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11. 发明授权

US09631265B2 Hot-rolled steel sheet and method for producing same 有权
公开(公告)号：US09631265B2
公开(公告)日：2017-04-25
申请号：US14119124
申请日：2012-05-24
申请人： Kohichi Sano , Kunio Hayashi , Kazuaki Nakano , Riki Okamoto , Nobuhiro Fujita
发明人： Kohichi Sano , Kunio Hayashi , Kazuaki Nakano , Riki Okamoto , Nobuhiro Fujita
IPC分类号： C21D8/02 , C22C38/38 , C21D9/46 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/60 , C22C38/22 , C22C38/28 , C22C38/32
CPC分类号： C22C38/38 , C21D8/005 , C21D8/02 , C21D8/0205 , C21D8/0226 , C21D8/0236 , C21D8/0263 , C21D8/0273 , C21D8/0278 , C21D9/46 , C21D2211/002 , C21D2211/005 , C21D2211/008 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/105 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/22 , C22C38/28 , C22C38/32 , C22C38/60 , Y10T428/12799
摘要： A hot-rolled steel sheet satisfies that average pole density of orientation group of {100} to {223} is 1.0 to 5.0 and pole density of crystal orientation {332} is 1.0 to 4.0. Moreover, the hot-rolled steel sheet includes, as a metallographic structure, by area %, ferrite and bainite of 30% to 99% in total and martensite of 1% to 70%. Moreover, the hot-rolled steel sheet satisfies following Expressions 1 and 2 when area fraction of the martensite is defined as fM in unit of area %, average size of the martensite is defined as dia in unit of μm, average distance between the martensite is defined as dis in unit of μm, and tensile strength of the steel sheet is defined as TS in unit of MPa. dia≦13 μm (Expression 1) TS/fM×dis/dia≧500 (Expression 2)

12. 发明授权

US08053445B2 Utilities of olefin derivatives 有权
标题翻译：烯烃衍生物的实用性
公开(公告)号：US08053445B2
公开(公告)日：2011-11-08
申请号：US12230993
申请日：2008-09-09
申请人： Teruo Yamamori , Kiyoshi Nagata , Kunio Hayashi
发明人： Teruo Yamamori , Kiyoshi Nagata , Kunio Hayashi
IPC分类号： A61K31/47
CPC分类号： C07D213/06 , A61K31/215 , A61K31/40 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/55 , C07D213/57 , C07D215/04 , C07D215/14 , C07D235/18 , C07D241/42 , C07D263/57 , C07D277/66 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04
摘要： Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2—, —CY2═CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.
摘要翻译：提供了具有增强载脂蛋白A表达的活性的化合物。式（I）化合物：其中Ar 1和Ar 2独立地为可任意取代的苯基，萘基或单环或双环芳族杂环基; -X-是-N = CZ2-，-CY2 = CZ2-，-CY2Y3-CHZ2-，-S-，-O-等; Y 1，Y 2，Y 3，Z 1和Z 2独立地为氢，卤素，低级烷基，苯基等; Z1和Z2可以独立地是可以与Ar2和Ar1结合形成稠环的连接基团; m为0或1，n为0至2; 其前药，其药学上可接受的盐或溶剂合物; 被披露。

