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11. 发明授权

US09273295B2 Mutant citrobacter freundii phytase polypeptide 有权
标题翻译：突变型富马酸柠檬酸肌醇六磷酸酶多肽
公开(公告)号：US09273295B2
公开(公告)日：2016-03-01
申请号：US13232588
申请日：2011-09-14
申请人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
发明人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
IPC分类号： C12N9/16
CPC分类号： C12N9/16
摘要： The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.
摘要翻译：本发明涉及酶和方法。特别地，描述了分离的多肽，其包含对应于弗氏柠檬酸杆菌植酸酶的氨基酸序列或其同源物，修饰形式，功能等同物或其有效片段。还描述了用编码细菌植酸酶或修饰形式的核酸转化或转染的宿主细胞，以及在食物或动物饲料中使用这种植酸酶或修饰形式。

12. 发明申请

US20130136825A2 ENZYMES 有权
公开(公告)号：US20130136825A2
公开(公告)日：2013-05-30
申请号：US13232588
申请日：2011-09-14
申请人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
发明人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
IPC分类号： C12N9/16 , C12N15/63 , A23K1/165 , C12N1/19 , C12N1/20 , A23L1/30 , C12N15/55 , C12N1/21
CPC分类号： C12N9/16
摘要： The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.

13. 发明申请

US20120064194A1 ENZYMES 审中-公开
公开(公告)号：US20120064194A1
公开(公告)日：2012-03-15
申请号：US13192032
申请日：2011-07-27
申请人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellengahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
发明人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellengahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
IPC分类号： C12N9/16 , A23L1/30 , A23P1/08 , C12N15/55 , A23K1/165
CPC分类号： C12N9/16
摘要： The present invention relates to enzymes and processes. In particular, there is described a host 3140 cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof.
摘要翻译：本发明涉及酶和方法。特别地，描述了用编码细菌植酸酶及其变体的核酸转化或转染的宿主3140细胞。

14. 发明授权

US08053221B2 Enzymes 有权
标题翻译：酶
公开(公告)号：US08053221B2
公开(公告)日：2011-11-08
申请号：US11737057
申请日：2007-04-18
申请人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellengahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
发明人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellengahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
IPC分类号： C12N9/16
CPC分类号： C12N9/16
摘要： The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof.
摘要翻译：本发明涉及酶和方法。特别地，描述了用编码细菌植酸酶及其变体的核酸转化或转染的宿主细胞。

15. 发明申请

US20090208474A1 BIOLOGICAL ENTITIES AND THE USE THEREOF 审中-公开
公开(公告)号：US20090208474A1
公开(公告)日：2009-08-20
申请号：US11963421
申请日：2007-12-21
申请人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Ketting
发明人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Ketting
IPC分类号： A61K38/43 , C12N9/00 , C12N11/02 , C12N11/10 , A61P43/00
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.

16. 发明授权

US08679795B2 Thermostable xylanase for the selective hydrolysis of pentose-containing polysaccharides 有权
标题翻译：用于选择性水解含糖的多糖的热稳定的木聚糖酶
公开(公告)号：US08679795B2
公开(公告)日：2014-03-25
申请号：US13517344
申请日：2010-12-15
申请人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
发明人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
IPC分类号： C12N9/24
CPC分类号： C12N9/248
摘要： The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is the selective hydrolysis of pentose sugar components of hemicellulose-containing plant biomass. The nucleotide sequence may be used for the production of the xylanase or optimized mutants thereof.
摘要翻译：本发明涉及具有木聚糖酶活性的多肽和编码此类多肽的核酸序列。本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。木聚糖酶的一个具体应用是含有半纤维素的植物生物质的戊糖糖成分的选择性水解。核苷酸序列可用于生产木聚糖酶或其优化的突变体。

17. 发明申请

US20120135475A1 LIQUEFIED BIOMASS 有权
标题翻译：液化生物量
公开(公告)号：US20120135475A1
公开(公告)日：2012-05-31
申请号：US13322395
申请日：2010-05-21
申请人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
发明人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
IPC分类号： C12P19/14 , C07H3/04 , C07H3/02 , C12P1/04 , C12P1/02
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

