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11. 发明授权

US07893028B2 Isolated mutant protein of fibroblast growth factor 18 and pharmaceutical composition comprising the same 有权
标题翻译：分离的成纤维细胞生长因子18的突变蛋白质和包含其的药物组合物
公开(公告)号：US07893028B2
公开(公告)日：2011-02-22
申请号：US12159854
申请日：2007-01-09
申请人： Toru Imamura , Nozomi Tsujino , Masashi Suzuki , Masahiro Asada
发明人： Toru Imamura , Nozomi Tsujino , Masashi Suzuki , Masahiro Asada
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K8/64 , A61K38/00 , A61Q7/00
摘要： Disclosed is a mutant protein having an altered fibroblast growth factor receptor specificity, which is produced by deleting one or more amino acid residues from the N-terminus of the amino acid sequence of naturally secreted fibroblast growth factor 18. The protein mutant can be used in a pharmaceutical composition for regulating hair regeneration or growth or a pharmaceutical composition for regulating bone or cartilage formation.
摘要翻译：公开了具有改变的成纤维细胞生长因子受体特异性的突变蛋白，其通过从天然分泌的成纤维细胞生长因子18的氨基酸序列的N末端缺失一个或多个氨基酸残基而产生。蛋白突变体可以用于用于调节毛发再生或生长的药物组合物或用于调节骨或软骨形成的药物组合物。

12. 发明申请

US20090286965A1 MUTANT GROWTH FACTORS WITH ALTERED RECEPTOR SPECIFICITIES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：具有改变的受体特异性的重要生长因子和包含其的药物组合物
公开(公告)号：US20090286965A1
公开(公告)日：2009-11-19
申请号：US12159854
申请日：2007-01-09
申请人： Toru Imamura , Nozomi Tsujino , Masashi Suzuki , Masahiro Asada
发明人： Toru Imamura , Nozomi Tsujino , Masashi Suzuki , Masahiro Asada
IPC分类号： C07K14/50
CPC分类号： C07K14/50 , A61K8/64 , A61K38/00 , A61Q7/00
摘要： Disclosed is a mutant protein having an altered fibroblast growth factor receptor specificity, which is produced by deleting one or more amino acid residues from the N-terminus of the amino acid sequence of naturally secreted fibroblast growth factor 18. The protein mutant can be used in a pharmaceutical composition for regulating hair regeneration or growth or a pharmaceutical composition for regulating bone or cartilage formation.
摘要翻译：公开了具有改变的成纤维细胞生长因子受体特异性的突变蛋白，其通过从天然分泌的成纤维细胞生长因子18的氨基酸序列的N末端缺失一个或多个氨基酸残基而产生。蛋白突变体可以用于用于调节毛发再生或生长的药物组合物或用于调节骨或软骨形成的药物组合物。

13. 发明授权

US07741078B2 Heparin-binding protein modified with heparan sulfate sugar chains, process for producing the same and pharmaceutical compositions containing the same 有权
标题翻译：用硫酸乙酰肝素糖链修饰的肝素结合蛋白，其制备方法和含有它的药物组合物
公开(公告)号：US07741078B2
公开(公告)日：2010-06-22
申请号：US11547346
申请日：2005-03-31
申请人： Toru Imamura , Masahiro Asada , Masashi Suzuki
发明人： Toru Imamura , Masahiro Asada , Masashi Suzuki
IPC分类号： C12N15/12 , C12N1/00 , C12P21/02
CPC分类号： C07K14/501 , A61K38/00 , C07K2319/35
摘要： A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.
摘要翻译：在其分子内具有共价键合的硫酸肝素糖链的肝素结合蛋白是通过将编码可以与硫酸肝素糖链修饰的肽选择性地编码到编码肝素结合蛋白的cDNA并在动物细胞中产生的cDNA来产生的所得连接的cDNA的基因产物。这种硫酸乙酰肝素糖链修饰的肝素结合蛋白通过共价键合含有少量硫酸软骨素的糖胺聚糖糖链来官能化。例如，该肝素结合蛋白质的稳定性优异，例如耐热性，耐酸性，耐碱性和体内稳定性。此外，硫酸乙酰肝素糖链修饰的肝素结合蛋白对细胞增殖和组织再生有效，具有调节FGFs生理功能的作用。因此，该肝素结合蛋白作为预防或治疗各种FGF相关疾病的药物是非常有用的。

