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11. 发明授权

US07493174B2 Implantable medical lead 有权
标题翻译：可植入医用铅
公开(公告)号：US07493174B2
公开(公告)日：2009-02-17
申请号：US10947813
申请日：2004-09-23
申请人： Hugo A. Belalcazar , James D. Reinke , Robert M. Ecker
发明人： Hugo A. Belalcazar , James D. Reinke , Robert M. Ecker
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61B5/02055 , A61B5/145 , A61B5/14532 , A61N1/05 , A61N1/056
摘要： An implantable medical lead includes a device, such as a physiological sensor, that is coupled to one or more stimulation/sensing sensing conductors within the lead. When the implantable medical lead is coupled to an implantable medical device, the device carried by the lead both receives power from, and communicates with the implantable medical device via the one or more stimulation/sensing sensing conductors. Each of the one or more stimulation/sensing sensing conductors is also coupled to an electrode that is exposed to body tissue.
摘要翻译：可植入医疗引线包括耦合到引线内的一个或多个刺激/感测感测导体的装置，例如生理传感器。当可植入医疗引线连接到可植入医疗设备时，由引线承载的设备都经由一个或多个刺激/感测感测导体从可植入医疗设备接收电力并与可植入医疗设备进行通信。一个或多个刺激/感测感测导体中的每一个还耦合到暴露于身体组织的电极。

12. 发明授权

US07139613B2 Implantable medical device communication system with pulsed power biasing 有权
标题翻译：具有脉冲功率偏置的植入式医疗设备通信系统
公开(公告)号：US07139613B2
公开(公告)日：2006-11-21
申请号：US10733000
申请日：2003-12-11
申请人： James D. Reinke , Robert M. Ecker
发明人： James D. Reinke , Robert M. Ecker
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61N1/37252 , A61N1/025 , A61N1/372
摘要： An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors, actuators and other implantable medical devices. The implantable medical device includes a communication unit to output commands and power pulses, and receive information from the slave devices over the two-wire bus. The implantable medical device and slaves communicate over the bus by selectively changing one of the lines of the bus between a first and second voltage, the second voltage substantially equal to a reference voltage of the second line, e.g., zero volts. In some embodiments, the power pulses take the form of bipolar pulse pairs. The slave device includes a recovery unit to recover power from the power pulses.
摘要翻译：可植入医疗装置通信系统通过两线总线在可植入医疗装置与至少一个从属装置之间传送信息。从设备可以包括远程传感器，致动器和其它可植入医疗设备。可植入医疗装置包括通信单元，用于输出命令和功率脉冲，并通过双线总线从从设备接收信息。可植入医疗装置和从动装置通过在第一和第二电压之间选择性地改变总线的一条线，第二电压基本上等于第二条线路的基准电压，例如零伏特，在总线上通信。在一些实施例中，功率脉冲采取双极性脉冲对的形式。从设备包括从功率脉冲恢复功率的恢复单元。

13. 发明申请

US20090118808A1 Implantable Medical Lead 有权
标题翻译：植入式医疗铅
公开(公告)号：US20090118808A1
公开(公告)日：2009-05-07
申请号：US12350382
申请日：2009-01-08
申请人： Hugo A. Belacazar , James D. Reinke , Robert M. Ecker
发明人： Hugo A. Belacazar , James D. Reinke , Robert M. Ecker
IPC分类号： A61N1/05
CPC分类号： A61N1/36514 , A61B5/02055 , A61B5/145 , A61B5/14532 , A61N1/05 , A61N1/056
摘要： An implantable medical lead includes a device, such as a physiological sensor, that is coupled to one or more stimulation/sensing sensing conductors within the lead. When the implantable medical lead is coupled to an implantable medical device, the device carried by the lead both receives power from, and communicates with the implantable medical device via the one or more stimulation/sensing sensing conductors. Each of the one or more stimulation/sensing sensing conductors is also coupled to an electrode that is exposed to body tissue.
摘要翻译：可植入医疗引线包括耦合到引线内的一个或多个刺激/感测感测导体的装置，例如生理传感器。当可植入医疗引线连接到可植入医疗设备时，由引线承载的设备都经由一个或多个刺激/感测感测导体从可植入医疗设备接收电力并与可植入医疗设备进行通信。一个或多个刺激/感测感测导体中的每一个还耦合到暴露于身体组织的电极。

14. 发明申请

US20120232354A1 OPTICAL SENSOR SYSTEM AND MEASUREMENT METHOD 有权
标题翻译：光传感器系统和测量方法
公开(公告)号：US20120232354A1
公开(公告)日：2012-09-13
申请号：US13044119
申请日：2011-03-09
申请人： Robert Michael Ecker , Timothy J. Davis , James D. Reinke
发明人： Robert Michael Ecker , Timothy J. Davis , James D. Reinke
IPC分类号： A61B5/00 , G01D18/00
CPC分类号： A61B5/14551 , A61B5/046 , A61B5/14552 , G01D5/34 , G01D18/008
摘要： A medical device including an optical sensor is configured to measure an optical signal by integrating a current induced on a light detector of the optical sensor to obtain a voltage signal. The voltage signal is compared to a threshold. Responsive to the voltage signal reaching the threshold, an optical sensor control parameter is adjusted. The optical sensor is operated to produce the voltage signal using the adjusted control parameter.
摘要翻译：包括光学传感器的医疗装置被配置为通过对在光学传感器的光检测器上感应的电流进行积分来测量光信号以获得电压信号。将电压信号与阈值进行比较。响应于电压信号达到阈值，调整光传感器控制参数。操作光学传感器以使用调整的控制参数产生电压信号。

