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11. 发明申请

US20100055076A1 Mesenchymal stem cell-mediated autologous dendritic cells with increased immunosuppression 审中-公开
标题翻译：间充质干细胞介导的自体树突细胞增加免疫抑制
公开(公告)号：US20100055076A1
公开(公告)日：2010-03-04
申请号：US12461694
申请日：2009-08-20
申请人： Dae Seog Lim , Ju Ah Jeong , Mi-Sun Kang , Hyun Soo Lee , Yong Soo Bae
发明人： Dae Seog Lim , Ju Ah Jeong , Mi-Sun Kang , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K35/12 , C12N5/00 , C12N5/02
CPC分类号： C12N5/064 , A61K2035/122 , C12N2502/1358
摘要： A method for preparing dendritic cells which have an enhanced potential to suppress immune responses, method for suppressing immune response by comprising administering them, dendritic cells carrying a potential to suppress immune responses, and a pharmaceutical composition comprising the dendritic cells capable of inducing immunosuppressive responses. The present dendritic cells having an enhanced potential to suppress immune responses can be utilized for treating or preventing various diseases or disorders through the suppression of immune responses. In addition, the enhanced immunotolerance potential of the dendritic cells ensures the cells to be effectively used as an immunosuppressive agent.
摘要翻译：一种制备具有增强的抑制免疫应答潜力的树突细胞的方法，包括施用它们来抑制免疫应答的方法，具有抑制免疫应答潜力的树突状细胞，以及包含能诱导免疫抑制反应的树突状细胞的药物组合物。具有增强的抑制免疫应答潜力的本发明的树突状细胞可用于通过抑制免疫应答来治疗或预防各种疾病或病症。此外，树突状细胞的增强的免疫耐受潜力确保细胞被有效地用作免疫抑制剂。

12. 发明申请

US20090131361A1 Novel Use of MLN51 Gene and Protein 有权
标题翻译：新的使用MLN51基因和蛋白质
公开(公告)号：US20090131361A1
公开(公告)日：2009-05-21
申请号：US12299919
申请日：2007-05-08
申请人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
发明人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K31/7052 , C12Q1/68 , C12Q1/02 , A61P37/00 , A61P19/02 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to novel uses of the MLN 51 gene or protein. The MLN 51 gene and protein is closely related to the development of rheumatoid arthritis, particularly chronic synovitis.
摘要翻译：本发明涉及MLN 51基因或蛋白质的新用途。 MLN 51基因和蛋白质与类风湿性关节炎的发展密切相关，特别是慢性滑膜炎。

13. 发明授权

US07061407B1 Encoding of 8B10B control characters 有权
标题翻译： 8B10B控制字符的编码
公开(公告)号：US07061407B1
公开(公告)日：2006-06-13
申请号：US11151935
申请日：2005-06-14
申请人： Hyun Soo Lee
发明人： Hyun Soo Lee
IPC分类号： H03M7/00
CPC分类号： H03M7/06
摘要： An encoder includes a first storage array having a first set of values, a second storage array having a second set of values, and a selection circuit. Each of the first and second storage arrays have address ports coupled to receive a first or second portion of an input value, and are adapted to output a first or second value of the first or second set in response to a value of the first or second portion of the input value, respectively. The selection circuit has input ports coupled to the first storage array, to the second storage array, and for receiving the input value. The selection circuit is adapted to output the second value from the second storage array as an encoded value of the input value or the first value from the first storage array as the encoded value.
摘要翻译：编码器包括具有第一组值的第一存储阵列，具有第二组值的第二存储阵列和选择电路。第一和第二存储阵列中的每一个具有耦合以接收输入值的第一或第二部分的地址端口，并且适于响应于第一或第二存储阵列的值输出第一或第二集合的第一或第二值输入值的一部分。选择电路具有耦合到第一存储阵列，第二存储阵列和用于接收输入值的输入端口。选择电路适于从第二存储阵列输出第二值作为来自第一存储阵列的输入值的编码值或作为编码值的第一值。

14. 发明授权

US06699689B1 Mass production method of antimicrobial peptide and DNA construct and expression system thereof 有权
标题翻译：抗菌肽和DNA构建体的大规模生产方法及其表达系统
公开(公告)号：US06699689B1
公开(公告)日：2004-03-02
申请号：US09485147
申请日：2000-04-25
申请人： Jeong Hyun Kim , Min Hyung Kang , Jae Hyun Lee , Se Ho Park , Joo Won Lee , Seung Suh Hong , Hyun Soo Lee
发明人： Jeong Hyun Kim , Min Hyung Kang , Jae Hyun Lee , Se Ho Park , Joo Won Lee , Seung Suh Hong , Hyun Soo Lee
IPC分类号： C12P2106
CPC分类号： C12N15/72 , C07K14/4723 , C07K2319/00 , C12N9/1077 , C12N15/70
摘要： The present invention relates to DNA constructs that can produce antimicrobial materials efficiently from microorganisms and the preparation method thereof. The present invention also relates to the useful vector for the DNA construct. The DNA construct according to the present invention comprises a first gene coding for entire, a part of or a derivative of purF gene and a second gene coding for antimicrobial peptide. According to the present invention, antimicrobial peptides can be mass-produced by the following steps: preparing an expression vector containing a DNA construct comprising a first gene coding for an entire, a part of or a derivative of purF gene and a second gene coding for antimicrobial peptide; transforming the bacterial host cells with the above-mentioned vector, culturing the transformed cell to express the above-mentioned DNA construct; and recovering the above antimicrobial peptide.
摘要翻译：本发明涉及能够从微生物有效生产抗微生物材料的DNA构建体及其制备方法。本发明还涉及DNA构建体的有用载体。根据本发明的DNA构建体包含编码purF基因的全部，一部分或衍生物的第一个基因和编码抗微生物肽的第二个基因。根据本发明，通过以下步骤可以大量生产抗微生物肽：制备含有DNA构建体的表达载体，所述构建体包含编码purF基因全部或部分或衍生物的第一个基因，以及编码抗菌肽; 用上述载体转化细菌宿主细胞，培养转化细胞以表达上述DNA构建体; 并回收上述抗微生物肽。