14. 发明申请

US20080119403A1 Haparin-Binding Protein Modified with Heparan Sulfate Sugar Chains, Process for Producing the Same and Pharmaceutical Compositions Containing the Same 有权
标题翻译：用硫酸肝素糖链修饰的Haparin结合蛋白，其制备方法和含有其的药物组合物
公开(公告)号：US20080119403A1
公开(公告)日：2008-05-22
申请号：US11547346
申请日：2005-03-31
申请人： Toru Imamura , Masahiro Asada , Masashi Suzuki
发明人： Toru Imamura , Masahiro Asada , Masashi Suzuki
IPC分类号： A61K31/70 , C07K16/00 , A61P43/00 , C07H21/04 , C12P21/04
CPC分类号： C07K14/501 , A61K38/00 , C07K2319/35
摘要： A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.
摘要翻译：在其分子内具有共价键合的硫酸肝素糖链的肝素结合蛋白是通过将编码可以与硫酸肝素糖链修饰的肽选择性地编码到编码肝素结合蛋白的cDNA并在动物细胞中产生的cDNA来产生的所得连接的cDNA的基因产物。这种硫酸乙酰肝素糖链修饰的肝素结合蛋白通过共价键合含有少量硫酸软骨素的糖胺聚糖糖链来官能化。例如，该肝素结合蛋白质的稳定性优异，例如耐热性，耐酸性，耐碱性和体内稳定性。此外，硫酸乙酰肝素糖链修饰的肝素结合蛋白对细胞增殖和组织再生有效，具有调节FGFs生理功能的作用。因此，该肝素结合蛋白作为预防或治疗各种FGF相关疾病的药物是非常有用的。

15. 发明申请

US20180356759A1 IMAGE FORMING APPARATUS AND IMAGE FORMING METHOD 审中-公开
公开(公告)号：US20180356759A1
公开(公告)日：2018-12-13
申请号：US15990317
申请日：2018-05-25
申请人： Susumu Narita , Yoshinobu Sakaue , Ryo Sato , Koichi Murota , Masashi Suzuki , Takuma Nishio , Hiroaki Nishina
发明人： Susumu Narita , Yoshinobu Sakaue , Ryo Sato , Koichi Murota , Masashi Suzuki , Takuma Nishio , Hiroaki Nishina
IPC分类号： G03G15/00 , G03G15/043
CPC分类号： G03G15/5062 , G03G15/043 , G03G15/6529 , G03G2215/00042
摘要： An image forming apparatus includes a latent image bearer, a latent image writing device, a developing device, a conveyance unit to convey a recording medium, a transfer device, a length data acquisition unit to obtain a length of the recording medium in a conveyance direction of the recording medium, an image forming processor to form a test pattern, and a light quantity correction calculator that acquires image density data of the test pattern and calculates a light quantity correction value to correct a light quantity. The image forming processor sets a position of the test pattern on the recording medium in the conveyance direction of the recording medium and a length of the test pattern in the conveyance direction of the recording medium based on the length of the recording medium in the conveyance direction of the recording medium obtained by the length data acquisition unit.

