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11. 发明授权

US06585763B1 Implantable therapeutic device and method 失效
标题翻译：可植入治疗装置及方法
公开(公告)号：US06585763B1
公开(公告)日：2003-07-01
申请号：US09028173
申请日：1998-02-23
申请人： George W. Keilman , George E. Cimochowski
发明人： George W. Keilman , George E. Cimochowski
IPC分类号： A61F206
CPC分类号： A61M37/0092 , A61B5/0031 , A61B5/026 , A61B5/04 , A61B5/4839 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/06 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2250/0001 , A61M1/3656
摘要： A system includes a first coil, a signal source and a first control module. The first control module regulates coupling between the signal source and the first coil. The system also includes an implantable device having a second coil coupled to a therapeutic transducer comprising an ultrasonic transducer. When the first coil is aligned with the second coil, the signal source is able to supply electrical power to the implantable device to enable the therapeutic transducer to operate. The control module is able to activate the therapeutic transducer under the control of a physician.
摘要翻译：系统包括第一线圈，信号源和第一控制模块。第一控制模块调节信号源和第一线圈之间的耦合。该系统还包括具有耦合到包括超声换能器的治疗换能器的第二线圈的可植入装置。当第一线圈与第二线圈对准时，信号源能够向可植入装置供电，以使得治疗传感器能够操作。控制模块能够在医生的控制下激活治疗换能器。

12. 发明授权

US07833265B2 Vascular anchoring system and method 有权
标题翻译：血管锚固系统及方法
公开(公告)号：US07833265B2
公开(公告)日：2010-11-16
申请号：US12048053
申请日：2008-03-13
申请人： Timothy Johnson , George W. Keilman
发明人： Timothy Johnson , George W. Keilman
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/848 , A61F2/954 , A61F2/966 , A61F2002/821 , A61F2002/9665 , A61F2220/0008 , A61F2230/0008
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

13. 发明申请

US20100233021A1 Systems and methods to deal with health-relevant fouling or plugging depositions and growths 审中-公开
标题翻译：处理与健康有关的结垢或堵塞沉积和生长的系统和方法
公开(公告)号：US20100233021A1
公开(公告)日：2010-09-16
申请号：US12381423
申请日：2009-03-11
申请人： John W. Sliwa , George W. Keilman , Bryan T. Oronsky , Carol A. Tosaya , Herbert L. Berman
发明人： John W. Sliwa , George W. Keilman , Bryan T. Oronsky , Carol A. Tosaya , Herbert L. Berman
IPC分类号： A61L2/10 , A61L2/03 , A61L2/025 , A61N1/32
CPC分类号： A61M25/0017 , A61B90/70 , A61M27/00 , A61M37/00 , A61M2025/0019 , A61N1/205 , A61N1/32 , A61N1/40
摘要： Disclosed are methods of inhibiting, avoiding or destroying existing, potential or incipient biodeposits, biofilms or pathogens any of (a) in or on a living body including in or on a medical device or implement placed, inserted or insertable in the body, (b) in, on or in contact with an ex vivo bodily tissue or fluid, or (c) in, on or in contact with a medium or matter to be consumed, ingested by or exposed to a living being or entity. Also disclosed are medical devices, implements, and prostheses that can be kept in a safe defouled, pathogen-free or pathogen-reduced condition with the help of an electric field(s). Also disclosed are medical or industrial devices, implements, equipment-articles and storage/handling-entities that can be kept in a safely defouled, pathogen-free or pathogen-reduced condition with the help of a membrane or orifice that has one or more of the antifouling or antipathogenic attributes.
摘要翻译：公开了抑制，避免或破坏现有的，潜在的或初期的生物沉积物，生物膜或病原体（a）在生物体内或之上的生物体，包括在放置，插入或插入体内的医疗装置或器具中或之上，（b））在离体身体组织或流体接触或接触时，或（c）在要消费的介质或物质中或与其接触或摄入或暴露于活体或实体时。还公开了医疗装置，器具和假体，其可以在电场的帮助下保持在安全的防污染，无病原体或病原体减少的状态。还公开了医疗或工业装置，器具，设备制品和储存/处理实体，其可以在具有一个或多个以下的膜或孔的帮助下保持在安全脱钩，无病原体或病原体减少的状态防污或抗病原性。