15. 发明授权

US08939596B2 Condensing type optical sheet 有权
标题翻译：冷凝型光学片
公开(公告)号：US08939596B2
公开(公告)日：2015-01-27
申请号：US13386606
申请日：2010-07-28
申请人： Hyun Soo Lee , Chang Pyo Hong , Chung Seock Kang
发明人： Hyun Soo Lee , Chang Pyo Hong , Chung Seock Kang
IPC分类号： G09F13/04 , G09F13/08 , G02B5/04 , G02B5/02 , G02F1/1335
CPC分类号： G02B5/045 , G02B5/0215 , G02F2001/133607
摘要： Disclosed is a condensing type optical sheet for use in a liquid crystal display, which prevents the generation of a yellow band or a rainbow phenomenon without using a protective sheet.
摘要翻译：公开了一种用于液晶显示器的聚光型光学片，其在不使用保护片的情况下防止产生黄色带或彩虹现象。

16. 发明授权

US08623348B2 Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP) 有权
标题翻译：包含IFN-α和细胞质转导肽（CTP）的干扰素-α（IFN-α）融合蛋白
公开(公告)号：US08623348B2
公开(公告)日：2014-01-07
申请号：US13260490
申请日：2009-03-27
申请人： Chan Kyu Lee , Seonyoung Yang , Eun Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
发明人： Chan Kyu Lee , Seonyoung Yang , Eun Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K38/21 , A61K39/00 , A61K39/385 , C07K14/56 , C12P21/04
CPC分类号： C07K14/56 , A61K38/00 , C07K2319/00 , C07K2319/10
摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.
摘要翻译：公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

17. 发明申请

US20120134961A1 Interferon-alpha (IFN-alpha) Fused Protein Having IFN-alpha and Cytoplasmic Transduction Peptide (CTP) 有权
标题翻译：具有IFN-α和细胞质转导肽（CTP）的干扰素-α（IFN-α）融合蛋白
公开(公告)号：US20120134961A1
公开(公告)日：2012-05-31
申请号：US13260490
申请日：2009-03-27
申请人： Chan Kyu Lee , Seonyoung Yang , Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
发明人： Chan Kyu Lee , Seonyoung Yang , Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K38/21 , C12N15/21 , C12N15/63 , A61P35/00 , C12N1/19 , C12N5/10 , C12P21/00 , A61P1/16 , C07K14/56 , C12N1/21
CPC分类号： C07K14/56 , A61K38/00 , C07K2319/00 , C07K2319/10
摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.
摘要翻译：公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

18. 发明授权

US5841472A MPEG2 transport decoder 失效
标题翻译： MPEG2传输解码器
公开(公告)号：US5841472A
公开(公告)日：1998-11-24
申请号：US559634
申请日：1995-11-20
申请人： Chai Yeol Rim , Hyun Soo Lee
发明人： Chai Yeol Rim , Hyun Soo Lee
IPC分类号： H04N19/102 , H04N5/00 , H04N7/52 , H04N19/00 , H04N19/152 , H04N19/423 , H04N19/44 , H04N19/70 , H04N7/24
CPC分类号： H04N21/434 , H04N19/00 , H04N19/61 , H04N7/52 , H04N19/70
摘要： Disclosed is an MPEG2 transport decoder including a transport parser unit for storing each syntax field value by parsing, outputting each data identified with the packet identifier PID after collecting from each packet data and outputting the interrupt signal if a pointed resister value of the resist values is set; a CPU interface unit for providing an interface between the resister file of said transport parser unit and each decoder and outputting a signal selecting a transport parser unit or a video decoder, an audio decoder, a data decoder and a memory by decoding the address; a CPU for reading the interrupt resister from said CPU interface unit once an interrupt signal is inputted, detecting if the interrupt signal is inputted from said transport parser unit or from the video decoder, the audio decoder and the data decoder, and decoding according to the program on a memory unit; a memory unit for storing a program of the operations of said CPU; and a decoder interface unit for controlling in order to exchanging the data among said CPU, said transport parser unit and said video, audio, data decoders.
摘要翻译：公开了一种MPEG2传输解码器，其包括用于通过解析来存储每个语法字段值的传输解析器单元，从每个分组数据收集之后输出由分组标识符PID识别的每个数据，并且如果抗蚀剂值的指向寄存器值为组; CPU接口单元，用于在所述传输解析器单元的寄存器文件和每个解码器之间提供接口，并通过解码地址来输出选择传输解析器单元或视频解码器，音频解码器，数据解码器和存储器的信号; 一旦中断信号被输入，CPU就从所述CPU接口单元读取中断电阻，检测中断信号是否从所述传输解析器单元或视频解码器，音频解码器和数据解码器输入，以及按照程序存储单元; 用于存储所述CPU的操作的程序的存储单元; 以及解码器接口单元，用于控制以便在所述CPU，所述传输解析器单元和所述视频，音频数据解码器之间交换数据。

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