16. 发明授权

US09242478B2 Writing controlling apparatus, image forming apparatus, and computer program product 有权
标题翻译：书写控制装置，图像形成装置和计算机程序产品
公开(公告)号：US09242478B2
公开(公告)日：2016-01-26
申请号：US14102738
申请日：2013-12-11
申请人： Masashi Suzuki , Katsuhiko Maeda , Yoshio Kanzaki , Masahiko Oikawa , Yasuhiro Abe , Hiroaki Nishina , Yuuki Honda
发明人： Masashi Suzuki , Katsuhiko Maeda , Yoshio Kanzaki , Masahiko Oikawa , Yasuhiro Abe , Hiroaki Nishina , Yuuki Honda
IPC分类号： B41J2/47 , B41J2/435 , G06K15/12
CPC分类号： B41J2/435 , B41J2/471 , G06K15/1209
摘要： The invention is concerning the writing controlling apparatus that includes an acquiring unit configured to acquire a plurality of light amounts of a light source driven while changing an input current in non-effective scanning periods during which an image carrier is not irradiated with light from the light source, as a plurality of output results; a detecting unit configured to detect characteristics of the light source using the output results thus acquired; and a correcting unit configured to correct a current to be applied to the light source based on the characteristics thus detected.
摘要翻译：本发明涉及一种写入控制装置，该写入控制装置包括获取单元，该获取单元被配置为在图像载体未被来自光的光照射的非有效扫描周期中改变输入电流，从而获取驱动的多个光量源，作为多个输出结果; 检测单元，被配置为使用如此获取的输出结果来检测光源的特性; 以及校正单元，其被配置为基于所检测的特性来校正要施加到光源的电流。

17. 发明授权

US08563618B2 Skin external preparation having excellent stability 有权
标题翻译：皮肤外用制剂具有优异的稳定性
公开(公告)号：US08563618B2
公开(公告)日：2013-10-22
申请号：US12305356
申请日：2007-04-24
申请人： Hisashi Akamatsu , Masashi Suzuki , Yuji Sakai
发明人： Hisashi Akamatsu , Masashi Suzuki , Yuji Sakai
IPC分类号： A61K47/26 , A61K47/10 , A61K31/05 , A61K31/734 , A61K8/06
CPC分类号： A61Q19/00 , A61K8/347 , A61K8/735
摘要： Disclosed is an agent for skin external preparation which is hardly reduced in viscosity even when stored for a long period under extreme high temperature storage conditions and is therefore stable. The preparation is in an emulsion form, and comprises (1) an alginic acid polyol ester having an esterification degree ranging from 75 to 95% (e.g., alginic acid propylene glycol ester) and/or a salt thereof; (2) a polyvalent metal ion (e.g., a calcium ion); and (3) a 4-alkylresolcinol (e.g., 4-n-butylresolcinol) and/or a salt thereof.
摘要翻译：公开了皮肤外用剂的制剂，即使在极高温保存条件下长期保存也难以降低粘度，因此稳定。该制剂是乳液形式，并且包括（1）酯化度为75-95％的藻酸多元醇酯（例如海藻酸丙二醇酯）和/或其盐; （2）多价金属离子（例如钙离子）; 和（3）4-烷基酚醛醇（例如4-正丁基甲酚醇）和/或其盐。

18. 发明授权

US08125670B2 Data processing apparatus and recording medium 有权
标题翻译：数据处理装置和记录介质
公开(公告)号：US08125670B2
公开(公告)日：2012-02-28
申请号：US11860163
申请日：2007-09-24
申请人： Hideo Ueno , Masashi Suzuki , Hiroshi Koie , Kazunari Taki , Takahiro Ikeno , Takahiro Hosokawa
发明人： Hideo Ueno , Masashi Suzuki , Hiroshi Koie , Kazunari Taki , Takahiro Ikeno , Takahiro Hosokawa
IPC分类号： G06F3/12
CPC分类号： G03G15/5016 , G03G15/502 , G03G15/5087 , G03G2215/00109
摘要： A data processing apparatus includes a data reading unit that reads data from a non-contact tag, and a restoration unit that restores a file when the data reading unit reads, from the non-contact tag, (i) location information indicating a storage location where the file is previously stored and (ii) at least one of a flag indicating that the file is to be restored and a restoration program for restoring the file, in accordance with the read at least one of the flag and the restoration program.
摘要翻译：数据处理装置包括从非接触式标签读取数据的数据读取单元和当数据读取单元从非接触式标签读取时恢复文件的恢复单元，（i）指示存储位置的位置信息其中文件被预先存储，以及（ii）根据读取的标志和恢复程序中的至少一个，指示要恢复文件的标志中的至少一个和用于恢复文件的恢复程序。

