开状态的罩内。成像元件可以被配置为将其自身安全地固定在导管内或者使其自身倾斜以调节视角。此外，也可以使用具有透明透镜的一次性可视护套来容纳其中的成像仪器。

13. 发明授权

US08419613B2 Tissue visualization device 有权
标题翻译：组织可视化装置
公开(公告)号：US08419613B2
公开(公告)日：2013-04-16
申请号：US13231774
申请日：2011-09-13
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir A. Abolfathi , Chris A. Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir A. Abolfathi , Chris A. Rothe
IPC分类号： A61B1/00
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Tissue visualization device having a fluid barrier is described herein where an imaging hood is temporarily sealed against a region of tissue to be treated while under direct visualization. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. The imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A field of view of the imaging element can be expanded and the blood can also be purged in part by inflating a balloon beyond the imaging hood where the balloon is integrally formed along an interior surface of the hood.
摘要翻译：本文描述了具有流体屏障的组织可视化装置，其中成像罩在直接可视化的同时临时密封待处理组织的区域。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。将成像罩放置在通常用不透明的体液如血液填充的体腔中的待成像组织上或邻近待成像的组织。可以扩大成像元件的视野，并且通过使球囊膨胀超过成像罩，部分地可以清除血液，其中气囊沿着罩的内表面一体形成。

14. 发明授权

US09226648B2 Off-axis visualization systems 有权
标题翻译：离轴可视化系统
公开(公告)号：US09226648B2
公开(公告)日：2016-01-05
申请号：US11961995
申请日：2007-12-20
申请人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B1/04 , A61B1/005 , A61B1/00 , A61B1/015 , A61B1/018 , A61B5/02 , A61B5/00
CPC分类号： A61B1/00096 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/00135 , A61B1/00154 , A61B1/005 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B2018/00577
摘要： Off-axis visualization systems are described herein which facilitate the deployment, visualization, and retraction of an imaging element from a catheter. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration as well as an imaging element, such as a CCD or CMOS imager, which may be deployed from a low profile configuration into a position which is off-axis relative to a longitudinal axis of the deployment catheter and/or imaging hood.
摘要翻译：本文描述了离轴可视化系统，其有助于来自导管的成像元件的展开，可视化和缩回。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩以及诸如CCD或CMOS成像器的成像元件，其可以从低轮廓配置展开到离轴的位置相对于展开导管和/或成像罩的纵向轴线。

15. 发明授权

US09101735B2 Catheter control systems 有权
标题翻译：导管控制系统
公开(公告)号：US09101735B2
公开(公告)日：2015-08-11
申请号：US12499011
申请日：2009-07-07
申请人： Chris A. Rothe , Juan Diego Perea , David Miller , Vahid Saadat , Zachary J. Malchano , Ruey-Feng Peh
发明人： Chris A. Rothe , Juan Diego Perea , David Miller , Vahid Saadat , Zachary J. Malchano , Ruey-Feng Peh
IPC分类号： A61B1/01 , A61M25/01 , A61M25/00
CPC分类号： A61M25/0147 , A61M25/0074 , A61M25/0082 , A61M25/0105 , A61M25/0136 , A61M2025/015
摘要： Catheter control systems which facilitate the tracking of an angle of deflection of a catheter distal end can be used for any number of procedures where catheter orientation relative to the body is desirable, e.g., in transseptal access procedures where an accurate angle of puncture of the septal wall is desirable. Such control systems may comprise a steerable handle which is oriented relative to the catheter steerable section to provide for consistent catheter articulation upon corresponding manipulation of the steering ring. Another variation may utilize an orientation indicator to track the deflectable distal end. For instance, an orientation marker as visualized through an imaging hood on the distal end may correspond to identical orientation markers on the control handle such that articulation of a steering mechanism in a direction relative to the orientation markers deflects the catheter distal end in a corresponding direction relative to the visualized orientation markers.
摘要翻译：促进跟踪导管远端的偏转角度的导管控制系统可用于任何数量的程序，其中导管相对于身体的取向是期望的，例如在中间通道的准确的穿刺角度墙是理想的。这样的控制系统可以包括相对于导管可转向部分定向的可操纵手柄，以在相应操纵转向环时提供一致的导管关节运动。另一种变型可以利用取向指示器来跟踪可偏转的远端。例如，通过远端上的成像罩可视化的取向标记可以对应于控制手柄上的相同的取向标记，使得转向机构在相对于定向标记的方向上的关节转动导管远端在相应方向相对于可视化的取向标记。

16. 发明申请

US20080009747A1 TRANSMURAL SUBSURFACE INTERROGATION AND ABLATION 审中-公开
标题翻译：传递式的表面介入和排除
公开(公告)号：US20080009747A1
公开(公告)日：2008-01-10
申请号：US11775837
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
IPC分类号： A61B8/14 , A61B1/04 , A61M31/00 , A61B18/04
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02007 , A61B8/12 , A61B8/4472 , A61B18/1477 , A61B18/1492 , A61B2018/00214 , A61B2018/00702 , A61B2018/00791 , A61B2018/00809 , A61B2018/00875 , A61B2018/1425 , A61B2090/3614
摘要： Transmural subsurface interrogation and ablation apparatus and methods are described where tissue to be ablated is monitored while under direct visualization for tissue parameters (e.g., temperature and impedance) prior to, during, or after ablation. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An ablation probe and one or more interrogation needles having sensors are advanced into the tissue to be ablated and monitored. Alternatively, a combined ablation and interrogation probe may be used.
摘要翻译：描述了跨壁地下询问和消融设备和方法，其中在消融之前，期间或之后的组织参数（例如，温度和阻抗）直接可视化的同时监测要消融的组织。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，将成像罩放置在通常填充有不透明体液（例如血液）的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体可被泵送到成像罩中，直到流体移动通过部署导管中的成像元件离开要成像的组织的清晰区域的任何血液。消融探针和具有传感器的一个或多个询问针被推进到待烧蚀和监测的组织中。或者，可以使用组合消融和询问探针。