13. 发明授权

US09567658B2 Cold-rolled steel sheet 有权
标题翻译：冷轧钢板
公开(公告)号：US09567658B2
公开(公告)日：2017-02-14
申请号：US14118968
申请日：2012-05-24
申请人： Yuri Toda , Riki Okamoto , Nobuhiro Fujita , Kohichi Sano , Hiroshi Yoshida , Toshio Ogawa , Kunio Hayashi , Kazuaki Nakano
发明人： Yuri Toda , Riki Okamoto , Nobuhiro Fujita , Kohichi Sano , Hiroshi Yoshida , Toshio Ogawa , Kunio Hayashi , Kazuaki Nakano
IPC分类号： C22C38/02 , C22C38/04 , C22C38/06 , C21D8/02 , C22C38/38 , C21D9/46 , C22C38/00 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/60 , C22C38/22 , C22C38/28 , C22C38/32
CPC分类号： C22C38/38 , C21D8/005 , C21D8/02 , C21D8/0205 , C21D8/0226 , C21D8/0236 , C21D8/0263 , C21D8/0273 , C21D8/0278 , C21D9/46 , C21D2211/002 , C21D2211/005 , C21D2211/008 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/105 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/22 , C22C38/28 , C22C38/32 , C22C38/60 , Y10T428/12799
摘要： A cold-rolled steel sheet satisfies that an average pole density of an orientation group of {100} to {223} is 1.0 to 5.0, a pole density of a crystal orientation {332} is 1.0 to 4.0, a Lankford-value rC in a direction perpendicular to a rolling direction is 0.70 to 1.50, and a Lankford-value r30 in a direction making an angle of 30° with the rolling direction is 0.70 to 1.50. Moreover, the cold-rolled steel sheet includes, as a metallographic structure, by area %, a ferrite and a bainite of 30% to 99% in total and a martensite of 1% to 70%.
摘要翻译：冷轧钢板满足{100} <011>〜{223} <110>的取向基团的平均极密度为1.0〜5.0，晶体取向{332} <113的极点密度为1.0 至4.0时，与轧制方向垂直的方向的兰克福特值rC为0.70〜1.50，轧制方向成为30°的方向的兰克福特值r30为0.70〜1.50。另外，作为金相结构，冷轧钢板以面积％计，总计为30％〜99％的铁素体和贝氏体为1％〜70％的马氏体。

14. 发明申请

US20130323112A1 HOT-ROLLED STEEL SHEET AND METHOD OF PRODUCING THE SAME 有权
标题翻译：热轧钢板及其制造方法
公开(公告)号：US20130323112A1
公开(公告)日：2013-12-05
申请号：US14000143
申请日：2012-03-05
申请人： Riki Okamoto , Nobuhiro Fujita , Manabu Takahashi , Kunio Hayashi , Tetsuo Kishimoto , Kazuaki Nakano , Takeshi Yamamoto
发明人： Riki Okamoto , Nobuhiro Fujita , Manabu Takahashi , Kunio Hayashi , Tetsuo Kishimoto , Kazuaki Nakano , Takeshi Yamamoto
IPC分类号： C22C38/38 , C22C38/02 , C22C38/04 , C22C38/06 , B21B1/26 , C22C38/12 , C22C38/34 , C22C38/16 , C22C38/10 , C22C38/08 , C22C38/00 , C22C38/14
CPC分类号： C22C38/38 , B21B1/26 , C21D6/005 , C21D6/008 , C21D8/0226 , C21D8/0263 , C21D9/46 , C21D2211/005 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/34
摘要： In a hot-rolled sheet, an average value of pole densities of an orientation group {100} to {223} , which is represented by an arithmetic mean of pole densities of orientations {100} , {116} , {114} , {112} , and {223} in a thickness center portion of a thickness range of ⅝ to ⅜ from a surface of the steel sheet, is 1.0 to 6.5 and a pole density of a crystal orientation {332} is 1.0 to 5.0; and a Lankford value rC in a direction perpendicular to a rolling direction is 0.70 to 1.10 and a Lankford value r30 in a direction that forms 30° with respect to the rolling direction is 0.70 to 1.10.
摘要翻译：在热轧板中，取向组{100} <011>至{223} <110>的极点密度的平均值由取向{100} <011>的极点密度的算术平均值表示，在厚度中心部分的厚度范围为5/8至3/8的{116} <110>，{114} <110>，{112} <110>和{223} <110> 钢板为1.0〜6.5，晶体取向{332} <113>的极点密度为1.0〜5.0，在与轧制方向垂直的方向上的兰克福德值rC为0.70〜1.10，相对于轧制方向形成30°的方向的兰克福德值r30为0.70〜1.10。

