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11. 发明申请

US20070110687A1 Antiperspirant Compositions 审中-公开
标题翻译：止汗组合物
公开(公告)号：US20070110687A1
公开(公告)日：2007-05-17
申请号：US11560677
申请日：2006-11-16
申请人： Jairajh Mattai , Xiaozhong Tang , Marian Holerca , Latonya Kilpatrick-Liverman
发明人： Jairajh Mattai , Xiaozhong Tang , Marian Holerca , Latonya Kilpatrick-Liverman
IPC分类号： A61K8/28
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/365 , A61K8/368 , A61K8/416 , A61K8/44 , A61K2800/51
摘要： An antiperspirant composition comprising a mixing product of at least one salt chosen from at least one aluminum salt, at least one aluminum-zirconium salt, at least one aluminum salt complex, and at least one aluminum-zirconium salt complex; at least one cosmetically acceptable hydroxy acid; and at least one cosmetically acceptable quaternary ammonium acid compound.
摘要翻译：一种止汗组合物，其包含至少一种选自至少一种铝盐，至少一种铝 - 锆盐，至少一种铝盐络合物和至少一种铝 - 锆盐络合物的盐的混合产物; 至少一种美容上可接受的羟基酸; 和至少一种美容上可接受的季铵酸化合物。

12. 发明授权

US6066314A Antiperspirant actives and formulations made therefrom 有权
标题翻译：止汗剂及其制剂
公开(公告)号：US6066314A
公开(公告)日：2000-05-23
申请号：US432462
申请日：1999-11-03
申请人： Xiaozhong Tang , Kathy Potechin , Jairajh Mattai , Anthony Esposito , Paul Joseph Vincenti
发明人： Xiaozhong Tang , Kathy Potechin , Jairajh Mattai , Anthony Esposito , Paul Joseph Vincenti
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61K8/60 , A61K8/891 , A61Q15/00 , C08L83/04 , A61K7/32 , A61K7/00 , A61K7/34 , A61K7/38
CPC分类号： A61K8/44 , A61K8/0229 , A61K8/28 , A61Q15/00
摘要： The present invention comprises stabilizing aqueous solutions of aluminum zirconium based salts with a water soluble amino acid, especially glycine, wherein the Zr:glycine weight ratios used to form solutions of the active itself or used to form cosmetic compositions made according to this invention are in the range from 1:1.2 to 1:5, particularly 1:2 to 1:4, and more particularly in the range of 1:2 to 1:3 on a weight:weight basis. By reducing the polymerization of small zirconium species with an elevated amount of amino acid(s), the efficacy of the antiperspirant salt is maintained.
摘要翻译：本发明包括用水溶性氨基酸，特别是甘氨酸稳定铝锆盐的水溶液，其中用于形成活性物质本身或用于形成根据本发明制备的化妆品组合物的溶液的Zr：甘氨酸重量比为重量比为1：1.2至1：5，特别是1：2至1：4，更特别为1：2至1：3。通过减少氨基酸含量较高的小锆物质的聚合，可以保持止汗盐的功效。

13. 发明授权

US06375937B1 Antiperspirant salts for enhanced cosmetic products 失效
标题翻译：用于增强化妆品的止汗盐
公开(公告)号：US06375937B1
公开(公告)日：2002-04-23
申请号：US09693231
申请日：2000-10-20
申请人： Suman Chopra , Xiaozhong Tang , Peter Hilliard, Jr.
发明人： Suman Chopra , Xiaozhong Tang , Peter Hilliard, Jr.
IPC分类号： A61K737
CPC分类号： A61Q15/00 , A61K8/28 , A61K8/44
摘要： This invention comprises aluminum zirconium salts which have a metal to chloride molar ratio in the range of 0.9-1.2:1 and a glycine:zirconium molar ratio greater than 1.3:1 and antiperspirant compositions made with such salts.
摘要翻译：本发明包括具有0.9-1.2:1范围内的金属氯化物摩尔比和甘氨酸：锆摩尔比大于1.3:1的铝锆盐和由这些盐制成的止汗组合物。