14. 发明申请

US20090264766A1 ENHANCED INTRALUMINAL FLOW MEASUREMENT METHOD USING REFERENCE AND SHIFTED SIGNALS 审中-公开
标题翻译：使用参考和移位信号的增强的内部流量测量方法
公开(公告)号：US20090264766A1
公开(公告)日：2009-10-22
申请号：US12105068
申请日：2008-04-17
申请人： George W. Keilman , Leigh Bartlett , Timothy Johnson
发明人： George W. Keilman , Leigh Bartlett , Timothy Johnson
IPC分类号： A61B8/06
CPC分类号： A61B8/12 , A61B8/06 , A61B8/565
摘要： An enhanced intraluminal flow measurement system and method is conducive for a low-power ultrasonic system that can use continuous-wave (CW) Doppler sensing and wireless RF telemetry. Applications include measurement of blood flow in situ in living organisms. Implementations include an extraluminal component located outside of a body, such as a human or animal body, containing a lumen. The extraluminal component can be wirelessly coupled via an RF magnetic field or other RF field to an implantable intraluminal component. The intraluminal component (i.e. implant) is implanted inside of the lumen of the body such as a heart or elsewhere in a vasculature (such as in a dialysis shunt). The intraluminal component can telemeter, via RF electromagnetic signals, flow data directly out of the body housing the intraluminal component to be received by the extraluminal component.
摘要翻译：增强的管腔内流量测量系统和方法有利于可以使用连续波（CW）多普勒感测和无线RF遥测的低功率超声波系统。应用包括在生物体内原位测量血流。实施方案包括位于身体外部的外阴部件，例如包含内腔的人体或动物体。管腔内部件可以经由RF磁场或其他RF场无线耦合到可植入的管腔内部件。管腔内成分（即植入物）植入体内的腔内，例如心脏或其它脉管系统（如透析分流）中。管腔内成分可以通过射频电磁信号将流量数据直接传送出外壳体内的腔内部件，以便由腔内部件接收。

15. 发明申请

US20090234436A1 VASCULAR ANCHOR TETHERING SYSTEM AND METHOD 审中-公开
标题翻译：血管锚固系统和方法
公开(公告)号：US20090234436A1
公开(公告)日：2009-09-17
申请号：US12048055
申请日：2008-03-13
申请人： Timothy Johnson , George W. Keilman , Brian Doll
发明人： Timothy Johnson , George W. Keilman , Brian Doll
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/848 , A61F2/954 , A61F2/966 , A61F2002/821 , A61F2002/9665 , A61F2220/0008 , A61F2230/0008
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

16. 发明申请

US20090005859A1 ENDOLUMINAL IMPLANT WITH THERAPEUTIC AND DIAGNOSTIC CAPABILITY 审中-公开
标题翻译：具有治疗和诊断能力的内膜植入物
公开(公告)号：US20090005859A1
公开(公告)日：2009-01-01
申请号：US12204470
申请日：2008-09-04
申请人： George W. Keilman
发明人： George W. Keilman
IPC分类号： A61F5/00 , A61B19/00
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/14532 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/12 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2/82 , A61F2002/072 , A61F2002/075 , A61F2250/0001 , A61F2250/0002 , A61M1/3656 , A61M37/0092 , A61N1/306 , A61N1/325 , A61N5/0601 , A61N5/062
摘要： An apparatus includes an endoluminal implant, a RF coupling coil coupled to the endoluminal implant and a therapeutic transducer electrically coupled to the RF coupling coil and physically coupled to the endoluminal implant. The RF coupling coil supplies electrical power to the therapeutic transducer. The therapeutic transducer has a capability for delivering therapeutic energy to a lumen disposed within the endoluminal implant in response to signals coupled via the RF coupling coil.
摘要翻译：一种装置包括腔内植入物，耦合到腔内植入物的RF耦合线圈和电耦合到RF耦合线圈并物理耦合到腔内植入物的治疗换能器。 RF耦合线圈向治疗换能器提供电力。所述治疗换能器响应于经由所述RF耦合线圈耦合的信号，具有将治疗能量递送至设置在所述腔内植入物内的内腔的能力。

