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11. 发明申请

US20100004559A1 BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译： BIOSENSOR CARTRIDGE，使用BIOSENSOR CARTRIDGE的方法，生物传感器设备和针式集成传感器
公开(公告)号：US20100004559A1
公开(公告)日：2010-01-07
申请号：US12519916
申请日：2007-12-17
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117
摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.
摘要翻译：一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作提供孔。当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

12. 发明申请

US20090299225A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090299225A1
公开(公告)日：2009-12-03
申请号：US12297387
申请日：2007-04-17
申请人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150511 , A61B5/150549 , A61B5/150717 , A61B5/15186
摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.
摘要翻译：提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作样品收集开口更靠近穿刺孔。当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集而不进行样品收集开口的定位。

13. 发明申请

US20080129280A1 Coupled Member Made of a Plurality of Sensor Chips and Manufacturing Method Thereof 审中-公开
标题翻译：传感器芯片制造的耦合构件及其制造方法
公开(公告)号：US20080129280A1
公开(公告)日：2008-06-05
申请号：US11795902
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： G01N27/327
CPC分类号： B82Y5/00 , G01N33/4875 , Y10T29/49002
摘要： A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed. More specifically, a method for manufacturing a coupled member made of the plurality of sensor chips is provided in which such sensor chips are coupled to each other under cuttable conditions, while each of these sensor chips includes: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer; a sensing member provided in the hollow reaction portion; an output terminal for outputting a signal sensed by the sensing member to the outside; and a sample introducing port for introducing a sample to the hollow reaction portion.
摘要翻译：由多个传感器芯片制成的耦合构件的特征在于相邻的传感器芯片在可切割的状态下彼此耦合; 相应的传感器芯片可以以更高的效率从耦合部件切割和分离; 并且即使在传感器芯片被分离之后，这些传感器芯片也可以容易且快速地存储在容器中; 此外，可以容易地检测传感器芯片，并且可以容易地去除故障芯片。更具体地说，提供了一种用于制造由多个传感器芯片制成的耦合构件的方法，其中这些传感器芯片在可切割的条件下彼此耦合，而这些传感器芯片中的每一个包括：基板; 覆盖层; 设置在所述基板和所述覆盖层之间的中空反应部; 设置在所述中空反应部中的检测部件; 输出端子，用于将由感测构件感测的信号输出到外部; 以及用于将样品引入中空反应部的样品引入口。

14. 发明授权

US08282813B2 Biosensor measurement machine, biosensor measurement system and biosensor measurement method 有权
标题翻译：生物传感器测量机，生物传感器测量系统和生物传感器测量方法
公开(公告)号：US08282813B2
公开(公告)日：2012-10-09
申请号：US11992102
申请日：2006-09-08
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： G01N27/416
CPC分类号： G01N27/3273
摘要： A biosensor measurement device for providing accurate measurement results within a short period of time by using only a very small amount of sample. The biosensor measurement device includes a power source, which is connected to a voltage regulator, a measurement instrument, and a controller for supplying power. When the biosensor chip is connected to the biosensor measurement device and a voltage is applied, the measurement instrument begins the measurement of a current value for the biosensor. When the measured current value or a measured charge value is greater than a reference value, the measurement is terminated in accordance with an instruction issued by the controller, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.
摘要翻译：一种生物传感器测量装置，其通过仅使用非常少量的样品在短时间内提供精确的测量结果。生物传感器测量装置包括连接到电压调节器的电源，测量仪器和用于供电的控制器。当生物传感器芯片连接到生物传感器测量装置并施加电压时，测量仪器开始测量生物传感器的当前值。当测量的电流值或测量的电荷值大于参考值时，根据控制器发出的指令来终止测量，并且当该值小于参考值时，根据a 控制器指令。