15. 发明授权

US09273370B2 Hot-rolled steel sheet, cold-rolled steel sheet, galvanized steel sheet, and methods of manufacturing the same 有权
标题翻译：热轧钢板，冷轧钢板，镀锌钢板及其制造方法
公开(公告)号：US09273370B2
公开(公告)日：2016-03-01
申请号：US13811902
申请日：2011-07-27
申请人： Nobuhiro Fujita , Kunio Hayashi , Riki Okamoto , Manabu Takahashi , Tetsuo Kishimoto , Hiroshi Yoshida
发明人： Nobuhiro Fujita , Kunio Hayashi , Riki Okamoto , Manabu Takahashi , Tetsuo Kishimoto , Hiroshi Yoshida
IPC分类号： C22C38/58 , C22C38/54 , C22C38/52 , C21D8/02 , C23C2/06 , C23C2/28 , C22C38/00 , C22C38/04 , B21B35/00 , C22C38/02 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/20 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/30 , C22C38/32 , C22C38/34 , C22C38/38 , C22C38/40 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , C23C2/02 , C25D5/36 , C23C2/40
CPC分类号： C25D3/22 , B21B35/00 , B32B15/013 , C21D6/004 , C21D6/005 , C21D6/007 , C21D6/008 , C21D8/0205 , C21D8/0226 , C21D8/0236 , C21D8/0247 , C21D8/0263 , C21D8/0273 , C21D9/46 , C21D2201/05 , C21D2211/00 , C21D2211/001 , C21D2211/002 , C21D2211/005 , C21D2211/009 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/105 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/20 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/30 , C22C38/32 , C22C38/34 , C22C38/38 , C22C38/40 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , C22C38/52 , C22C38/54 , C22C38/58 , C23C2/02 , C23C2/06 , C23C2/28 , C23C2/40 , C25D5/36
摘要： A hot-rolled steel sheet has an average value of the X-ray random intensity ratio of a {100} to {223} orientation group at least in a sheet thickness central portion that is in a sheet thickness range of ⅝ to ⅜ from a steel sheet surface of 1.0 to 6.0, an X-ray random intensity ratio of a {332} crystal orientation of 1.0 to 5.0, rC which is an r value in a direction perpendicular to a rolling direction of 0.70 to 1.10, and r30 which is an r value in a direction that forms an angle of 30° with respect to the rolling direction of 0.70 to 1.10.
摘要翻译：热轧钢板至少在片材厚度范围的板厚中央部具有{100} <011>〜{223} <110>取向基团的X射线随机强度比的平均值从1.0〜6.0的钢板表面的⅝至⅝，{332} <113>晶体取向的X射线随机强度比为1.0〜5.0，rC为与轧制方向垂直的方向的r值为0.70〜1.10，r30为相对于轧制方向为30°的方向的r值，为0.70〜1.10。

16. 发明授权

US09267196B2 Method of producing a hot rolled steel sheet 有权
标题翻译：热轧钢板的制造方法
公开(公告)号：US09267196B2
公开(公告)日：2016-02-23
申请号：US14000143
申请日：2012-03-05
申请人： Riki Okamoto , Nobuhiro Fujita , Manabu Takahashi , Kunio Hayashi , Tetsuo Kishimoto , Kazuaki Nakano , Takeshi Yamamoto
发明人： Riki Okamoto , Nobuhiro Fujita , Manabu Takahashi , Kunio Hayashi , Tetsuo Kishimoto , Kazuaki Nakano , Takeshi Yamamoto
IPC分类号： C21D8/04 , C22C38/04 , C22C38/02 , C22C38/38 , C22C38/00 , C22C38/06 , B21B1/26 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/34 , C21D9/46 , C21D8/02 , C22C38/18 , C21D6/00
CPC分类号： C22C38/38 , B21B1/26 , C21D6/005 , C21D6/008 , C21D8/0226 , C21D8/0263 , C21D9/46 , C21D2211/005 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/34
摘要： In a hot-rolled sheet, an average value of pole densities of an orientation group {100} to {223} , which is represented by an arithmetic mean of pole densities of orientations {100} , {116} , {114} , {112} , and {223} in a thickness center portion of a thickness range of ⅝ to ⅜ from a surface of the steel sheet, is 1.0 to 6.5 and a pole density of a crystal orientation {332} is 1.0 to 5.0; and a Lankford value rC in a direction perpendicular to a rolling direction is 0.70 to 1.10 and a Lankford value r30 in a direction that forms 30° with respect to the rolling direction is 0.70 to 1.10.
摘要翻译：在热轧板中，取向组{100} <011>至{223} <110>的极点密度的平均值由取向{100} <011>的极点密度的算术平均值表示，在钢板表面的厚度范围为⅝〜a的厚度中心部分的{116} <110>，{114} <110>，{112} <110>和{223} <110> 1.0〜6.5，晶体取向{332} <113>的极点密度为1.0〜5.0; 在与轧制方向垂直的方向上的兰克福德值rC为0.70〜1.10，相对于轧制方向形成30°的方向的兰克福特值r30为0.70〜1.10。