15. 发明申请

US20090156918A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR USE 有权
标题翻译：可植入的光学传感器及其使用方法
公开(公告)号：US20090156918A1
公开(公告)日：2009-06-18
申请号：US11955025
申请日：2007-12-12
申请人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
发明人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/0233 , A61B2562/043
摘要： An implantable medical device includes a hermetically sealed housing and a first light emitting diode (LED) enclosed within the housing configured to detect light corresponding to a selected light wavelength. A conductive element extends from the LED for carrying a current signal corresponding to the light detected by the LED, the intensity of the detected light being correlated to a change in a physiological condition in a body fluid volume or a tissue volume proximate the LED.
摘要翻译：可植入医疗装置包括密封的壳体和封装在壳体内的第一发光二极管（LED），其被配置为检测对应于所选择的光波长的光。导电元件从LED延伸，用于承载对应于由LED检测到的光的电流信号，检测到的光的强度与体液体积或接近LED的组织体积的生理状态的变化相关。

16. 发明授权

US09693716B2 Optical sensor system and measurement method 有权
公开(公告)号：US09693716B2
公开(公告)日：2017-07-04
申请号：US13044119
申请日：2011-03-09
申请人： Robert Michael Ecker , Timothy J. Davis , James D. Reinke
发明人： Robert Michael Ecker , Timothy J. Davis , James D. Reinke
IPC分类号： A61B5/1455 , A61B5/046 , G01D5/34 , G01D18/00
CPC分类号： A61B5/14551 , A61B5/046 , A61B5/14552 , G01D5/34 , G01D18/008
摘要： A medical device including an optical sensor is configured to measure an optical signal by integrating a current induced on a light detector of the optical sensor to obtain a voltage signal. The voltage signal is compared to a threshold. Responsive to the voltage signal reaching the threshold, an optical sensor control parameter is adjusted. The optical sensor is operated to produce the voltage signal using the adjusted control parameter.

17. 发明授权

US08290557B2 Implantable optical sensor and method for use 有权
标题翻译：植入式光学传感器及其使用方法
公开(公告)号：US08290557B2
公开(公告)日：2012-10-16
申请号：US11955025
申请日：2007-12-12
申请人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
发明人： Timothy J. Davis , Jonathan P. Roberts , James D. Reinke , Jonathan L. Kuhn , Shawn D. Knowles
IPC分类号： A61B5/1455 , A61B5/02
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/0233 , A61B2562/043
摘要： An implantable medical device includes a hermetically sealed housing and a first light emitting diode (LED) enclosed within the housing configured to detect light corresponding to a selected light wavelength. A conductive element extends from the LED for carrying a current signal corresponding to the light detected by the LED, the intensity of the detected light being correlated to a change in a physiological condition in a body fluid volume or a tissue volume proximate the LED.
摘要翻译：可植入医疗装置包括密封的壳体和封装在壳体内的第一发光二极管（LED），其被配置为检测对应于所选择的光波长的光。导电元件从LED延伸，用于承载对应于由LED检测到的光的电流信号，检测到的光的强度与体液体积或接近LED的组织体积的生理状态的变化相关。

18. 发明授权

US09968788B2 Timing coordination of implantable medical sensor modules 有权
公开(公告)号：US09968788B2
公开(公告)日：2018-05-15
申请号：US12361977
申请日：2009-01-29
申请人： Robert Michael Ecker , Kaustubh R. Patil , John Robert Hamilton , James D. Reinke , Timothy Davis
发明人： Robert Michael Ecker , Kaustubh R. Patil , John Robert Hamilton , James D. Reinke , Timothy Davis
IPC分类号： A61B5/00 , A61N1/365 , A61B5/02 , A61B5/145 , A61B5/1459
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/14542 , A61B5/1459 , A61B5/7203
摘要： In general, the disclosure is directed toward an implantable medical device that includes a plurality of sensor modules that are implanted within a patient. The sensor modules may cooperate with each other to coordinate the timing for performance of one or more sensor actions across the modules when making a measurement. Example measurements include tissue perfusion measurements, oxygen sensing measurements, sonomicrometry measurements, and pressure measurements. The coordination of the sensor modules may be controlled by a signal that is transmitted from a host controller to the sensor modules via a bus. In some examples, the bus may have two wires that transmit both timing information and data information to the sensor modules. The signal may be a signal that is substantially periodic, such as a pulsed signal. In additional examples, the signal may supply operating power and timing information to the sensor modules.

19. 发明授权

US08774918B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08774918B2
公开(公告)日：2014-07-08
申请号：US12362838
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3621 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3706 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

20. 发明授权

US08688210B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08688210B2
公开(公告)日：2014-04-01
申请号：US12362859
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/0424 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7217 , A61B2560/0271 , A61N1/36185 , A61N1/3622 , A61N1/365 , A61N1/3686 , A61N1/37247 , A61N1/37288 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

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