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12. 发明授权

US07090868B2 Materials and methods for drug delivery and uptake 失效
标题翻译：用于药物输送和摄取的材料和方法
公开(公告)号：US07090868B2
公开(公告)日：2006-08-15
申请号：US10243340
申请日：2002-09-13
申请人： Laurie A. Gower , Vishal M. Patel , Piyush Sheth , Allison Gallup , Michael Ossenbeck
发明人： Laurie A. Gower , Vishal M. Patel , Piyush Sheth , Allison Gallup , Michael Ossenbeck
IPC分类号： A61K9/14
CPC分类号： A61K9/107 , A61K9/501
摘要： The subject invention pertains to novel materials and methods for use in delivering and sequestering substances, such as pharmacological agents, within a patient. One aspect of the invention is directed towards core-shell particles having a core encapsulated within a calcium carbonate shell, with an intermediate layer composed of an amphiphilic compound surrounding the core. When the particles of the subject invention are administered to a patient, they are capable of removing lipophilic drugs by absorption of the drug through their mineral shell and into their core. The particles of the subject invention can also be administered to a patient as controlled release, drug delivery vehicles. Thus, in another aspect, the subject invention concerns a method of delivering pharmacological agents by administering the core-shell particles of the subject invention to a patient in need of such administration.
摘要翻译：本发明涉及用于在患者体内递送和螯合物质（例如药理学试剂）的新型材料和方法。本发明的一个方面涉及具有包封在碳酸钙壳内的核的核 - 壳颗粒，中间层由围绕芯的两亲化合物组成。当将本发明的颗粒施用于患者时，它们能够通过吸收药物通过其矿物壳并进入其核心来除去亲脂性药物。本发明的颗粒也可以作为受控释放药物递送载体施用于患者。因此，在另一方面，本发明涉及通过将本发明的核 - 壳颗粒给予需要这种给药的患者来递送药理学试剂的方法。

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