17. 发明申请

US20130153091A1 HOT-ROLLED STEEL SHEET, COLD-ROLLED STEEL SHEET, GALVANIZED STEEL SHEET, AND METHODS OF MANUFACTURING THE SAME 有权
标题翻译：热轧钢板，冷轧钢板，钢化钢板及其制造方法
公开(公告)号：US20130153091A1
公开(公告)日：2013-06-20
申请号：US13811902
申请日：2011-07-27
申请人： Nobuhiro Fujita , Kunio Hayashi , Riki Okamoto , Manabu Takahashi , Tetsuo Kishimoto , Hiroshi Yoshida
发明人： Nobuhiro Fujita , Kunio Hayashi , Riki Okamoto , Manabu Takahashi , Tetsuo Kishimoto , Hiroshi Yoshida
IPC分类号： C21D8/02 , C25D5/36 , C22C38/58 , C22C38/54 , C22C38/52 , C22C38/50 , C22C38/48 , C22C38/46 , C22C38/44 , C22C38/42 , C22C38/40 , C22C38/38 , C22C38/34 , C22C38/32 , C22C38/30 , C22C38/28 , C22C38/26 , C22C38/24 , C22C38/22 , C22C38/20 , C22C38/18 , C22C38/16 , C22C38/14 , C22C38/12 , C22C38/10 , C22C38/08 , C22C38/06 , C22C38/04 , C22C38/02 , C22C38/00 , B21B35/00 , C23C2/02
CPC分类号： C25D3/22 , B21B35/00 , B32B15/013 , C21D6/004 , C21D6/005 , C21D6/007 , C21D6/008 , C21D8/0205 , C21D8/0226 , C21D8/0236 , C21D8/0247 , C21D8/0263 , C21D8/0273 , C21D9/46 , C21D2201/05 , C21D2211/00 , C21D2211/001 , C21D2211/002 , C21D2211/005 , C21D2211/009 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/005 , C22C38/008 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/10 , C22C38/105 , C22C38/12 , C22C38/14 , C22C38/16 , C22C38/18 , C22C38/20 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/30 , C22C38/32 , C22C38/34 , C22C38/38 , C22C38/40 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , C22C38/52 , C22C38/54 , C22C38/58 , C23C2/02 , C23C2/06 , C23C2/28 , C23C2/40 , C25D5/36
摘要： A hot-rolled steel sheet has an average value of the X-ray random intensity ratio of a {100} to {223} orientation group at least in a sheet thickness central portion that is in a sheet thickness range of ⅝ to ⅜ from a steel sheet surface of 1.0 to 6.0, an X-ray random intensity ratio of a {332} crystal orientation of 1.0 to 5.0, rC which is an r value in a direction perpendicular to a rolling direction of 0.70 to 1.10, and r30 which is an r value in a direction that forms an angle of 30° with respect to the rolling direction of 0.70 to 1.10.
摘要翻译：热轧钢板至少在片材厚度范围的板厚中央部具有{100} <011>〜{223} <110>取向基团的X射线随机强度比的平均值从钢板表面1.0〜6.0的5/8〜3/8，{332} <113>晶体取向的X射线随机强度比为1.0〜5.0，rC为垂直方向的r值轧制方向为0.70〜1.10，r30为相对于轧制方向形成30°角度的方向的r值，r30为0.70〜1.10。

