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11. 发明授权

US07601159B2 Interlocking tissue anchor apparatus and methods 有权
标题翻译：联锁组织锚装置和方法
公开(公告)号：US07601159B2
公开(公告)日：2009-10-13
申请号：US10955244
申请日：2004-09-30
申请人： Richard C. Ewers , Tracy D. Maahs , Cang C. Lam , Vahid Saadat , Chris Rothe
发明人： Richard C. Ewers , Tracy D. Maahs , Cang C. Lam , Vahid Saadat , Chris Rothe
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Interlocking tissue anchor apparatus and methods are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. Anchor assemblies can be delivered via the tissue manipulation assembly into or through the tissue. The anchors can incorporate various temporary interlocking features or spacing elements between one another to ensure that an anchor is not prematurely ejected from the needle assembly. This allows the anchor assembly to be advanced distally as well as withdrawn proximally within a deployment sheath while avoiding inadvertently ejecting an anchor.
摘要翻译：本文描述了联锁组织锚装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。锚固组件可以经由组织操纵组件输送到组织或穿过组织。锚固件可以在彼此之间结合各种临时互锁特征或间隔元件，以确保锚不会从针组件过早地弹出。这允许锚固组件在部署护套内远端地向远侧推进，同时避免无意中弹出锚固件。

12. 发明申请

US20050251162A1 Apparatus and methods for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置和方法
公开(公告)号：US20050251162A1
公开(公告)日：2005-11-10
申请号：US10955245
申请日：2004-09-29
申请人： Chris Rothe , Richard Ewers , Cang Lam , Vahid Saadat , Kenneth Michlitsch
发明人： Chris Rothe , Richard Ewers , Cang Lam , Vahid Saadat , Kenneth Michlitsch
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B1/0014 , A61B17/0401 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

13. 发明申请

US20050251161A1 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US20050251161A1
公开(公告)日：2005-11-10
申请号：US10955243
申请日：2004-09-30
申请人： Vahid Saadat , Chris Rothe , Richard Ewers
发明人： Vahid Saadat , Chris Rothe , Richard Ewers
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

14. 发明申请

US20050250986A1 Removable apparatus and methods for manipulating and securing tissue 审中-公开
公开(公告)号：US20050250986A1
公开(公告)日：2005-11-10
申请号：US11002404
申请日：2004-12-01
申请人： Chris Rothe , Richard Ewers , Vahid Saadat , Cang Lam
发明人： Chris Rothe , Richard Ewers , Vahid Saadat , Cang Lam
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0401 , A61B1/0014 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Removable apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have tissue stabilizing members adapted to stabilize tissue therebetween, an engagement member slidably disposed through the stabilizing members and having a distal end adapted to engage tissue, and a delivery tube pivotable about the tissue stabilizing members. The tissue manipulation assembly optionally may be configured for removable attachment to an endoscope.

15. 发明申请

US20050075653A1 Apparatus and methods for forming and securing gastrointestinal tissue folds 审中-公开
公开(公告)号：US20050075653A1
公开(公告)日：2005-04-07
申请号：US10994101
申请日：2004-11-18
申请人： Vahid Saadat , Kenneth Michlitsch , Rich Ewers , Chris Rothe , Rodney Brenneman , Cang Lam , Eugene Chen
发明人： Vahid Saadat , Kenneth Michlitsch , Rich Ewers , Chris Rothe , Rodney Brenneman , Cang Lam , Eugene Chen
IPC分类号： A61B1/00 , A61B1/005 , A61B1/018 , A61B1/273 , A61B1/31 , A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/10 , A61B17/28 , A61B19/00
CPC分类号： A61B1/0055 , A61B1/00135 , A61B1/018 , A61B1/2736 , A61B1/31 , A61B17/00234 , A61B17/0218 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/062 , A61B17/0625 , A61B17/0644 , A61B17/29 , A61B17/295 , A61B17/3421 , A61B17/3468 , A61B17/3478 , A61B2017/00269 , A61B2017/003 , A61B2017/00353 , A61B2017/00827 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0443 , A61B2017/0451 , A61B2017/0454 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/061 , A61B2017/06176 , A61B2017/0649 , A61B2017/2905 , A61B2017/2927 , A61B2017/2943 , A61B2017/3445 , A61B2017/3488 , A61B2090/3614 , A61F5/0086
摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

16. 发明申请

US20060287666A1 Apparatus and methods for endoluminal advancement 审中-公开
标题翻译：用于腔内推进的装置和方法
公开(公告)号：US20060287666A1
公开(公告)日：2006-12-21
申请号：US11154168
申请日：2005-06-15
申请人： Vahid Saadat , Eugene Chen , Tung Le , Tracy Maahs , Richard Ewers , John Cox , Chris Rothe
发明人： Vahid Saadat , Eugene Chen , Tung Le , Tracy Maahs , Richard Ewers , John Cox , Chris Rothe
IPC分类号： A61M29/00
CPC分类号： A61M25/1011 , A61B2017/22068 , A61B2017/22069 , A61M2025/1015 , A61M2025/1052
摘要： Apparatus and methods for endoluminal advancement are described herein. A shape-lockable tissue anchoring assembly generally has an elongate body, a handle assembly, and an anchoring assembly positioned at or proximal to a distal tip of the elongate body. A distal portion of the elongate body may optionally be steerable or curvable. The anchoring assembly may include various expandable or projecting anchoring features to contact and retain tissue relative to the elongate body such that pleated tissue is temporarily immobile relative to the elongate body. This anchoring can be actuated simultaneously with or independently from shape-locking of elongate body. The anchoring assembly can be actuated simultaneously with the shape-locking of the elongate body. Alternatively, the steerable distal portion of the elongate body can be angled against the pleated tissue to retain it while the endoscope is advanced relative to the pleated tissue.
摘要翻译：本文描述了腔内前进的装置和方法。可锁定形状的组织锚固组件通常具有细长主体，手柄组件和定位在细长主体的远侧末端处或近侧的锚固组件。细长主体的远端部分可以可选地是可操纵的或可调节的。锚定组件可以包括各种可膨胀或突出的锚固特征，以相对于细长体接触和保持组织，使得褶皱组织相对于细长体临时固定不动。这种锚固可以与细长体的形状锁定同时或独立地致动。锚固组件可以与细长体的形状锁定同时致动。或者，细长主体的可转向远端部分可以相对于打褶组织成角度，以在内窥镜相对于打褶组织前进时保持它。

