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11. 发明授权

US10751273B2 Compounds for the treatment of pathologies associated with aging and degenerative disorders 有权
公开(公告)号：US10751273B2
公开(公告)日：2020-08-25
申请号：US14956272
申请日：2015-12-01
申请人： University of Pittsburgh—of the Commonwealth System of Higher Education
发明人： Laura J. Niedernhofer , Paul D. Robbins , Peter Wipf
IPC分类号： A61K8/64 , A61K31/40 , A61K8/49 , A61Q19/08 , A61K31/445 , A61K31/454 , A61K31/54 , A61K31/541 , A61K31/4468 , A61K31/4545 , A61K38/06
摘要： The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. “Inhibiting a sign of aging or degenerative disorder” means reducing the risk of occurrence, delaying the onset, slowing the progression, and/or reducing the severity and/or manifestation, of a sign of aging or degenerative disorder, and includes, but is not limited to, preventing the occurrence, development or progression of a sign of aging or degenerative disorder.

12. 发明授权

US10544110B2 Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer 有权
公开(公告)号：US10544110B2
公开(公告)日：2020-01-28
申请号：US15961475
申请日：2018-04-24
申请人： University of Pittsburgh-Of the Commonwealth System of Higher Education
发明人： Peter Wipf , James K. Johnson , Erin M. Skoda , Joel B. Nelson , Zhou Wang
IPC分类号： C07D261/08 , C07D451/00 , C07D413/12 , A61K31/454 , C07D295/185 , A61K31/495 , A61K31/496 , A61K31/42 , A61K31/46 , A61K31/4166 , A61K45/06 , A61K31/58
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), —S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

13. 发明授权

US10172795B2 Formulations and carrier systems including compound interactive domains 有权
公开(公告)号：US10172795B2
公开(公告)日：2019-01-08
申请号：US14651840
申请日：2013-12-12
申请人： University of Pittsburgh—Of The Commonwealth System of Higher Education
发明人： Xiang Gao , Song Li , Peter Wipf , Michael Wayne Epperly , Joel S. Greenberger
IPC分类号： A61K31/45 , A61K9/107 , A61K9/127 , A61K31/337 , A61K31/704
摘要： A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.

14. 发明申请

US20180185322A1 COMPOUNDS FOR BONE HEALING 审中-公开
公开(公告)号：US20180185322A1
公开(公告)日：2018-07-05
申请号：US15906856
申请日：2018-02-27
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , The Brigham and Women's Hospital, Inc.
发明人： Michael W. Epperly , Joel S. Greenberger , Peter Wipf , Julianne Glowacki
IPC分类号： A61K31/337 , A61P19/00
CPC分类号： A61K31/337 , A61P19/00 , C07D305/06
摘要： Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further comprise selecting or identifying a subject that has bone damage, or is a risk of developing bone damage. The compound may be administered after bone damage has occurred, or it may be administered prophylactically. The compound may be administered to a subject that has not and/or will not be exposed to radiation. In other embodiments, the subject has been and/or will be exposed to radiation.

15. 发明授权

US10004730B2 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer 有权
公开(公告)号：US10004730B2
公开(公告)日：2018-06-26
申请号：US15457782
申请日：2017-03-13
申请人： University of Pittsburgh-Of the Commonwealth System of Higher Education
发明人： Zhou Wang , Joel Byron Nelson , Minh Bao Nguyen , John S. Lazo , Paul A. Johnston , Peter Wipf
IPC分类号： A61K31/69 , A61K31/66 , A61K31/497 , A61K31/4965 , A61K31/415 , A61K31/16 , A61K31/496 , A61K31/4188 , A61K31/495
CPC分类号： A61K31/496 , A61K31/407 , A61K31/4188 , A61K31/495 , A61K31/4965 , A61K31/58 , A61K45/06 , C07D235/02 , C07D241/04 , C07D261/04 , C07D261/08 , C07D295/16 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/08 , C07D487/04 , A61K2300/00
摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

16. 发明授权

US09981974B2 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer 有权
公开(公告)号：US09981974B2
公开(公告)日：2018-05-29
申请号：US15457774
申请日：2017-03-13
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
发明人： Zhou Wang , Joel Byron Nelson , Minh Bao Nguyen , John S. Lazo , Paul A. Johnston , Peter Wipf
IPC分类号： C07D487/04 , C07D471/08
CPC分类号： A61K31/496 , A61K31/407 , A61K31/4188 , A61K31/495 , A61K31/4965 , A61K31/58 , A61K45/06 , C07D235/02 , C07D241/04 , C07D261/04 , C07D261/08 , C07D295/16 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/08 , C07D487/04 , A61K2300/00
摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

