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11. 发明授权

US08616590B2 Hydraulic tensioning flange connector 有权
标题翻译：液压张紧法兰连接器
公开(公告)号：US08616590B2
公开(公告)日：2013-12-31
申请号：US13019795
申请日：2011-02-02
申请人： Todd Travis , Brandon M. Cain , Ping Cai
发明人： Todd Travis , Brandon M. Cain , Ping Cai
IPC分类号： F16L23/00
CPC分类号： F16L23/024 , F16L23/036 , Y10T29/49947 , Y10T29/49963
摘要： Hydraulic flange connectors connect two flange components together, and hydraulic pressure applied to ports in connector holes of one of the flanges tension the flange studs and crush the gasket between the flange components. Each connector has a piston that dispose in the connector hole and can move therein when hydraulic pressure is applied through the port by a pump. A first stud connected to the piston extends beyond one open end of the hole for connection to a first nut, while a second stud connected to the piston extending beyond another open end of the to the second flange component for connection to a second nut. A retainer having seals threads in this other open end of the hole and seals between the hole and the second stud.
摘要翻译：液压法兰连接器将两个法兰部件连接在一起，并且施加到其中一个法兰的连接器孔中的端口的液压力拉紧法兰螺柱，并将垫圈压在凸缘部件之间。每个连接器具有配置在连接器孔中的活塞，并且当通过泵通过端口施加液压时可以在其中移动。连接到活塞的第一螺柱延伸超过孔的一个开口端，用于连接到第一螺母，而连接到活塞的第二螺柱延伸超过第二凸缘部件的另一开口端，用于连接到第二螺母。具有在孔的另一个开口端中的密封螺纹的保持器，并且在孔和第二螺柱之间进行密封。

12. 发明申请

US20120136127A1 Polymerization Reaction System 失效
标题翻译：聚合反应体系
公开(公告)号：US20120136127A1
公开(公告)日：2012-05-31
申请号：US13377205
申请日：2010-07-20
申请人： F. David Hussein , Michael E. Muhle , Ping Cai , Mark W. Blood
发明人： F. David Hussein , Michael E. Muhle , Ping Cai , Mark W. Blood
IPC分类号： C08F2/01 , B01J19/00
CPC分类号： C08F10/02 , B01J8/22 , B01J2208/00256 , B01J2208/00274 , B01J2208/00283 , B01J2208/00734 , B01J2219/0025 , B01J2219/00254 , C08F110/02 , C08F210/16 , C08F2/34 , C08F2/01 , C08F2/14 , C08F2500/24 , C08F210/14
摘要： A process for the polymerization of olefins is disclosed. The process may include: feeding a catalyst, a liquid diluent, and an olefin to a polymerization vessel having, from a polymerization vessel bottom to a polymerization vessel top, a vapor introduction zone, a three-phase reaction zone and a vapor disengagement zone; contacting the catalyst and olefin under conditions of temperature and pressure in the presence of the liquid diluent as a continuous phase in the three-phase reaction zone to form a solid phase polyolefin; withdrawing a gas phase composition from an outlet in fluid communication with the vapor disengagement zone; circulating the gas phase composition through a gas circulation loop to an inlet in fluid communication with the vapor distribution zone at a rate sufficient to agitate the solid and liquid phases within the three-phase reaction zone; and withdrawing a reaction mixture comprising polyolefin and diluents from the three-phase reaction zone.
摘要翻译：公开了一种烯烃聚合方法。该方法可以包括：将催化剂，液体稀释剂和烯烃进料到聚合容器中，所述聚合容器具有从聚合容器底部到聚合容器顶部的蒸气引入区，三相反应区和蒸气分离区; 在温度和压力条件下，在作为连续相的液体稀释剂存在下在三相反应区中使催化剂和烯烃接触以形成固相聚烯烃; 从与蒸气分离区流体连通的出口抽出气相组合物; 将气相组合物通过气体循环回路循环到与蒸汽分配区流体连通的入口，其速率足以搅拌三相反应区内的固相和液相; 并从三相反应区取出包含聚烯烃和稀释剂的反应混合物。

