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11. 发明授权

US4819210A Optical information writing method 失效
标题翻译：光学信息写作方法
公开(公告)号：US4819210A
公开(公告)日：1989-04-04
申请号：US205542
申请日：1988-06-06
申请人： Akira Miura , Nobuhiro Gemma , Koichi Mizushima , Makoto Azuma , Takano Iwakiri
发明人： Akira Miura , Nobuhiro Gemma , Koichi Mizushima , Makoto Azuma , Takano Iwakiri
IPC分类号： G11B7/0045 , G11B7/244 , G11B7/248 , G11C7/00 , G11C11/42
CPC分类号： G11B7/0045 , G11B7/244 , G11B7/248 , G11B7/2531
摘要： An information writing method of an optical recording device selectively irradiates light on an optical recording medium, having a thin organic film containing donor and acceptor molecules, and a pair of electrodes for applying a voltage to the thin organic film, in order to cause charge transfer between the donor and acceptor molecules, and records a change in optical or electric characteristics of the thin organic film by the charge transfer as information. Selective light irradiation is performed while a voltage is applied to the electrodes.
摘要翻译：光学记录装置的信息写入方法选择性地将光照射在具有含有供体和受体分子的薄的有机膜的光学记录介质上，以及用于向薄的有机膜施加电压的一对电极，以引起电荷转移在供体和受体分子之间，通过电荷转移记录薄有机膜的光学或电特性的变化作为信息。在对电极施加电压的同时进行选择性光照射。

12. 发明授权

US4757364A Light emitting element 失效
标题翻译：发光元件
公开(公告)号：US4757364A
公开(公告)日：1988-07-12
申请号：US795161
申请日：1985-11-05
申请人： Akira Miura , Koichi Mizushima , Keijiro Hirahara , Nobuhiro Gemma , Taiji Furuno , Hiroyuki Sasabe
发明人： Akira Miura , Koichi Mizushima , Keijiro Hirahara , Nobuhiro Gemma , Taiji Furuno , Hiroyuki Sasabe
IPC分类号： H01L51/05 , H01L21/368 , H01L29/94 , H01L33/28 , H01L33/32 , H01L33/34 , H01L33/40 , H01L51/50 , H05B33/12 , H05B33/22 , H01L29/78 , H01L33/00
CPC分类号： H01L29/94 , H01L33/0037 , H01L51/5012 , Y10S930/29
摘要： A light emitting element formed of a metal-insulator-semiconductor junction, the improvement wherein the insulator is a Langmuir-Blodgett film of an organic substance containing at least one of a synthetic protein and a natural protein. According to the element of this invention, stability of dynamic characteristics, luminescence efficiency and long-term stability can be significantly improved.
摘要翻译：由金属 - 绝缘体 - 半导体结形成的发光元件，其中绝缘体是含有合成蛋白质和天然蛋白质中的至少一种的有机物质的Langmuir-Blodgett膜。根据本发明的要素，可以显着提高动态特性的稳定性，发光效率和长期稳定性。

13. 发明授权

US4871236A Organic thin film display element 失效
标题翻译：有机薄膜显示元件
公开(公告)号：US4871236A
公开(公告)日：1989-10-03
申请号：US908014
申请日：1986-09-16
申请人： Nobuhiro Gemma , Akira Miura , Koichi Mizushima , Makoto Azuma , Yasushi Mori
发明人： Nobuhiro Gemma , Akira Miura , Koichi Mizushima , Makoto Azuma , Yasushi Mori
IPC分类号： G02F1/017 , G02F1/15 , H01L51/30 , H01L51/42
CPC分类号： H01L51/0078 , B82Y20/00 , G02F1/017 , G02F1/15 , H01L51/0051 , H01L51/0052 , H01L51/0053 , H01L51/0054 , H01L51/0055 , H01L51/0064 , H01L51/0067 , H01L51/0068 , H01L51/0072 , H01L51/0077 , H01L51/0084 , H01L51/0059 , H01L51/0075 , H01L51/0083 , H01L51/424
摘要： An organic thin film display element comprises an organic thin film containing donor moleculaes and acceptor molecules and a pulse voltage source for causing a charge transfer between the donor molecules and the acceptor molecules. The charge transfer varies the optical characteristic of the organic thin film, whereby the organic thin film displays an image.
摘要翻译：有机薄膜显示元件包括含有供体分子和受体分子的有机薄膜和用于在供体分子和受体分子之间引起电荷转移的脉冲电压源。电荷转移改变有机薄膜的光学特性，由此有机薄膜显示图像。

