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11. 发明申请

US20050131363A1 Odor-reducing quinone compounds 有权
标题翻译：气味降低醌化合物
公开(公告)号：US20050131363A1
公开(公告)日：2005-06-16
申请号：US10955316
申请日：2004-09-30
申请人： John MacDonald , Stephanie Martin , Jaeho Kim
发明人： John MacDonald , Stephanie Martin , Jaeho Kim
IPC分类号： A23L1/00 , A23L1/22 , A23L1/236 , A61K9/00 , A61K9/14 , A61K9/51 , A61K9/70 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61K47/48 , A61Q5/10 , A61L9/01 , A61F13/15 , A61K31/12
CPC分类号： D06M13/005 , A23L27/32 , A23L27/77 , A23V2002/00 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61L9/01 , A61L9/014 , A61L15/46 , A61L2300/216 , A61L2300/442 , A61L2300/624 , D21H17/06 , D21H21/14 , D21H21/28 , Y10T442/2525 , A23V2200/25
摘要： An odor control composition that comprises an odor-reducing quinone compound and optionally high surface area particles is provided. In one embodiment, the odor-reducing quinone compound is an anthraquinone having the following structure: wherein the numbers 1 through 8 refer to optional substitution positions for functional groups. For example, positions 5 through 8 of the anthraquinone may be unsubstituted with functional groups. Examples of such quinone compounds may include those obtained from a dye selected from the group consisting of Acid Blue 25, Acid Green 41, Acid Blue 45, Mordant Violet 5, Acid Blue 129, Acid Green 25, D&C Green No. 5, Acid Green 27, and combinations thereof.
摘要翻译：提供了包含气味降低醌化合物和任选的高表面积颗粒的气味控制组合物。在一个实施方案中，气味降低醌化合物是具有以下结构的蒽醌：其中数字1至8表示官能团的任选取代位置。例如，蒽醌的5至8位可以被官能团取代。这样的醌化合物的实例可以包括从由酸性蓝25，酸性绿41，酸性蓝45，媒染紫5，酸性蓝129，酸性绿25，D＆C绿5，酸性绿 27及其组合。

12. 发明申请

US20100248299A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20100248299A1
公开(公告)日：2010-09-30
申请号：US12749814
申请日：2010-03-30
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

13. 发明授权

US07687245B2 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US07687245B2
公开(公告)日：2010-03-30
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/22
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

14. 发明申请

US20070249012A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20070249012A1
公开(公告)日：2007-10-25
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.
摘要翻译：溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜，机织和非织造织物，纸巾，共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。

15. 发明申请

US20070140971A1 Method for screening for bacterial conjunctivitis 有权
标题翻译：筛选细菌性结膜炎的方法
公开(公告)号：US20070140971A1
公开(公告)日：2007-06-21
申请号：US11303001
申请日：2005-12-15
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/14
摘要： A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.
摘要翻译：提供了一种快速检测宿主感染性结膜炎的方法。该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体（例如，Reichardt's染料）接触。本发明人已经发现，颜色变化的程度可以根据微生物是细菌还是病毒而变化。不期望受理论的限制，本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。相信这种相互作用在细菌中比在病毒中更大程度地发生。因此，虽然染色体在病毒存在的情况下仍可能发生颜色变化，但通常其程度要小得多。以这种方式，在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。

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