17. 发明授权

US06398734B1 Ultrasonic sensors for monitoring the condition of flow through a cardiac valve 失效
标题翻译：超声波传感器用于监测通过心脏瓣膜的流量状况
公开(公告)号：US06398734B1
公开(公告)日：2002-06-04
申请号：US09373445
申请日：1999-08-12
申请人： George E. Cimochowski , George W. Keilman
发明人： George E. Cimochowski , George W. Keilman
IPC分类号： A61B812
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/6876 , A61B5/6884 , A61B8/04 , A61B8/12 , A61B8/4227 , A61B8/4472 , A61B8/56 , A61B2560/0219 , A61M1/3656
摘要： A parameter indicative of the condition of a cardiac valve is determined by monitoring blood flow and/or velocity in a vessel that is coupled to the cardiac valve or in a chamber adjacent to an artificial cardiac valve. One or more ultrasonic transducers are provided either in a wall or a cuff disposed about a cardiac vessel to monitor the parameter in regard to a natural or artificial cardiac valve, or in a support sewing ring of an artificial cardiac valve. A conformal array transducer or a tilted element is used to monitor fluid flow or velocity based on the effect of the blood on ultrasonic waves produced by the transducers. The conformal array transducer comprises a plurality of elements that are excited with an input signal provided by an implantable electronics circuit, producing ultrasonic waves. Transit time or Doppler measurements are made using an appropriate number of these transducers to determine either blood volumetric flow or velocity. Various implantable electronic circuits are disclosed that enable a transducer to be driven and to receive an ultrasonic signal indicative of the status of blood flow and thus, the condition of the cardiac valve. A radio frequency (RF) coil is coupled to an external coil. The external coil is connected to a power supply and monitoring console, conveying power to the ultrasonic transducers and receiving data signals that enable the condition of the cardiac valve to be determined.
摘要翻译：通过监测联接到心脏瓣膜或邻近人造心脏瓣膜的腔室的血管中的血流和/或速度来确定指示心脏瓣膜状况的参数。一个或多个超声波换能器设置在围绕心脏血管设置的壁或袖带中，以监测关于天然或人造心脏瓣膜的参数，或在人造心脏瓣膜的支撑缝合环中。根据血液对由换能器产生的超声波的影响，使用保形阵列换能器或倾斜元件来监测流体流动或速度。共形阵列换能器包括由可植入电子电路提供的输入信号激励的多个元件，产生超声波。使用适当数量的这些传感器进行运输时间或多普勒测量，以确定血液体积流量或速度。公开了各种可植入的电子电路，其能够驱动换能器并接收指示血流状态的超声波信号，并因此接收心脏瓣膜的状况。射频（RF）线圈耦合到外部线圈。外部线圈连接到电源和监视控制台，向超声波换能器输送功率，并接收能够确定心脏瓣膜状态的数据信号。

18. 发明授权

US06231516B1 Endoluminal implant with therapeutic and diagnostic capability 失效
标题翻译：具有治疗和诊断能力的腔内植入物
公开(公告)号：US06231516B1
公开(公告)日：2001-05-15
申请号：US09028154
申请日：1998-02-23
申请人： George W. Keilman , George E. Cimochowski
发明人： George W. Keilman , George E. Cimochowski
IPC分类号： A61B502
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/14532 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/12 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2/82 , A61F2002/072 , A61F2002/075 , A61F2250/0001 , A61F2250/0002 , A61M1/3656 , A61M37/0092 , A61N1/306 , A61N1/325 , A61N5/0601 , A61N5/062
摘要： An apparatus includes an endoluminal implant, a RF coupling coil coupled to the endoluminal implant and a therapeutic transducer electrically coupled to the RF coupling coil and physically coupled to the endoluminal implant. The RF coupling coil supplies electrical power to the therapeutic transducer. The therapeutic transducer has a capability for delivering therapeutic energy to a lumen disposed within the endoluminal implant in response to signals coupled via the RF coupling coil.
摘要翻译：一种装置包括腔内植入物，耦合到腔内植入物的RF耦合线圈和电耦合到RF耦合线圈并物理耦合到腔内植入物的治疗换能器。 RF耦合线圈向治疗换能器提供电力。所述治疗换能器响应于经由所述RF耦合线圈耦合的信号，具有将治疗能量递送至设置在所述腔内植入物内的内腔的能力。

