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    • 12. 发明授权
    • Method of making catheters with porous structure for carrying agents
    • 制造带有多孔结构导管的导管的方法
    • US08703229B2
    • 2014-04-22
    • US12759249
    • 2010-04-13
    • Matt D. Pursley
    • Matt D. Pursley
    • A61L33/00B05D3/02A61M25/00B05D1/12B05D5/00
    • A61M25/0012B05D1/04B05D1/34B05D1/36B05D3/067B05D3/107B05D5/00
    • A method of making catheters is disclosed in which the wall of the catheter has a porous structure for carrying additional agents, such as therapeutic agents, diagnostic agents and/or device enhancements. The method includes applying a base polymer material and an inert material over the outer surface of a core, and curing or consolidating the base polymer material to form a catheter having a porous polymer layer with the inert material contained within the pores thereof. The inert material can be applied with the base polymer material or in a separate step after the base polymer material has been partially cured or consolidated to form the porous polymer layer. Additional agents can be mixed with the inert material before it is applied to the catheter, or can be applied to the porous polymer layer of the catheter in a separate step after the inert material is removed therefrom.
    • 公开了制造导管的方法,其中导管的壁具有用于承载附加试剂(例如治疗剂,诊断剂和/或装置增强)的多孔结构。 该方法包括在芯的外表面上施加基础聚合物材料和惰性材料,以及固化或固结基础聚合物材料以形成具有多孔聚合物层的导管,惰性材料包含在其孔内。 惰性材料可以与基础聚合物材料一起施用,或者在基础聚合物材料已经被部分固化或固化以形成多孔聚合物层之后的单独步骤中。 在将惰性材料施用于导管之前,可以将其它试剂与惰性材料混合,或者在惰性材料从其中除去之后,可以在单独的步骤中将其施加到导管的多孔聚合物层。
    • 13. 发明授权
    • Method and apparatus for curving a catheter
    • 用于弯曲导管的方法和装置
    • US08241267B2
    • 2012-08-14
    • US13019962
    • 2011-02-02
    • Matt D. Pursley
    • Matt D. Pursley
    • A61M25/00
    • A61M25/0152
    • An apparatus and method for curving a catheter after deployment include a catheter having a primary lumen, a secondary lumen, and a resilient fiber contained within the secondary lumen. The resilient fiber and the secondary lumen have corresponding, preformed curve shapes when the catheter is in a straight, unstressed condition. The resilient fiber is slidable within the secondary lumen to create a desired curve shape in the catheter as the curved portion of the resilient fiber slides into an originally straight portion of the secondary lumen. In another embodiment, the preformed curve shape of the resilient fiber is held in a straight condition within a stiff, marker ring segment of the catheter until after the catheter is deployed. Once deployed, the resilient fiber is slid out of the marker ring segment, and the preformed curve shape of the resilient fiber creates a corresponding curve shape in the catheter.
    • 用于在展开后弯曲导管的装置和方法包括具有主腔,辅管腔和包含在次腔内的弹性纤维的导管。 当导管处于直的不受应力状态时,弹性纤维和次内腔具有相应的预成型曲线形状。 当弹性纤维的弯曲部分滑入第二内腔的原始直线部分时,弹性纤维可以在次内腔内滑动以在导管中产生期望的曲线形状。 在另一个实施例中,将弹性纤维的预成形曲线形状保持在导管的刚性标记环段内的直线状态,直到导管部署之后。 一旦部署,弹性纤维从标记环段滑出,并且弹性纤维的预成型曲线形状在导管中产生相应的曲线形状。
    • 15. 发明授权
    • Method of making catheters with additives consolidated into polymer wall
    • 使用固定在聚合物壁上的添加剂制成导管的方法
    • US07776380B2
    • 2010-08-17
    • US11234514
    • 2005-09-22
    • Matt D. Pursley
    • Matt D. Pursley
    • A61M25/00B05D3/02B05D1/02B05D1/36
    • A61M25/0012A61M25/0009
    • A method of making catheters is disclosed in which various additives are consolidated into polymer walls of the catheters. The method includes providing a core, spraying a base polymer material over the outer surface of the core, spraying an additive material over or together with the base polymer material, and consolidating the additive material and the base polymer material together to form the catheter wall. The base polymer material and additive material are each applied as a fine particulate powder or solution of fine particulate, which can be sprayed over an outer surface of the core and the catheter wall as the catheter is formed. The additive material can be selected from several therapeutic agents, diagnostic agents, and/or polymers for modifying the base polymer materials. The additive material can be consolidated with the base polymer material throughout the polymer wall or primarily on the outer surface of the polymer wall.