18. 发明申请

US20060147909A1 Microstructures and use thereof for the directed evolution of biomolecules 审中-公开
标题翻译：微结构及其在生物分子定向进化中的应用
公开(公告)号：US20060147909A1
公开(公告)日：2006-07-06
申请号：US10478809
申请日：2002-05-31
申请人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
发明人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
IPC分类号： C40B40/08 , C40B40/02
CPC分类号： C12N15/1079 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0864 , B01L2400/0633 , B01L2400/0661
摘要： The invention relates to microstructures and the use thereof for the directed evolution of biomolecules.
摘要翻译：本发明涉及微结构及其在生物分子定向进化中的应用。

19. 发明申请

US20050112682A9 Two coloured fluorimetric protease assay 审中-公开
标题翻译：两色荧光测定法
公开(公告)号：US20050112682A9
公开(公告)日：2005-05-26
申请号：US10343977
申请日：2001-08-07
申请人： Rene Kuhlemann , Andre Koltermann , Ulrich Kettling , Petra Schwille
发明人： Rene Kuhlemann , Andre Koltermann , Ulrich Kettling , Petra Schwille
IPC分类号： A01K67/033 , C07K14/435 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/37 , G01N21/64 , G01N21/78 , G01N33/573 , G01N33/58 , C12Q1/70 , C07H21/04 , C12N5/06 , C12P21/04 , G01N33/53
CPC分类号： C12Q1/37 , G01N33/582
摘要： The invention concerns an autofluorescent fusion protein suitable for use as a protease substrate, a nucleic acid sequence which encodes this fusion protein, and a method of using the fusion protein and/or the nucleic acid sequence in a dual color, confocal fluorometric assay for the detection and quantification of proteolytic activity or proteolytic inhibitory activity in samples or cells.
摘要翻译：本发明涉及适合用作蛋白酶底物的自发荧光融合蛋白，编码该融合蛋白的核酸序列，以及在双色共焦荧光测定法中使用融合蛋白和/或核酸序列的方法，检测和定量样品或细胞中的蛋白水解活性或蛋白水解抑制活性。

20. 发明授权

US06200818B1 Method for detecting reactions by means of coincidence analysis 有权
标题翻译：通过重合分析检测反应的方法
公开(公告)号：US06200818B1
公开(公告)日：2001-03-13
申请号：US09581217
申请日：2000-06-22
申请人： Manfred Eigen , Thorsten Winkler , Jens Stephan , Petra Schwille , Andre Koltermann , Ulrich Kettling , Klaus Dörre , Jan Bieschke
发明人： Manfred Eigen , Thorsten Winkler , Jens Stephan , Petra Schwille , Andre Koltermann , Ulrich Kettling , Klaus Dörre , Jan Bieschke
IPC分类号： G01N2164
CPC分类号： G01N21/6408 , G01N2021/6421
摘要： The invention relates to a method for detecting reactions and conformational changes of analytes in a sample by coincidence analysis, as follows: the sample is marked with at least two different fluorescent dyes and then illuminated with at least one laser in order to stimulate the emission of fluorescence; the fluorescence signals are detected by at least two detection units and each signal is broken down into any simultaneous time segments with the desired time slot widths; the number of signals contained in at least one time segment and/or the time intervals between signals in the time segments are detected; a coincidence analysis of the data detected is carried out for at least one time segment of the first detection unit with at least one isochronous time segment of the second detection unit; statistics are produced showing the results of the coincidence analysis and/or the results are subjected to a threshold value analysis, and these statistics or a combination of more statistics are evaluated for the presence of characteristic features.
摘要翻译：本发明涉及通过重合分析检测样品中分析物的反应和构象变化的方法，如下：样品用至少两种不同的荧光染料标记，然后用至少一种激光照射，以刺激样品的发射荧光; 荧光信号由至少两个检测单元检测，并且每个信号被分解成具有所需时隙宽度的任何同步时间段; 检测包含在至少一个时间段中的信号数量和/或时间段中的信号之间的时间间隔; 对于具有第二检测单元的至少一个等时时间段的第一检测单元的至少一个时间段执行检测到的数据的一致性分析; 产生显示符合分析的结果和/或对结果进行阈值分析的统计量，并且对特征特征的存在来评估这些统计量或更多统计量的组合。

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