13. 发明申请

US20120116029A1 METHOD FOR POLYMERIZING POLYPROPYLENE 审中-公开
标题翻译：聚丙烯聚合方法
公开(公告)号：US20120116029A1
公开(公告)日：2012-05-10
申请号：US12941440
申请日：2010-11-08
申请人： Jan W. Van Egmond , Ping Cai
发明人： Jan W. Van Egmond , Ping Cai
IPC分类号： C08F2/34
CPC分类号： C08F10/06 , C08F10/00 , C08F110/06 , C08F210/06 , C08F2/34 , C08F210/16 , C08F4/6494 , C08F4/6465
摘要： The present disclosure relates to a method for polymerizing polypropylene, optionally with one or more additional comonomers in a gas phase reactor in the presence of a mixed electron donor system comprising at least one selectivity control agent and at least one activity limiting agent. The process involves controlling the polymerization process to ensure that the difference between the reactor temperature and the dew point temperature of the incoming monomer stream is 12° C. or greater.
摘要翻译：本公开涉及在包含至少一种选择性控制剂和至少一种活性限制剂的混合电子给体系的存在下，在气相反应器中聚合聚丙烯，任选地与一种或多种另外的共聚单体聚合的方法。该方法包括控制聚合过程以确保反应器温度与进入的单体流的露点温度之差为12℃或更高。

14. 发明申请

US20100028952A1 FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES 审中-公开
标题翻译： ACTINOMADURA CHROMOPROTEIN及相关物种的发酵和纯化
公开(公告)号：US20100028952A1
公开(公告)日：2010-02-04
申请号：US12305428
申请日：2007-06-21
申请人： Eugene Joseph Vidunas , Gow-Jen Tsai , Ping Cai , Justin Moran , Pamela Sue Fink , Lourdes Jeanette Gordon
发明人： Eugene Joseph Vidunas , Gow-Jen Tsai , Ping Cai , Justin Moran , Pamela Sue Fink , Lourdes Jeanette Gordon
IPC分类号： C12P21/00 , C12N1/20 , C07K1/00
CPC分类号： C07D413/12 , A61K47/6829 , A61K47/6849 , A61K47/6851 , C07K14/36 , C12N1/20 , C12P17/16 , C12R1/03
摘要： The present invention provides methods for production and purification of active chromoproteins produced by Actinomadura sp. 21G792. The chromoproteins are useful for developing pharmaceutical compositions and treating diseases such as cancer or bacterial infections.
摘要翻译：本发明提供了由Actinomadura sp。生产和生产活性色素的方法。 21G792。生色蛋白可用于开发药物组合物和治疗疾病如癌症或细菌感染。

15. 发明授权

US07445916B2 Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies 有权
标题翻译：用二羧酸制备雷帕霉素42-酯和FK-50632-酯的方法，雷帕霉素缀合物和抗体的前体
公开(公告)号：US07445916B2
公开(公告)日：2008-11-04
申请号：US11104349
申请日：2005-04-12
申请人： Jianxin Gu , Ping Cai , Mark E. Ruppen
发明人： Jianxin Gu , Ping Cai , Mark E. Ruppen
IPC分类号： C12P17/16 , C12P17/18
CPC分类号： C07D498/18 , C12P17/188
摘要： Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
摘要翻译：描述了用二羧酸合成区域特异性雷帕霉素42-半酯和区域特异性FK50632-酯的方法。所述方法包括催化雷帕霉素或FK-506与二羧酸酐或二酸的双功能活化酯与脂肪酶之间的反应。

16. 发明授权

US07268144B2 Regiospecific synthesis of rapamycin 42-ester derivatives 失效
标题翻译：雷帕霉素42-酯衍生物的区域特异性合成
公开(公告)号：US07268144B2
公开(公告)日：2007-09-11
申请号：US11103799
申请日：2005-04-12
申请人： Jianxin Gu , Ping Cai , Mark E. Ruppen
发明人： Jianxin Gu , Ping Cai , Mark E. Ruppen
IPC分类号： C07D498/18 , A61K31/395
CPC分类号： C07D498/18 , C12P17/188
摘要： A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.
摘要翻译：描述了雷帕霉素42-酯衍生物的区域特异性合成的方法。该方法包括在合适的有机溶剂中用酰基供体如乙烯基酯，异丙烯基酯或酸酐对雷帕霉素的42-羟基进行脂肪酶催化的乙酰化。