17. 发明授权

US10335131B2 Methods for preventing tissue migration 有权
公开(公告)号：US10335131B2
公开(公告)日：2019-07-02
申请号：US11877386
申请日：2007-10-23
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund A. Tam , Chris A. Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund A. Tam , Chris A. Rothe
IPC分类号： A61B1/00 , A61B17/02 , A61B1/313 , A61B17/34 , A61B1/005 , A61B6/00 , A61B8/08
摘要： A method of inhibiting tissue migration comprises positioning an open area of a hood against or adjacent to a tissue region. The method also comprises displacing an opaque fluid with a transparent fluid from the open area. The method includes engaging a portion of the tissue region within the open area via an end effector advanced through the open area and which grasps onto the portion. The end effector includes a tapered section, tapered along its entire length, through which a lumen extends. The tapered section includes threads extending from a surface of the tapered section in a direction orthogonal to the longitudinal axis. The tissue region is pierced while displacing the opaque fluid with the transparent fluid through the distal opening of the hood and while maintaining engagement of the portion of the tissue region such that distal movement of the tissue is inhibited.

18. 发明授权

US08235985B2 Visualization and ablation system variations 有权
标题翻译：可视化和消融系统的变化
公开(公告)号：US08235985B2
公开(公告)日：2012-08-07
申请号：US12209057
申请日：2008-09-11
申请人： Vahid Saadat , Ruey-Feng Peh , Zachary J. Malchano , Chris A. Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Zachary J. Malchano , Chris A. Rothe
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B1/00165 , A61B18/1477 , A61B90/37 , A61B2018/00214 , A61B2018/00285 , A61B2018/00351 , A61B2018/00577 , A61B2018/00898 , A61B2018/1425 , A61B2218/002
摘要： Visualization and ablation system variations are described which utilize various tissue ablation arrangements. Such assemblies are configured to facilitate the application of bipolar energy delivery, such as RF ablation, to an underlying target tissue for treatment in a controlled manner while directly visualizing the tissue during the bipolar ablation process.
摘要翻译：描述了利用各种组织消融装置的可视化和消融系统变化。这种组件被配置为便于将双极能量输送（例如RF消融）应用于潜在的靶组织，以受控的方式进行治疗，同时在双极烧蚀过程期间直接使组织可视化。

19. 发明授权

US10004388B2 Coronary sinus cannulation 有权
公开(公告)号：US10004388B2
公开(公告)日：2018-06-26
申请号：US11848207
申请日：2007-08-30
申请人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund A. Tam
发明人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund A. Tam
IPC分类号： A61B6/00 , A61B1/04 , A61B1/00 , A61B1/005 , A61B5/00 , A61B17/00 , A61B17/04 , A61B17/12 , A61B17/34 , A61M25/10 , A61B1/06 , A61B17/221 , A61M25/00 , A61B90/00
CPC分类号： A61B1/042 , A61B1/00089 , A61B1/0051 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/6853 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/12045 , A61B17/221 , A61B17/3417 , A61B2017/00221 , A61B2017/00243 , A61B2017/00278 , A61B2017/00296 , A61B2017/00575 , A61B2017/00778 , A61B2017/00884 , A61B2017/00893 , A61B2017/00907 , A61B2017/00986 , A61B2017/12127 , A61B2017/3484 , A61B2017/3488 , A61B2090/373 , A61M25/007 , A61M25/1002 , A61M2025/0058
摘要： Coronary sinus cannulation apparatus and methods relating to tissue visualization catheters that can locate and/or cannulate a morphological feature within a body lumen, such as the coronary sinus, are described. Such devices can also perform a variety of therapeutic tissue treatments under direct in vivo visualization thereafter. Moreover, such apparatus and methods may also be utilized with guidewires to facilitate delivery into the coronary sinus to eliminate repositioning of the device and/or repeating an entire sequence of operations, consequently improving procedure effectiveness and reducing procedure time.

20. 发明授权

US08657805B2 Complex shape steerable tissue visualization and manipulation catheter 有权
标题翻译：复杂形状可控组织可视化和操作导管
公开(公告)号：US08657805B2
公开(公告)日：2014-02-25
申请号：US12117655
申请日：2008-05-08
申请人： Ruey-Feng Peh , Vahid Saadat , Chris A. Rothe
发明人： Ruey-Feng Peh , Vahid Saadat , Chris A. Rothe
IPC分类号： A61M25/098
CPC分类号： A61B1/008 , A61B1/00016 , A61B1/00082 , A61B1/00085 , A61B1/0051 , A61B1/0052 , A61B1/0055 , A61B1/015 , A61B1/05 , A61B1/3137 , A61M25/0147 , A61M25/04
摘要： Complex steerable catheter visualization and tissue manipulation systems and their methods of use are disclosed herein. The deployment catheter is articulated using various steering mechanisms. Tissue visualization is accomplished from the visualization hood at the distal end of the deployment catheter, the hood having an ability to expand and other features to facilitate visualization and articulation at the tissue surface.
摘要翻译：本文公开了复杂的可导向导管可视化和组织操纵系统及其使用方法。部署导管使用各种转向机构进行铰接。组织可视化是从部署导管远端的可视化罩罩完成的，罩具有扩展能力和其他特征以便于组织表面处的可视化和关节连接。

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