15. 发明申请

US20090255810A1 BIOSENSOR CHIP, BIOSENSOR SYSTEM AND MEASURING INSTRUMENT THEREOF 有权
标题翻译：生物传感器芯片，生物传感器系统及其测量仪器
公开(公告)号：US20090255810A1
公开(公告)日：2009-10-15
申请号：US12280721
申请日：2007-02-27
申请人： Moriyasu Ichino , Toshifumi Hosoya , Shingo Kaimori , Takahiko Kitamura
发明人： Moriyasu Ichino , Toshifumi Hosoya , Shingo Kaimori , Takahiko Kitamura
IPC分类号： C25B11/06 , G01N33/50
CPC分类号： G01N33/48785
摘要： In a biosensor system and its measuring instrument which determine that a biosensor chip has been inserted and measure biological information on a biological material supplied to the biosensor chip, the size of the biosensor chip is made small, the reliability of the measuring instrument is improved, and the product life becomes long. In addition, a measurement error of the biological information is suppressed in measuring the biological information by inserting a biosensor chip, which has a sensor electrode formed of an electrode member with an electric resistance value higher than a conductive metal, into the measuring instrument. An electrode portion provided in an insertion portion 5 of a measuring instrument 1 is configured such that a ground electrode 12 is used in both a sensor insertion determining circuit 14 and a blood sugar level measuring circuit 15. In addition, a first sensor electrode 21 of the biosensor chip 20 is configured to be shared by the sensor insertion determining circuit 14 and the blood sugar level measuring circuit 15. The biosensor chip includes: the first sensor electrode 21 provided to come in contact with an insertion determining circuit side connector electrode 13 when inserted into the insertion portion 5; a second sensor electrode 22 provided such that one end thereof comes in contact with a measuring circuit side connector electrode 13 and the other end is electrically connected to a reaction portion when inserted into the insertion portion 5; and a third sensor electrode 25 provided such that one end thereof comes in contact with the ground electrode 13 and the other end is electrically connected to the reaction portion 23 when inserted into the insertion portion 5. The first sensor electrode 21 is electrically connected to the reaction portion 23 through the third sensor electrode 25.
摘要翻译：在生物传感器系统及其测量仪器中，确定生物传感器芯片已被插入，并且测量生物传感器芯片上提供的生物材料上的生物信息，生物传感器芯片的尺寸变小，测量仪器的可靠性得到改善，产品寿命长。此外，通过将具有电阻值高于导电金属的电极部件形成的传感器电极的生物传感器芯片插入到测量仪器中来测量生物信息，抑制了生物信息的测量误差。设置在测量仪器1的插入部分5中的电极部分构造成使得接地电极12用于传感器插入确定电路14和血糖水平测量电路15中。此外，第一传感器电极21 生物传感器芯片20被配置为由传感器插入确定电路14和血糖水平测量电路15共享。生物传感器芯片包括：第一传感器电极21，设置成与插入确定电路侧连接器电极13接触，当第插入插入部5; 第二传感器电极22，其设置成使其一端与测量电路侧连接器电极13接触，另一端在插入插入部5时与反应部电连接; 以及第三传感器电极25，其设置成使其一端与接地电极13接触，另一端在插入插入部5时与反应部23电连接。第一传感器电极21电连接到反应部23通过第三传感器电极25。

16. 发明申请

US20080248457A1 Sensor Chip and Manufacturing Method Thereof 审中-公开
标题翻译：传感器芯片及其制造方法
公开(公告)号：US20080248457A1
公开(公告)日：2008-10-09
申请号：US11630475
申请日：2005-06-21
申请人： Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino , Isao Karube , Masao Gotoh , Hideaki Nakamura , Fumiyo Kurusu , Tomoko Ishikawa
发明人： Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino , Isao Karube , Masao Gotoh , Hideaki Nakamura , Fumiyo Kurusu , Tomoko Ishikawa
IPC分类号： C12Q1/00
CPC分类号： G01N27/26
摘要： Provided are a sensor chip and a manufacturing method of this sensor chip, that includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, and a hollow reaction section between the substrate and the cover layer, wherein warping due to changes in the environmental temperature and humidity does not occur.A sensor chip is provided including: a substrate; a cover layer; a spacer layer sandwiched between the substrate and the cover layer; a hollow reaction section provided between the substrate and the cover layer; and a detection section provided in the hollow reaction section, wherein the substrate and the cover layer are made of the same material and have the same thickness, and a material and a shape of the spacer layer are symmetrical with respect to a plane which is parallel to the substrate and located at equal distances from the substrate and from the cover layer, and a manufacturing method of the sensor chip is provided.
摘要翻译：提供了一种传感器芯片和该传感器芯片的制造方法，其包括基板，覆盖层，夹在基板和覆盖层之间的间隔层，以及基板和覆盖层之间的中空反应部，其中翘曲由于环境温度和湿度的变化不会发生。提供一种传感器芯片，包括：基板; 覆盖层; 夹在基板和覆盖层之间的间隔层; 设置在所述基板和所述覆盖层之间的中空反应部; 以及设置在所述中空反应部中的检测部，其中所述基板和所述覆盖层由相同的材料制成并且具有相同的厚度，并且所述间隔层的材料和形状相对于平行的平面对称并且设置在距离基板和覆盖层相等的距离处，并且提供了传感器芯片的制造方法。