17. 发明申请

US20060036091A1 CCI-779 derivatives and methods of making same 失效
标题翻译： CCI-779衍生物及其制作方法
公开(公告)号：US20060036091A1
公开(公告)日：2006-02-16
申请号：US11200383
申请日：2005-08-09
申请人： Ping Cai , Mark Ruppen , Russ Tsao
发明人： Ping Cai , Mark Ruppen , Russ Tsao
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D405/06
摘要： A method of generating synthetic metabolites of CCI-779 is provided. Five novel CCI-779 derivatives are described, as are methods of using these derivatives for detecting CCI-779 metabolites in samples.
摘要翻译：提供了一种产生CCI-779合成代谢产物的方法。描述了五种新型CCI-779衍生物，以及使用这些衍生物检测样品中的CCI-779代谢物的方法。

18. 发明申请

US20050234087A1 Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies 有权
标题翻译：用二羧酸制备雷帕霉素42-酯和FK-50632-酯的方法，雷帕霉素缀合物和抗体的前体
公开(公告)号：US20050234087A1
公开(公告)日：2005-10-20
申请号：US11104349
申请日：2005-04-12
申请人： Jianxin Gu , Ping Cai , Mark Ruppen
发明人： Jianxin Gu , Ping Cai , Mark Ruppen
IPC分类号： C07D498/18 , C12P17/10 , C12P17/18
CPC分类号： C07D498/18 , C12P17/188
摘要： Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
摘要翻译：描述了用二羧酸合成区域特异性雷帕霉素42-半酯和区域特异性FK50632-酯的方法。所述方法包括催化雷帕霉素或FK-506与二羧酸酐或二酸的双功能活化酯与脂肪酶之间的反应。

19. 发明申请

US20050215561A1 Pharmaceutical dosage forms and compositions 审中-公开
标题翻译：药物剂型和组合物
公开(公告)号：US20050215561A1
公开(公告)日：2005-09-29
申请号：US11082548
申请日：2005-03-17
申请人： Krishnendu Ghosh , Arwinder Nagi , Xiaohong Pan , Melissa Lin , Leonid Linberg , Ping Cai , Eric Browne , Michel Bernatchez , Mark Lankau
发明人： Krishnendu Ghosh , Arwinder Nagi , Xiaohong Pan , Melissa Lin , Leonid Linberg , Ping Cai , Eric Browne , Michel Bernatchez , Mark Lankau
IPC分类号： A61K31/00 , A61K31/496 , C07D405/12 , C07D405/14 , C07D45/14
CPC分类号： C07D405/12 , C07D405/14
摘要： This invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-{(2R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
摘要翻译：本发明涉及例如用于递送4-氰基-N - {（2R）-2- [4-（2,3-二氢 - 苯并[1,4]二恶英-5-基） - 哌嗪-1-基] - 丙基} -N-吡啶-2-基 - 苯甲酰胺，其药学上可接受的盐，结构相关的化合物和/或代谢物; 以及使用这些用于治疗疾病的制剂和方法。

20. 发明申请

US20130005923A1 PROCESS FOR GAS-PHASE POLYMERIZATION HAVING HIGH BED BULK DENSITY 审中-公开
标题翻译：具有高温大气密度的气相聚合方法
公开(公告)号：US20130005923A1
公开(公告)日：2013-01-03
申请号：US13172969
申请日：2011-06-30
申请人： Ping Cai , Jan W. Van Egmond , Matthew J. Fedec , Jeffrey D. Goad , Robert C. Brady, III , Linfeng Chen
发明人： Ping Cai , Jan W. Van Egmond , Matthew J. Fedec , Jeffrey D. Goad , Robert C. Brady, III , Linfeng Chen
IPC分类号： C08F110/06 , C08F210/14 , C08F210/06
CPC分类号： C08F10/06 , C08F110/06 , C08F210/06 , C08F2/34 , C08F2/005 , C08F2500/18 , C08F2500/24
摘要： The present invention relates to an improvement for gas-phase olefin polymerization process having relatively high bed bulk density. The improvement involves the use of mixed external electron donors when polymerizing propylene in a gas-phase reactor having a polymer bed with a bulk density greater than 128 kg/m3, optionally with one or more comonomers, wherein the mixed electron donor system comprises at least a first external electron donor and a second external electron donor, and wherein the first external electron donor is a carboxylate compound.
摘要翻译：本发明涉及具有较高床堆密度的气相烯烃聚合方法的改进。该改进涉及当在具有大于128kg / m 3的堆积密度的聚合物床的气相反应器中聚合丙烯时，使用混合的外部电子给体，任选地具有一种或多种共聚单体，其中混合电子给体系统至少包括第一外电子给体和第二外电子给体，其中第一外电子给体是羧酸酯化合物。

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