18. 发明授权

US5675200A Dynamic pressure air bearing type electric motor with air circulating arrangement 失效
标题翻译：具有空气循环装置的动压空气轴承型电动机
公开(公告)号：US5675200A
公开(公告)日：1997-10-07
申请号：US502617
申请日：1995-07-14
申请人： Kunio Hayashi
发明人： Kunio Hayashi
IPC分类号： F16C17/02 , F16C33/10 , H02K5/16 , H02K5/167 , H02K7/08 , H02K7/09 , H02K7/14 , H02K9/26 , H02K17/02 , H02K21/24 , F16C32/06
CPC分类号： F16C33/107 , F16C17/026 , F16C17/045 , H02K5/1675 , H02K7/09
摘要： A dynamic pressure air bearing type electric motor includes a motor casing comprising a base having a bearing cylinder and a cover which is attached to the base to cover the bearing cylinder. A rotor assembly is enclosed in the motor casing and has a rotational shaft inserted and held in the bearing cylinder for rotation. The rotational shaft has at least one pair of herringbone grooves formed in the outer circumferential face. A bearing gap is defined between the rotational shaft and the inner circumferential face. A bearing gap is defined between the rotational shaft and the inner circumference of the bearing cylinder. The base has an air flow path formed therein. Upon rotation of the rotor assembly, air is caused to flow through the bearing gap axially along the rotational shaft. An air circulating path is formed in the motor casing so that the air is circulated through the bearing gap, the air flow path in the motor casing, and a gap between a mounting member and the outer circumference of the bearing cylinder.
摘要翻译：动压式空气轴承型电动机包括：电动机壳体，其包括具有轴承缸和底座的底座，该底座安装在基座上以覆盖轴承缸。转子组件封装在电动机壳体中，并且具有插入并保持在轴承气缸中以用于旋转的旋转轴。旋转轴具有形成在外周面中的至少一对人字形槽。在旋转轴和内周面之间限定轴承间隙。轴承间隙被限定在旋转轴和轴承圆筒的内圆周之间。底座具有形成在其中的气流通道。当转子组件旋转时，使空气沿着旋转轴轴向流过轴承间隙。空气循环路径形成在电动机壳体中，使得空气通过轴承间隙，电动机壳体中的空气流动路径以及安装构件与轴承气缸的外周之间的间隙循环。

19. 发明授权

US5272268A Dipeptide derivatives 失效
标题翻译：二肽衍生物
公开(公告)号：US5272268A
公开(公告)日：1993-12-21
申请号：US974211
申请日：1992-11-10
申请人： Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
发明人： Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
IPC分类号： A61K38/00 , C07D213/56 , C07D233/54 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/065 , C07D401/06 , C07D249/14 , C07D277/18
CPC分类号： C07D233/64 , C07D213/56 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06078 , A61K38/00
摘要： A following dipeptide derivative of the following formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 --, or C.sub.3 -C.sub.10 cycloalkyl-S--;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloaklyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.
摘要翻译：提供下述式（I）的二肽衍生物，其能够抑制肾素的酶活性，从而抑制肾素 - 血管紧张素系统并降低血压。（I）其中：R1是C1-C12烷基，C2-C6烯基，C2-C6炔基，C3-C10环烷基，芳基或杂环基; R2是氨基甲酰基，芳基，5-或6-元杂环基，C1-C12烷基-S-，C1-C12烷基-S-CH2-或C3-C10环烷基-S-; R3是芳基或5-或6-元杂环基; R4是R4'-SO2或R4'-CO; R 4'是芳基，C 1 -C 12烷基，C 2 -C 6烯基，C 2 -C 6炔基; C 3 -C 10环烷基或杂环基; X是CH 2，NH，O或S; 并且Y是CO或NHSO 2，其中R 1，R 2，R 3和R 4'各自可被一至三个取代基取代。

20. 发明授权

US5194608A Dipeptide derivatives 失效
标题翻译：替代衍生物
公开(公告)号：US5194608A
公开(公告)日：1993-03-16
申请号：US719492
申请日：1991-06-24
申请人： Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
发明人： Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
IPC分类号： A61K38/00 , C07D213/56 , C07D233/54 , C07D233/64 , C07D263/06 , C07D277/30 , C07D277/46 , C07D277/56 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/065
CPC分类号： C07D233/64 , C07D213/56 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06078 , A61K38/00
摘要： A dipeptide derivative of formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 --, or C.sub.3 -C.sub.10 cycloalkyl-S--;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloalkyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.

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