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11. 发明授权

US09464097B2 Gold complexes 有权
标题翻译：金色复合体
公开(公告)号：US09464097B2
公开(公告)日：2016-10-11
申请号：US13580772
申请日：2011-03-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： C07F1/12 , B01J31/22 , B01J31/02 , B01J31/24
CPC分类号： C07F1/12 , B01J31/0211 , B01J31/181 , B01J31/2273 , B01J31/24 , B01J2531/18 , C07C45/26 , C07C67/333 , C07C231/065 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07D207/06 , C07D213/81 , C07F1/00
摘要： Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclization of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclization of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
摘要翻译：提供Z-Au-OH形式的金（I）氢氧化物络合物和Z-Au-（μOH）-Au-Z形式的二价配合物，其中基团Z是两个电子给体。基团Z可以是卡宾，例如含氮杂环卡宾（NHC），膦或亚磷酸酯。络合物可以用作催化剂，例如在诸如腈水合，烯炔的骨架排列，烯炔的烷基环化，炔烃水合，Meyer-Shuster反应，烯丙基乙酸酯的3,3'重排，炔丙基乙酸酯的环化，贝克曼重排和水文。该复合物可用于医学中，例如用于治疗癌症。

12. 发明授权

US07767841B1 Gold complexes for catalysIS and preparation thereof 有权
标题翻译：用于催化的金络合物及其制备
公开(公告)号：US07767841B1
公开(公告)日：2010-08-03
申请号：US12098863
申请日：2008-04-07
申请人： Steven P. Nolan , Pierre de Fremont
发明人： Steven P. Nolan , Pierre de Fremont
IPC分类号： C07F1/12 , C01F1/00
CPC分类号： C07F1/00
摘要： A number of cationic gold(I) and neutral gold(III) complexes have been synthesized and found to be stabilized by the use of N-heterocyclic carbene ligands. These species are often employed as in situ-generated reactive intermediates in gold catalyzed organic transformations. An isolated, well-defined cationic species was tested in gold mediated carbene transfer reactions from ethyl diazoacetate.
摘要翻译：已经合成了许多阳离子金（I）和中性金（III）络合物，发现通过使用N-杂环卡宾配体来稳定。这些物质通常用作金催化有机转化中的原位产生的反应中间体。在乙基重氮乙酸酯的金介导的卡宾转移反应中测试了分离的，明确定义的阳离子物质。

13. 发明申请

US20100160642A1 Catalyst Complex With Carbene Ligand 有权
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US20100160642A1
公开(公告)日：2010-06-24
申请号：US12622225
申请日：2009-11-19
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00 , C07C2/42 , C07C1/20
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbine ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配位体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

14. 发明申请

US20090069569A1 CYCLOADDITION OF AZIDES AND ALKYNES 审中-公开
标题翻译：氨基酸和碱基的循环
公开(公告)号：US20090069569A1
公开(公告)日：2009-03-12
申请号：US12209323
申请日：2008-09-12
申请人： Steven P. Nolan , Silvia Diez-Gonzalez
发明人： Steven P. Nolan , Silvia Diez-Gonzalez
IPC分类号： C07D249/04
CPC分类号： C07D249/04 , C07D249/06 , C07D401/04 , C07D405/06
摘要： This invention provides a process which comprises contacting, in a reaction zone, at least one organic azide, at least one alkyne, and at least one N-heterocyclic carbene copper compound in which the ligands are either (i) a halide and an N-heterocyclic carbene or (ii) two N-heterocyclic carbenes and a BF4− or PF6− anion, to form a 1,2,3-triazole in which at least the 1 and 4 positions each has a substituent. The N-heterocyclic carbene either an imidazol-2-ylidene in which the 1 and the 3 positions each has a substituent which has at least one carbon atom, or a 4,5-dihydro-imidazol-2-ylidene in which the 1 and the 3 positions each has a substituent which has at least one carbon atom.
摘要翻译：本发明提供了一种方法，该方法包括在反应区中使至少一种有机叠氮化物，至少一种炔和至少一种N-杂环卡宾铜化合物接触，其中配体为（i）卤化物和N- 杂环卡宾或（ii）两个N-杂环卡宾和BF4-或PF6-阴离子形成1,2,3-三唑，其中至少1和4位各自具有取代基。 N-杂环卡宾或其中1个和3个位置各自具有至少一个碳原子的取代基的咪唑-2-亚基或4,5-二氢 - 咪唑-2-亚基，其中1和 3个位置各自具有至少一个碳原子的取代基。