14. 发明申请

US20060204463A1 Enhanced efficacy aluminum or aluminum-zirconium antiperspirant salt compositions containing calcium salt(s) and betaine 有权
标题翻译：增强功效的含有钙盐和甜菜碱的铝或铝 - 锆止汗剂盐组合物
公开(公告)号：US20060204463A1
公开(公告)日：2006-09-14
申请号：US11348499
申请日：2006-02-06
申请人： Xiaozhong Tang , Marian Holerca , Donghui Wu , Christine Popoff
发明人： Xiaozhong Tang , Marian Holerca , Donghui Wu , Christine Popoff
IPC分类号： A61K8/28 , A61K8/26
CPC分类号： A61K8/28 , A61K8/19 , A61K8/26 , A61K8/44 , A61Q15/00
摘要： An antiperspirant composition comprising an antiperspirant salt selected from an aluminum antiperspirant salt, an aluminum-zirconium antiperspirant salt, and a mixture thereof; a betaine component selected from betaine, betaine hydrochloride, and a mixture thereof; a calcium salt; and water.
摘要翻译：一种止汗组合物，其包含选自止汗剂盐，铝 - 锆止汗盐及其混合物的止汗盐; 选自甜菜碱，盐酸甜菜碱及其混合物的甜菜碱成分; 钙盐; 和水。

15. 发明授权

US07897799B2 Oxo-hexameric zirconium-octaamino acid antiperspirant salts 有权
标题翻译：氧六氟锆 - 八氨基酸止汗盐
公开(公告)号：US07897799B2
公开(公告)日：2011-03-01
申请号：US12293463
申请日：2008-09-12
申请人： Long Pan , LaTonya Kilpatrick , Xiaozhong Tang
发明人： Long Pan , LaTonya Kilpatrick , Xiaozhong Tang
IPC分类号： C07F7/00 , A61Q15/00
CPC分类号： A61Q15/00 , A61K8/28 , A61K8/44 , A61K2800/58 , C07F7/003
摘要： A process for preparing oxo-hexameric zirconium-octaamino acid, such as glycine, salt comprising: mixing zirconium (Zr):amino acid:and mineral acid, in a molar ratio of 1:about 1 to about 15:about 1.5 to about 3 to form a mixture; optionally, filtering the mixture; and optionally, drying the mixture. An oxo-hexameric zirconium-octaamino acid salt of the molecular formula: oxo-[Zr6AminoAcid8].Xy.nH2O, wherein Zr is zirconium, X is an anion of a mineral acid, and n and y are numerical values from 0 to 20. A method of making an antiperspirant active zirconium-aluminum-amino acid compound comprising mixing an oxo-hexameric zirconium-octaamino acid salt with aluminum chlorohydrex and/or aluminum chloride, and drying the mixture. The smallest oxo-hexameric zirconium-octaamino acid salt of this invention provides stability, efficacy, and shelf life of zirconium-amino acid species for formulations in antiperspirant and/or deodorant compositions.
摘要翻译：一种制备氧代 - 六聚锆 - 八氨基酸如甘氨酸盐的方法，包括：将锆（Zr）：氨基酸和无机酸以摩尔比1：约1：约15：约1.5至3 形成混合物任选地，过滤混合物; 并任选地干燥混合物。分子式为氧代 - [Zr6AminoAcid8] Xy.nH2O的氧代六聚体锆 - 八氨基酸盐，其中Zr是锆，X是无机酸的阴离子，n和y是0至20的数值。一种制备止汗活性锆 - 铝 - 氨基酸化合物的方法，包括将氧代六聚体锆 - 八氨基酸盐与氯化铝和/或氯化铝混合并干燥该混合物。本发明的最小的氧代 - 六聚体锆 - 八氨基酸盐为止汗剂和/或除臭剂组合物中的制剂提供了锆 - 氨基酸种类的稳定性，有效性和保质期。

16. 发明申请

US20050191256A1 Glycine-free antiperspirant salts with betaine for enhanced cosmetic products 审中-公开
标题翻译：不含甘氨酸的止汗剂盐与甜菜碱用于增强的化妆品
公开(公告)号：US20050191256A1
公开(公告)日：2005-09-01
申请号：US11120336
申请日：2005-05-03
申请人： Marian Holerca , Xiaozhong Tang , Heng Cai
发明人： Marian Holerca , Xiaozhong Tang , Heng Cai
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61Q15/00 , C07F5/06 , C07F7/00 , C07F7/28 , A61K7/38 , A61K7/34
CPC分类号： A61K8/28 , A61K8/26 , A61K8/44 , A61Q15/00 , C07F5/069 , C07F7/003
摘要： A glycine-free aluminum and/or zirconium Betaine salt having a metal to chloride molar ratio in the range of 0.3-2.5:1, a Betaine:aluminum molar ratio in the range of 0.05-1.0:1 and/or a Betaine:zirconium molar ratio in the range of 0.2-3.0:1, wherein the Betaine is used in its normal form described in Formula I, or in its derivative form of Betaine hydrochloride, described in Formula IA:
摘要翻译：一种不含甘氨酸的铝和/或锆甜菜碱盐，其金属与氯化物的摩尔比在0.3-2.5:1的范围内，甜菜碱：铝的摩尔比在0.05-1.0:1的范围内和/或甜菜碱：锆摩尔比在0.2-3.0:1的范围内，其中甜菜碱以其在式I中所述的正常形式使用，或以其如式IA所述的其盐酸甜菜碱的衍生形式使用：