14. 发明申请

US20120171673A1 SAMPLE ANALYSIS METHOD AND ASSAY KIT USED THEREIN 失效
标题翻译：样品分析方法和使用的试剂盒
公开(公告)号：US20120171673A1
公开(公告)日：2012-07-05
申请号：US13340572
申请日：2011-12-29
申请人： Naoko NAKAMURA , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko NAKAMURA , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6809 , C12Q1/6853 , C12Q2525/161 , C12Q2525/301 , C12Q2537/143 , C12Q2563/179 , C12Q2565/514
摘要： One embodiment is related to a method of analyzing plural samples. The method includes amplifying a plurality of samples using a first primer and second primer, wherein the first primer includes a tag sequence having a sequence different from a sample to one another and wherein a second primer used in pair with the first primer in independent reaction systems for the respective samples to obtain an amplified product in which the tag sequence is introduced, mixing amplified products obtained in the plurality of reaction systems, making the mixed amplified product react with a nucleic acid probe immobilized on a substrate, and detecting the amount of hybridization that has occurred.
摘要翻译：一个实施例涉及分析多个样本的方法。该方法包括使用第一引物和第二引物扩增多个样品，其中第一引物包含具有不同于样品的序列的标签序列，并且其中与独立反应体系中的第一引物成对配对的第二引物对于各样品获得其中引入标签序列的扩增产物，混合在多个反应体系中获得的扩增产物，使得混合的扩增产物与固定在底物上的核酸探针反应，并检测杂交的量已经发生了。

15. 发明授权

US07728119B2 Nucleotide primer set and nucleotide probe for detecting genotype of methylene tetrahydrofolate reductase (MTHFR) 失效
标题翻译：用于检测亚甲基四氢叶酸还原酶（MTHFR）基因型的核苷酸引物组和核苷酸探针
公开(公告)号：US07728119B2
公开(公告)日：2010-06-01
申请号：US12015645
申请日：2008-01-17
申请人： Naoko Nakamura , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2537/137 , C12Q2525/301
摘要： There is provided is a nucleotide primer set for LAMP amplification used for detecting genotypes of single-nucleotide polymorphisms C677T and A1298C of an MTHFR gene. There is also provided a nucleotide probe for detecting an amplification product amplified by the primer set according to the present invention. There is also provided a method of detecting the genotypes of the single-nucleotide polymorphisms C677T and A1298C in the MTHFR gene, by using the primer set according to the present invention.
摘要翻译：提供了用于检测MTHFR基因的单核苷酸多态性C677T和A1298C的基因型的LAMP扩增的核苷酸引物组。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用根据本发明的引物组来检测MTHFR基因中单核苷酸多态性C677T和A1298C的基因型的方法。

16. 发明申请

US20090275028A1 METHOD OF DETECTING TARGET NUCLEIC ACID 审中-公开
标题翻译：检测目标核酸的方法
公开(公告)号：US20090275028A1
公开(公告)日：2009-11-05
申请号：US12329898
申请日：2008-12-08
申请人： Naoko Nakamura , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6837 , C12Q2527/101 , C12Q2525/204 , C12Q2565/501
摘要： The present invention provides a method of detecting a target nucleic acid which includes a step of examining whether a washing step has been normally conducted. In an aspect of the invention, a monitoring nucleic acid probe to monitor the washing level is used. The probe shows a change in signal intensity by washing at a washing temperature changed in the optimum temperature range for washing the target nucleic acid and in a temperature range in the vicinity of the optimum temperature range for washing.
摘要翻译：本发明提供了检测目标核酸的方法，其包括检查洗涤步骤是否正常进行的步骤。在本发明的一个方面，使用监测洗涤水平的监测核酸探针。探针通过在洗涤目标核酸的最适温度范围内和在用于洗涤的最佳温度范围附近的温度范围内改变的洗涤温度下洗涤来显示信号强度的变化。

17. 发明申请

US20080153714A1 NUCLEIC ACID DETECTION CASSETTE AND NUCLEIC ACID DETECTION SYSTEM 审中-公开
标题翻译：核酸检测CASSETTE和核酸检测系统
公开(公告)号：US20080153714A1
公开(公告)日：2008-06-26
申请号：US11848623
申请日：2007-08-31
申请人： Sadato HONGO , Jun Okada , Kenji Ooki , Nobuhiro Gemma
发明人： Sadato HONGO , Jun Okada , Kenji Ooki , Nobuhiro Gemma
IPC分类号： C40B60/10
CPC分类号： G01N35/1095 , G01N33/5308 , G01N33/54366
摘要： A nucleic acid cassette includes a main body in which first and second channels are formed. A sample containing a target nucleic acid is input in a sample chamber of the second channel via an injection port. In the cassette, a detecting part includes a detection chamber communicated to the first and second channels and a nucleic detection unit. The first channel has a first reagent reservoir storing a first reagent and a second reagent reservoir storing a second reagent. The first and second reagents reservoirs are separated by a gaseous body in the channel. The sample and the first and second reagents are supplied to the detecting part due to an action of a pump part communicated to the first and second channels.
摘要翻译：核酸盒包括其中形成有第一和第二通道的主体。含有靶核酸的样品通过注射口输入到第二通道的样品室中。在盒中，检测部分包括与第一和第二信道通信的检测室和核心检测单元。第一通道具有存储第一试剂的第一试剂储存器和存储第二试剂的第二试剂储存器。第一和第二试剂储存器在通道中被气体体分开。由于与第一和第二通道相通的泵部件的动作，将样品和第一和第二试剂供给到检测部。

