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11. 发明授权

US09380965B2 Analyte sensors having a membrane with low temperature sensitivity 有权
标题翻译：具有低温敏感性的膜的分析物传感器
公开(公告)号：US09380965B2
公开(公告)日：2016-07-05
申请号：US13332103
申请日：2011-12-20
申请人： Tianmei Ouyang , Zenghe Liu , Yohannes Goti , Benjamin J. Feldman , Udo Hoss
发明人： Tianmei Ouyang , Zenghe Liu , Yohannes Goti , Benjamin J. Feldman , Udo Hoss
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/1468 , A61B5/14865 , A61B2560/0223 , A61L31/047 , A61L31/048 , A61L31/06 , A61M5/1723 , A61M2205/3569 , A61M2205/3592 , A61M2230/005 , A61M2230/201
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施方案涉及具有低温敏感性的膜的分析物确定方法和装置（例如，电化学分析物监测系统）。感测层设置在体内和/或体外分析物传感器的工作电极上，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

12. 发明申请

US20110046466A1 Analyte Sensors Including Nanomaterials and Methods of Using Same 审中-公开
标题翻译：包含纳米材料的分析物传感器及其使用方法
公开(公告)号：US20110046466A1
公开(公告)日：2011-02-24
申请号：US12544061
申请日：2009-08-19
申请人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu , Brian Cho
发明人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu , Brian Cho
IPC分类号： A61B5/1468 , G01N27/26
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B2562/0295 , A61B2562/12 , A61B2562/125 , G01N27/3272
摘要： Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components, improved stability, and improved response time of the sensor by inclusion of a nanomaterial, such as inert inorganic nanomaterials, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本发明的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包括纳米材料，改进了传感器的一个或多个组分的分布的均匀性，改进的稳定性和改善的响应时间，作为惰性无机纳米材料，其中组分靠近体内和/或体外分析物传感器的工作电极设置，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

13. 发明申请

US20100065441A1 CATIONIC POLYMER BASED WIRED ENZYME FORMULATIONS FOR USE IN ANALYTE SENSORS 有权
标题翻译：用于分析仪传感器的阳离子聚合物基线配方
公开(公告)号：US20100065441A1
公开(公告)日：2010-03-18
申请号：US12211014
申请日：2008-09-15
申请人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu
发明人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu
IPC分类号： C12Q1/54
CPC分类号： C12Q1/006 , A61K38/28 , C12Q1/004 , C12Q1/005 , C12Q1/32 , G01N27/3272 , G01N27/3273 , G01N2333/904
摘要： Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.
摘要翻译：本发明的实施方案包括分析物响应组合物和电化学分析物传感器，其具有包含分析物响应酶和阳离子聚合物的感测层。还提供了制造传感器并在分析物监测中使用电化学分析物传感器的系统和方法。

14. 发明授权

US08155722B2 Reference electrodes having an extended lifetime for use in long term amperometric sensors 有权
标题翻译：参考电极具有延长的使用寿命，用于长期电流传感器
公开(公告)号：US08155722B2
公开(公告)日：2012-04-10
申请号：US12131862
申请日：2008-06-02
申请人： Benjamin J. Feldman , Zenghe Liu , Tianmei Ouyang
发明人： Benjamin J. Feldman , Zenghe Liu , Tianmei Ouyang
IPC分类号： A61B5/05
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/1495
摘要： The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
摘要翻译：本申请提供了具有适用于长期电流计传感器的延长寿命的基于Ag / AgCl的参比电极。配备有本文所述的参考电极的电化学传感器在各种条件下显示出相当大的稳定性和延长的寿命。

15. 发明申请

US20090294307A1 REDOX POLYMER BASED REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS 审中-公开
标题翻译：具有延长寿命的基于REDOX聚合物的参考电极可用于长时间放大传感器
公开(公告)号：US20090294307A1
公开(公告)日：2009-12-03
申请号：US12131744
申请日：2008-06-02
申请人： Zenghe Liu , Benjamin J. Feldman , Christopher Thomas , Tianmei Ouyang
发明人： Zenghe Liu , Benjamin J. Feldman , Christopher Thomas , Tianmei Ouyang
IPC分类号： G01N27/26 , G01F1/64
CPC分类号： A61B5/0031 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B2562/12 , G01N27/301
摘要： The present application provides redox polymer based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
摘要翻译：本申请提供了具有延长寿命的基于氧化还原聚合物的参考电极，其适用于长期电流传感器。配备有本文所述的参考电极的电化学传感器在各种条件下显示出相当大的稳定性和延长的寿命。

16. 发明授权

US08636884B2 Cationic polymer based wired enzyme formulations for use in analyte sensors 有权
标题翻译：用于分析物传感器的阳离子聚合物基有线酶配方
公开(公告)号：US08636884B2
公开(公告)日：2014-01-28
申请号：US12211014
申请日：2008-09-15
申请人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu
发明人： Benjamin J. Feldman , Tianmei Ouyang , Zenghe Liu
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , A61K38/28 , C12Q1/004 , C12Q1/005 , C12Q1/32 , G01N27/3272 , G01N27/3273 , G01N2333/904
摘要： Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.
摘要翻译：本发明的实施方案包括分析物响应组合物和电化学分析物传感器，其具有包含分析物响应酶和阳离子聚合物的感测层。还提供了制造传感器并在分析物监测中使用电化学分析物传感器的系统和方法。