17. 发明申请

US20050251189A1 Multi-position tissue manipulation assembly 审中-公开
标题翻译：多位置组织操作组件
公开(公告)号：US20050251189A1
公开(公告)日：2005-11-10
申请号：US10956009
申请日：2004-09-29
申请人： Vahid Saadat , Chris Rothe , Richard Ewers , Cang Lam , Robert Vaughan
发明人： Vahid Saadat , Chris Rothe , Richard Ewers , Cang Lam , Robert Vaughan
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Multi-position tissue manipulation assemblies are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. One or all the articulation controls and functions can be integrated into a singular handle enclosure connectable to the tissue manipulation assembly via a rigid or flexible tubular body. A needle deployment mechanism may be positioned within the enclosure. Such a mechanism can have multiple positions adapted to lock and/or advance a needle assembly within the enclosure in a controlled manner as well as for deploying the anchor assembly.
摘要翻译：本文描述了多位置组织操作组件。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄外壳中。针展开机构可以定位在外壳内。这种机构可以具有多个位置，以适应于以受控的方式锁定和/或推进外壳内的针组件以及用于展开锚固组件。

18. 发明申请

US20050250985A1 Self-locking removable apparatus and methods for manipulating and securing tissue 审中-公开
标题翻译：自锁可移除装置和操纵和固定组织的方法
公开(公告)号：US20050250985A1
公开(公告)日：2005-11-10
申请号：US11002369
申请日：2004-12-01
申请人： Vahid Saadat , Cang Lam , Chris Rothe , Richard Ewers
发明人： Vahid Saadat , Cang Lam , Chris Rothe , Richard Ewers
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0401 , A61B1/0014 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Self-locking removable apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have tissue stabilizing members adapted to stabilize tissue therebetween, an engagement member slidably disposed through the stabilizing members and having a distal end adapted to engage tissue, and a delivery tube pivotable about the tissue stabilizing members. The tissue manipulation assembly optionally may be configured for removable attachment to an endoscope.
摘要翻译：本文中描述了用于操纵和固定组织的自锁可移除装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可具有适于在其间稳定组织的组织稳定部件，可滑动地设置穿过稳定部件并且具有适于接合组织的远端的接合部件和输送管可围绕组织稳定构件枢转。组织操作组件可选地可以被配置为可拆卸地附接到内窥镜。

19. 发明授权

US08236009B2 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US08236009B2
公开(公告)日：2012-08-07
申请号：US12579295
申请日：2009-10-14
申请人： Vahid Saadat , Chris Rothe , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Richard C. Ewers
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

20. 发明申请

US20060183975A1 Methods and apparatus for performing endoluminal procedures 审中-公开
标题翻译：用于进行腔内手术的方法和装置
公开(公告)号：US20060183975A1
公开(公告)日：2006-08-17
申请号：US11400580
申请日：2006-04-07
申请人： Vahid Saadat , Chris Rothe , Richard Ewers , Gilbert Madrid
发明人： Vahid Saadat , Chris Rothe , Richard Ewers , Gilbert Madrid
IPC分类号： A61B1/00
CPC分类号： A61B1/0051 , A61B1/0008 , A61B1/00179 , A61B1/00183 , A61B1/018 , A61B1/04 , A61B17/29
摘要： Methods and apparatus for performing endoluminal procedures are described herein. An endoluminal tissue manipulation assembly is disclosed which provides for a stable endoluminal platform and which also provides for effective triangulation of tools. Such an apparatus may comprise an optionally shape-lockable elongate body defining a longitudinal axis and adapted for endoluminal advancement in a patient body, at least one articulatable visualization lumen disposed near or at a distal region of the elongate body, the at least one articulating visualization lumen being adapted to articulate off-axis relative to a longitudinal axis of the elongate body, and at least one articulatable tool arm member disposed near or at the distal region of the elongate body, the at least one articulatable tool arm member being adapted to articulate off-axis and manipulate a tissue region of interest.
摘要翻译：本文描述了用于进行腔内手术的方法和装置。公开了一种腔内组织操作组件，其提供稳定的内腔平台，并且还提供工具的有效三角测量。这种装置可以包括限定纵向轴线并且适于在患者体内进行腔内前进的可选形状可锁定细长体，至少一个可伸长的可视腔，其设置在细长体的远端区域附近或位于该远端区域处，该至少一个铰接可视化内腔适于相对于细长主体的纵向轴线偏轴关节，以及设置在细长主体的远侧区域附近或其附近的至少一个可铰接工具臂构件，所述至少一个可铰接工具臂构件适于铰接离轴并且操纵感兴趣的组织区域。

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