18. 发明申请

US20070227885A1 NUCLEIC ACID DETECTION DEVICE 有权
标题翻译：核酸检测装置
公开(公告)号：US20070227885A1
公开(公告)日：2007-10-04
申请号：US11682484
申请日：2007-03-06
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： G01N33/487
CPC分类号： B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0883 , G01N27/3275
摘要： A nucleic acid detection device includes a flow channel through which a solution containing a nucleic acid recognition body flows, probe electrodes having immobilized nucleic acid probes, and a counter electrode used to measure an electrochemical response of the nucleic acid recognition body. The flow channel includes a curved portion and a straight portion continued from and located downstream of the curved portion. The probe electrodes are arranged at intervals along the straight portion, avoiding an upstream end of the straight portion that is located within a distance L from the curved portion. The distance L is given by L=0.065×Re×D, Re=ρuD/μ, and D=4 S/Lp where ρ, u, and μ are a concentration, a flow velocity, and a viscosity of the solution, and S and Lp are a sectional area and a wall peripheral perimeter of the flow channel, respectively.
摘要翻译：核酸检测装置包括含有核酸识别体的溶液流过的流路，具有固定化的核酸探针的探针电极和用于测定核酸识别体的电化学响应的对极。流动通道包括弯曲部分和从弯曲部分连续并位于弯曲部分下游的直线部分。探针电极沿着直线部分间隔设置，避免了直线部分的距弯曲部分的距离L内的上游端。距离L由L = 0.065xRexD，Re = rhouD / mu和D = 4S / Lp给出，其中rho，u和μ是溶液的浓度，流速和粘度，S和Lp 分别是流动通道的截面积和壁周边周长。

19. 发明申请

US20070215466A1 NUCLEIC ACID DETECTION DEVICE AND NUCLEIC ACID DETECTION APPARATUS 审中-公开
标题翻译：核酸检测装置和核酸检测装置
公开(公告)号：US20070215466A1
公开(公告)日：2007-09-20
申请号：US11555936
申请日：2006-11-02
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： G01N33/487
CPC分类号： G01N27/4473
摘要： A nucleic acid detection device includes a flow channel which allows a solution containing a nucleic acid recognition body to flow therethrough, at least two first electrode portions including a probe electrode to which at least one nucleic acid probe is immobilized, and at least two second electrode portions including a reference electrode to be used for measuring a reference value. The first and second electrode portions are arranged in the flow channel to form a row along the flow channel. One of the second electrode portions is adjacent to one of the first electrode portions.
摘要翻译：核酸检测装置包括允许含有核酸识别体的溶液流过其中的流动通道，至少两个第一电极部分，包括固定有至少一个核酸探针的探针电极和至少两个第二电极包括用于测量参考值的参考电极的部分。第一和第二电极部分布置在流动通道中以沿着流动通道形成一排。第二电极部分中的一个与第一电极部分中的一个相邻。

20. 发明申请

US20080242554A1 NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF METHYLENE TETRAHYDROFOLATE REDUCTASE (MTHFR) 失效
标题翻译：用于检测甲基四氢叶酸还原酶（MTHFR）基因组的核酸酶和核苷酸探针
公开(公告)号：US20080242554A1
公开(公告)日：2008-10-02
申请号：US12015645
申请日：2008-01-17
申请人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68 , C40B30/04 , C07H21/00 , C40B40/06
CPC分类号： C12Q1/6827 , C12Q2537/137 , C12Q2525/301
摘要： There is provided is a nucleotide primer set for LAMP amplification used for detecting genotypes of single-nucleotide polymorphisms C677T and A1298C of an MTHFR gene. There is also provided a nucleotide probe for detecting an amplification product amplified by the primer set according to the present invention. There is also provided a method of detecting the genotypes of the single-nucleotide polymorphisms C677T and A1298C in the MTHFR gene, by using the primer set according to the present invention.
摘要翻译：提供了用于检测MTHFR基因的单核苷酸多态性C677T和A1298C的基因型的LAMP扩增的核苷酸引物组。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用根据本发明的引物组来检测MTHFR基因中单核苷酸多态性C677T和A1298C的基因型的方法。

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