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11. 发明申请

US20210330770A1 Use of Car and Bite Technology Coupled with an SCFV from an Antibody Against Human Thymidine Kinase 1 to Specifically Target Tumors 有权
公开(公告)号：US20210330770A1
公开(公告)日：2021-10-28
申请号：US17366708
申请日：2021-07-02
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： A61K39/00 , C07K16/46 , C07K16/28 , C07K16/40 , C07K14/725 , A61P35/00
摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

12. 发明授权

US11052138B2 Use of car and bite technology coupled with an SCFV from an antibody against human thymidine kinase 1 to specifically target tumors 有权
公开(公告)号：US11052138B2
公开(公告)日：2021-07-06
申请号：US16122564
申请日：2018-09-05
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： A61K39/00 , C07K16/28 , C07K16/40 , C07K16/46 , C07K14/725 , A61P35/00
摘要： A nucleic acid encoding a chimeric antigen receptor (CAR) comprising a single-chain variable fragment (scFv) operatively linked to a signaling domain that polarizes a macrophage to an M1 macrophage; wherein the nucleic acid is operatively linked to a macrophage specific promoter; and wherein the scFv is specific for a human antigen. Monocytes or macrophages comprising such a nucleic acid.

13. 发明授权

US10828355B2 Use of car and bite technology coupled with an ScFv from an antibody against human thymidine kinase 1 to specifically target tumors 有权
公开(公告)号：US10828355B2
公开(公告)日：2020-11-10
申请号：US16122563
申请日：2018-09-05
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： A47J31/18 , A61K39/00 , C07K16/28 , C07K16/40 , C07K16/46 , C07K14/725 , A61P35/00
摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

14. 发明授权

US10821162B2 Use of car and bite technology coupled with an SCFV from an antibody against human thymidine kinase 1 to specifically target tumors 有权
公开(公告)号：US10821162B2
公开(公告)日：2020-11-03
申请号：US16122557
申请日：2018-09-05
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： A61K39/00 , C07K16/28 , C07K16/40 , C07K16/46 , C07K14/725 , A61P35/00
摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

15. 发明申请

US20190070277A1 Use of Car and Bite Technology Coupled with an SCFV from an Antibody Against Human Thymidine Kinase 1 to Specifically Target Tumors 审中-公开
公开(公告)号：US20190070277A1
公开(公告)日：2019-03-07
申请号：US16122564
申请日：2018-09-05
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： A61K39/00 , C07K16/46 , C07K16/28 , C07K16/40
摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

16. 发明申请

US20170166657A1 Macrophage CAR (MOTO-CAR) In Immunotherapy 审中-公开
公开(公告)号：US20170166657A1
公开(公告)日：2017-06-15
申请号：US15358395
申请日：2016-11-22
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： C07K16/40 , C07K14/57 , C07K16/30 , C07K16/18 , C12N5/0786 , A61K35/15 , C07K14/705 , C07K16/28
CPC分类号： C07K16/40 , A61K35/15 , A61K38/00 , A61K2039/505 , C07K14/57 , C07K14/705 , C07K14/70503 , C07K16/18 , C07K16/2866 , C07K16/30 , C07K2317/31 , C07K2317/622 , C07K2319/74 , C12N5/0645 , C12N2510/00 , C12Y204/02008 , C12Y207/01021
摘要： Modified macrophage immune cells are provided for treatment of cancer and other diseases.

17. 发明申请

US20150302245A1 ADJUSTING DIFFERENT AREAS OF A PAYMENT INSTRUMENT IMAGE INDEPENDENTLY 有权
标题翻译：独立调整付款仪器图像的不同领域
公开(公告)号：US20150302245A1
公开(公告)日：2015-10-22
申请号：US14256471
申请日：2014-04-18
申请人： Scott Weber , Rian Maloney
发明人： Scott Weber , Rian Maloney
IPC分类号： G06K9/00 , G06Q20/04
CPC分类号： G06K9/00463 , G06K9/2081 , G06Q20/042 , G06Q20/0425 , H04N1/44
摘要： The present disclosure involves systems, software, and computer-implemented methods for allowing independent adjustment for different areas of a payment instrument image. An example method includes receiving an original payment instrument image associated with a tangible payment instrument; creating a clearing payment instrument image based on the original payment instrument image associated with a first contrast value; presenting the clearing payment instrument image in a user interface in response to creating the clearing payment instrument image; in response to presenting the clearing payment instrument image: receiving an indication of an area of the clearing payment instrument image from the user interface; receiving an indication of a second contrast value to which to update the indicated area from the user interface; and updating a contrast value of the indicated area of the clearing payment instrument image to the second contrast value.
摘要翻译：本公开涉及用于允许对支付工具图像的不同区域进行独立调整的系统，软件和计算机实现的方法。示例性方法包括接收与有形支付工具相关联的原始支付工具图像; 基于与第一对比度值相关联的原始支付工具图像来创建清算支付工具图像; 响应于创建清算支付工具图像，在用户界面中呈现清算支付工具图像; 响应于提供清算支付工具图像：从用户界面接收清算支付工具图像的区域的指示; 从所述用户界面接收用于更新所述指示区域的第二对比度值的指示; 以及将清算支付工具图像的指示区域的对比度值更新为第二对比度值。

18. 发明申请

US20070166750A1 Compositions and Methods for Nucleic Acid Extraction from Biological Samples 审中-公开
公开(公告)号：US20070166750A1
公开(公告)日：2007-07-19
申请号：US11687960
申请日：2007-03-19
申请人： Scott Weber , Derek Douglas , Carol Kreader
发明人： Scott Weber , Derek Douglas , Carol Kreader
IPC分类号： C12Q1/68 , C12N1/08
CPC分类号： C12N15/1003
摘要： Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue samples and at elevated temperatures for certain plant tissues.

19. 发明申请

US20060206522A1 Electronic calendar systems and methods 审中-公开
标题翻译：电子日历系统和方法
公开(公告)号：US20060206522A1
公开(公告)日：2006-09-14
申请号：US11078064
申请日：2005-03-11
申请人： Paul Austin , Scott Weber
发明人： Paul Austin , Scott Weber
IPC分类号： G06F17/00
CPC分类号： G06Q10/109
摘要： Embodiments herein use a centralized calendar database to store calendar entries for a plurality of entities. Each of the entities has a computing device separate from the centralized calendar database, and each of the computing devices has a graphic user interface. In addition, multiple calendar processors are utilized. Each calendar processor operates within an associated computing device, and each calendar processor is in communication with the centralized calendar database. The calendar processors generate a continuously updated calendar display on a corresponding graphic user interface. The actual calendar entries are stored only in the centralized calendar database, and the calendar entries are not stored locally within the computing device.
摘要翻译：本文的实施例使用集中日历数据库来存储多个实体的日历条目。每个实体具有与集中日历数据库分离的计算设备，并且每个计算设备具有图形用户界面。另外，使用多个日历处理器。每个日历处理器在相关联的计算设备内操作，并且每个日历处理器与集中日历数据库通信。日历处理器在相应的图形用户界面上生成不断更新的日历显示。实际的日历条目仅存储在集中式日历数据库中，并且日历条目不会本地存储在计算设备中。

20. 发明授权

US10434153B1 Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors 有权
公开(公告)号：US10434153B1
公开(公告)日：2019-10-08
申请号：US15161045
申请日：2016-05-20
申请人： Kim Leslie O'Neill , Scott Weber
发明人： Kim Leslie O'Neill , Scott Weber
IPC分类号： C07K16/46 , A61K35/17 , C07K16/28 , A61K39/00 , C07K16/40
摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

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