19. 发明授权

US4475376A Apparatus for testing ultrasonic transducers 失效
标题翻译：超声换能器测试装置
公开(公告)号：US4475376A
公开(公告)日：1984-10-09
申请号：US445795
申请日：1982-12-01
申请人： George W. Keilman
发明人： George W. Keilman
IPC分类号： G01H3/00 , G01N29/30 , G10K11/22 , G01N29/00 , H04R29/00
CPC分类号： G10K11/22 , G01H3/005 , G01N29/30
摘要： A probe for testing ultrasound transducers is described. The probe is made of a body of material which absorbs ultrasound. There is a conical opening in the body, and a spherical transducer is mounted in the wider opening at the base of the conical opening. When the probe is used as a surface probe, a transducer undergoing tests is placed at the opening at the apex of the cone. Typically the conical opening is filled with a fluid which simulates the absorption qualities of the material with which the tested transducer will ultimately be used. For example, the transducer undergoing the test will be used with human body tissue, so a fluid such as water or light mineral oil would typically fill the cone-shaped opening. The present invention can also be used as a hydrophone, because of the manner in which it generates, or senses, pressure waves at a point in space.
摘要翻译：描述了用于测试超声换能器的探头。探头由吸收超声的材料体制成。体内有一个圆锥形开口，球形换能器安装在锥形开口底部的较宽开口处。当探针用作表面探针时，经过测试的传感器放置在锥体顶点的开口处。典型地，圆锥形开口填充有流体，该流体模拟最终将使用所测试的换能器的材料的吸收质量。例如，经受测试的换能器将与人体组织一起使用，因此诸如水或轻质矿物油的流体通常将填充锥形开口。本发明也可以用作水听器，因为它在空间中产生或感测压力波的方式。

20. 发明授权

US08128566B2 Enhanced intraluminal flow measurement method using pulsed signals 有权
标题翻译：使用脉冲信号增强管腔内流量测量方法
公开(公告)号：US08128566B2
公开(公告)日：2012-03-06
申请号：US12105050
申请日：2008-04-17
申请人： George W. Keilman , Leigh Bartlett , Timothy Johnson
发明人： George W. Keilman , Leigh Bartlett , Timothy Johnson
IPC分类号： A61B8/06
CPC分类号： A61B5/026 , A61B5/0031 , A61B5/0265 , A61B5/6846 , A61B8/06 , A61B8/12
摘要： An enhanced intraluminal flow measurement system and method is conducive for a low-power ultrasonic system that can use continuous-wave (CW) Doppler sensing and wireless RF telemetry. Applications include measurement of blood flow in situ in living organisms. Implementations include an extraluminal component located outside of a body, such as a human or animal body, containing a lumen. The extraluminal component can be wirelessly coupled via an RF magnetic field or other RF field to an implantable intraluminal component. The intraluminal component (i.e. implant) is implanted inside of the lumen of the body such as a heart or elsewhere in a vasculature (such as in a dialysis shunt). The intraluminal component can telemeter, via RF electromagnetic signals, flow data directly out of the body housing the intraluminal component to be received by the extraluminal component.
摘要翻译：增强的管腔内流量测量系统和方法有利于可以使用连续波（CW）多普勒感测和无线RF遥测的低功率超声波系统。应用包括在生物体内原位测量血流。实施方案包括位于身体外部的外阴部件，例如包含内腔的人体或动物体。管腔内部件可以经由RF磁场或其他RF场无线耦合到可植入的管腔内部件。管腔内成分（即植入物）植入体内的腔内，例如心脏或其它脉管系统（如透析分流）中。管腔内成分可以通过射频电磁信号将流量数据直接传送出外壳体内的腔内部件，以便由腔内部件接收。

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