15. 发明授权

US06403802B1 Use of catalyst system comprising nickel, palladium, or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in amination reactions 失效
标题翻译：在胺化反应中使用包含镍，钯或铂和咪唑啉-2-亚基或咪唑烷-2-亚基的催化剂体系
公开(公告)号：US06403802B1
公开(公告)日：2002-06-11
申请号：US09511420
申请日：2000-02-22
申请人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
发明人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
IPC分类号： C07F980
CPC分类号： C07F15/0046 , B01J31/2265 , B01J31/2273 , B01J2231/4283 , B01J2531/824 , B01J2531/828 , B01J2531/847 , C07B37/04 , C07B43/04 , C07B49/00 , C07C1/321 , C07C67/343 , C07C209/10 , C07C213/08 , C07D295/023 , C07D295/073 , C07D295/096 , C07F15/002 , C07C69/76
摘要： This invention provides a process for conducting amination reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in aminations of aryl halides and aryl pseudohalides. An amination can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than amino groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one primary amine and/or at least one secondary amine; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formula wherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group.
摘要翻译：本发明提供了进行胺化反应的方法。本发明的方法利用N-杂环卡宾作为芳基卤化物和芳基拟卤化物的胺化剂中的辅助配体。胺化可以通过在液体介质中混合至少一个强碱来进行; 至少一种其中所有取代基不是氨基的芳基卤或芳基拟卤化物，其中所述芳基卤具有直接键合到所述芳环上的至少一个卤素原子，所述卤素原子选自氯原子，溴原子和碘原子; 至少一种伯胺和/或至少一种仲胺; 至少一种金属化合物，其包含至少一种选自镍，钯和铂的金属原子，其中所述金属的形式氧化态为零或二; 和至少一个N-杂环卡宾。 N-杂环卡宾的一种优选类型是式R 2的咪唑啉-2-亚基，R 2各自独立地为具有至少3个碳原子的烷基或芳基，R 3和R 4各自独立地为氢原子，卤素原子或烃基。

16. 发明授权

US06403801B1 Use of a catalyst system comprising nickel, palladium, or platinum and imidazoline-2-ylidene of imidazolidine-2-ylidene in suzuki coupling reactions 失效
标题翻译：在铃木耦合反应中使用包含镍，钯或铂和咪唑啉-2-亚基或咪唑烷-2-亚基的催化剂体系
公开(公告)号：US06403801B1
公开(公告)日：2002-06-11
申请号：US09507959
申请日：2000-02-22
申请人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
发明人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
IPC分类号： C07F980
CPC分类号： C07B37/04
摘要： This invention provides a process for conducting Suzuki coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Suzuki couplings of aryl halides and aryl pseudohalides. A Suzuki coupling can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than boronic acid groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one arylboronic acid in which all substituents are other than chlorine atoms, bromine atoms, iodine atoms, or pseudohalide groups; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formula wherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group.
摘要翻译：本发明提供了进行Suzuki偶联反应的方法。本发明的方法利用N-杂环卡宾作为芳基卤化物和芳基拟卤化物的Suzuki偶联中的辅助配体。 Suzuki偶联可以通过在液体介质中混合至少一个强碱来进行; 至少一种芳族卤化物或芳基拟卤化物，其中所有取代基都不是硼酸基团，其中所述芳基卤具有直接键合到芳族环上的至少一个选自氯原子，溴原子和碘原子; 至少一个芳基硼酸，其中所有取代基不是氯原子，溴原子，碘原子或拟卤化物基团; 至少一种金属化合物，其包含至少一种选自镍，钯和铂的金属原子，其中所述金属的形式氧化态为零或二; 和至少一个N-杂环卡宾。 N-杂环卡宾的一种优选类型是式R 2的咪唑啉-2-亚基，R 2各自独立地为具有至少3个碳原子的烷基或芳基，R 3和R 4各自独立地为氢原子，卤素原子或烃基。

