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11. 发明授权

US5144412A Process for manufacturing plastic pin grid arrays and the product produced thereby 失效
标题翻译：制造塑料针格栅阵列的方法及由此产生的产品
公开(公告)号：US5144412A
公开(公告)日：1992-09-01
申请号：US562281
申请日：1990-08-02
申请人： Kin-Shiung Chang , Thomas A. Armer , William G. Bridges
发明人： Kin-Shiung Chang , Thomas A. Armer , William G. Bridges
IPC分类号： H01L21/00 , H01L21/48 , H05K7/10
CPC分类号： H01L21/67132 , H01L21/486 , H05K7/1084 , H01L2224/16 , H01L2224/48091 , H01L2224/48227 , H01L2924/01014 , H01L2924/01078 , H01L2924/01079 , H01L2924/01322 , H01L2924/09701 , H01L2924/15312 , H01L2924/16195 , H01L2924/30107
摘要： A pin grid array package is provided. An array of terminal pins pass through apertures formed in an interconnect tape. The terminal pins are electrically connected to circuit traces formed on interconnect tape. The electrically conductive bond between the terminal pins and circuit traces is either by a mechanical cinch by soldering. In one embodiment, at least a portion of the interconnect tape, terminal pins and a heat sink are embedded in a molding polymer resin.
摘要翻译：提供引脚格栅阵列封装。一组端子引脚穿过形成在互连带中的孔。端子引脚电连接到形成在互连带上的电路迹线。端子引脚和电路迹线之间的导电接合是通过焊接的机械束带。在一个实施例中，互连带，端子销和散热器的至少一部分嵌入在模制聚合物树脂中。

12. 发明授权

US4948642A Multiple layer container for storage of high purity chemicals 失效
标题翻译：用于储存高纯度化学品的多层容器
公开(公告)号：US4948642A
公开(公告)日：1990-08-14
申请号：US362637
申请日：1989-05-23
申请人： David J. Shantz , Thomas A. Armer , David V. Olson
发明人： David J. Shantz , Thomas A. Armer , David V. Olson
IPC分类号： B32B27/08 , B65D1/02
CPC分类号： B65D1/0215 , B32B27/08 , Y10T428/1352 , Y10T428/31507 , Y10T428/3154 , Y10T428/31544 , Y10T428/31931
摘要： This invention relates generally to multiple-layered thermoplastic structures. More specifically, it is concerned with a hollow multiple-layered container, preferably formed by co-extruding or co-injecting a first chemically resistant and non-contaminating inner layer and a second structurally reinforcing outer layer into a blow mold, together with a third layer comprising a copolymer blend and functioning as a tie-layer to bond said first layer and said second layer. The hollow multiple-layered container is used for the storage of high purity and highly reactive chemicals.
摘要翻译：本发明一般涉及多层热塑性结构。更具体地，涉及一种中空多层容器，优选通过将第一耐化学腐蚀性和无污染性内层和第二结构增强外层共同挤出或共注入吹塑模具中而形成，层，其包含共聚物共混物并且用作粘合层以粘结所述第一层和所述第二层。中空多层容器用于储存高纯度和高反应性的化学品。

13. 发明授权

US08604035B2 Fluoroergoline analogs 有权
公开(公告)号：US08604035B2
公开(公告)日：2013-12-10
申请号：US13531371
申请日：2012-06-22
申请人： Robert O. Cook , Jian Zhang , Thomas A. Armer
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

