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    • 11. 发明授权
    • Raman spectrum measuring method for drug inspection
    • 用于药物检查的拉曼光谱测量方法
    • US09250180B2
    • 2016-02-02
    • US14495233
    • 2014-09-24
    • Nuctech Company LimitedTsinghua University
    • Zhiqiang ChenLi ZhangJianhong ZhangHongqiu WangZiran ZhaoYumin YiJianping GuQingping Huang
    • G01J3/44G01N21/47G01N33/15G01N21/65
    • G01N21/47G01J3/44G01N21/65G01N21/658G01N33/15
    • A raman spectrum measuring method for drug inspection is provided, comprising: measuring raman spectrum of a sample to be inspected to acquire an original raman spectrum curve of the sample; determining whether the original raman spectrum curve has a characterizing portion, and if not, measuring a mixture of the sample and an enhancing agent to acquire an enhanced raman spectrum curve of the sample; and if the original raman spectrum curve of the sample to be inspected has a characterizing portion, comparing the original raman spectrum curve of the sample with data in an original raman spectrum database of a drug to determine whether the sample contains the drug, otherwise, comparing the enhanced raman spectrum curve of the sample with data in an enhanced raman spectrum database of the drug to determine whether the sample to be inspected contains the drug.
    • 提供了用于药物检查的拉曼光谱测量方法,包括:测量被检样品的拉曼光谱以获得样品的原始拉曼光谱曲线; 确定原始拉曼光谱曲线是否具有特征部分,如果不是,则测量样品和增强剂的混合物以获得样品的增强的拉曼光谱曲线; 如果要检查的样本的原始拉曼光谱曲线具有特征部分,则将样品的原始拉曼光谱曲线与药物的原始拉曼光谱数据库中的数据进行比较,以确定样品是否含有药物,否则比较 增强的拉曼光谱曲线的样品与增强的拉曼光谱数据库中的数据,以确定待检样品是否含有药物。
    • 13. 发明授权
    • Raman spectroscopy method of measuring melamine contents in dairy products having different matrixes
    • 测量具有不同基质的乳制品中三聚氰胺含量的拉曼光谱法
    • US08891081B1
    • 2014-11-18
    • US14145454
    • 2013-12-31
    • Nuctech Company LimitedTsinghua University
    • Zhiqiang ChenLi ZhangJianhong ZhangHongqui WangZiran ZhaoJianping GuZhiming WangQingping HuangYumin Yi
    • G01J3/44G01N21/65
    • G01N21/65
    • A raman spectroscopy method of measuring melamine contents in dairy products having different matrixes. The method includes: (a) establishing a database of characteristic curves of dairy products having different matrixes; (b) taking several copies of the dairy products having one certain unknown matrix and adding melamine standard solutions having different concentrations therein, to obtain a series of dairy product samples in which the relative concentrations of the melamine are known; (c) performing raman spectrum testing analysis and obtaining corresponding characteristic peak intensities to obtain a slope of the characteristic curve showing variation of the characteristic peak intensities with the relative concentrations of the melamine; (d) searching the database of step (a) using the slope of the characteristic curve of the dairy product samples to find a matching characteristic curve, and (e) calculating concentration of melamine in the dairy products by using the matched characteristic curve and the characteristic peak intensity.
    • 测量具有不同基质的乳制品中三聚氰胺含量的拉曼光谱法。 该方法包括:(a)建立具有不同矩阵的乳制品特征曲线数据库; (b)取几份具有一定未知基质的乳制品,并加入其中浓度不同的三聚氰胺标准溶液,以获得其中已知三聚氰胺的相对浓度的一系列乳制品样品; (c)进行拉曼光谱测试分析并获得相应的特征峰强度,以获得特征曲线的斜率,显示特征峰强度与三聚氰胺的相对浓度的变化; (d)使用乳制品样品的特征曲线的斜率来搜索步骤(a)的数据库,以找到匹配的特征曲线,以及(e)通过使用匹配的特征曲线计算乳制品中三聚氰胺的浓度, 特征峰强度。