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    • 18. 发明授权
    • Piperidine derivative and pharmaceutical composition containing the same
    • 哌啶衍生物和含有其的药物组合物
    • US5179095A
    • 1993-01-12
    • US798963
    • 1991-11-26
    • Hitoshi OinumaMotosuke YamanakaKazutoshi MiyakeTomonori HoshikoNorio MinamiTadao ShojiYoshiharu DaikuKohei SawadaKenichi Nomoto
    • Hitoshi OinumaMotosuke YamanakaKazutoshi MiyakeTomonori HoshikoNorio MinamiTadao ShojiYoshiharu DaikuKohei SawadaKenichi Nomoto
    • C07D211/28C07D401/04C07D401/06C07D401/14C07D405/04C07D409/04C07D417/04C07D471/04C07D473/10
    • C07D401/04C07D211/28C07D401/06C07D401/14C07D405/04C07D409/04C07D417/04C07D471/04C07D473/10
    • A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sup.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, CH.sup.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,--(CH.sub.2)k--S--, k being an integer of 2 to 5, --(CH.sub.2)p--CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.
    • 新的哌啶化合物在治疗心律失常方面是药理学有效的,并由下式定义:其中R1是低级烷基或甲苯基,R2是氢,羟基,低级烷氧基或低级烷基,R3是氢 低级烷基,低级烯基,环烷基或环烷基烷基,X为-CO-,-CH 2 - 或-CHOH-,g为1〜3的整数,h为1〜3的整数,Y为氢 ,低级烷基,低级烯基,氰基,CH 2 COOR,R为氢或低级烷基,环烷基,环烷基烷基,A为1或2,-AB,A为 - (CH 2)n - ,n为 1至5的整数,具有1至5个碳原子的直链亚烷基,其是衍生自直接与一个或多个碳原子键合的低级烷基,苯基或羟基的直链烷烃的二价基团 通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃,具有1至5个碳原子的直链亚烷基,其是 通过除去与位于其两端的每个碳原子键合的氢原子,通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团, - (CH 2)k S - ,k为 2〜5的整数, - (CH 2)p -CO-,p为1〜4的整数,B为氰基,-NR 4 R 5,杂环或稠合芳环。