17. 发明授权

US06369265B1 Use of a catalyst system comprising nickel, palladium, or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in kumada coupling reactions 失效
标题翻译：在kumada偶联反应中使用包含镍，钯或铂和咪唑啉-2-亚基或咪唑烷-2-亚基的催化剂体系
公开(公告)号：US06369265B1
公开(公告)日：2002-04-09
申请号：US09511122
申请日：2000-02-22
申请人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
发明人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
IPC分类号： C07C6976
CPC分类号： C07D295/096 , B01J31/2265 , B01J31/2273 , B01J2231/4233 , B01J2531/824 , B01J2531/828 , B01J2531/847 , C07B37/04 , C07B43/04 , C07B49/00 , C07C1/321 , C07C41/30 , C07C67/293 , C07C67/343 , C07C209/10 , C07C213/08 , C07D295/023 , C07D295/073 , C07C69/76 , C07C69/157 , C07C43/205 , C07C43/225
摘要： This invention provides a process for conducting Kumada coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Kumada couplings of aryl halides. A Kumada coupling can be carried out by mixing, in a liquid medium, at least one aryl halide, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one Grignard reagent; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formula wherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group. Homocoupling of aryl pseudohalides is also feasible using the processes of this invention.
摘要翻译：本发明提供了一种进行Kumada偶联反应的方法。本发明的方法利用N-杂环卡宾作为芳基卤化物的Kumada偶联中的辅助配位体。 Kumada偶联可以通过在液体介质中混合至少一种芳基卤化物进行，其中芳基卤与直接键合到芳香环上的至少一个卤素原子选自氯原子，溴原子和碘原子; 至少一种格氏试剂; 至少一种金属化合物，其包含至少一种选自镍，钯和铂的金属原子，其中所述金属的形式氧化态为零或二; 和至少一个N-杂环卡宾。 N-杂环卡宾的一种优选类型是式R 2的咪唑啉-2-亚基，R 2各自独立地为具有至少3个碳原子的烷基或芳基，R 3和R 4各自独立地为氢原子，卤素原子或烃基。芳基拟卤化物的同相偶联也是可行的，使用本发明的方法。

18. 发明申请

US20130035322A1 GOLD COMPLEXES 有权
标题翻译：金复合体
公开(公告)号：US20130035322A1
公开(公告)日：2013-02-07
申请号：US13580772
申请日：2011-03-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： A61K31/555 , C07F15/00 , C07D207/16 , A61P35/00 , C07C231/06 , C07C45/26 , C07C17/37 , C07D213/81 , C07C69/74
CPC分类号： C07F1/12 , B01J31/0211 , B01J31/181 , B01J31/2273 , B01J31/24 , B01J2531/18 , C07C45/26 , C07C67/333 , C07C231/065 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07D207/06 , C07D213/81 , C07F1/00
摘要： Gold (I) hydroxide complexes of the form Z-Au-OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
摘要翻译：提供Z-Au-OH形式的金（I）氢氧化物络合物和Z-Au-（μOH）-Au-Z形式的二价配合物，其中基团Z是两个电子给体。基团Z可以是卡宾，例如含氮杂环卡宾（NHC），膦或亚磷酸酯。络合物可以用作催化剂，例如在诸如腈水合，烯炔的骨架排列，烯炔的烷基环化，炔烃水合，Meyer-Shuster反应，烯丙基乙酸酯的3,3'重排，炔丙基乙酸酯的环化，贝克曼重排和水文。该复合物可用于医学中，例如用于治疗癌症。

19. 发明申请

US20120004418A1 Catalyst Complex With Carbene Ligand 审中-公开
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US20120004418A1
公开(公告)日：2012-01-05
申请号：US13041573
申请日：2011-03-07
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbine ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配位体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

20. 发明授权

US07109348B1 Synthesis of 1,3 distributed imidazolium salts 失效
标题翻译： 1,3分散咪唑鎓盐的合成
公开(公告)号：US07109348B1
公开(公告)日：2006-09-19
申请号：US10653688
申请日：2003-09-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： C07D233/54
CPC分类号： C07D233/56
摘要： Imidazolium salts are the immediate precursors to N-heterocyclic carbenes (NHC) yet a simple, general synthetic route to a wide variety of imidazolium salts is not yet available. Such a straightforward route is described for two specific members of this family of ligand precursor: 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride (IMes.HCl) and 1,3-Bis(2,6-diispropylphenyl)imidazolium chloride (IPr.HCl). The procedure appears general and similar protocols can be used to isolate various imidazolium salts.
摘要翻译：咪唑盐是N-杂环卡宾（NHC）的直接前体，但是尚未提供到各种咪唑鎓盐的简单的通用合成途径。对这种配体前体家族的两个特定成员描述了这种简单的途径：1,3-双（2,4,6-三甲基苯基）氯化咪唑（IMes.HCl）和1,3-双（2,6-二）氯化咪唑（IPr.HCl）。该方法看起来通用，并且可以使用类似的方案来分离各种咪唑鎓盐。

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