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11. 发明申请

US20060184092A1 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
公开(公告)号：US20060184092A1
公开(公告)日：2006-08-17
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

12. 发明授权

US08703168B2 Medical devices for releasing therapeutic agent and methods of making the same 有权
标题翻译：用于释放治疗剂的医疗装置及其制造方法
公开(公告)号：US08703168B2
公开(公告)日：2014-04-22
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

13. 发明授权

US08152759B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US08152759B2
公开(公告)日：2012-04-10
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

14. 发明授权

US08070718B2 Medical devices formed with a sacrificial structure and processes of forming the same 有权
标题翻译：用牺牲结构形成的医疗器械及其形成方法
公开(公告)号：US08070718B2
公开(公告)日：2011-12-06
申请号：US11010810
申请日：2004-12-13
申请人： Jan Weber , Scott Schewe , Thomas J. Holman
发明人： Jan Weber , Scott Schewe , Thomas J. Holman
IPC分类号： A61M29/00 , B29C33/40
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/0045 , A61M25/1036 , A61M25/104 , A61M2025/1075 , A61M2025/1086
摘要： Medical devices formed using a sacrificial structure, and processes of forming the devices therefrom.
摘要翻译：使用牺牲结构形成的医疗器械，以及由其形成器件的工艺。

15. 发明申请

US20110251653A1 IMPLANTABLE ELECTRODES CONTAINING POLYOXOMETALATE ANIONS AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：含有聚羟基乙酸酯阴离子的可植入电极及其制造和使用方法
公开(公告)号：US20110251653A1
公开(公告)日：2011-10-13
申请号：US13166528
申请日：2011-06-22
申请人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
发明人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/372 , A61N1/05 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/37205
摘要： An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode.
摘要翻译：可植入装置包括至少一个电极，其包括设置在导电基底上或内部的导电基底和多金属氧酸盐阴离子; 以及至少一个连接到所述至少一个电极的导体，用于将电能传导到所述至少一个电极。

16. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

17. 发明申请

US20070244501A1 Medical balloons 审中-公开
标题翻译：医用气球
公开(公告)号：US20070244501A1
公开(公告)日：2007-10-18
申请号：US11406022
申请日：2006-04-18
申请人： Daniel Horn , John Jianhua Chen , John Blix , Jan Weber , Angela Volk , Richard Gunderson , Daniel Tomaschko , Scott Schewe
发明人： Daniel Horn , John Jianhua Chen , John Blix , Jan Weber , Angela Volk , Richard Gunderson , Daniel Tomaschko , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61L29/085 , A61L29/123 , A61L29/126 , A61M25/1029 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088
摘要： Described herein are medical balloons which contain one or more material regions that are configured to cause the balloons to preferentially fold into predetermined orientations upon deflation.
摘要翻译：这里描述的是包含一个或多个材料区域的医疗气囊，其被构造成使得气囊在放气时优先折叠成预定取向。

18. 发明申请

US20060182873A1 Medical devices 审中-公开
标题翻译：医疗设备
公开(公告)号：US20060182873A1
公开(公告)日：2006-08-17
申请号：US11060151
申请日：2005-02-17
申请人： Leo Klisch , Jan Weber , Thomas Holman , Scott Schewe , Afsar Ali , Richard Noddin , James Shippy , Karl Jagger , Jan Seppala
发明人： Leo Klisch , Jan Weber , Thomas Holman , Scott Schewe , Afsar Ali , Richard Noddin , James Shippy , Karl Jagger , Jan Seppala
IPC分类号： A61L33/00
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/10 , A61M25/1029 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088
摘要： Medical devices, for example, those that have balloons, and methods of making the devices are described. In some embodiments, a method includes providing a medical balloon having a first cone portion and a body portion, and removing material from an outer surface the body portion of the balloon such that the balloon includes a first region and a second region, the first region being recessed relative to the second region.
摘要翻译：描述了医疗设备，例如具有气球的设备，以及制造设备的方法。在一些实施例中，一种方法包括提供具有第一锥形部分和主体部分的医疗气囊，以及从球囊的主体部分的外表面移除材料，使得球囊包括第一区域和第二区域，第一区域相对于第二区域凹进。

19. 发明申请

US20050228428A1 Balloon catheters and methods for manufacturing balloons for balloon catheters 审中-公开
标题翻译：球囊导管及球囊导管球囊的制造方法
公开(公告)号：US20050228428A1
公开(公告)日：2005-10-13
申请号：US10819469
申请日：2004-04-07
申请人： Afsar Ali , Daniel Horn , Jan Weber , Scott Schewe
发明人： Afsar Ali , Daniel Horn , Jan Weber , Scott Schewe
IPC分类号： A61F2/958 , A61M25/00 , B29C35/08 , B29C49/00 , B29C49/14 , B29C55/00 , A61M29/00 , B29C49/64
CPC分类号： A61M25/1027 , A61M2025/1063 , B29C49/00 , B29C2035/0838 , B29C2035/0855 , B29C2049/0089 , B29C2791/001 , B29C2791/009 , B29K2105/258 , B29L2031/7542
摘要： Catheters, balloons, and methods of manufacturing balloons for balloon catheters using lasers are disclosed. A catheter with a shaft sized for use with a 0.014 inch guide wire includes a polymeric balloon having a body portion with an inflated outer diameter of more than 6 millimeters. An inflatable balloon includes an inflated outer diameter to inner waist diameter ratio of 12.5 to 1. An inflatable polymeric balloon that has a body portion with two regions that have different molecular orientations is also provided. A method of processing an elongate polymeric material includes heating a portion of the polymeric material with a laser while longitudinally stretching the portion of the polymeric material. A method of manufacturing a balloon includes heating and longitudinally stretching a first and second portion of an elongate polymeric tube to form first and second end portion. The remaining body portion is radially expanded to form the balloon.
摘要翻译：公开了使用激光器的球囊导管制造气球的导管，球囊和方法。具有尺寸与0.014英寸导丝一起使用的轴的导管包括具有膨胀外径大于6毫米的主体部分的聚合物球囊。可充气气囊包括膨胀的外径至内腰直径比为12.5:1。还提供具有主体部分的充气聚合球囊，其具有不同分子取向的两个区域。处理细长聚合材料的方法包括在纵向拉伸聚合材料的一部分的同时用激光加热聚合材料的一部分。制造球囊的方法包括加热并纵向拉伸细长聚合物管的第一和第二部分以形成第一和第二端部。剩余的主体部分被径向扩张以形成气球。

20. 发明授权

US09364678B2 Implantable electrodes containing polyoxometalate anions and methods of manufacture and use 有权
标题翻译：含有多金属氧酸盐阴离子的可植入电极及其制造和使用方法
公开(公告)号：US09364678B2
公开(公告)日：2016-06-14
申请号：US13166528
申请日：2011-06-22
申请人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
发明人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
IPC分类号： A61N1/372 , A61N1/05 , A61N1/36
CPC分类号： A61N1/372 , A61N1/05 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/37205
摘要： An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode.
摘要翻译：可植入装置包括至少一个电极，其包括设置在导电基底上或内部的导电基底和多金属氧酸盐阴离子; 以及至少一个连接到所述至少一个电极的导体，用于将电能传导到所述至少一个电极。

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