17. 发明申请

US20050151253A1 Bonding wire and an integrated circuit device using the same 审中-公开
标题翻译：接合线和使用其的集成电路器件
公开(公告)号：US20050151253A1
公开(公告)日：2005-07-14
申请号：US10508052
申请日：2003-03-24
申请人： Tsuyoshi Nonaka , Masanori Ioka , Shingo Kaimori , Masato Fukagaya
发明人： Tsuyoshi Nonaka , Masanori Ioka , Shingo Kaimori , Masato Fukagaya
IPC分类号： H01L23/49 , H01L23/48
CPC分类号： H01L24/45 , H01L24/43 , H01L2224/4321 , H01L2224/43825 , H01L2224/43848 , H01L2224/45015 , H01L2224/45144 , H01L2224/45147 , H01L2224/45565 , H01L2224/45572 , H01L2224/45611 , H01L2224/45618 , H01L2224/45623 , H01L2224/45624 , H01L2224/45639 , H01L2224/45644 , H01L2224/45655 , H01L2224/45657 , H01L2224/4566 , H01L2224/45664 , H01L2224/45666 , H01L2224/45669 , H01L2224/4567 , H01L2224/45671 , H01L2224/45673 , H01L2224/45676 , H01L2224/45678 , H01L2224/45683 , H01L2924/00011 , H01L2924/00014 , H01L2924/01204 , H01L2924/014 , H01L2924/14 , H01L2924/15787 , H01L2924/19043 , H01L2924/20751 , H01L2924/20752 , H01L2924/20753 , H01L2924/20754 , H01L2924/01016 , H01L2924/01004 , H01L2924/01047 , H01L2924/0104 , H01L2924/01008 , H01L2924/01026 , H01L2924/0105 , H01L2924/01024 , H01L2924/0103 , H01L2924/01001 , H01L2924/00015 , H01L2224/48 , H01L2924/00 , H01L2924/01006
摘要： A bonding wire comprising a core mainly consisting of copper, a different metal layer formed of a metal other than copper and formed on the core, and a coating layer formed of an oxidation-resistant metal having a melting point higher than that of copper and formed on the different metal layer, from which balls having the shape of a true sphere in a wide ball diameter range can be formed stably, which can be produced without causing the deterioration of a plating solution at the time of plating, and in which the adhesiveness between the coating layer and the core thereof is excellent; and an integrated circuit device using the bonding wire are provided.
摘要翻译：一种接合线，包括主要由铜组成的芯，由铜以外的金属形成的不同的金属层，形成在芯上，以及由熔点高于铜形成的抗氧化金属形成的涂层，形成在不同的金属层上，可以稳定地形成具有宽球直径范围内的真球形状的球，其可以在不导致镀覆时的电镀液的劣化的情况下制造，并且其中的粘附性涂层和其核心之间是优异的; 并提供使用接合线的集成电路器件。

18. 发明申请

US20100228149A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20100228149A1
公开(公告)日：2010-09-09
申请号：US12528660
申请日：2008-02-25
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2562/0295
摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.
摘要翻译：传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件传感器芯片，刺针针固定到该传感器芯片上。传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧）在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