    • 公开了制造导管的方法,其中各种添加剂被固结到导管的聚合物壁中。 该方法包括提供芯部,在基体聚合物材料的外表面上喷涂基础聚合物材料,在基体聚合物材料上或与基体聚合物材料一起喷涂添加剂材料,以及将添加剂材料和基础聚合物材料固结在一起以形成导管壁。 基础聚合物材料和添加剂材料各自作为细颗粒粉末或细颗粒溶液施用,其可以在形成导管时喷射在芯部和导管壁的外表面上。 添加剂材料可以选自用于改性基础聚合物材料的几种治疗剂,诊断剂和/或聚合物。 添加剂材料可以在整个聚合物壁上或主要在聚合物壁的外表面上与基础聚合物材料固结。
    • 16. 发明申请
    • METHOD AND APPARATUS FOR CURVING A CATHETER
    • 用于弯曲导管的方法和装置
    • US20090018528A1
    • 2009-01-15
    • US12237248
    • 2008-09-24
    • Matt D. Pursley
    • Matt D. Pursley
    • A61M25/01
    • A61M25/0152
    • An apparatus and method for curving a catheter after deployment include a catheter having a primary lumen, a secondary lumen, and a resilient fiber contained within the secondary lumen. The resilient fiber and the secondary lumen have corresponding, preformed curve shapes when the catheter is in a straight, unstressed condition. The resilient fiber is slidable within the secondary lumen to create a desired curve shape in the catheter as the curved portion of the resilient fiber slides into an originally straight portion of the secondary lumen. In another embodiment, the preformed curve shape of the resilient fiber is held in a straight condition within a stiff, marker ring segment of the catheter until after the catheter is deployed. Once deployed, the resilient fiber is slid out of the marker ring segment, and the preformed curve shape of the resilient fiber creates a corresponding curve shape in the catheter.
    • 用于在展开后弯曲导管的装置和方法包括具有主腔,辅管腔和包含在次腔内的弹性纤维的导管。 当导管处于直的不受应力状态时,弹性纤维和次内腔具有相应的预成型曲线形状。 当弹性纤维的弯曲部分滑入第二内腔的原始直线部分时,弹性纤维可以在次内腔内滑动以在导管中产生期望的曲线形状。 在另一个实施例中,将弹性纤维的预成型曲线形状保持在导管刚性的标记环段内的直线状态,直到导管部署之后。 一旦部署,弹性纤维从标记环段滑出,并且弹性纤维的预成型曲线形状在导管中产生相应的曲线形状。
    • 20. 发明授权
    • Catheters and method for nonextrusion manufacturing of catheters
    • 导尿管和非导管制造导管的方法
    • US6030371A
    • 2000-02-29
    • US918713
    • 1997-08-22
    • Matt D. Pursley
    • Matt D. Pursley
    • A61M25/00A61M25/16B05B13/04B05C3/12B05D1/00B05D1/06B05D1/10B05D1/12B05D1/34B05D3/02B05D7/20B23K26/08B29C53/68B29C53/80B29D23/00A61M25/092A61M25/095
    • A61M25/0012A61M25/0009B05D1/002B05D1/34B05D7/20B23K26/0823B29C53/8075B29D23/001A61M25/0043A61M25/005A61M25/0053B05B13/0442B05C3/12B05D1/06B05D1/10B05D1/12B05D2401/32B05D3/0218B29C2791/009B29C53/68B29L2031/7542
    • An apparatus and method for nonextrusion manufacturing of catheters that can be used to produce catheters having a simple or complex configuration. A polymer material in a particulate preform is applied in a layer over an outer surface of a core member. By applying the polymer material in a particulate preform, a composition of the polymer material can be varied continuously as it is being applied to provide a variable hardness over the length of the catheter. A fibrous reinforcement can be used having a constant or variable pitch and a constant or variable number of fibers and fiber types. Sensors can be easily placed in a wall of the catheter as the catheter is being fabricated, thereby allowing more sensors to be used without placing conductors in the lumen of the catheter. Deflection passages can be provided in a wall of the catheter for inserting a wire to deflect the catheter. The polymer material can be heated into molten form as it is being applied, or the core mandrel or liner can be heated to cause the polymer material to consolidate upon impact. A mandrel in the preferred embodiment is rotated about its longitudinal axis while a spray head and filament winding head traverse the length of the mandrel and apply polymer material and filament, respectively. Other arrangements can also be used, including a spray head and filament winding head that rotate about a continuous core mandrel, and a fluidized bed or other container into which a heated core mandrel is immersed. A plurality of mandrels can be placed side-by-side to form a multiple lumen tubing.
    • 可以用于制造具有简单或复杂构型的导管的导管非渗出制造的装置和方法。 颗粒状预制件中的聚合物材料被涂覆在芯构件的外表面上。 通过将聚合物材料应用于微粒预制件中,聚合物材料的组合物可随着其应用而连续变化,以在导管的长度上提供可变的硬度。 可以使用具有恒定或可变节距以及恒定或可变数量的纤维和纤维类型的纤维增强材料。 当制造导管时,传感器可以容易地放置在导管的壁中,从而允许使用更多的传感器而不将导体放置在导管的内腔中。 可以在导管的壁中设置偏转通道,用于插入导线以使导管偏转。 聚合物材料在被施加时可以被加热成熔融形式,或者可以加热芯心轴或衬里以使聚合物材料在冲击时固结。 优选实施例中的心轴围绕其纵向轴线旋转,同时喷头和细丝缠绕头横穿心轴的长度并分别施加聚合物材料和细丝。 还可以使用其它布置,包括围绕连续芯心旋转的喷头和细丝缠绕头,以及浸入加热芯心的流化床或其它容器。 多个心轴可以并排放置以形成多管腔管。