17. 发明授权

US06511657B2 Two-phase roll-on cosmetic product 失效
标题翻译：两相卷发化妆品
公开(公告)号：US06511657B2
公开(公告)日：2003-01-28
申请号：US09838802
申请日：2001-04-20
申请人： Esther Avendano , Adriana Urrutia-Gutierrez , Wilson Lee , Xiaozhong Tang
发明人： Esther Avendano , Adriana Urrutia-Gutierrez , Wilson Lee , Xiaozhong Tang
IPC分类号： A61K732
CPC分类号： A61Q15/00 , A61K8/03 , A61K8/37 , A61K8/39 , A61K8/585 , A61K8/731 , A61K2800/262 , A61K2800/874 , Y10S514/947
摘要： A two-phase roll-on antiperspirant and/or deodorant is described which comprises: (a) a clear, translucent or opaque non-polar phase having a viscosity in the range of 20 cps-9,000 made by combining: a cross-linked or partially cross-linked non-emulsifying siloxane elastomer; 0.1-70 weight % of one or more low viscosity, lipophilic emollients; (b) a clear, translucent or opaque polar phase have a viscosity in the range of 20-9,000 cps made by combining: one or more members selected from the group consisting of water, glycols and polyhydric alcohols; and an antiperspirant active salt which is soluble or suspendible in the polar phase; wherein the polar phase comprises (i) a sufficient amount of water, glycols or polyhydric alcohols to dissolve or suspend the antiperspirant active, and (ii) optionally may comprise up to 30 weight % water; up to 16.00 weight % of ethyl alcohol; up to 16 weight % isopropyl alcohol; or mixtures of the foregoing; (iii) 0.1-2.5 weight % of a water soluble cationic derivative selected from the group consisting of hydroxyethyl cellulose and its copolymers provided that the viscosity of the polar phase does not exceed 9,000 cps.
摘要翻译：描述了两相辊式止汗剂和/或除臭剂，其包括：（a）透明，半透明或不透明的非极性相，其粘度在20cps-9,000的范围内，其通过以下组合制成：交联或部分交联的非乳化硅氧烷弹性体; 0.1-70重量％的一种或多种低粘度亲脂性润肤剂; （b）透明，半透明或不透明极性相的粘度在20-9,000cps的范围内，通过组合：一种或多种选自水，二醇和多元醇的成员; 和可溶于或悬浮于极性相中的止汗剂活性盐; 其中极性相包含（i）足够量的水，二醇或多元醇以溶解或悬浮止汗活性剂，和（ii）任选地可包含至多30重量％的水; 高达16.00重量％的乙醇; 高达16重量％的异丙醇; 或上述的混合物; （iii）0.1-2.5重量％的选自羟乙基纤维素及其共聚物的水溶性阳离子衍生物，条件是极性相的粘度不超过9,000cps。

18. 发明授权

US06969510B2 Glycine-free antiperspirant salts with Betaine for enhanced cosmetic products 有权
标题翻译：不含甘氨酸的止汗剂与甜菜碱用于增强化妆品
公开(公告)号：US06969510B2
公开(公告)日：2005-11-29
申请号：US10462200
申请日：2003-06-16
申请人： Marian Holerca , Xiaozhong Tang , Heng Cai
发明人： Marian Holerca , Xiaozhong Tang , Heng Cai
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61Q15/00 , C07F5/06 , C07F7/00 , A61K7/34 , A61K7/38 , C07F7/28
CPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61Q15/00 , C07F5/069 , C07F7/003
摘要： A glycine-free aluminum and/or zirconium Betaine salt having a metal to chloride molar ratio in the range of 0.3-2.5:1, a Betaine:aluminum molar ratio in the range of 0.05-1.0:1 and/or a Betaine:zirconium molar ratio in the range of 0.2-3.0:1, wherein the Betaine is used in its normal form described in Formula I, or in its derivative form of Betaine hydrochloride, described in Formula IA:
摘要翻译：一种不含甘氨酸的铝和/或锆甜菜碱盐，其金属与氯化物的摩尔比在0.3-2.5:1的范围内，甜菜碱：铝的摩尔比在0.05-1.0:1的范围内和/或甜菜碱：锆摩尔比在0.2-3.0:1的范围内，其中甜菜碱以其在式I中所述的正常形式使用，或以其如式IA所述的其盐酸甜菜碱的衍生形式使用：