19. 发明申请

US20100069792A1 BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, SAMPLE COLLECTING METHOD, MANUFACTURING METHOD OF BIOSENSOR CARTRIDGE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译：生物传感器盒，生物传感器装置，样品采集方法，生物传感器盒的制造方法和针状集成传感器
公开(公告)号：US20100069792A1
公开(公告)日：2010-03-18
申请号：US12513458
申请日：2007-11-01
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151 , H01R43/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B2562/0295 , Y10T29/49002
摘要： A biosensor cartridge capable of performing puncturing in an exact position, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When tip portion 11a of biosensor chip body 11 is pushed against a subject M, elastic body 20 protruding from a tip portion 11a of biosensor chip body 11 is compressed, and puncturing tool 12 for puncturing protrudes. Thus, the subject M can be punctured. Additionally, if a pushing force is weakened, puncturing tool 12 is extracted from the subject M by the restoring force of elastic body 20, and the sample R flows out of the puncture hole. Additionally, cover member 19 is provided around biosensor chip body 11. Thus, when puncturing is performed by thin plate-shaped biosensor cartridge 10, biosensor chip body 11 can be prevented from deforming, and puncturing can be accurately performed in a desired puncturing position.
摘要翻译：本发明提供一种生物传感器盒，其能够在精确位置进行穿刺，并且容易地收集和测量穿刺孔的样本，而不需要使样本收集开口靠近穿刺孔的操作。当生物传感器芯体11的尖端部分11a被压靠在被检体M上时，从生物传感器芯体11的尖端部分11a突出的弹性体20被压缩，并且用于穿刺的穿刺工具12突出。因此，可以对被检体M进行穿刺。此外，如果推力减弱，则通过弹性体20的恢复力从被检体M取出穿刺工具12，并且样本R流出穿刺孔。另外，盖体19设置在生物传感器芯体11周围。因此，当通过薄板状生物传感器盒10进行穿刺时，可以防止生物传感器芯体11变形，并且可以在期望的穿刺位置精确地进行穿刺。

20. 发明申请

US20090257917A1 Sensor Chip and Sensor Chip Production Method 审中-公开
标题翻译：传感器芯片和传感器芯片生产方法
公开(公告)号：US20090257917A1
公开(公告)日：2009-10-15
申请号：US12083694
申请日：2006-10-16
申请人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
发明人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
IPC分类号： B01J19/00 , B32B37/00
CPC分类号： G01N27/3271 , Y10T156/1051
摘要： It is intended to provide a sensor chip which has a small size and is easily produced and capable of determining quantities of at least two components of multiple samples rapidly, conveniently, and correctly as well as to provide a production method capable of producing the sensor chip easily and with high productivity.A sensor chip includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, multiple reaction portions disposed between the substrate and the cover layer, multiple detection units exposed in the hollow reaction portions, and a sample inlet communicated with the hollow reaction portions and a method for producing the sensor chip.A sensor chip includes two substrates opposed to each other, a spacer layer sandwiched between the substrates, and multiple measurement units disposed between the substrates and including two or more hollow reaction portions that share one sample inlet opened on outer surfaces of the substrates and detection electrode units respectively exposed in the hollow reaction portions and a method for producing the sensor chip.
摘要翻译：本发明旨在提供一种具有体积小且容易制造且能够快速，方便和正确地确定多个样品的至少两个组分的量的传感器芯片，以及提供能够生产传感器芯片的制造方法容易和高生产力。传感器芯片包括衬底，覆盖层，夹在衬底和覆盖层之间的间隔层，设置在衬底和覆盖层之间的多个反应部分，暴露在中空反应部分中的多个检测单元和连通的样品入口中空反应部分和传感器芯片的制造方法。传感器芯片包括彼此相对的两个基板，夹在基板之间的间隔层和设置在基板之间的多个测量单元，并且包括两个或更多个中空反应部分，其共享在基板的外表面上开放的一个样品入口和检测电极分别暴露在中空反应部分中的单元和传感器芯片的制造方法。

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