17. 发明申请

US20120296186A1 Analyte Sensors Having a Membrane with Low Temperature Sensitivity 有权
标题翻译：具有低温敏感性膜的分析物传感器
公开(公告)号：US20120296186A1
公开(公告)日：2012-11-22
申请号：US13332103
申请日：2011-12-20
申请人： Tianmei Ouyang , Zenghe Liu , Yohannes Goti , Benjamin J. Feldman , Udo Hoss
发明人： Tianmei Ouyang , Zenghe Liu , Yohannes Goti , Benjamin J. Feldman , Udo Hoss
IPC分类号： A61B5/1455 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/1468 , A61B5/14865 , A61B2560/0223 , A61L31/047 , A61L31/048 , A61L31/06 , A61M5/1723 , A61M2205/3569 , A61M2205/3592 , A61M2230/005 , A61M2230/201
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施方案涉及具有低温敏感性的膜的分析物确定方法和装置（例如，电化学分析物监测系统）。感测层设置在体内和/或体外分析物传感器的工作电极上，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供在分析物监测中使用例如电化学分析物传感器的系统和方法。

18. 发明申请

US20120078070A1 Redox Polymer Based Reference Electrodes Having An Extended Lifetime For Use In Long Term Amperometric Sensors 审中-公开
标题翻译：具有延长寿命的基于氧化还原聚合物的参比电极用于长期电流传感器
公开(公告)号：US20120078070A1
公开(公告)日：2012-03-29
申请号：US13090533
申请日：2011-04-20
申请人： Zenghe Liu , Benjamin J. Feldman , Christopher Thomas , Tianmei Ouyang
发明人： Zenghe Liu , Benjamin J. Feldman , Christopher Thomas , Tianmei Ouyang
IPC分类号： A61B5/1468 , A61B5/145
CPC分类号： A61B5/0031 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B2562/12 , G01N27/301
摘要： The present application provides redox polymer based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
摘要翻译：本申请提供了具有延长寿命的基于氧化还原聚合物的参考电极，其适用于长期电流传感器。配备有本文所述的参考电极的电化学传感器在各种条件下显示出相当大的稳定性和延长的寿命。

19. 发明授权

US07699964B2 Membrane suitable for use in an analyte sensor, analyte sensor, and associated method 有权
标题翻译：适用于分析物传感器，分析物传感器和相关方法的膜
公开(公告)号：US07699964B2
公开(公告)日：2010-04-20
申请号：US10819498
申请日：2004-04-06
申请人： Benjamin Feldman , Zenghe Liu , Fei Mao , Adam Heller
发明人： Benjamin Feldman , Zenghe Liu , Fei Mao , Adam Heller
IPC分类号： G01N27/40 , G01N27/327
CPC分类号： C12Q1/005
摘要： A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating/catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and/or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.
摘要翻译：提供多功能膜。多功能膜适用于分析物传感器。在特定应用中，多功能膜可以与电流计生物传感器（例如经皮电流生物传感器）结合使用。膜的一些功能与膜本身的性质相关，膜本身由包含杂环氮基团的交联聚合物组成。例如，膜由于其聚合物组合物可以将分析物的通量调节到传感器。这种调节通常改善传感器在宽范围的分析物浓度下的动力学性能。膜的其它功能与可以结合到由膜提供的支架结合的酶或酶模拟物的形式的功能组分如超氧化物歧化/过氧化氢酶催化剂相关联。任何此类酶或酶模拟物的作用是降低生物传感器感应层附近代谢物如超氧化物和/或过氧化氢的浓度。降低通常对传感器功能有害的代谢物的浓度通常保护或增强生物传感器的完整性和性能。因此，膜是分析物传感器，电流传感器，生物传感器，特别是经皮生物传感器的重要工具。还提供了膜覆盖传感器及其制造方法。

20. 发明申请

US20070203407A1 Analyte sensors and methods of use 有权
标题翻译：分析物传感器和使用方法
公开(公告)号：US20070203407A1
公开(公告)日：2007-08-30
申请号：US11365169
申请日：2006-02-28
申请人： Udo Hoss , Zenghe Liu , Benjamin Feldman
发明人： Udo Hoss , Zenghe Liu , Benjamin Feldman
IPC分类号： A61B5/05
CPC分类号： A61B5/1477 , A61B5/0002 , A61B5/0008 , A61B5/01 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/6843 , A61B2560/0276 , G01N27/327 , G01N27/4035
摘要： An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.
摘要翻译：一种分析物传感器系统，包括衬底，设置在衬底的第一表面上的第一电极，设置在衬底的第二表面上的第二电极，与第一或第二电极中的至少一个电接触地设置的第三电极，其中第一电极和第二电极的至少一部分皮下定位在患者体内，并且其中第三电极基本上完全位于患者外部，并且提供相应的方法。

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