19. 发明申请

US20100234627A1 OXO-HEXAMERIC ZIRCONIUM-OCTAAMINO ACID ANTIPERSPIRANT SALTS 有权
标题翻译： OXO-HEXAMERIC ZIRCONIUM-OCTAAMINO ACID抗感染剂
公开(公告)号：US20100234627A1
公开(公告)日：2010-09-16
申请号：US12293463
申请日：2008-09-12
申请人： Long Pan , LaTonya Kilpatrick , Xiaozhong Tang
发明人： Long Pan , LaTonya Kilpatrick , Xiaozhong Tang
IPC分类号： C07F5/06
CPC分类号： A61Q15/00 , A61K8/28 , A61K8/44 , A61K2800/58 , C07F7/003
摘要： A process for preparing oxo-hexameric zirconium-octaamino acid, such as glycine, salt comprising: mixing zirconium (Zr): amino acid: and mineral acid, in a molar ratio of 1: about 1 to about 15: about 1.5 to about 3 to form a mixture; optionally, filtering the mixture; and optionally, drying the mixture. An oxo-hexameric zirconium-octaamino acid salt of the molecular formula: oxo-[Zr6AminoAcid8].Xy.nH2O, wherein Zr is zirconium, X is an anion of a mineral acid, and n and y are numerical values from 0 to 20. A method of making an antiperspirant active zirconium-aluminum-amino acid compound comprising mixing an oxo-hexameric zirconium-octaamino acid salt with aluminum chlorohydrex and/or aluminum chloride, and drying the mixture. The smallest oxo-hexameric zirconium-octaamino acid salt of this invention provides stability, efficacy, and shelf life of zirconium-amino acid species for formulations in antiperspirant and/or deodorant compositions.
摘要翻译：一种制备氧代 - 六聚锆 - 八氨基酸如甘氨酸盐的方法，包括：将锆（Zr）：氨基酸和无机酸以摩尔比1：约1：约15：约1.5至3 形成混合物任选地，过滤混合物; 并任选地干燥混合物。分子式为氧代 - [Zr6AminoAcid8]·Xy·nH2O的氧代 - 六聚体 - 八 - 八烷基酸盐，其中Zr是锆，X是无机酸的阴离子，n和y是0至20的数值。一种制备止汗活性锆 - 铝 - 氨基酸化合物的方法，包括将氧代六聚体锆 - 八氨基酸盐与氯化铝和/或氯化铝混合并干燥该混合物。本发明的最小的氧代 - 六聚体锆 - 八氨基酸盐为止汗剂和/或除臭剂组合物中的制剂提供了锆 - 氨基酸种类的稳定性，有效性和保质期。

20. 发明申请

US20080233067A1 Method Of Making Enhanced Efficacy Antiperspirant Actives 审中-公开
标题翻译：增强功效止汗剂活性物质的方法
公开(公告)号：US20080233067A1
公开(公告)日：2008-09-25
申请号：US12106700
申请日：2008-04-21
申请人： Wilson Lee , Xiaozhong Tang , John Brahms , James Cush , Anthony Esposito , Marie Johansson
发明人： Wilson Lee , Xiaozhong Tang , John Brahms , James Cush , Anthony Esposito , Marie Johansson
IPC分类号： A61K8/26 , A61K8/28 , B02C23/18
CPC分类号： A61Q15/00 , A61K8/28
摘要： This invention comprises: (1) a wet grinding method for enhancing the activity of an aluminum or an aluminum/zirconium salt without the dilution and heating traditionally required wherein the enhancement is described as forming a salt wherein the amount of smaller aluminum species as represented by Peak 4+Peak 5 is increased by an amount of at least 10% over the parent salt; and, if zirconium is present, the area of Peak 1 in the parent salt is at least 10% greater than the area of Peak 1 after grinding; (2) an enhanced aluminum or aluminum/zirconium salt itself, and (3) anhydrous (less than 4% water excluding waters of hydration for the enhanced salt) antiperspirant and/or deodorant products made with the salts described in (2).
摘要翻译：本发明包括：（1）用于提高铝或铝/锆盐的活性的湿法研磨方法，而不需要传统上需要的稀释和加热，其中增强物被描述为形成盐，其中较小的铝物质的量由峰4 +峰5比母盐增加至少10％的量; 并且如果存在锆，则母盐中的峰1的面积比研磨后的峰1的面积大至少10％（2）增强的铝或铝/锆盐本身，和（3）用（2）中描述的盐制成的无水（除增强盐的除水水分以外的少于4％的水）止汗剂和/或除臭产物。

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