14. 发明申请

US20110263492A1 METHOD TO GENERATE WATER SOLUBLE OR NONWATER SOLUBLE IN NANOPARTICULATES DIRECTLY IN SUSPENSION OF DISPERSION MEDIA 审中-公开
标题翻译：在分散介质悬浮液中直接生产纳米材料中的水溶性或非水溶性溶剂的方法
公开(公告)号：US20110263492A1
公开(公告)日：2011-10-27
申请号：US12907749
申请日：2010-10-19
申请人： Nahed M. Mohsen , Thomas A. Armer
发明人： Nahed M. Mohsen , Thomas A. Armer
IPC分类号： A61K38/28 , A61K31/4985 , A61K31/167 , A61P29/00 , A61P37/08 , A61P35/00 , A61P25/06 , A61P25/04 , A61P25/24 , A61P25/18 , A61P7/12 , A61P31/00 , B29B9/10 , A61K31/58 , B82Y5/00
CPC分类号： A61K9/008 , A61K9/14 , A61K31/48 , A61K31/573
摘要： A method for preparing a formulation containing nanoparticles of a compound is described. The method includes forming the compound into nanoparticles and then delivering the nanoparticles directly to a collection media. The collection media is a desired component of the formulation.
摘要翻译：描述了制备含有化合物纳米颗粒的制剂的方法。该方法包括将化合物形成纳米颗粒，然后将纳米颗粒直接递送至收集介质。收集介质是制剂的所需组分。

15. 发明申请

US20110082150A1 Headache pre-emption by dihydroergotamine treatment during headache Precursor events 审中-公开
标题翻译：头痛先兆子痫治疗头痛前兆事件
公开(公告)号：US20110082150A1
公开(公告)日：2011-04-07
申请号：US12592287
申请日：2009-11-19
申请人： Robert Owen Cook , Paul L. Durham , Shashidhar Kori , Thomas A. Armer
发明人： Robert Owen Cook , Paul L. Durham , Shashidhar Kori , Thomas A. Armer
IPC分类号： A61K31/4985 , A61P29/00 , A61P25/06
CPC分类号： A61K31/4985 , A61K9/007 , A61K9/0075 , A61K31/48
摘要： Disclosed are methods that address providing a subject experiencing, or who has experienced, a headache precursor event and administering dihydroergotamine, or a pharmaceutically acceptable salt or complex thereof, to the subject by oral inhalation, in an amount effective to pre-empt a subsequent headache in the subject. Also disclosed are compositions that are related to those methods.
摘要翻译：披露的方法是提供经历或经历头痛前体事件的受试者或通过口服吸入给予受试者的二氢麦角胺或其药学上可接受的盐或复合物的方法，其量有效预防随后的头痛在主题。还公开了与这些方法相关的组合物。

16. 发明申请

US20100183725A1 MULTIPLE ACTIVE PHARMACEUTICAL INGREDIENTS COMBINED IN DISCRETE INHALATION PARTICLES AND FORMULATIONS THEREOF 审中-公开
标题翻译：多种活性药物成分组合在分离的吸入颗粒中及其配方
公开(公告)号：US20100183725A1
公开(公告)日：2010-07-22
申请号：US11988913
申请日：2006-07-17
申请人： Nahed M. Mohsen , Thomas A. Armer , Robert O. Cook
发明人： Nahed M. Mohsen , Thomas A. Armer , Robert O. Cook
IPC分类号： A61K9/12 , A61K9/14 , A61K31/58
CPC分类号： A61K9/0073 , A61K31/167 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： The present disclosure describe inhalation particles where each discrete unagglomerated inhalation particle comprising 2 or more active pharmaceutical ingredients. In one embodiment, the inhalation particles comprise a first and a second API where the second API covers, at least partially, and protects the first API from degradation or instability. Inhalation particles comprising a first and a second API as described herein have many advantages over present means of delivering two or more APIs. Formulations comprising such inhalation particles are also described.
摘要翻译：本公开描述了吸入颗粒，其中每个离散的未聚集的吸入颗粒包含2种或更多种活性药物成分。在一个实施方案中，吸入颗粒包含第一和第二API，其中第二API至少部分地覆盖并保护第一API免于退化或不稳定。包含如本文所述的第一和第二API的吸入颗粒与递送两个或更多个API的现有手段相比具有许多优点。还描述了包含这种吸入颗粒的制剂。