17. 发明申请

US20180127357A1 (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES 审中-公开
公开(公告)号：US20180127357A1
公开(公告)日：2018-05-10
申请号：US15526668
申请日：2015-11-13
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人： Peter Wipf , Athanassios Tzounopoulos
IPC分类号： C07C271/28 , C07C323/33 , C07D333/20 , C07D277/28 , C07D305/06 , A61P27/16 , A61P25/00 , A61P1/00 , A61P25/28 , C07B59/00
CPC分类号： C07C271/28 , A61P1/00 , A61P25/00 , A61P25/28 , A61P27/16 , C07B59/001 , C07B2200/05 , C07C323/33 , C07C381/00 , C07D277/28 , C07D305/06 , C07D333/20 , Y02P20/582
摘要： A compound, or pharmaceutically acceptable salt thereof, having a formula I of: wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted alkyl; R3 and R4 are each independently H or optionally-substituted alkyl; R5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R6 and R7 are each independently H, deuterium, optionally-substituted alkyl, or R6 and R7 together form a carbocyclic; R8 is optionally-substituted thiazolyl, optionally-substituted thiophenyl, or substituted phenyl, provided that if R8 is 4-halophenyl, then R2 is substituted alkyl or branched alkyl or at least one of R6 or R7 is not H; and R30, R31 and R32 are each independently H, deuterium, halogen, substituted sulfanyl, or optionally-substituted alkoxy.

18. 发明申请

US20170226074A1 ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES 有权
公开(公告)号：US20170226074A1
公开(公告)日：2017-08-10
申请号：US15499535
申请日：2017-04-27
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , MUSC Foundation for Research Development
发明人： Peter Wipf , Carol A. Feghali-Bostwick
IPC分类号： C07D305/08
CPC分类号： C07D305/08 , C07D305/06
摘要： A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl; X is —S—, —S(O)—, or S(O)2—; R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl; one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; and R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.

19. 发明申请

US20160264540A1 COMPOUNDS FOR TREATING PROSTATE CANCER 审中-公开
标题翻译：用于治疗前列腺癌的化合物
公开(公告)号：US20160264540A1
公开(公告)日：2016-09-15
申请号：US15023349
申请日：2014-09-18
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Peter Wipf , Erin M. Skoda , Zhou Wang
IPC分类号： C07D295/192 , A61K45/06 , A61K31/495 , C07D295/26 , C07D213/70 , C07D333/16 , C07D261/08 , C07D317/54 , C07D413/12 , A61K31/4525 , A61K31/551 , A61K31/58 , A61K31/496
CPC分类号： C07D295/192 , A61K31/4525 , A61K31/495 , A61K31/496 , A61K31/551 , A61K31/58 , A61K45/06 , C07D213/70 , C07D261/08 , C07D295/26 , C07D317/54 , C07D333/16 , C07D413/12 , A61K2300/00
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R20—(Z)b—(Y)c—(R21)a—X—R22-R23 wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(=0)- or —S(=0)(=0)-; R22 is a moiety that includes at least one divalent amino radical; R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; a is 0 or 1; b is 0 or 1; and c is 0 or 1; provided that if X is —C(=0)- then Y is not S.
摘要翻译：具有式I的化合物或其药学上可接受的盐或酯：R20-（Z）b-（Y）c-（R21）a-X-R22-R23，其中R20是芳基，取代的芳基，杂芳基，取代的杂芳基，杂环烷基，取代的杂环烷基，烷氧基，芳氧基，含甲硅烷基的基团，含硼基的基团，含膦基团，氨基，含硫基团，含硒基团，卤化物或硝基包含组; Z是烷二基，取代的烷二基，环烷二基或取代的环烷二基; Y是S，O或NR10，其中R10是H或烷基; R21是烷二基，取代的烷二基，环烷二基，取代的环烷二基，链二烯基，取代的链二烯基，亚三链烯基，取代的链三烯基; X是-C（= O） - 或-S（= O）（= O） - ; R 22是包含至少一个二价氨基的部分; R 23是芳基，取代的芳基，杂芳基，取代的杂芳基，杂环烷基，取代的杂环烷基，烷氧基，芳氧基，含甲硅烷基的基团，含硼基的基团，含膦基团，氨基，含硫基团，含卤基，卤素或硝基的基团; a是0或1; b为0或1; 且c为0或1; 条件是如果X是-C（= 0） - 则Y不是S.

20. 发明申请

US20160008127A1 PROSTHETIC IMPLANT FOR MEDIALIZATION THYROPLASTY 有权
标题翻译：用于医学化疗的植入物
公开(公告)号：US20160008127A1
公开(公告)日：2016-01-14
申请号：US14772344
申请日：2014-03-04
申请人： LOYOLA UNIVERSITY CHICAGO , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： James J. Jaber , Steven Charous , Peter Wipf , Christopher Siviy , April J. Chambers
IPC分类号： A61F2/20
CPC分类号： A61F2/20 , A61F2210/0057 , A61F2220/0025 , A61M16/04
摘要： Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the medial portions. Either the medial portion or the lateral portion can be adjustable in two dimensions which are not parallel to the length of the strut, which can also be adjustable. In some embodiments, the medial portion and/or the lateral portion can each comprise two adjustable arms and a base member which has a curvilinear configuration.
摘要翻译：公开了用于中断瘫痪声带的系统和方法。在一些实施例中，装置包括侧向部分，中间部分和联接到侧向部分和内侧部分的支柱。中间部分或侧面部分可以在不平行于支柱的长度的两个维度上可调节，这也可以是可调节的。在一些实施例中，中间部分和/或侧向部分可以各自包括两个可调节的臂和具有曲线构造的基部构件。

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