19. 发明授权

US08031361B2 Image forming apparatus 有权
标题翻译：图像形成装置
公开(公告)号：US08031361B2
公开(公告)日：2011-10-04
申请号：US11853386
申请日：2007-09-11
申请人： Kazunari Taki , Masashi Suzuki , Hiroshi Koie , Hideo Ueno , Takahiro Ikeno , Takahiro Hosokawa
发明人： Kazunari Taki , Masashi Suzuki , Hiroshi Koie , Hideo Ueno , Takahiro Ikeno , Takahiro Hosokawa
IPC分类号： H04N1/04
CPC分类号： B41J3/50 , B41J11/485 , B65H3/44 , B65H2511/40 , B65H2511/415 , B65H2701/1244 , B65H2220/01
摘要： An aspect of the invention provides an image forming apparatus including: a image forming section that forms an image based on a print data on at least one sheet equipped with a non-contact tag; a writing section that wirelessly writes a tag data into the non-contact tag of the at least one sheet; a first cassette that holds a plurality of sheets equipped with first type non-contact tags having a first storage capacity; a second cassette that holds a plurality of sheets equipped with second type non-contact tags having a second storage capacity larger than the first storage capacity; and a selecting section that selects a print cassette from among the first and second cassettes based on a data size of the tag data. The at least one sheet on which the image is formed by the image forming section is provided from the print cassette.
摘要翻译：本发明的一个方面提供了一种图像形成装置，包括：图像形成部，其在至少配备有非接触标签的纸张上基于打印数据形成图像; 写入部分，其将标签数据无线地写入所述至少一个片材的非接触标签中; 第一盒，其保持配备有具有第一存储容量的第一类型非接触式标签的多个纸张; 第二盒，其保持配备有具有大于第一存储容量的第二存储容量的第二类型非接触标签的多个纸张; 以及选择部，其基于标签数据的数据大小从第一和第二盒中选择打印盒。从打印盒提供由图像形成部分形成图像的至少一个片材。

20. 发明授权

US07738507B2 Network relay system and control method thereof 有权
标题翻译：网络中继系统及其控制方法
公开(公告)号：US07738507B2
公开(公告)日：2010-06-15
申请号：US12234174
申请日：2008-09-19
申请人： Masashi Suzuki , Manabu Fujita , Hiroyuki Isogai , Shinji Nozaki
发明人： Masashi Suzuki , Manabu Fujita , Hiroyuki Isogai , Shinji Nozaki
IPC分类号： H04J3/06
CPC分类号： H04L49/555 , H04L49/351 , H04L49/557
摘要： The network relay device of the invention carries out data transmission to and from an opposite device to relay data in a network. The network relay device includes: multiple ports connecting with corresponding multiple ports of the opposite device via multiple links; and a link aggregation control module that aggregates the multiple links to establish a link aggregation, which is regarded as one logic link, and carries out transmission of a control frame signal including a synchronization bit, as well as data transmission, at each port via the link aggregation. In response to detection of occurrence of a trouble in at least one of the aggregated multiple links, the link aggregation control module causes a port that connects with a normal link without the trouble among the multiple ports to stop the data transmission and send the control frame signal including the synchronization bit set equal to a first value. Here the first value functions to stop the data transmission at a corresponding port of the opposite device connecting with the normal link.
摘要翻译：本发明的网络中继装置对来自对方装置的数据进行数据传输，以中继网络中的数据。网络中继设备包括：多个端口通过多个链路与相对设备的相应多个端口连接; 以及链路聚合控制模块，其聚合所述多个链路以建立被认为是一个逻辑链路的链路聚合，并且经由所述多个链路在每个端口上执行包括同步位的控制帧信号以及数据传输的传输链接聚合。响应于在至少一个聚合多个链路中发现故障的响应，链路聚合控制模块使得在多个端口中没有故障的与正常链路连接的端口停止数据传输并发送控制帧包括等于第一值的同步位的信号。这里，第一个值用于停止在与正常链路连接的相对设备的相应端口处的数据传输。

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