17. 发明申请

US20090081297A1 Use of surface tension reducing agents in aerosol formulations 审中-公开
标题翻译：在气溶胶配方中使用表面张力降低剂
公开(公告)号：US20090081297A1
公开(公告)日：2009-03-26
申请号：US11412523
申请日：2006-04-27
申请人： Robert O. Cook , Thomas A. Armer
发明人： Robert O. Cook , Thomas A. Armer
IPC分类号： A61K9/14 , C07J5/00
CPC分类号： C07J5/00 , A61K9/0073 , A61K9/10 , A61K9/12 , A61K47/24 , A61K47/26
摘要： The present disclosure describes aerosol formulations that are particularly effective for pulmonary aerosol delivery. The aerosol formulations comprise an aqueous dispersion of active agent particles, said aqueous dispersion having an excess of a surface tension reducing agent. As a result of the reduced surface tension of the aqueous dispersion, the resulting aerosol droplets formed have a particle size less in one embodiment of than 10 microns in size or in an alternate embodiment of less than 6 microns in size. The present disclosure also provides for a method for forming an aerosol from said aerosol formulation, a method of treating a mammal in need of said treatment using said aerosol formulation, and a method of diagnosing a mammal in need of such diagnosis using said aerosol formulation.
摘要翻译：本公开描述了对肺部气雾剂递送特别有效的气雾剂制剂。气溶胶制剂包含活性剂颗粒的水分散体，所述水分散体具有过量的表面张力降低剂。由于水性分散体的表面张力降低，所形成的所得气溶胶微滴的尺寸在一个实施方案中的尺寸小于10微米，或在尺寸小于6微米的替代实施方案中具有较小的粒度。本公开还提供了用于从所述气溶胶制剂形成气溶胶的方法，使用所述气溶胶制剂治疗需要所述治疗的哺乳动物的方法，以及使用所述气溶胶制剂诊断需要进行诊断的哺乳动物的方法。

18. 发明授权

US4948641A Multiple layer container for storage of high purity chemicals 失效
公开(公告)号：US4948641A
公开(公告)日：1990-08-14
申请号：US448454
申请日：1989-12-11
申请人： David J. Shantz , Thomas A. Armer , David V. Olson
发明人： David J. Shantz , Thomas A. Armer , David V. Olson
IPC分类号： B32B27/08 , B65D1/02
CPC分类号： B65D1/0215 , B32B27/08 , Y10T428/1352 , Y10T428/24967 , Y10T428/31507 , Y10T428/3154 , Y10T428/31544 , Y10T428/31924 , Y10T428/31928
摘要： This invention relates generally to multiple-layered thermoplastic structures. More specifically, it is concerned with a hollow multiple-layered container, preferably formed by co-extruding or co-injecting a first chemically resistant and non-contaminating inner layer and a second structurally reinforcing outer layer into a blow mold, together with a third layer comprising a copolymer blend and functioning as a tie-layer to bond said first layer and said second layer. The hollow multiple-layered container is used for the storage of high purity and highly reactive chemicals.

19. 发明申请

US20110152280A1 NOVEL ERGOLINE ANALOGS 有权
标题翻译：新的胆固醇类似物
公开(公告)号：US20110152280A1
公开(公告)日：2011-06-23
申请号：US12978314
申请日：2010-12-23
申请人： ROBERT O. COOK , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
发明人： ROBERT O. COOK , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
IPC分类号： A61K31/4985 , C07D519/02 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/00 , A61P1/08 , A61P3/00
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are novel ergoline derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and or 5-HT1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了新的麦角灵衍生物及其药物组合物。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

20. 发明授权

US4871618A Laminar structures prepared with polyketone structural adhesives 失效
标题翻译：用聚酮结构粘合剂制备的层状结构
公开(公告)号：US4871618A
公开(公告)日：1989-10-03
申请号：US128972
申请日：1987-12-04
申请人： Peter A. Kinneberg , Thomas A. Armer
发明人： Peter A. Kinneberg , Thomas A. Armer
IPC分类号： C08G67/02 , C08J3/24 , C09J187/00
CPC分类号： C08J7/08 , C08G67/02 , C08J3/24 , C08J2373/00 , Y10T428/31692 , Y10T428/31938
摘要： A laminar structure consisting of a substrate and the structural adhesive consisting of:a linear alternating copolymer or interpolymer consisting of carbon monoxide and at least one ethylenically unsaturated hydrocarbon.
摘要翻译：由基材和结构粘合剂组成的层状结构体由以下组成：由一氧化碳和至少一种烯属不饱和烃组成的线性交替共聚物或互聚物。

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